Article
Materials Science, Multidisciplinary
Sara Saber Younes Mohamed, Alberto Gambino, Mauro Banchero, Silvia Ronchetti, Luigi Manna, Roberta Cavalli, Barbara Onida
Summary: The aim of this study was to develop a hemostat based on mesoporous silica particles for bleeding control. The synthesized mesoporous silica microspheres loaded with tranexamic acid showed promising hemostatic activity and blood compatibility. In vitro release tests demonstrated the complete release of tranexamic acid from the carrier within one hour. This material can be considered as a potential candidate for the development of new hemostats.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Mai El Halawany, Randa Latif, Mohamed H. H. AbouGhaly
Summary: Wound control in patients on anticoagulants can be challenging. The study developed alginate/nano-hydroxyapatite aerogels loaded with tranexamic acid, which showed a significant reduction in clotting time and recalcification time. The aerogels demonstrated a porous structure and the ability to activate and adhere platelets. However, the TXA aerogel caused a delay in wound healing compared to the control sample.
Article
Engineering, Chemical
Maria Carolina Fernandes dos Santos, Luiza Peixoto dos Santos Cavalcante, Karlivania Ferreira de Andrade, Alan Frazao da Silva, Isis de Araujo Ferreira Muniz, Jefferson Muniz de Lima, Rebeca Tibau Aguiar, Josean Fechine Tavares, Lucio Roberto Cancado Castellano, Sabrina Daniela da Silva, Paulo Rogerio Ferreti Bonan
Summary: This study synthesized chitosan sponges with hemostatic ability and used polycaprolactone nanoparticles to deliver tranexamic acid. The sponges exhibited stability and porosity, allowing complete hemagglutination and significant reduction in clotting time.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Engineering, Chemical
Sara Darakhshan, Farjam Goudarzi, Sattar Mirzaie, Afshin Karami, Amir Kiani
Summary: The purpose of this study was to prepare and evaluate a hemostatic polyurethane sponge containing kaolin, tannic acid, and tranexamic acid. The K4TA3 sponge showed the best hemostatic effect, and it exhibited no cytotoxicity and had antibacterial activity. In the rat-tail amputation model, the K4TA3 sponge demonstrated excellent hemostatic capability. Overall, this study successfully developed a simple and efficient polyurethane hemostatic sponge that acts via multiple clotting mechanisms.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Mary E. Law, Bradley J. Davis, Amanda F. Ghilardi, Elham Yaaghubi, Zaafir M. Dulloo, Mengxiong Wang, Olga A. Guryanova, Coy D. Heldermon, Stephan C. Jahn, Ronald K. Castellano, Brian K. Law
Summary: Tranexamic Acid (TA) is not only an antifibrinolytic agent but also exhibits anticancer activity by blocking extracellular Plasmin formation. It reduces the viability of various cancer cell lines and inhibits tumor growth in vivo. In addition to blocking extracellular Plasmin production, it perturbs intracellular signaling pathways, inhibits protein synthesis, reduces activating phosphorylation of certain proteins, decreases expression of MYC oncoprotein, and suppresses Lys acetylation. It also inhibits the uptake of Lys and Arg by cancer cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xinhong Zhao, Yunbo Sun, Zhiyun Meng, Zhiyuan Yang, Shan Fan, Tong Ye, Lei Yang, Tong Li, Ruolan Gu, Zhuona Wu, Hui Gan, Guifang Dou, Yongxiu Qi, Shuchen Liu
Summary: The study demonstrates that TAMPS, a novel hemostatic material, has better hemostatic effects compared to the traditional Quickclean. TAMPS can promote coagulation through mechanisms such as rapid fluid absorption and high erythrocyte aggregation capacity. Additionally, TAMPS is safe, non-toxic, and has good blood compatibility, making it a promising hemostatic material for future clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Isabelle Denry, Jean-Marie Nedelec, Julie A. Holloway
Summary: The study focused on investigating the physical properties, loading capacity, and hemostatic efficacy of newly developed nanoclay microsphere frameworks loaded with tranexamic acid. Results showed successful incorporation of TA into the nanoclay structure, leading to improved clot stiffness and thinner fibrin fibers, ultimately enhancing coagulation control.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Hematology
Stephanie Roullet, Timothee Rivoire, Clemence Houssin, Sylvie Labrouche, Sandrine Paquin, Karine Nouette-Gaulain, Catherine Deneux-Tharaux, Jean Amiral, Chloe James, Loic Sentilhes
Summary: This study aimed to assess the effect of TXA in preventing PPH following cesarean delivery. The results showed that fibrinolysis activation is an important factor in postpartum hemorrhage, and TXA has a significant antifibrinolytic effect compared to placebo.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Obstetrics & Gynecology
Helen C. Okoye, Maha Othman, Theresa U. Nwagha, Daniel N. Onwusulu, Robinson C. Onoh, Chibuike O. Chigbu
Summary: This study evaluated the hemostatic effects of tranexamic acid (TXA) ex vivo in women with pre-eclampsia. The results showed that TXA did not significantly affect the levels of D-dimer and plasmin-antiplasmin complex (PAP) in pre-eclampsia patients, suggesting that TXA may not increase the thrombotic risks in these patients.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Chemistry, Physical
E. Skwarek, W. Janusz
Summary: This study investigated the adsorption of malonic acid at the hydroxyapatite/aqueous NaCl solution interface by measuring adsorption/desorption kinetics and the relationship between adsorption and pH. The adsorption of malonate ions was determined using 14C-labeled malonic acid to measure the loss of ion concentration in solution. The adsorption measurements were further supported by electrophoretic zeta potential and FTIR measurements. The kinetics of adsorption proceeded in three stages, with a rapid increase in adsorption observed in the last stage, indicating the precipitation of a new phase by the malonate ions.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Materials Science, Ceramics
Reka Barabas, Noemi-Izabella Farkas, Csaba Levente Nagy, Oana Cadar, Corina Moisa, Liliana Bizo
Summary: The study showed that various additives had limited impact on improving drug adsorption, and density functional theory evaluated the interactions of nano-Hap-based NCs. In desorption experiments, functionalized multiwall carbon nanotubes and graphene oxide had positive effects on anti-inflammatory drugs, while gelatin increased the adsorption capacity of NCs.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Ceramics
Yue Hu, Degeng Xia, Huizhen Shen, Jinxuan Nan, Ning Ma, Zuoxing Guo, Xiaolong Wang, Quan Jin
Summary: Hydroxyapatite is commonly used as a bone substitute material, but its brittleness and low fatigue strength make it challenging to meet the long-term requirements of implants. This study developed a drug-loaded hydroxyapatite-polylactic acid composite through cold sintering process at 80 degrees Celsius, which achieved high densification, improved mechanical properties, and in-situ drug loading capability.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Environmental
Ruifeng Li, Yongqiang Liu, Guihong Lan, Haiyan Qiu, Bo Xu, Qianxia Xu, Ningyan Sun, Lihui Zhang
Summary: Adding graphene oxide into Fe3O4 improved the acid resistance of PMGO, leading to increased surface area, decreased pore size, and enhanced adsorption capacity under acidic conditions. PMGO maintained good adsorption performance after 5 cycles of reuse, showing promising potential for application in acidic wastewater treatment in the mining industry.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Materials Science, Ceramics
Dilay Sezer, Emir Zafer Hosgun
Summary: Drug delivery systems aim to reduce dosage, extend dosing intervals, eliminate side effects, and ensure controlled and effective drug delivery to target tissues. Hydroxyapatite (HAP), a biocompatible and bioactive material similar to human bone mineral components, was investigated as an adsorbent for acetylsalicylic acid (ASA) in this study. The HAP was synthesized using a chemical precipitation method and modified with different templates. Characterization techniques such as XRD, BET, FT-IR, TGA, and SEM were utilized. The Langmuir isotherm best represented the equilibrium adsorption isotherms and kinetics of ASA-HAP adsorption. The results suggest that HAP can serve as a suitable carrier for the adsorption and controlled release of ASA, with improved adsorption capacity and more controlled release profile when modified with CTAB as a template.
JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
(2023)
Article
Engineering, Environmental
Ahmad Mahmoodzadeh, Jafarsadegh Moghaddas, Seyedhosein Jarolmasjed, Abbas Ebrahimi Kalan, Mahdi Edalati, Roya Salehi
Summary: The developed superabsorbent material NDS shows excellent potential in controlling massive bleeding, with rapid absorption of blood components and strong adhesion to damaged tissue, outperforming commercial hemostatic powders. In vivo studies demonstrate its biodegradability and lack of adverse effects on liver, renal tissues, and blood parameters, supporting its potential for future clinical trials.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Spectroscopy
A. Cousin, V Sautter, C. Fabre, G. Dromart, G. Montagnac, C. Drouet, P. Y. Meslin, O. Gasnault, O. Beyssac, S. Bernard, E. Cloutis, O. Forni, P. Beck, T. Fouchet, J. R. Johnson, J. Lasue, A. M. Ollila, P. De Parseval, S. Gouy, B. Caron, J. M. Madariaga, G. Arana, M. Bo Madsen, J. Laserna, J. Moros, J. A. Manrique, G. Lopez-Reyes, F. Rull, S. Maurice, R. C. Wiens
Summary: This article acknowledges the assistance and support from various institutions and individuals in sample preparation, machining, and observations.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
J. M. Madariaga, J. Aramendia, G. Arana, K. Castro, L. Gomez-Nubla, S. Fdez-Ortiz de Vallejuelo, C. Garcia-Florentino, M. Maguregui, J. A. Manrique, G. Lopez-Reyes, J. Moros, A. Cousin, S. Maurice, A. M. Ollila, R. C. Wiens, F. Rull, J. Laserna, V. Garcia-Baonza, M. B. Madsen, O. Forni, J. Lasue, S. M. Clegg, S. Robinson, P. Bernardi, A. J. Brown, P. Cais, J. Martinez-Frias, P. Beck, S. Bernard, M. H. Bernt, O. Beyssac, E. Cloutis, C. Drouet, G. Dromart, B. Dubois, C. Fabre, O. Gasnault, I. Gontijo, J. R. Johnson, J. Medina, P. -Y. Meslin, G. Montagnac, V. Sautter, S. K. Sharma, M. Veneranda, P. A. Willis
Summary: The aim of this study is to analyze and verify the homogeneity of major mineral samples in the SuperCam calibration targets for proper calibration on Mars. Surface analysis of the targets was conducted using micro-EDXRF imaging and micro-Raman spectroscopy imaging to identify elements with homogeneous distribution and provide uncertainty values for further calibration.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
K. Pascaud, M. Merce, A. Roucher, M. Destribats, R. Backov, V Schmitt, R. Sescousse, F. Brouillet, S. Sarda, M. Re
Summary: This study developed biomimetic low temperature apatite ceramics with tunable porosity using biocompatible high internal phase Pickering emulsions. Two types of porous bioceramics were produced by low temperature processes, demonstrating bioactivity and bioresorption in-vivo. These bioceramics could be used as drug delivery disposals for filling bone defects in surgical applications.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Materials Science, Multidisciplinary
Hyoung-Jun Kim, Tae-Hyun Kim, Jae-Min Oh, Fabrice Salles, Geoffroy Chevallier, Carole Thouron, Philippe Trens, Jeremy Soulie, Sophie Cazalbou, Christophe Drouet
Summary: Cohesive monoliths of different LDH compositions and structures were successfully obtained by cold sintering. The low temperature involved in this approach preserved the structure and chemical stability of LDHs, allowing for the preparation of densified LDH scaffolds with internal cohesion. The interfacial/interlayer spaces of the LDH structure remained accessible after cold sintering and the porous network and interfacial surface of the monoliths were tunable by adding a leachable pore-forming agent. The findings have potential applications in electronics, energy storage, catalysis, biomaterials, and depollution.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2022)
Article
Geochemistry & Geophysics
Amaury Fau, Olivier Beyssac, Michel Gauthier, Gerard Panczer, Olivier Gasnault, Pierre-Yves Meslin, Sylvain Bernard, Sylvestre Maurice, Olivier Forni, Jean-Claude Boulliard, Francoise Bosc, Christophe Drouet
Summary: Using continuous and time-resolved spectroscopy, this study investigates Raman and luminescence signals from synthetic and natural hydroxylapatites doped with trivalent REE. Time-resolved spectroscopy is shown to be an efficient method to reduce luminescence from Raman spectra or investigate luminescence signals without interference. Time-resolved luminescence spectroscopy is a powerful technique for generating specific high-quality luminescence spectra and detecting and identifying activators in apatites. It is especially useful in natural samples with multiple luminescence activators. Luminescence is a powerful technique for detecting REE in apatites, though quantifying the concentration remains a challenge.
AMERICAN MINERALOGIST
(2022)
Article
Polymer Science
Nandy Canavy, Antoine Rouilly, Christophe Drouet, Carole Thouron, Maelenn Aufray
Summary: Flax fibers are important in composite fabrication due to their natural availability and mechanical properties close to glass fibers. This study investigates the interaction between flax fibers and epoxy-amine polymers. The results show that flax fibers exhibit significant exothermic interaction with DETA, while there is no quantitative interaction with DGEBA. Cellulose, a major component of flax fibers, contributes the most to the overall effect on the glass transition temperature.
Article
Geochemistry & Geophysics
Christophe Drouet, Matteo Loche, Sebastien Fabre, Pierre-Yves Meslin
Summary: This study estimated the formation enthalpy, Gibbs free energy, and entropy of Jahnsite/whiteite and related hydrated minerals using a thermodynamic approach. The calculations were validated with laboratory experiments, which suggested that the formation of Jahnsite is unlikely and simpler phosphate compounds are more likely. These findings are important for mineralogical research on Mars.
AMERICAN MINERALOGIST
(2022)
Article
Chemistry, Physical
Clementine Aubry, Christophe Drouet, Thierry Azais, Hyoung-Jun Kim, Jae-Min Oh, Ipek Karacan, Joshua Chou, Besim Ben-Nissan, Severine Camy, Sophie Cazalbou
Summary: The research team developed an innovative coating approach to remodel the surface of commercial BCP scaffolds via hydrothermal treatment under supercritical CO2. By observing dissolution-reprecipitation phenomena, they successfully generated highly bioactive biomimetic CaP phases. Additionally, they discovered that doping the remodeled BCP scaffolds with antibacterial Cu2+ ions can provide additional functionality.
Article
Chemistry, Multidisciplinary
Edoardo Cianflone, Fabien Brouillet, David Grossin, Jeremy Soulie, Claudie Josse, Sanjana Vig, Maria Helena Fernandes, Christophe Tenailleau, Benjamin Duployer, Carole Thouron, Christophe Drouet
Summary: Biomimetic apatites have high reactivity and can be modulated by ion substitutions for in vivo response. A novel approach was developed to combine bioactive ions in a spatially controlled manner for subsequent releases. The concept was validated by developing core-shell particles with antibacterial ions in the outer shell and pro-angiogenic or osteogenic ions in the inner core.
Article
Biotechnology & Applied Microbiology
Christophe Drouet, Nicolas Vandecandelaere, Anke Burger-Kentischer, Iris Trick, Christina G. Kohl, Tanja Maucher, Michaela Mueller, Franz E. Weber
Summary: Biomimetic nanocrystalline apatites analogous to bone mineral can be prepared using soft chemistry. However, immersion in aqueous media of dried non-carbonated biomimetic apatite crystals may generate an acidification event, which could limit their further development. In this study, the acidification phenomenon was explored, and a practical strategy to circumvent it was proposed. The non-cytotoxicity and antibacterial features of the post-equilibrated nanocrystalline apatites were demonstrated, suggesting their relevance in the field of antibacterial bone substitutes.
BIOENGINEERING-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Zineb Fritah, Christophe Drouet, Fabrice Salles, Olivier Marsan, Maelenn Aufray
Summary: This study investigated the impact of water on epoxy-amine-metal interphase. The presence of water was found to noticeably affect the performance of the epoxy-amine matrix. Mixing calorimetry and computational modeling were proven effective tools in understanding such complex systems.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Book Review
Veterinary Sciences
Catherine Trumel
VETERINARY CLINICAL PATHOLOGY
(2023)
Article
Veterinary Sciences
Maud Guerlin, Kevin Mourou, Valeria Martini, Nicolas Soetart, Stefano Comazzi, Catherine Trumel, Fanny Granat
Summary: A 2-year-old neutered female Small Munsterlander dog presented with an insect bite. Physical examination revealed poor body condition, lymphadenomegaly, and suspected splenomegaly. Blood tests showed leukocytosis, abnormal lymphoid cells, and rouleaux formation. Tissues from various organs also showed abnormal cell populations. The diagnosis was Waldenstrom's macroglobulinemia, and chemotherapy was initiated, but the dog was euthanized 12 months later due to clinical degradation.
VETERINARY SCIENCES
(2023)
Editorial Material
Veterinary Sciences
Theo Chenal, Maud Guerlin, Maxime Jurrus, Rachel Tante, Fanny Granat, Catherine Trumel
VETERINARY CLINICAL PATHOLOGY
(2023)
Article
Engineering, Biomedical
Ika Dewi Ana, Any Lestari, Prescillia Lagarrigue, Jeremy Soulie, Rahmi Anggraeni, Francoise Maube-Bosc, Carole Thouron, Benjamin Duployer, Christophe Tenailleau, Christophe Drouet
Summary: This study establishes a safe-by-design bone substitute approach by combining bone-like apatite to peroxide ions close to natural in vivo oxygenated species aimed at fighting pathogens. The doped apatites demonstrated significant antibacterial properties and high biocompatibility, making them promising candidates in dentistry and orthopedics.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
