New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease

Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors

(2014) Slavka Hamulakova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and neuroprotective evaluation of novel tacrine–benzothiazole hybrids as multi-targeted compounds against Alzheimer’s disease

(2013) Rangappa S. Keri et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer’s disease

(2013) Alejandro Romero et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alzheimer’s Disease and Antioxidant Therapy: How Long How Far?

(2013) J. Teixeira et al.   CURRENT MEDICINAL CHEMISTRY

Polypharmacology in a Single Drug: Multitarget Drugs

(2013) M. L. Bolognesi   CURRENT MEDICINAL CHEMISTRY

Multifunctional iron-chelators with protective roles against neurodegenerative diseases

(2013) Andreia Nunes et al.   DALTON TRANSACTIONS

A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation

(2013) Akiko Kochi et al.   Chemical Science

Design, synthesis and pharmacological evaluation of novel tacrine–caffeic acid hybrids as multi-targeted compounds against Alzheimer’s disease

(2012) Xiaojuan Chao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

(2012) Cristina Rodríguez-Rodríguez et al.   COORDINATION CHEMISTRY REVIEWS

Multifunctional Mercapto-tacrine Derivatives for Treatment of Age-Related Neurodegenerative Diseases

(2012) Yue Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties

(2012) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

General and Scalable Amide Bond Formation with Epimerization-Prone Substrates Using T3P and Pyridine

(2011) Joshua R. Dunetz et al.   ORGANIC LETTERS

S-Propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-κB pathway in rats

(2010) Qi-Hai Gong et al.   BRAIN BEHAVIOR AND IMMUNITY

Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors

(2010) Jaroslav Šebestík et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

(2010) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antioxidant and Iron-Binding Properties of Curcumin, Capsaicin, andS-Allylcysteine Reduce Oxidative Stress in Rat Brain Homogenate

(2008) Amichand Dairam et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY