期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 86, 期 4, 页码 776-782出版社
WILEY-BLACKWELL
DOI: 10.1111/cbdd.12550
关键词
AChE inhibition; Alzheimer's disease; derivatives; icariin; synthesis
资金
- Science and Technology Support Program of Sichuan Province [2014SZ0071]
A new series of icariin derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) inhibitory activity. Most of the tested compounds exhibited high AChE inhibition and low toxicity, and among which compounds 1, 2, and 10 were the most potent (IC50=71.52 +/- 22.43, 8.28 +/- 1.45, 5.830 +/- 1.78nm, respectively).
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