Review
Infectious Diseases
Catarina Mendes Silva, Joao Pedro Baptista, Iolanda Santos, Paulo Martins
Summary: This systematic review searched for recommendations on antibiotic dosage adjustment for critically ill patients with augmented renal clearance (ARC). The findings suggest that increasing dosage and/or adjusting infusion modality are frequently needed to achieve the desired pharmacokinetic/pharmacodynamic (PK/PD) targets.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Microbiology
Pedro Povoa, Patricia Moniz, Joao Goncalves Pereira, Luis Coelho
Summary: Choosing and managing antimicrobial dosing in critically ill patients is a significant challenge. The unstable pharmacokinetic status and rapidly changing clinical condition of these patients require consideration of multiple factors to maximize treatment effectiveness.
Article
Pharmacology & Pharmacy
Shamir Kalaria, Sarah Williford, Dong Guo, Yan Shu, Christopher Medlin, Matthew Li, Siu Yan Amy Yeung, Farhan Ali, Wisna Jean, Mathangi Gopalakrishnan, Mojdeh Heavner
Summary: This study aimed to characterize the pharmacokinetics of ceftaroline in critically ill patients undergoing CRRT and to provide individualized dosing recommendations. Results showed that ceftaroline clearance is mainly influenced by non-renal pathways in these patients, impacting the achievement of pharmacodynamic targets.
Article
Pharmacology & Pharmacy
Lu Shi, Zhiwei Zhuang, Lufen Duan, Chenqi Zhu, Hongzhi Xue, Xiao Wang, Xiaowen Xu, Yunlong Yuan, Ling Shi, Jiahui Li, Jiantong Sun, Xin Liu, Qin Zhou, Jian Lu, Lian Tang
Summary: This study aims to optimize the dosage regimen of teicoplanin in renal dysfunction patients, evaluate the factors affecting the eradication of Gram-positive bacteria, and assess the effect of continuous renal replacement therapy on the clearance of teicoplanin.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiaojiao Chen, Sihan Li, Quanfang Wang, Chuhui Wang, Yulan Qiu, Luting Yang, Ruiying Han, Qian Du, Lei Chen, Yalin Dong, Taotao Wang
Summary: The optimal dosage regimens of vancomycin, teicoplanin, and daptomycin were investigated for critically ill patients undergoing continuous renal replacement therapy (CRRT) using Monte Carlo simulation. The study found that the dosage should be adjusted based on the CRRT dose, and only teicoplanin was influenced by the CRRT modality.
Article
Infectious Diseases
Andrew J. Fratoni, John W. Mah, David P. Nicolau, Joseph L. Kuti
Summary: This study describes the pharmacokinetics of imipenem/relebactam in critically-ill patients with augmented renal clearance. Despite enhanced clearance, the currently approved dosing regimen was predicted to achieve optimal exposure and treat most susceptible pathogens in these patients.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Urology & Nephrology
Shruti Gupta, Steven G. Coca, Lili Chan, Michal L. Melamed, Samantha K. Brenner, Salim S. Hayek, Anne Sutherland, Sonika Puri, Anand Srivastava, Amanda Leonberg-Yoo, Alexandre M. Shehata, Jennifer E. Flythe, Arash Rashidi, Edward J. Schenck, Nitender Goyal, S. Susan Hedayati, Rajany Dy, Anip Bansal, Ambarish Athavale, H. Bryant Nguyen, Anitha Vijayan, David M. Charytan, Carl E. Schulze, Min J. Joo, Allon N. Friedman, Jingjing Zhang, Marie Anne Sosa, Eric Judd, Juan Carlos Q. Velez, Mary Mallappallil, Roberta E. Redfern, Amar D. Bansal, Javier A. Neyra, Kathleen D. Liu, Amanda D. Renaghan, Marta Christov, Miklos Z. Molnar, Shreyak Sharma, Omer Kamal, Jeffery Owusu Boateng, Samuel A. P. Short, Andrew J. Admon, Meghan E. Sise, Wei Wang, Chirag R. Parikh, David E. Leaf
Summary: The study found that AKI-RRT is common among critically ill patients with COVID-19, with a mortality rate of over 50%. For patients with AKI-RRT, older age, severe oliguria, and admission to a hospital with fewer ICU beds or higher density of COVID-19 were associated with higher 28-day mortality rates.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Computer Science, Information Systems
Garrett Eickelberg, Lazaro Nelson Sanchez-Pinto, Adrienne Sarah Kline, Yuan Luo
Summary: This study assessed the transportability of a bacterial infection risk model in three different types of intensive care units and explored the impact of multisite learning techniques on model transportability. The model performed well in internal validations but showed variation in transportability in external validations. The findings highlight the importance of external model validation on diverse clinical populations prior to implementation.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Critical Care Medicine
Charles Tacquard, Alexandre Mansour, Alexandre Godon, Julien Godet, Julien Poissy, Delphine Garrigue, Eric Kipnis, Sophie Rym Hamada, Paul Michel Mertes, Annick Steib, Mathilde Ulliel-Roche, Belaid Bouhemad, Maxime Nguyen, Florian Reizine, Isabelle Gouin-Thibault, Marie Charlotte Besse, Nived Collercandy, Stefan Mankikian, Jerrold H. Levy, Yves Gruel, Pierre Albaladejo, Sophie Susen, Anne Godier
Summary: High-dose prophylactic anticoagulation is associated with a reduced risk of thrombotic complications in critically ill patients with COVID-19 without increasing the risk of bleeding. Further randomized controlled trials comparing prophylaxis with higher doses of anticoagulants are needed to confirm these results.
Review
Pharmacology & Pharmacy
Cornelia B. Landersdorfer, Roger L. Nation
Summary: Early initiation of effective antibiotic therapy is essential for critically ill patients with sepsis or septic shock, but current guidelines are lacking. Renal function is a key determinant for achieving the required antibiotic exposure. Model-informed approaches are suggested to individualize treatment regimens and adjust them based on monitoring antibiotic concentrations and other clinical data during treatment.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Critical Care Medicine
G. Umberto Meduri, Mei-Chiung Shih, Lisa Bridges, Thomas J. Martin, Ali El-Solh, Nitin Seam, Anne Davis-Karim, Reba Umberger, Antonio Anzueto, Peruvemba Sriram, Charlie Lan, Marcos I. Restrepo, Juan J. Guardiola, Teresa Buck, David P. Johnson, Anthony Suffredini, W. Andrew Bell, Julia Lin, Lan Zhao, Lauren Uyeda, Lori Nielsen, Grant D. Huang
Summary: Prolonged low-dose methylprednisolone treatment did not significantly improve clinical outcomes in patients with severe community-acquired pneumonia.
INTENSIVE CARE MEDICINE
(2022)
Article
Infectious Diseases
David P. Nicolau, Jan De Waele, Joseph L. Kuti, Luzelena Caro, Kajal B. Larson, Brian Yu, Elaine Gadzicki, Zhen Zeng, Elizabeth G. Rhee, Matthew L. Rizk
Summary: This study aimed to determine the adequacy of established ceftolozane/tazobactam dosing for patients with augmented renal clearance (ARC) and bacterial infection. The results showed that a 3 g C/T dose met pharmacodynamic targets for ceftolozane and tazobactam in patients with ARC, with mild to moderate treatment-emergent adverse events observed.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Review
Critical Care Medicine
Ron Wald, William Beaubien-Souligny, Rahul Chanchlani, Edward G. Clark, Javier A. Neyra, Marlies Ostermann, Samuel A. Silver, Suvi Vaara, Alexander Zarbock, Sean M. Bagshaw
Summary: This review provides a comprehensive update on key aspects of renal replacement therapy (RRT) prescription and delivery for critically ill patients. Recent trials have enhanced the evidence base regarding RRT practices, but more evidence is still needed to clarify multiple aspects of care.
INTENSIVE CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Agustin Clemente-Moragon, Juan Martinez-Milla, Eduardo Oliver, Arnoldo Santos, Javier Flandes, Iker Fernandez, Lorena Rodriguez-Gonzalez, Cristina Serrano del Castillo, Ana-Maria Ioan, Maria Lopez-Alvarez, Sandra Gomez-Talavera, Carlos Galan-Arriola, Valentin Fuster, Cesar Perez-Calvo, Borja Ibanez
Summary: In this study, metoprolol treatment in patients with COVID-19-associated ARDS was shown to be safe and effective in reducing lung inflammation and improving oxygenation, resulting in fewer days on invasive mechanical ventilation. Repurposing metoprolol for COVID-19-associated ARDS could be a cost-effective strategy to alleviate the burden of the pandemic.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Nutrition & Dietetics
Roland N. Dickerson, Christin N. Crawford, Melissa K. Tsiu, Cara E. Bujanowski, Edward T. Van Matre, Joseph M. Swanson, Dina M. Filiberto, Gayle Minard
Summary: This study aimed to determine the prevalence of augmented renal clearance (ARC) in trauma patients receiving nutrition therapy. Results showed that 50% of patients exhibited ARC, with factors such as male gender, traumatic brain injury, higher injury severity score, younger age, lower serum creatinine concentration, and protein intake being associated with ARC. Patients with multiple risk factors for ARC should be closely monitored for renal dosing of electrolytes, nutrients, and medications.
Editorial Material
Critical Care Medicine
M. C. Martinez-Avila, C. I. Herrera-Arrieta, Z. M. Mondol-Almeida
MEDICINA INTENSIVA
(2023)
Article
Gastroenterology & Hepatology
Pedro Luis Imbeth-Acosta, Maria Cristina Martinez-Avila, Mario Andres Pineda Paternina, Zulay Margarita Mondol Almeida, Kevin Llanos Almario, Alejandro Blanquicett Diaz, Kelly Carolina Meza Gamarra
Summary: Gastrocolocutaneous fistula is a serious but rare complication post percutaneous endoscopic gastrostomy (PEG) placement, which requires prompt intervention.
Article
Medicine, General & Internal
Kevin Cantillo Garcia, Oscar Calderon Duran, Tomas Acosta Perez, Angel Vasquez Jimenez, Emerson Madrid Perez, Maria Cristina Martinez-Avila, Tomas Rodriguez Yanez, Amilkar Almanza-Hurtado
Summary: Alcaligenes faecalis, a rare gram-negative pathogenic bacterium, is primarily found in newborns and immunosuppressed hosts. The optimal treatment for this bacterium remains uncertain. We report a case of an immunocompetent patient who developed meningitis due to A. faecalis after a dental procedure, highlighting the potential emergence of this pathogen in immunocompetent adults.
CASE REPORTS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Alvano Trespalacios Sierra, Barbara Arroyo-Salgado, Jesus Rodriguez-Blanco, Ingrid Tibocha Gordon, Maria Cristina Martinez-Avila
Summary: We present a case of a 59-year-old man from rural area of Colombia who developed septic shock and isolation of Prototheca wickerhamii from blood culture. The patient was successfully treated with fluconazole and Amphotericin B.
TROPICAL DISEASES TRAVEL MEDICINE AND VACCINES
(2022)
Review
Biochemistry & Molecular Biology
Jorge Rico-Fontalvo, Gustavo Aroca-Martinez, Rodrigo Daza-Arnedo, Jose Cabrales, Tomas Rodriguez-Yanez, Maria Cardona-Blanco, Juan Montejo-Hernandez, Dairo Rodelo Barrios, Jhonny Patino-Patino, Elber Osorio Rodriguez
Summary: Diabetic kidney disease (DKD) is a common complication of diabetes mellitus (DM) and the leading cause of end-stage kidney disease (ESKD) worldwide. Its development involves hemodynamic, metabolic, and inflammatory factors. Persistent albuminuria along with a decline in glomerular filtration rate (GFR) defines this disease, but novel biomarkers originating from its pathogenesis need to be discussed to aid in diagnosis, follow-up, treatment response, and prognosis.
Article
Medicine, General & Internal
Orlando Gonzalez-Macea, Maria Cristina Martinez-Avila, Marien Perez, Ingrid Tibocha Gordon, Barbara Arroyo Salgado
Summary: This case report describes a patient from Africa who presented with acute febrile illness and thrombocytopenia in Colombia and was eventually diagnosed with concurrent infection of Plasmodium falciparum malaria and dengue. Coinfection of dengue and malaria is rarely reported, and should be suspected in patients living or returning from endemic areas for both diseases or during dengue outbreaks. This case serves as a reminder of the importance of early diagnosis and treatment for this significant condition, which can result in high morbidity and mortality if not promptly addressed.
CLINICAL MEDICINE INSIGHTS-CASE REPORTS
(2023)
Review
Obstetrics & Gynecology
Maria Fernanda Toro-Wills, Angelica Imitola-Madero, Angelina Alvarez-Londono, Abraham Hernandez-Blanquisett, Maria Cristina Martinez-avila
Summary: Women with thyroid cancer face a significant burden on their fertility. Delaying childbirth has become a common trend in maternity, but women with thyroid cancer may want to get pregnant after treatment, posing a multidisciplinary issue for their doctors. This review focuses on addressing key aspects of the strategy, with emphasis on the importance of fertility in women with thyroid cancer diagnosis and remission, including the role of thyroid hormones in pregnancy and fertility.
Article
Obstetrics & Gynecology
Luisa Rodriguez Quejada, Maria Fernanda Toro Wills, Maria Cristina Martinez-Avila, Andres Felipe Patino-Aldana
Summary: After COVID-19 vaccination, women of reproductive age experienced changes in their menstrual cycle. A retrospective study revealed alterations in the frequency, regularity, duration, and volume of menstruation among a group of women.
Article
Medicine, General & Internal
Diana Borre-Naranjo, Tomas Rodriguez-Yanez, Amilkar Almanza-Hurtado, Maria Cristina Martinez-Avila, Carmelo Duenas-Castell
Summary: Neuromuscular complications in the ICU are common and difficult to recognize, but can be identified and diagnosed through physical examination and electrophysiology studies. Early identification and management, as well as preventive measures, are essential to reduce chronic disability and morbidity.
CLINICAL MEDICINE INSIGHTS-CASE REPORTS
(2022)
Article
Medicine, General & Internal
Amilkar Almanza-Hurtado, Maria Cristina Martinez-Avila, Tomas Rodriguez-Yanez, Maria Carolina Paternina-Mendoza, Juan Camilo Gutierrez-Ariza, Gino Gomez-Arroyo
Summary: This article reports three cases of cardiovascular manifestations associated with SARS-CoV-2 infection, highlighting the diagnostic approach and variety of presentations, ranging from acute myocardial infarction, myocarditis, heart failure, shock, arrhythmias to sudden death. It suggests that the impact of COVID-19 on the cardiovascular system is increasingly recognized in terms of development and prognosis.
CLINICAL MEDICINE INSIGHTS-CASE REPORTS
(2022)
Article
Infectious Diseases
Mario Lora-Andosilla, Amilkar Almanza-Hurtado, Tomas Rodriguez-Yanez, Maria Cristina Martinez-Avila, Carmelo Duenas-Castell
Summary: This case report presents a previously healthy 32-year-old male with severe dengue fever and associated coagulopathy and encephalitis. The patient showed improvement after receiving supportive treatment.
REVISTA CHILENA DE INFECTOLOGIA
(2022)
Article
Medicine, General & Internal
Alejandro Blanquicett, Maria Cristina Martinez-Avila, Zulay Mondol, Pedro Imbeth Acosta
Summary: Drug-induced liver injury is a rare but serious condition that can lead to severe complications and even require liver transplantation. It is diagnosed by excluding other possible causes as there are no specific diagnostic tests. This case report describes a patient who developed liver dysfunction after using injectable contraceptives, and achieved full recovery with drug suspension and supportive measures.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
