Article
Immunology
Jo Salkeld, Yrene Themistocleous, Jordan R. Barrett, Celia H. Mitton, Thomas A. Rawlinson, Ruth O. Payne, Mimi M. Hou, Baktash Khozoee, Nick J. Edwards, Carolyn M. Nielsen, Diana Munoz Sandoval, Florian A. Bach, Wiebke Nahrendorf, Raquel Lopez Ramon, Megan Baker, Fernando Ramos-Lopez, Pedro M. Folegatti, Doris Quinkert, Katherine J. Ellis, Ian D. Poulton, Alison M. Lawrie, Jee-Sun Cho, Fay L. Nugent, Philip J. Spence, Sarah E. Silk, Simon J. Draper, Angela M. Minassian
Summary: Repeated controlled human malaria infection (CHMI) with the same parasite did not show clear evidence of anti-parasite immunity in most participants, although some individuals exhibited variation in parasite growth dynamics. However, repeat homologous blood-stage CHMI proved to be safe and offers a model for studying naturally acquired immunity to blood-stage infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Roos M. de Jong, Manon Alkema, Tate Oulton, Elin Dumont, Karina Teelen, Rie Nakajima, Rafael Ramiro de Assis, Kathleen W. Dantzler Press, Priscilla Ngotho, Kevin K. A. Tetteh, Phil Felgner, Matthias Marti, Katharine A. Collins, Chris Drakeley, Teun Bousema, Will J. R. Stone
Summary: This study investigates the antibody responses to sexual stage antigens in individuals infected with P. falciparum. The results show that even after exposure to relatively low gametocyte densities, a significant anti-sexual stage humoral response is induced in malaria-naive individuals. The study identifies novel antigens associated with gametocyte exposure, which can be used for surveillance of the malaria infectious reservoir and support vaccine development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Edwin Kamau, Jason W. Bennett, Anjali Yadava
Summary: Safety data on Plasmodium vivax controlled human malaria infection (PvCHMI) is limited due to the small number of studies conducted. However, mosquito bite-induced PvCHMI was found to be safe, with most infections being detected before clinical symptoms appeared. Sensitive molecular methods were effective in diagnosing infections early on, indicating their potential to alleviate clinical symptoms.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Manon Alkema, X. Zen Yap, Gerdie M. de Jong, Isaie J. Reuling, Quirijn de Mast, Reinout van Crevel, Christian F. Ockenhouse, Katharine A. Collins, Teun Bousema, Matthew B. B. McCall, Robert W. Sauerwein
Summary: Malaria infection caused by Plasmodium falciparum through mosquito bites induces stronger inflammation response in healthy volunteers compared to intravenous administration of infected red blood cells.
Article
Immunology
Hannah W. Kimingi, Ann W. Kinyua, Nicole A. Achieng, Kennedy M. Wambui, Shaban Mwangi, Roselyne Nguti, Cheryl A. Kivisi, Anja T. R. Jensen, Philip Bejon, Melisa C. Kapulu, Abdirahman I. Abdi, Samson M. Kinyanjui, CHMI-SIKA Study Team
Summary: The breadth of IgG antibodies to VSAs, but not to individual isolate VSAs, is associated with protection in controlled human malaria infection (CHMI).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Stephen D. Woolley, Louise Marquart, John Woodford, Stephan Chalon, Joerg J. Moehrle, James S. McCarthy, Bridget E. Barber
Summary: Early experimental P. falciparum and P. vivax infection resulted in a small but significant fall in hemoglobin despite parasitemia only just at the level of microscopic detection. Loss of parasitized erythrocytes accounted for < 0.2% of the total malaria-attributable hemoglobin loss.
Article
Multidisciplinary Sciences
Brendan Fries, Carlos A. Guerra, Guillermo A. Garcia, Sean L. Wu, Jordan M. Smith, Jeremias Nzamio Mba Oyono, Olivier T. Donfack, Jose Osa Osa Nfumu, Simon Hay, David L. Smith, Andrew J. Dolgert
Summary: Different population layers performed differently in matching the gold standard distribution at different population densities. Choosing the appropriate population map has a significant impact on burden estimates in a malaria model.
Article
Immunology
James G. Kublin, Sean C. Murphy, Janine Maenza, Annette M. Seilie, Jay Prakash Jain, David Berger, Danielle Spera, Rong Zhao, Rachel L. Soon, Julie L. Czartoski, Meredith A. Potochnic, Elizabeth Duke, Ming Chang, Ashley Vaughan, Stefan H. Kappe, F. Joel Leong, Peter Pertel, William T. Prince
Summary: KAF156, a novel antimalarial drug with high protective efficacy, was found to be safe and well tolerated in a controlled human malaria infection model. Different doses of KAF156 showed varying levels of protection against malaria infection, with higher doses providing greater protection.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Stephen D. Woolley, Melissa Fernandez, Maria Rebelo, Stacey A. Llewellyn, Louise Marquart, Fiona H. Amante, Helen E. Jennings, Rebecca Webster, Katharine Trenholme, Stephan Chalon, Joerg J. Moehrle, James S. McCarthy, Bridget E. Barber
Summary: A new MCB, 3D7-MBE-008, was developed by expanding the 3D7-V2 MCB in vitro, showing higher infectivity compared to the existing MCBs. The safety, growth, and clearance profiles of the expanded 3D7-MBE-008 MCB closely resemble that of its parent, indicating its suitability for future studies.
Article
Immunology
Wanlapa Roobsoong, Anjali Yadava, Simon J. Draper, Angela M. Minassian, Jetsumon Sattabongkot
Summary: Controlled Human Malaria Infection models (CHMI) are crucial for advancing malaria vaccines. However, the difficulty in producing the Plasmodium vivax parasite in vitro has limited the production of qualified parasites for CHMI and screening potential vaccines to combat this globally distributed parasite. This article discusses the challenges, lessons learned, and the way forward in effectively performing PvCHMI to support vaccine development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Carlos Lamsfus Calle, Rolf Fendel, Anurag Singh, Thomas L. Richie, Stephen L. Hoffman, Peter G. Kremsner, Benjamin Mordmuller
Summary: Malaria can lead to severe complications and chronic infections, causing conditions like anemia and immunologic hyporesponsiveness. The study on controlled human malaria infection revealed that malaria-induced immunosuppression, with circulating PMN-MDSC serving as an early indicator of infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Melissa D. Conrad, Victor Asua, Shreeya Garg, David Giesbrecht, Karamoko Niare, Sawyer Smith, Jane F. Namuganga, Thomas Katairo, Jennifer Legac, Rebecca M. Crudale, Patrick K. Tumwebaze, Samuel L. Nsobya, Roland A. Cooper, Moses R. Kamya, Grant Dorsey, Jeffrey A. Bailey, Philip J. Rosenthal
Summary: This study identified multifocal emergence and spread of Plasmodium falciparum with partial resistance to artemisinins in Uganda. The emergence and spread of resistance were predominantly observed in areas where effective malaria control had been discontinued or transmission was unstable.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Romeo Karl Imboumy-Limoukou, Jean-Claude Biteghe-Bi-Essone, Judicael Boris Lendongo Wombo, Sonia Etenna Lekana-Douki, Virginie Rougeron, Steede-Seinnat Ontoua, Lydie Sandrine Oyegue-Liabagui, Cherone Nancy Mbani Mpega Ntigui, Lady Charlene Kouna, Jean-Bernard Lekana-Douki
Summary: Due to the difficulty of obtaining blood samples, alternative non-invasive diagnostic sampling methods for the detection of Plasmodium spp. are needed. Saliva and stool samples contain trace amounts of Plasmodium DNA, but their detection rate is lower compared to blood samples. Therefore, they cannot be considered as alternatives to current blood-based malaria detection processes.
Article
Infectious Diseases
Melissa C. Kapulu, Domtila Kimani, Patricia Njuguna, Mainga Hamaluba, Edward Otieno, Rinter Kimathi, James Tuju, B. Kim Lee Sim
Summary: This study assessed the controlled human malaria infection (CHMI) model as a means of studying naturally acquired immunity to malaria in Kenyan adults. The results showed that anti-schizont antibodies and location of residence were more closely associated with naturally acquired immunity than other parasite parameters. Therefore, the CHMI model is highly effective in studying markers of naturally acquired immunity to malaria.
BMC INFECTIOUS DISEASES
(2022)
Article
Immunology
Johanna Hoshizaki, Hannah Jagoe, Marcus C. S. Lee
Summary: CRISPR editing enables efficient generation of fluorescently labeled parasite lines, facilitating a deeper understanding of parasite biology.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Marijke C. C. Langenberg, Olaf M. Dekkers, Meta Roestenberg
LANCET INFECTIOUS DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Marijke C. C. Langenberg, Marie-Astrid Hoogerwerf, Jan Pieter R. Koopman, Jacqueline J. Janse, Janneke Kos-van Oosterhoud, Carola Feijt, Simon P. Jochems, Claudia J. de Dood, Roos van Schuijlenburg, Arifa Ozir-Fazalalikhan, Mikhael D. Manurung, Erliyani Sartono, Martha T. van der Beek, Beatrice M. F. Winkel, Petra H. Verbeek-Menken, Koen A. Stam, Fijs W. B. van Leeuwen, Pauline Meij, Angela van Diepen, Lisette van Lieshout, Govert J. van Dam, Paul L. A. M. Corstjens, Cornelis H. Hokke, Maria Yazdanbakhsh, Leo G. Visser, Meta Roestenberg
Article
Biotechnology & Applied Microbiology
Johan L. Van der Plas, Pauline Verdijk, Emilie M. J. Van Brummelen, Rienk E. Jeeninga, Meta Roestenberg, Jacobus Burggraaf, Ingrid M. C. Kamerling
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2020)
Article
Immunology
Manon Alkema, Isaie J. Reuling, Gerdie M. de Jong, Kjerstin Lanke, Luc E. Coffeng, Geert-Jan van Gemert, Marga van de Vegte-Bolmer, Quirijn de Mast, Reinout van Crevel, Karen Ivinson, Christian F. Ockenhouse, James S. McCarthy, Robert Sauerwein, Katharine A. Collins, Teun Bousema
Summary: The study found that the method of infection through mosquito bites or induced blood-stage malaria has a significant impact on gametocyte production, despite similar asexual parasite densities. The findings suggest that induced blood-stage malaria may be more conducive to gametocyte production compared to mosquito bites.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Miriam Casacuberta-Partal, Jacqueline J. Janse, Roos van Schuijlenburg, Jutte J. C. de Vries, Marianne A. A. Erkens, Kitty Suijk, Marielle van Aalst, Jaap J. Maas, Martin P. Grobusch, Perry J. J. van Genderen, Claudia de Dood, Paul L. A. M. Corstjens, Govert J. van Dam, Lisette van Lieshout, Meta Roestenberg
JOURNAL OF TRAVEL MEDICINE
(2020)
Article
Infectious Diseases
Abena S. Amoah, Pytsje T. Hoekstra, Miriam Casacuberta-Partal, Luc E. Coffeng, Paul L. A. M. Corstjens, Beatrice Greco, Lisette van Lieshout, Mark D. Lim, Christine F. Markwalter, Maurice R. Odiere, Jutta Reinhard-Rupp, Meta Roestenberg, Russell Stothard, Louis-Albert Tchuem Tchuente, Sake J. de Vlas, Govert J. van Dam
LANCET INFECTIOUS DISEASES
(2020)
Editorial Material
Multidisciplinary Sciences
Seema K. Shah, Franklin G. Miller, Thomas C. Darton, Devan Duenas, Claudia Emerson, Holly Fernandez Lynch, Euzebiusz Jamrozik, Nancy S. Jecker, Dorcas Kamuya, Melissa Kapulu, Jonathan Kimmelman, Douglas MacKay, Matthew J. Memoli, Sean C. Murphy, Ricardo Palacios, Thomas L. Richie, Meta Roestenberg, Abha Saxena, Katherine Saylor, Michael J. Selgelid, Vina Vaswani, Annette Rid
Article
Infectious Diseases
Pytsje T. Hoekstra, Miriam Casacuberta-Partal, Lisette van Lieshout, Paul L. A. M. Corstjens, Roula Tsonaka, Rufin K. Assare, Kigbafori D. Silue, Aboulaye Meite, Eliezer K. N'Goran, Yves K. N'Gbesso, Abena S. Amoah, Meta Roestenberg, Stefanie Knopp, Jurg Utzinger, Jean T. Coulibaly, Govert J. van Dam
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Editorial Material
Pharmacology & Pharmacy
Johan L. van der Plas, Meta Roestenberg, Adam F. Cohen, Ingrid M. C. Kamerling
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Mick M. Welling, Nikolas Duszenko, Danny M. van Willigen, Wiep Klaas Smits, Tessa Buckle, Meta Roestenberg, Fijs W. B. van Leeuwen
Summary: The study demonstrates the use of cyclodextrin (CD) and adamantane (Ad) host-guest interactions for in vivo cell functionalization and delivery of chemical cargo to living cells. The concept was validated in two rodent Staphylococcus aureus models, showing successful outcomes in both muscle and liver tissues.
BIOCONJUGATE CHEMISTRY
(2021)
Review
Immunology
Emmanuella Driciru, Jan Pieter R. Koopman, Stephen Cose, Afzal A. Siddiqui, Maria Yazdanbakhsh, Alison M. Elliott, Meta Roestenberg
Summary: The development of schistosomiasis vaccines faces immunological challenges, with prior exposure impacting vaccine response. Factors such as age, exposure levels, and co-infections contribute to the complexity of vaccine responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Sanne E. de Jong, Vincent van Unen, Mikhael D. Manurung, Koen A. Stam, Jelle J. Goeman, Simon P. Jochems, Thomas Hollt, Nicola Pezzotti, Yoanne D. Mouwenda, Madeleine Eunice Betouke Ongwe, Freia-Raphaella Lorenz, Yvonne C. M. Kruize, Shohreh Azimi, Marion H. Konig, Anna Vilanova, Elmar Eisemann, Boudewijn P. F. Lelieveldt, Meta Roestenberg, B. Kim Lee Sim, Marcel J. T. Reinders, Rolf Fendel, Stephen L. Hoffman, Peter G. Kremsner, Frits Koning, Benjamin Mordmuller, Bertrand Lell, Maria Yazdanbakhsh
Summary: Controlled human infections were used to compare immune responses of Europeans and Africans to Plasmodium falciparum, revealing differences in immune cell populations and gene expression profiles. Africans capable of controlling parasitemia were characterized by specific immune cell clusters and transcriptional responses after inoculation. These findings provide insights for developing effective malaria vaccines in endemic regions.
Article
Materials Science, Biomaterials
M. M. Welling, N. Duszenko, D. M. van Willigen, A. W. Hensbergen, T. Buckle, D. D. D. Rietbergen, M. Roestenberg, F. W. B. van Leeuwen
Summary: The study successfully demonstrated in vivo imaging and targeting of functionalized microspheres and bacteria using a copper-free click chemistry strategy. Results showed increased accumulation of imaging agents at target sites, indicating the efficacy of this conjugation approach in achieving targeted delivery.
BIOMATERIALS SCIENCE
(2021)
Meeting Abstract
Pharmacology & Pharmacy
Johan van der Plasi, Pauline Verdijk, Emilie van Brummelen, Meta Roestenberg, Jacobus Burggraaf, Ingrid Kamerling
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Cell Biology
Meta Roestenberg, Jona Walk, Saskia C. van der Boor, Marijke C. C. Langenberg, Marie-Astrid Hoogerwerf, Jacqueline J. Janse, Mikhael Manurung, X. Zen Yap, Amanda Fabra Garcia, Jan Pieter R. Koopman, Pauline Meij, Els Wessels, Karina Teelen, Youri M. van Waardenburg, Marga van de Vegte-Bolmer, Geert Jan van Gemert, Leo G. Visser, Andre J. A. M. van der Ven, Quirijn de Mast, K. C. Natasha, Yonas Abebe, Tooba Murshedkar, Peter F. Billingsley, Tom L. Richie, B. Kim Lee Sim, Chris J. Janse, Stephen L. Hoffman, Shahid M. Khan, Robert W. Sauerwein
SCIENCE TRANSLATIONAL MEDICINE
(2020)