Nanofiber-Based Hydrocolloid from Colloid Electrospinning Toward Next Generation Wound Dressing

Nanofiber-based hydrocolloid scaffold is prepared by colloid electrospinning of thermoplastic polyurethane (TPU)/sodium carboxymethyl cellulose (S.CMC) in tetrahydrofuran (THF)/dimethylformamide (DMF). The most suitable process of electrospinning for successful formation of fibers is investigated by controlling the concentration of polymeric solution and co-solvent ratio. In order to accomplish high wettability, the amount of colloid (S.CMC) and the co-solvent ratio (THF/DMF), which affects the morphology of fibers, are adjusted. Finally, the open wound healing effect is confirmed using nanofiber-hydrocolloid from in vivo animal studies. A detailed study of the wound healing process is also demonstrated for the first time.