Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice

Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

(2015) Sophie M. Lehar et al.   NATURE

Fecal Microbiota Transplant for Relapsing Clostridium difficile Infection Using a Frozen Inoculum From Unrelated Donors: A Randomized, Open-Label, Controlled Pilot Study

(2014) Ilan Youngster et al.   CLINICAL INFECTIOUS DISEASES

Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates

(2014) Siddharth Sukumaran et al.   PHARMACEUTICAL RESEARCH

Bioanalysis of antibody–drug conjugates: American Association of Pharmaceutical Scientists Antibody–Drug Conjugate Working Group position paper

(2013) Boris Gorovits et al.   Bioanalysis

Bioanalytical assay strategies for the development of antibody–drug conjugate biotherapeutics

(2013) Surinder Kaur et al.   Bioanalysis

Predictors of Mortality in Staphylococcus aureus Bacteremia

(2012) S. J. van Hal et al.   CLINICAL MICROBIOLOGY REVIEWS

Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?

(2012) Rong Deng et al.   Expert Opinion on Drug Metabolism & Toxicology

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

(2011) W. Wang et al.   DRUG METABOLISM AND DISPOSITION

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data

(2011) Rong Deng et al.   mAbs

Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?

(2011) Guy E. Thwaites et al.   NATURE REVIEWS MICROBIOLOGY

Characterisation of a Staphylococcus aureus strain with progressive loss of susceptibility to vancomycin and daptomycin during therapy

(2009) Fred C. Tenover et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era

(2009) Frank R. DeLeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY