Target-independent variable region mediated effects on antibody clearance can be FcRn independent

High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

(2015) Ryan L Kelly et al.   mAbs

The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies

(2015) Amita Datta-Mannan et al.   mAbs

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

(2015) Amita Datta-Mannan et al.   mAbs

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity

(2015) Yasmina Noubia Abdiche et al.   mAbs

Effect of protein aggregates on characterization of FcRn binding of Fc-fusion therapeutics

(2015) Adriana Bajardi-Taccioli et al.   MOLECULAR IMMUNOLOGY

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

(2015) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics

(2015) Angela Schoch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody engineering for increased potency, breadth and half-life

(2015) Stuart A. Sievers et al.   Current Opinion in HIV and AIDS

Plasmonic measurements of monoclonal antibody self-association using self-interaction nanoparticle spectroscopy

(2014) Jayapriya Jayaraman et al.   BIOTECHNOLOGY AND BIOENGINEERING

Polyreactivity and Autoreactivity among HIV-1 Antibodies

(2014) Mengfei Liu et al.   JOURNAL OF VIROLOGY

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

(2014) Bing Li et al.   mAbs

Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

(2013) Tilman Schlothauer et al.   mAbs

High throughput solution-based measurement of antibody-antigen affinity and epitope binning

(2013) Patricia Estep et al.   mAbs

High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy

(2013) Yuqi Liu et al.   mAbs

Are endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity?

(2013) Brian Gurbaxani et al.   MOLECULAR IMMUNOLOGY

Rapid Analysis of Antibody Self-Association in Complex Mixtures Using Immunogold Conjugates

(2013) Shantanu V. Sule et al.   MOLECULAR PHARMACEUTICS

Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool

(2013) Y. Xu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn

(2012) Yang Chen et al.   AAPS Journal

A strategy for risk mitigation of antibodies with fast clearance

(2012) Isidro Hötzel et al.   mAbs

Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

(2011) W. Wang et al.   DRUG METABOLISM AND DISPOSITION

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

(2010) C. Andrew Boswell et al.   BIOCONJUGATE CHEMISTRY

Importance of Neonatal FcR in Regulating the Serum Half-Life of Therapeutic Proteins Containing the Fc Domain of Human IgG1: A Comparative Study of the Affinity of Monoclonal Antibodies and Fc-Fusion Proteins to Human Neonatal FcR

(2010) Takuo Suzuki et al.   JOURNAL OF IMMUNOLOGY

Structural Basis for the Dual Recognition of IL-12 and IL-23 by Ustekinumab

(2010) Jinquan Luo et al.   JOURNAL OF MOLECULAR BIOLOGY

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

(2010) Tomoyuki Igawa et al.   NATURE BIOTECHNOLOGY

Enhanced antibody half-life improves in vivo activity

(2010) Jonathan Zalevsky et al.   NATURE BIOTECHNOLOGY

Reduced elimination of IgG antibodies by engineering the variable region

(2010) T. Igawa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Anti-p40 Antibodies Ustekinumab and Briakinumab: Blockade of Interleukin-12 and Interleukin-23 in the Treatment of Psoriasis

(2010) Mona Gandhi et al.   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates

(2009) Y. A. Yeung et al.   JOURNAL OF IMMUNOLOGY

Cross-Interaction Chromatography: A Rapid Method to Identify Highly Soluble Monoclonal Antibody Candidates

(2009) Steven A. Jacobs et al.   PHARMACEUTICAL RESEARCH

The Intrinsic Contributions of Tyrosine, Serine, Glycine and Arginine to the Affinity and Specificity of Antibodies

(2008) Sara Birtalan et al.   JOURNAL OF MOLECULAR BIOLOGY