Antibody production using a ciliate generates unusual antibody glycoforms displaying enhanced cell-killing activity

Effect of high mannose glycan pairing on IgG antibody clearance

(2016) Yaoqing Diana Liu et al.   BIOLOGICALS

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

(2015) Nathaniel Washburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards the development of a surface plasmon resonance assay to evaluate the glycosylation pattern of monoclonal antibodies using the extracellular domains of CD16a and CD64

(2014) July Dorion-Thibaudeau et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Antibodies to watch in 2015

(2014) Janice M Reichert   mAbs

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

A Novel Malaria Vaccine Candidate Antigen Expressed in Tetrahymena thermophila

(2014) Graeme J. M. Cowan et al.   PLoS One

Emerging Principles for the Therapeutic Exploitation of Glycosylation

(2014) Martin Dalziel et al.   SCIENCE

Impact of Immune Complex Size and Glycosylation on IgG Binding to Human Fc Rs

(2013) A. Lux et al.   JOURNAL OF IMMUNOLOGY

A high-throughput media design approach for high performance mammalian fed-batch cultures

(2013) Yolande Rouiller et al.   mAbs

Crystal structure of sialylated IgG Fc: Implications for the mechanism of intravenous immunoglobulin therapy

(2013) M. Crispin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Recombinant Antibodies

(2013) André Frenzel et al.   Frontiers in Immunology

Selective Deactivation of Serum IgG: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions

(2012) Kavitha Baruah et al.   JOURNAL OF MOLECULAR BIOLOGY

Chemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan Biosynthesis

(2012) Thomas A. Bowden et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lepidopteran cells, an alternative for the production of recombinant antibodies?

(2012) Martine Cérutti et al.   mAbs

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Development and validation of an antibody-dependent cell-mediated cytotoxicity-reporter gene assay

(2012) Bhavin S. Parekh et al.   mAbs

Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans

(2012) Marcella Yu et al.   mAbs

Use of the α-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells

(2011) Chao Yu et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Expression, secretion and surface display of a human alkaline phosphatase by the ciliate Tetrahymena thermophila

(2011) Ingo Aldag et al.   BMC BIOTECHNOLOGY

Isolation and characterization of IgG1 with asymmetrical Fc glycosylation

(2011) S. Ha et al.   GLYCOBIOLOGY

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

Chemoenzymatic Synthesis and Fcγ Receptor Binding of Homogeneous Glycoforms of Antibody Fc Domain. Presence of a Bisecting Sugar Moiety Enhances the Affinity of Fc to FcγIIIa Receptor

(2011) Guozhang Zou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biochemical and biophysical characterization of humanized IgG1 produced inPichia pastoris

(2011) Sha Ha et al.   mAbs

Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study

(2011) Ningyan Zhang et al.   mAbs

Tetrahymena Gene Expression Database (TGED): A resource of microarray data and co-expression analyses for Tetrahymena

(2011) Jie Xiong et al.   Science China-Life Sciences

Separation of post-translational modifications in monoclonal antibodies by exploiting subtle conformational changes under mildly acidic conditions

(2010) Shiyi Wang et al.   JOURNAL OF CHROMATOGRAPHY A

Optimal and consistent protein glycosylation in mammalian cell culture

(2009) P. Hossler et al.   GLYCOBIOLOGY

Carbohydrate and Domain Architecture of an Immature Antibody Glycoform Exhibiting Enhanced Effector Functions

(2009) Max Crispin et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and quantitative analysis of N-linked glycans by matrix-assisted laser desorption ionization and negative ion nanospray mass spectrometry

(2008) David J. Harvey et al.   ANALYTICAL BIOCHEMISTRY

C-terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes

(2008) Lawrence W. Dick et al.   BIOTECHNOLOGY AND BIOENGINEERING

Applications of CE SDS gel in development of biopharmaceutical antibody-based products

(2008) Richard R. Rustandi et al.   ELECTROPHORESIS

New downstream processing strategy for the purification of monoclonal antibodies from transgenic tobacco plants

(2008) D. Platis et al.   JOURNAL OF CHROMATOGRAPHY A

Development of a Single Column Method for the Separation of Lipid- and Protein-Derived Oligosaccharides

(2008) David C. A. Neville et al.   JOURNAL OF PROTEOME RESEARCH

Glycosylation of Recombinant Antibody Therapeutics

(2005) Royston Jefferis   BIOTECHNOLOGY PROGRESS