Sweet but dangerous – the role of immunoglobulin G glycosylation in autoimmunity and inflammation

Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis

(2015) Yoann Rombouts et al.   ANNALS OF THE RHEUMATIC DISEASES

bIgG time for large eaters: monocytes and macrophages as effector and target cells of antibody-mediated immune activation and repression

(2015) Sina Gordan et al.   IMMUNOLOGICAL REVIEWS

A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis

(2015) Alison E. Mahan et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 2: Mass spectrometric methods

(2015) Dietmar Reusch et al.   mAbs

Rational design of therapeutic mAbs against aggregation through protein engineering and incorporation of glycosylation motifs applied to bevacizumab

(2015) Fabienne Courtois et al.   mAbs

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

(2015) Nathaniel Washburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

(2015) Ulrike Harre et al.   Nature Communications

A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors

(2015) Daniela Kao et al.   Cell Reports

The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation

(2015) Christoph Fickentscher et al.   Journal of Immunology Research

Role of sialylation in the anti-inflammatory activity of intravenous immunoglobulin - F(ab′)2versus Fc sialylation

(2014) I. Schwab et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Altered glycosylation of complexed native IgG molecules is associated with disease activity of systemic lupus erythematosus

(2014) C Sjöwall et al.   LUPUS

Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis

(2013) Parawee Suwannalai et al.   ANNALS OF THE RHEUMATIC DISEASES

Obinutuzumab: First Global Approval

(2013) Fiona Cameron et al.   DRUGS

The carbohydrate switch between pathogenic and immunosuppressive antigen-specific antibodies

(2013) Mattias Collin et al.   EXPERIMENTAL DERMATOLOGY

Impact of Immune Complex Size and Glycosylation on IgG Binding to Human Fc Rs

(2013) A. Lux et al.   JOURNAL OF IMMUNOLOGY

IgG glycan hydrolysis by endoglycosidase S diminishes the proinflammatory properties of immune complexes from patients with systemic lupus erythematosus: A possible new treatment?

(2012) Christian Lood et al.   ARTHRITIS AND RHEUMATISM

IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1

(2012) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Quantitative glycan profiling of normal human plasma derived immunoglobulin and its fragments Fab and Fc

(2012) Kalyan Rao Anumula   JOURNAL OF IMMUNOLOGICAL METHODS

Expression of Natural Autoantibodies in MRL-lpr Mice Protects from Lupus Nephritis and Improves Survival

(2012) K. Mannoor et al.   JOURNAL OF IMMUNOLOGY

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1

(2012) Christian M Karsten et al.   NATURE MEDICINE

Monocyte Subsets Responsible for Immunoglobulin G-Dependent Effector Functions In Vivo

(2011) Markus Biburger et al.   IMMUNITY

Enrichment of Sialylated IgG by Lectin Fractionation Does Not Enhance the Efficacy of Immunoglobulin G in a Murine Model of Immune Thrombocytopenia

(2011) Theresa Guhr et al.   PLoS One

Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid

(2010) Hans U. Scherer et al.   ARTHRITIS AND RHEUMATISM

The other side of immunoglobulin G: suppressor of inflammation

(2010) S. Aschermann et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The role of differential IgG glycosylation in the interaction of antibodies with FcγRs in vivo

(2010) Robert M Anthony et al.   Current Opinion in Organ Transplantation

Functional analysis of agalactosyl IgG in inflammatory bowel disease patients

(2010) Sachiko Nakajima et al.   INFLAMMATORY BOWEL DISEASES

Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins

(2010) V. Coelho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is IgG galactosylation the relevant factor for pregnancy-induced remission of rheumatoid arthritis?

(2010) Frauke Förger et al.   ARTHRITIS RESEARCH & THERAPY

Sugar-free Antibodies-The Bacterial Solution to Autoimmunity?

(2009) Maria Allhorn et al.   Annals of the New York Academy of Sciences

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study

(2009) Fleur E van de Geijn et al.   ARTHRITIS RESEARCH & THERAPY

Anti-Inflammatory Actions of Intravenous Immunoglobulin

(2008) Falk Nimmerjahn et al.   Annual Review of Immunology

In vivo enzymatic modulation of IgG glycosylation inhibits autoimmune disease in an IgG subclass-dependent manner

(2008) H. Albert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE

The Role of Secretory IgA and Complement in IgA Nephropathy

(2008) Beatrijs D. Oortwijn et al.   SEMINARS IN NEPHROLOGY

Glycosylation of Recombinant Antibody Therapeutics

(2005) Royston Jefferis   BIOTECHNOLOGY PROGRESS