Article
Obstetrics & Gynecology
Wei Li, Tao Wang
Summary: This study compared breastfeeding initiation, duration, and associated factors in patients with systemic lupus erythematosus (SLE) with non-SLE mothers. The results showed that the breastfeeding rate in the SLE group was significantly lower and the duration of breastfeeding was shorter compared to the non-SLE group. The main reason for not initiating breastfeeding in the SLE group was fear of adverse effects of drugs on infants. Factors associated with breastfeeding among SLE patients included higher infant weight and Apgar scores, primiparity, and having a college degree.
BREASTFEEDING MEDICINE
(2022)
Article
Rheumatology
Valeria Orefice, Fulvia Ceccarelli, Carmelo Pirone, Paola Galoppi, Francesca Romana Spinelli, Cristiano Alessandri, Roberto Brunelli, Giuseppina Perrone, Fabrizio Conti
Summary: The study found that almost all SLE pregnant women planned to breastfeed (96.5%), but only 71.9% actually did, with a median duration of 3 months. Non-breastfeeding women had a higher likelihood of c-section, IUGR, and disease relapse after pregnancy. Early discontinuation of breastfeeding was associated with smoking, BMI, joint involvement, while longer duration was linked to disease duration and HCQ treatment during postpartum.
Article
Rheumatology
Duarte Andre Ferreira, Filipa Taborda, Teresa Mendonca, Fatima Farinha
Summary: Pregnancy and lactation-associated osteoporosis is a rare disease that is often seen in late pregnancy or early postpartum, and it is characterized by multiple vertebral fractures. Early diagnosis, cessation of breastfeeding, and targeted therapy are crucial for symptom control, improving the quality of life, and preventing future fractures.
Article
Rheumatology
Karel Venne, Susan Scott, Sasha Bernatsky, Evelyne Vinet
Summary: The study found that the rate of induced abortions in women with SLE is similar to that of the general population. Through multivariable analysis, it was observed that women exposed to teratogenic immunosuppressives or using corticosteroids did not have higher rates of induced abortions.
Article
Rheumatology
Julia F. Simard, Marios Rossides, Iva Gunnarsson, Elisabet Svenungsson, Elizabeth Arkema
Summary: Patients with incident systemic lupus erythematosus (SLE) had a significantly higher infection rate compared to the general population, especially in the first year of follow-up. Starting treatment with disease-modifying antirheumatic drugs (DMARDs) was associated with a higher risk of serious infection, with azathioprine having the highest risk among the DMARDs.
LUPUS SCIENCE & MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Xinghua Zhao, Jiaojiao Zhang, Yutong Liang, Jie Li, Shi Ding, Yang Wang, Ye Chen, Ju Liu
Summary: This review article analyzes the pathogenesis of systemic lupus erythematosus and summarizes the traditional and new therapeutic drugs, providing important reference significance for the future development of new systemic lupus erythematosus drugs.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Rheumatology
Maddalena Larosa, Veronique Le Guern, Gaelle Guettrot-Imbert, Nathalie Morel, Noemie Abisror, Chafika Morati-Hafsaoui, Pauline Orquevaux, Elisabeth Diot, Andrea Doria, Francoise Sarrot Reynauld, Nicolas Limal, Viviane Queyrel, Odile Souchaud-Debouverie, Laurent Sailler, Maelle Le Besnerais, Tiphaine Goulenok, Anna Molto, Emmanuelle Pannier-Metzger, Loic Sentilhes, Luc Mouthon, Estibaliz Lazaro, Nathalie Costedoat-Chalumeau
Summary: The specific roles of remission status, lupus low disease activity state (LLDAS), and damage accrual on the prognosis of pregnancies in women with SLE are unknown. This study found that damage at conception and lupus anticoagulant were significantly associated with adverse pregnancy outcomes, while hypocomplementemia in the first trimester was associated with maternal flares later in pregnancy.
Article
Rheumatology
Raisa Lomanto Silva, Gretchen M. Swabe, Sebastian Eduardo Sattui, Jared W. Magnani
Summary: This study investigated the association between medication copayment and treatment adherence to hydroxychloroquine and immunosuppressants for systemic lupus erythematosus (SLE). The results showed that higher copayment was associated with reduced adherence to prescribed medications for SLE.
LUPUS SCIENCE & MEDICINE
(2023)
Review
Rheumatology
Danielle H. Wang, Daniel J. Wallace
Summary: This article discusses new therapies for systemic lupus erythematosus (SLE) in the past 10 years, including lifestyle interventions, medication treatments, and other modalities.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ann E. Maltby, Belinda C. Odhiambo, Maureen Nyaura, Rosemary Shikari, Emily L. Tuthill
Summary: This study tested a personalized infant feeding support program among perinatal women living with HIV in Kenya. The findings showed that through face-to-face and frequent infant feeding support sessions, women were able to successfully practice exclusive breastfeeding.
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Giovanni Orsolini, Francesca Mastropaolo, Eleonora Favaro, Anna Piccinelli, Davide Bertelle, Ombretta Viapiana, Maurizio Rossini, Riccardo Bixio
Summary: The aim of this study was to characterize lupus-related arthritis and assess the efficacy of belimumab in treating articular manifestations of SLE. The results showed that belimumab treatment significantly improved disease activity in patients without erosions, but had no effect on patients with erosions. Additionally, the presence of ultrasound-detected erosions was associated with a decreased efficacy of belimumab. However, further research is needed to confirm these findings due to the small sample size.
CLINICAL RHEUMATOLOGY
(2023)
Review
Obstetrics & Gynecology
Kathryn H. Dao, Bonnie L. Bermas
Summary: Family planning is important for women with systemic lupus erythematosus (SLE). Pregnancy may lead to disease flares and adverse outcomes. Disease control and the use of safe medications prior to conception are recommended. Aspirin can reduce the risk of pre-eclampsia.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Article
Endocrinology & Metabolism
Zhi-Ju Li, Hao-Yue Hu, Zi-Ling Ding, Zi-Wei Bian, Ying-Hua Xu, Hui-Ting Wen, Ya-Li Qu, Jin-Dong Wang, Xiao-Li Huang, Dong Li, Jing Li, Gui-Fang Hu
Summary: This study found that women with cSLE have more aggressive disease activity during pregnancy compared to those with aSLE, with higher risks of active SLE and LN. However, after adjusting for pre-pregnancy characteristics and pregnancy factors, no significant association was found between cSLE and adverse pregnancy outcomes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Rheumatology
Hieronymus T. W. Smeele, Luis F. Perez-Garcia, Koen Grimminck, Sam Schoenmakers, Annemarie G. M. G. J. Mulders, Radboud J. E. M. Dolhain
Summary: The clinical characteristics of COVID-19 in pregnant patients with autoimmune disease like SLE are currently lacking. Two pregnant SLE patients with mild symptomatic COVID-19 infection had good outcomes without COVID-19 treatment, giving birth to healthy babies. One patient experienced a flare in SLE disease activity after discontinuing SLE treatment. Collaborative multidisciplinary care and individualized treatment decisions are important during unprecedented times like the current COVID-19 pandemic.