Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease

Differential gene expression in iPSC-derived human intestinal epithelial cell layers following exposure to two concentrations of butyrate, propionate and acetate

(2022) Menno Grouls et al.   Scientific Reports

Application of perfluoropolyether elastomers in microfluidic drug metabolism assays

(2022) Mengyang Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

In vitro hepatic steatosis model based on gut–liver‐on‐a‐chip

(2021) Joong‐won Jeon et al.   BIOTECHNOLOGY PROGRESS

Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system

(2021) Tomasz Kostrzewski et al.   Communications Biology

In vitro models for non-alcoholic fatty liver disease: Emerging platforms and their applications

(2021) Maria Jimenez Ramos et al.   iScience

Microfluidic chip for culturing intestinal epithelial cell layers: Characterization and comparison of drug transport between dynamic and static models

(2020) Kornphimol Kulthong et al.   TOXICOLOGY IN VITRO

Intestine-Liver Axis On-Chip Reveals the Intestinal Protective Role on Hepatic Damage by Emulating Ethanol First-Pass Metabolism

(2020) Vincenza De Gregorio et al.   Frontiers in Bioengineering and Biotechnology

Palmitic Acid Affects Intestinal Epithelial Barrier Integrity and Permeability In Vitro

(2020) Manuele Gori et al.   Antioxidants

Redox cycling of copper by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated modulation of redox scavengers, DNA damage and cell death in diethylnitrosamine induced hepatocellular carcinoma

(2020) Saman Khan et al.   BIOORGANIC CHEMISTRY

Cell cycle regulation in NAFLD: when imbalanced metabolism limits cell division

(2020) Matias J. Caldez et al.   Hepatology International

Beyond polydimethylsiloxane: Alternative materials for fabrication of organ on a chip devices and microphysiological systems

(2020) Scott Campbell et al.   ACS Biomaterials-Science & Engineering

Dual Behavior of Long-Chain Fatty Acids and Their Cyclooxygenase/Lipoxygenase Metabolites on Human Intestinal Caco-2 Cell Growth

(2020) Carolina E. Storniolo et al.   Frontiers in Pharmacology

Recapitulation of Human Embryonic Heartbeat to Promote Differentiation of Hepatic Endoderm to Hepatoblasts

(2020) Koki Yoshimoto et al.   Frontiers in Bioengineering and Biotechnology

Advances and Current Challenges in Intestinal in vitro Model Engineering: A Digest

(2019) Joana Costa et al.   Frontiers in Bioengineering and Biotechnology

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models

(2019) Ludivine C. Delon et al.   BIOMATERIALS

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

(2019) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Copper complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin induced apoptosis in breast cancer cell

(2018) Jhi Biau Foo et al.   BIOMETALS

Gut-liver on a chip towards an in vitro model of hepatic steatosis

(2018) Seung Yeon Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Lipotoxicity and the gut-liver axis in NASH pathogenesis

(2018) Fabio Marra et al.   JOURNAL OF HEPATOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Fluid Shear Stress Promotes Autophagy in Hepatocellular Carcinoma Cells

(2018) Xiaoli Wang et al.   International Journal of Biological Sciences

Implementation of a dynamic intestinal gut-on-a-chip barrier model for transport studies of lipophilic dioxin congeners

(2018) Kornphimol Kulthong et al.   RSC Advances

Palmitate-induced lipotoxicity is crucial for the pathogenesis of nonalcoholic fatty liver disease in cooperation with gut-derived endotoxin

(2018) Yuji Ogawa et al.   Scientific Reports

Application of chemical reaction engineering principles to “body-on-a-chip” systems

(2018) Jong Hwan Sung et al.   AICHE JOURNAL

DNA binding, cleavage and cytotoxicity studies of three mononuclear Cu(II) chloro-complexes containing N–S donor Schiff base ligands

(2018) Sidhali U. Parsekar et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

(2017) Chris Estes et al.   HEPATOLOGY

Current and future pharmacological therapies for NAFLD/NASH

(2017) Yoshio Sumida et al.   JOURNAL OF GASTROENTEROLOGY

Targeting the gut-liver axis in liver disease

(2017) Reiner Wiest et al.   JOURNAL OF HEPATOLOGY

Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip

(2017) Yu Du et al.   LAB ON A CHIP

WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit

(2017) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

Systems biology for organotypic cell cultures

(2017) Sonia Grego   ALTEX-Alternatives to Animal Experimentation

Integrated heart/cancer on a chip to reproduce the side effects of anti-cancer drugs in vitro

(2017) Ken-ichiro Kamei et al.   RSC Advances

Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro

(2017) Remi Villenave et al.   PLoS One

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

(2016) Yaron Rotman et al.   GUT

Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis

(2016) Petra Hirsova et al.   JOURNAL OF LIPID RESEARCH

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The role of the gut microbiota in NAFLD

(2016) Christopher Leung et al.   Nature Reviews Gastroenterology & Hepatology

Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions

(2016) Maria Grazia Clemente et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Experimental Study of Numerical Optimization for 3-D Microstructuring Using DMD-Based Grayscale Lithography

(2015) Xiaoxu Ma et al.   JOURNAL OF MICROELECTROMECHANICAL SYSTEMS

Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease

(2015) Shobha H. Ganji et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

High-Content High-Throughput Assays for Characterizing the Viability and Morphology of Human iPSC-Derived Neuronal Cultures

(2014) Oksana Sirenko et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Inhibitory effect of phospholipids on P-glycoprotein: Cellular studies in Caco-2, MDCKII mdr1 and MDCKII wildtype cells and P-gp ATPase activity measurements

(2012) S. Simon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Phenotypic and Transcriptional Modulation of Human Pluripotent Stem Cells Induced by Nano/Microfabrication Materials

(2012) Ken-ichiro Kamei et al.   Advanced Healthcare Materials

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

A Novel Multiplex Cell Viability Assay for High-Throughput RNAi Screening

(2011) Daniel F. Gilbert et al.   PLoS One

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Integrated microfluidic devices for combinatorial cell-based assays

(2009) Zeta Tak For Yu et al.   BIOMEDICAL MICRODEVICES

Biological implications of polydimethylsiloxane-based microfluidic cell culture

(2009) Keil J. Regehr et al.   LAB ON A CHIP

Surface molecular property modifications for poly(dimethylsiloxane) (PDMS) based microfluidic devices

(2009) Ieong Wong et al.   Microfluidics and Nanofluidics

An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells

(2008) Ken-ichiro Kamei et al.   LAB ON A CHIP

Generation of human induced pluripotent stem cells from dermal fibroblasts

(2008) W. E. Lowry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA