Article
Immunology
Thomas Resch, Hubert Hackl, Hannah Esser, Julia Gunther, Hubert Schwelberger, Paul Viktor Ritschl, Susanne Ebner, Manuel Maglione, Vanessa Mellitzer, Matthias Biebl, Robert Oellinger, Heinz Zoller, Stefan Schneeberger, Katja Kotsch
Summary: The study investigated the predictive value of candidate genes for outcomes after liver transplantation, finding that MICA mRNA expression in donors correlated with graft survival and patient mortality risk, suggesting MICA as a potential biomarker for pre-transplant evaluation of graft quality.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tamara Horvath, David Kurszan Jasz, Balint Barath, Marietta Zita Poles, Mihaly Boros, Petra Hartmann
Summary: This study summarized the effects of various preservation methods on mitochondrial function in preclinical models of liver transplantation (LT), indicating that hypothermic and subnormothermic machine perfusion have protective effects on mitochondria of donor organs, while shorter storage time at lower temperatures in static cold storage yields better results in terms of ATP preservation and respiratory capacity of complexes. Additional clinical studies are needed to confirm these findings in human patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pathology
Neha Bakshi, Archana Rastogi, Viniyendra Pamecha, Chhagan Bihari
Summary: Sinusoidal dilatation and congestion in post-liver transplant patients may be obstructive or non-obstructive, and is associated with transaminitis and graft rejection.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Surgery
Joanna T. Swinarska, Robert J. Stratta, Jeffrey Rogers, Amy Chang, Alan C. Farney, Giuseppe Orlando, Amber Reeves-Daniel, Venkat Gurram, Michael D. Gautreaux, Colleen L. Jay
Summary: Patients experiencing early graft loss (EGL) have lower retransplantation rates and inferior patient survival. High Kidney Donor Profile Index (KDPI) and donation after circulatory death (DCD) do not increase the risk of EGL or primary nonfunction (PNF) unless combined with prolonged cold ischemic time (CIT).
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Surgery
Giacomo Germani, Debora Angrisani, Giovanni Addolorato, Manuela Merli, Chiara Mazzarelli, Claudia Tarli, Barbara Lattanzi, Adelaide Panariello, Paola Prandoni, Lucia Craxi, Giovanni Forza, Alessandra Feltrin, Andrea Ronzan, Paolo Feltracco, Antonio Grieco, Salvatore Agnes, Antonio Gasbarrini, Massimo Rossi, Luciano De Carlis, D'Amico Francesco, Umberto Cillo, Luca S. Belli, Patrizia Burra
Summary: This study assessed the outcomes of early liver transplantation (eLT) in patients with severe alcoholic hepatitis (sAH) and found that eLT significantly improved survival in non-responders to medical therapy, when a strict selection process was applied.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Gastroenterology & Hepatology
Lucija Virovic-Jukic, Dominik Ljubas, Sanja Stojsavljevic-Shapeski, Neven Ljubicic, Tajana Filipec Kanizaj, Ivana Mikolasevic, Ivica Grgurevic
Summary: Severe alcoholic hepatitis has limited treatment options and poor outcomes with current supportive medical care and corticosteroids. While new treatment options like granulocyte colony-stimulating factor and stem cell transplantation are being explored, evidence for their efficacy remains scarce and further research is needed. Insights into the pathogenesis of AH and liver regeneration processes are crucial for the development of new treatment options, but high-quality studies and reliable experimental models are lacking.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Jia Huang, Jiachi Yu, Jianan Wang, Jiayu Liu, Wei Xie, Ruibing Li, Chengbin Wang
Summary: This study identified three novel candidate proteins as promising circulating biomarkers for clinical diagnosis and disease progression in ALD. The combination of these biomarkers showed superior efficacy in monitoring disease progression compared to existing liver fibrosis evaluation indices.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Naoto Fujiwara, Eric Trepo, Indu Raman, Quan-Zhen Li, Delphine Degre, Thierry Gustot, Christophe Moreno, Yujin Hoshida
Summary: The study identified a 6-plasma-protein panel as a surrogate for the 123-gene signature in severe alcoholic hepatitis patients. The composite score ps-MELD, combining plasma signature with MELD score, showed a strong association with short-term survival, outperforming existing clinical scores.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hye Gyo Chung, Dong Hyun Sinn, Wonseok Kang, Gyu-Seong Choi, Jong Man Kim, Jae-Won Joh
Summary: The study found that the alcohol relapse rate was lower for patients receiving LDLT compared to DDLT, and factors associated with alcohol relapse for DDLT recipients included short abstinence period and current smoking status. Smokers and those with a short abstinence period need careful attention to prevent alcohol relapse.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Stefan G. Hubscher, Sandy Feng, Annette S. H. Gouw, Hironori Haga, Hyo Jeong Kang, Deirdre A. Kelly, Mina Komuta, Andrew Lesniak, Benjamin A. Popp, Henkjan J. Verkade, Eunsil Yu, Anthony J. Demetris
Summary: This study aimed to establish a standardized approach for assessing long-term graft histology in pediatric liver transplant recipients. The results showed a high level of agreement among pathologists in assessing various histological features relevant to graft health. This standardized assessment could aid in improving outcomes for children undergoing liver transplantation.
LIVER TRANSPLANTATION
(2022)
Article
Biology
Brett D. Anderson, Erek D. Nelson, DongJin Joo, Bruce P. Amiot, Aleksandr A. Katane, Alyssa Mendenhall, Benjamin G. Steiner, Aron R. Stumbras, Victoria L. Nelson, R. Noelle Palumbo, Thomas W. Gilbert, Dominique S. Davidow, Jeffrey J. Ross, Scott L. Nyberg
Summary: Organ bioengineering provides a promising solution to the shortage of donor organs. Anderson et al. demonstrate a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver scaffold that had been previously reendothelialized, a significant advancement in generating transplantable livers of a clinically relevant size for humans.
COMMUNICATIONS BIOLOGY
(2021)
Article
Urology & Nephrology
Zhengzi Yi, Fadi Salem, Madhav C. Menon, Karen Keung, Caixia Xi, Sebastian Hultin, M. Rizwan Haroon Al Rasheed, Li Li, Fei Su, Zeguo Sun, Chengguo Wei, Weiqing Huang, Samuel Fredericks, Qisheng Lin, Khadija Banu, Germaine Wong, Natasha M. Rogers, Samira Farouk, Paolo Cravedi, Meena Shingde, R. Neal Smith, Ivy A. Rosales, Philip J. O'Connell, Robert B. Colvin, Barbara Murphy, Weijia Zhang
Summary: This study utilized deep-learning to objectively and quantitatively assess the pathological lesions in kidney transplant recipients. The findings showed that this method accurately detected and quantified the lesions, and demonstrated superior predictive ability for post-transplant graft loss. This research has significant implications for medical prediction and monitoring of transplant recipients.
KIDNEY INTERNATIONAL
(2022)
Review
Gastroenterology & Hepatology
Mamatha Bhat, Madhumitha Rabindranath, Beatriz Sordi Chara, Douglas A. Simonetto
Summary: Liver transplantation (LT) is a life-saving treatment for end-stage liver disease, and artificial intelligence (AI) offers a data-driven approach to improve clinical decision-making in LT. AI can be applied in optimizing transplant candidacy decision-making, donor-recipient matching, and guiding the management of LT recipients. However, limitations such as dataset imbalances, data privacy issues, and a lack of research practices to benchmark model performance in the real world need to be addressed. Overall, AI has the potential to enhance personalized clinical decision-making in liver transplant medicine.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Brittany Rocque, Aaron Zaldana, Carly Weaver, Julia Huang, Arianna Barbetta, Victoria Shakhin, Cameron Goldbeck, George Yanni, Shannon Zielsdorf, Yong Kwon, Kambiz Etesami, Yuri Genyk, Shengmei Zhou, Rohit Kohli, Juliet Emamaullee
Summary: Surveillance biopsies (SBs) in pediatric liver transplantation can provide valuable information about subclinical rejection episodes and guide immunosuppression management. Patients in the SB group had better transplant outcomes and no serious complications compared to those who had for-cause biopsies. SBs can detect subclinical rejection and prompt adjustments in immunosuppression.
LIVER TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Armando Tripodi, Rosa Lombardi, Massimo Primignani, Vincenzo La Mura, Flora Peyvandi, Anna L. Fracanzani
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is closely related to metabolic diseases. Assessing hypercoagulability can help understand the coagulation balance in NAFLD patients, and it plays a significant role in studying treatment methods and reducing the risk of cardiovascular diseases.
Article
Economics
Jerome Dumortier, Miguel Carriquiry, Amani Elobeid
Summary: Future agricultural production is influenced by climate change and policies/behavior. The increase in sales of battery electric vehicles (BEV) in the United States has a significant impact on agricultural commodity prices, reducing demand for maize ethanol and reducing cropland requirements. It also has implications for food security and changes in trade relationships.
ENVIRONMENTAL & RESOURCE ECONOMICS
(2023)
Article
Gastroenterology & Hepatology
Yasmina Chouik, Claire Francoz, Eleonora De Martin, Olivier Guillaud, Armand Abergel, Mario Altieri, Louise Barbier, Camille Besch, Olivier Chazouilleres, Filomena Conti, Christophe Corpechot, Sebastien Dharancy, Francois Durand, Christophe Duvoux, Jean Gugenheim, Jean Hardwigsen, Marie-Noelle Hilleret, Pauline Houssel-Debry, Nassim Kamar, Anne Minello, Martine Neau-Cransac, Georges-Philippe Pageaux, Sylvie Radenne, Olivier Roux, Faouzi Saliba, Didier Samuel, Claire Vanlemmens, Marie-Lorraine Woehl-Jaegle, Vincent Leroy, Jean-Charles Duclos-Vallee, Jerome Dumortier
Summary: This study describes the early outcomes of liver transplantation for autoimmune hepatitis (AIH). The prognosis is good for AIH patients after transplantation, and pre-transplant immunosuppression does not affect the outcomes. However, the presence of acute kidney injury at the time of transplantation can negatively impact the prognosis.
LIVER INTERNATIONAL
(2023)
Article
Clinical Neurology
Christelle Nilles, Mickael Alexandre Obadia, Rodolphe Sobesky, Jerome Dumortier, Olivier Guillaud, Chloe Laurencin, Caroline Moreau, Claire Vanlemmens, Fabienne Ory-Magne, Victor de Ledinghen, Edouard Bardou-Jacquet, Frederique Fluchere, Corinne Collet, Nouzha Oussedik-Djebrani, France Woimant, Aurelia Poujois
Summary: This study characterized the clinical presentation, therapeutic management, and outcomes of late-onset Wilson's disease (WD). Late-onset WD mainly presented with neurological symptoms, and 30% of neurological symptoms were atypical. Personalized treatment improved prognosis, highlighting the importance of considering WD at any age and in cases of atypical presentation.
MOVEMENT DISORDERS
(2023)
Article
Virology
Lucy Meunier, Mohamed Belkacemi, George Philippe Pageaux, Sylvie Radenne, Anais Vallet-Pichard, Pauline Houssel-Debry, Christophe Duvoux, Danielle Botta-Fridlund, Victor de Ledinghen, Filomena Conti, Rodolphe Anty, Vincent Di Martino, Marilyne Debette-Gratien, Vincent Leroy, Theophile Gerster, Pascal Lebray, Laurent Alric, Armand Abergel, Jerome Dumortier, Camille Besch, Helene Montialoux, Didier Samuel, Jean-Charles Duclos-Vallee, Audrey Coilly
Summary: This study examined the clinical outcomes of patients with cirrhosis or hepatocellular carcinoma who were treated with direct-acting antiviral agents while awaiting liver transplantation. The results showed that these drugs are safe and effective in achieving viral eradication and improving the clinical condition of patients.
Review
Medicine, General & Internal
Olivier Guillaud, Jerome Dumortier, Eduardo Couchonnal-Bedoya, Mathias Ruiz
Summary: Wilson disease and alpha1-antitrypsin deficiency are rare genetic diseases that primarily affect the liver and/or the brain, and the liver and/or the lung, respectively. Early diagnosis is crucial for timely treatment initiation and family screening. This review focuses on non-invasive diagnostic tests for clinicians, which are essential for reducing diagnostic delay, assessing organ involvement, and monitoring disease progression and treatment efficacy.
Editorial Material
Gastroenterology & Hepatology
Jerome Dumortier, Helene Gimonet, Pierre-Jean Valette, Benedicte Cayot
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiqing Huang, Benjamin Leporq, Valerie Hervieu, Jerome Dumortier, Olivier Beuf, Helene Ratiney
Summary: This study investigated the relationship between DWI's parameters and CLD-related features, especially fibrosis assessment. The results showed that the Bayesian method provided the most accurate parameters, which can be used for the noninvasive evaluation of fibrosis.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Editorial Material
Gastroenterology & Hepatology
Jerome Dumortier, Hubert Rebaudet, Jean Champagnac, Pierre -Jean Valette
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Emma Wischlen, Noemie Laverdure, Domitille Erard, Barbara Rohmer, Olivier Boillot, Remi Dubois, Alain Lachaux, Sophie Collardeau-Frachon, Valerie Hervieu, Jerome Dumortier
Summary: Post-transplantation evolution of progressive familial intrahepatic cholestasis type 2 patients can be complicated by antibody-induced bile salt export pump deficiency (AIBD). There is no consensus on its management. We describe a patient who presented two episodes, 9 years apart. The first episode was refractory to plasmapheresis and intravenous immunoglobulin (IVIG) started 2 months after AIBD onset, leading to graft loss. The second episode responded to plasmapheresis, IVIG and rituximab initiated less than 2 weeks after the beginning of symptoms, allowing for long-term recovery. This case suggests that intensive treatment with minimum delay after symptoms onset could sponsor a better evolution.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Article
Physiology
Arnaud Riff, Muzhda Haem Rahimi, Marie-Charlotte Delignette, Morgane Gossez, Remy Coudereau, Solene Pantel, Teresa Antonini, Francois Villeret, Fabien Zoulim, Jean-Yves Mabrut, Jerome Dumortier, Fabienne Venet, Fanny Lebosse, Guillaume Monneret
Summary: This study found that the phenotypes of neutrophils and lymphocytes, along with the expression of immune checkpoint proteins, were altered in cirrhotic patients before and after liver transplantation. These findings highlight the potential importance of immune monitoring in cirrhotic patients during liver transplantation to better assess the risk of infection.
FRONTIERS IN PHYSIOLOGY
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Laurent Milot, Romain L'Huillier, Jerome Dumortier, Laura Gerard, Pierre-Jean Valette
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2023)
Article
Endocrinology & Metabolism
Cyrielle Caussy, Charlene Telliam, Bader Al-Nuaimi, Marianne Maynard-Muet, Jerome Dumortier, Fabien Zoulim, Emmanuel Disse, Cyrille Colin, Massimo Levrero, Philippe Moulin
Summary: A pathway-referral using transient elastography (TE) performed in diabetology and nutrition clinics significantly improves the liver fibrosis risk stratification and avoids over-referral. However, collaboration between diabetologists, nutritionists, and hepatologists is needed to avoid under-referral.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2023)
Article
Gastroenterology & Hepatology
Francois Villeret, Sebastien Dharancy, Domitille Erard, Armand Abergel, Louise Barbier, Camille Besch, Olivier Boillot, Karim Boudjema, Audrey Coilly, Filomena Conti, Christophe Corpechot, Christophe Duvoux, Francois Faitot, Stephanie Faure, Claire Francoz, Emiliano Giostra, Jean Gugenheim, Jean Hardwigsen, Marie-Noelle Hilleret, Jean-Baptiste Hiriart, Pauline Houssel-Debry, Nassim Kamar, Guillaume Lassailly, Marianne Latournerie, Georges-Philippe Pageaux, Didier Samuel, Claire Vanlemmens, Faouzi Saliba, Jerome Dumortier
Summary: This study evaluated the risk of disease recurrence after liver transplantation for non-alcoholic fatty liver disease (NAFLD) and identified several factors influencing recurrence. The study found a high cumulative recurrence rate of steatosis, steatohepatitis, and fibrosis after transplantation for NAFLD. Age at transplantation, post-transplant high-density lipoprotein-cholesterol level, and steatosis grade were significant risk factors for recurrence. The study highlights the need for further evaluation of preventive measures for disease recurrence after transplantation for NAFLD.
Article
Gastroenterology & Hepatology
Jerome Dumortier, Domitille Erard, Francoi Villeret, Francois Faitot, Christophe Duvoux, Stephanie Faure, Claire Francoz, Jean Gugenheim, Jean Hardwigsen, Jean-Baptiste Hiriart, Pauline Houssel-Debry, Arnaud Del Bello, Guillaume Lassailly, Claire Vanlemmens, Faouzi Saliba, Clara Altman, Marianne Latournerie, Sebastien Dharancy, Tarek Debs
Summary: During the obesity epidemic, liver transplantation and metabolic syndrome closely interact, as non-alcohol-related fatty liver disease is a common indication for liver transplantation, and metabolic syndrome can occur after transplantation due to immunosuppressive medications and weight gain. Bariatric surgery plays an important role in managing these conditions due to its long-lasting effectiveness. A retrospective study was conducted on French liver transplant recipients who had a history of bariatric surgery, revealing differences in patient characteristics and liver disease between pre- and post-transplantation bariatric surgery cases.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Camille Legeai, Corinne Antoine, Carine Jasseron, Francois Kerbaul, Jerome Dumortier
Summary: This study aimed to investigate the impact of COVID-19 pandemic on liver transplantation waitlist patients' outcomes in France in 2020. The study compared the 2020 cohort with the 2018/2019 cohorts and found that there were fewer liver transplants and brain dead donors in 2020. The risk of deaths and delisting for worsening condition increased significantly in 2020, particularly for patients with hepatocellular carcinoma and certain MELD score ranges.
SCIENTIFIC REPORTS
(2023)