Controversial Properties of Amyloidogenic Proteins and Peptides: New Data in the COVID Era

For a long time, studies of amyloidogenic proteins and peptides (amyloidogenic PPs) have been focused basically on their harmful properties and association with diseases. A vast amount of research has investigated the structure of pathogenic amyloids forming fibrous deposits within or around cells and the mechanisms of their detrimental actions. Much less has been known about the physiologic functions and beneficial properties of amyloidogenic PPs. At the same time, amyloidogenic PPs have various useful properties. For example, they may render neurons resistant to viral infection and propagation and stimulate autophagy. We discuss here some of amyloidogenic PPs' detrimental and beneficial properties using as examples beta-amyloid ( fi-amyloid), implicated in the pathogenesis of Alzheimer's disease (AD), and ff-synuclein-one of the hallmarks of Parkinson's disease (PD). Recently amyloidogenic PPs' antiviral and antimicrobial properties have attracted attention because of the COVID-19 pandemic and the growing threat of other viral and bacterialinduced diseases. Importantly, several COVID-19 viral proteins, e.g., spike, nucleocapsid, and envelope proteins, may become amyloidogenic after infection and combine their harmful action with the effect of endogenous APPs. A central area of current investigations is the study of the structural properties of amyloidogenic PPs, defining their beneficial and harmful properties, and identifying triggers that transform physiologically important amyloidogenic PPs into vicious substances.

Automated summary

For a long time, research on amyloidogenic PPs has mainly focused on their harmful properties and association with diseases. However, there is a lack of understanding regarding the physiological functions and beneficial properties of these proteins and peptides. Furthermore, recent studies have highlighted their antiviral and antimicrobial properties, which have become of interest due to the COVID-19 pandemic and other viral and bacterial-induced diseases.