Review
Biochemistry & Molecular Biology
Angelo Zinellu, Stefania Sedda, Arduino A. Mangoni
Summary: The presence of a pro-oxidant state in patients with schizophrenia may contribute to the higher risk of atherosclerosis and cardiovascular disease in this group. This study investigated the associations between paraoxonase-1 levels and oxidative stress in schizophrenia patients. The results suggest that alterations in paraoxonase-1 may reflect a pro-oxidant state in specific subgroups of patients with schizophrenia.
Article
Medicine, Research & Experimental
Alexander Sorokin, Christin G. Hong, Angel M. Aponte, Elizabeth M. Florida, Jingrong Tang, Nidhi Patel, Irina N. Baranova, Haiou Li, Philip M. Parel, Vicky Chen, Sierra R. Wilson, Emily L. Ongstad, Anna Collen, Martin P. Playford, Thomas L. Eggerman, Marcus Y. Chen, Kazuhiko Kotani, Alexander Bocharov, Alan T. Remaley
Summary: In this study, we found that oxidized apolipoprotein B and oxidized ApoA-I are associated with high-risk coronary plaque features and progression in patients with cardiovascular disease.
Review
Nutrition & Dietetics
Trine L. Wilkens, Kaare Tranaes, Jane N. Eriksen, Lars O. Dragsted
Summary: Moderate alcohol consumption is associated with changes in lipoprotein subfractions that could influence cardiovascular health positively, but the heterogeneous laboratory methods and risk of bias in studies limit comparability between studies.
Article
Medicine, General & Internal
Polyxeni Papadea, Marianna Skipitari, Electra Kalaitzopoulou, Athina Varemmenou, Maria Spiliopoulou, Marios Papasotiriou, Evangelos Papachristou, Dimitrios Goumenos, Anny Onoufriou, Eleftheria Rosmaraki, Irene Margiolaki, Christos D. Georgiou
Summary: The present study uses simple, innovative methods to isolate, characterize, and fractionate LDL in its main components for the study of specific oxidations on them. It aims to understand the oxidized low-density lipoprotein (oxLDL) status and its relation to cardiovascular disease (CVD) risk assessment. The study provides protocols for LDL isolation, purity verification, fractionation, and measurement of specific LDL component oxidative modifications, which can help in studying atherosclerosis and developing CVD prevention strategies.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Petri Kresanov, Juha Mykkanen, Markku Ahotupa, Mika Ala-Korpela, Markus Juonala, Jari Kaikkonen, Mika Kahonen, Terho Lehtimaki, Tommi Vasankari, Jorma Viikari, Olli T. Raitakari
Summary: The study found that oxidized HDL lipids were not significantly associated with lipoprotein subclass lipid concentrations and composition after adjusting for certain factors, while oxidized LDL lipids were associated with multiple markers of lipoprotein subclass lipid concentrations and composition. Additionally, HDL and LDL subclass measures, such as phospholipid and triglyceride composition, were directly associated with oxidized LDL lipids, while cholesterol ester and free cholesterol composition in HDL and LDL were inversely associated. These results suggest that LDL oxidation may play a role in atherogenesis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Hiroyuki Itabe, Naoko Sawada, Tomohiko Makiyama, Takashi Obama
Summary: Oxidative modification of lipoproteins is involved in the development of atherosclerotic lesions, with oxLDL and oxHDL dynamics in circulation playing a crucial role in cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Gunther Marsche, Julia T. Stadler, Julia Kargl, Michael Holzer
Summary: Atherosclerosis is a disease characterized by increased oxidative stress, leading to modifications of proteins and lipids in the blood vessel wall. Myeloperoxidase (MPO), an enzyme mainly found in neutrophils and monocytes, plays a crucial role in this oxidative process. Research has shown that MPO interacts with lesion derived high-density lipoprotein (HDL) and modifies its components, leading to dysfunction of HDL. Understanding the impact of MPO-induced changes on the structure and function of HDL is important for the future use of HDL in diagnostics and therapy.
Article
Endocrinology & Metabolism
Marcos Tadashi K. Toyoshima, Monique F. M. Santana, Amanda R. M. Silva, Gabriela B. B. Mello, Daniele P. P. Santos-Bezerra, Marisa F. S. Goes, Adriana A. A. Bosco, Bruno Caramelli, Graziella E. E. Ronsein, Maria Lucia Correa-Giannella, Marisa Passarelli
Summary: This study explores the proteomics of HDL subfractions in type 1 diabetes (T1D) and its association with clinical variables and subclinical atherosclerosis. Different protein expressions were observed in HDL2 and HDL3 of T1D patients compared to controls, and these proteins were related to lipid metabolism, inflammation, and antioxidant response. HDL proteomics was found to be predictive of subclinical atherosclerosis in T1D.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Review
Pharmacology & Pharmacy
Ali Ahmadi, Yunes Panahi, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Cardiovascular disease is a leading cause of mortality globally, and diabetic patients are at a greater risk of developing atherosclerosis. Antidiabetic drugs exert various mechanisms to counter the undesirable effects of oxLDL, which can be extremely beneficial in controlling atherosclerosis in diabetic patients.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medical Laboratory Technology
Silvia de la Cruz-Ares, Ana Leon-Acuna, Elena M. Yubero-Serrano, Jose D. Torres-Pena, Antonio P. Arenas-de Larriva, Magdalena P. Cardelo, Oriol A. Rangel-Zuniga, Raul M. Luque, Juan F. Alcala-Diaz, Jose M. Ordovas, Pablo Perez-Martinez, Jose Lopez-Miranda, Javier Delgado-Lista
Summary: This study investigated the association between lipoprotein subfractions and the severity of coronary heart disease (CHD) using high-throughput nuclear magnetic resonance (NMR) spectroscopy. The results showed that small and medium HDL subclasses concentration, as measured by NMR, were inversely related to angiographic CHD severity. These particles were also found to be independent predictors of multivessel coronary disease (MVD) and improved the prediction of this condition compared to traditional risk factors.
CLINICA CHIMICA ACTA
(2022)
Review
Cardiac & Cardiovascular Systems
Abdolreza Chary, Maryam Tohidi, Mehdi Hedayati
Summary: This study evaluated the association between LDL subfractions and cardiovascular disorders through a systematic review. The results showed that a higher LDL particle number was consistently associated with increased risk for cardiovascular disease, and the presence of small dense LDL was also associated with an increased risk of CVDs. Further studies are needed to identify the mechanisms involved.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Multidisciplinary Sciences
Juana Maria Sanz, Andrea D'Amuri, Domenico Sergi, Sharon Angelini, Valeria Fortunato, Elda Favari, Giovanni Vigna, Giovanni Zuliani, Edoardo Dalla Nora, Angelina Passaro
Summary: Familial Hypercholesterolemia (FH) is associated with high LDL cholesterol and premature cardiovascular disease. This study aimed to investigate the impact of FH on cholesterol efflux capacity (CEC) and its relationship with lipoprotein subfraction distribution. The results showed that FH patients had higher concentrations of all LDL subfractions, a shift towards small HDL subfractions, and increased CEC compared to controls.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Laura Adina Stanciulescu, Alexandru Scafa-Udriste, Maria Dorobantu
Summary: Cardiovascular disease (CVD) is a leading cause of death worldwide, with atherosclerosis being the most common form of manifestation. Recent studies have shown that small, dense low-density lipoproteins (LDLs) are more frequently associated with a higher risk for developing atherosclerotic CVD. This review aims to comprehensively evaluate the association between LDL subfractions and the risk of major adverse cardiovascular events, by assessing their genetic and clinical features, physiopathological characteristics, and ability to predict long-term cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Athina Trakaki, Peter Wolf, Wolfgang Weger, Thomas O. Eichmann, Hubert Scharnagl, Julia T. Stadler, Wolfgang Salmhofer, Eva Knuplez, Michael Holzer, Gunther Marsche
Summary: The study found that psoriasis patients had impaired HDL function at baseline compared to controls, but short-term and especially intermediate-term therapy with biologics markedly reduced HDL cholesterol efflux capacity and rendered HDL pro-inflammatory. However, it increased paraoxonase and lecithin-cholesterol acyltransferase activities. All biologics caused similar changes in HDL composition, subclass distribution and cholesterol efflux capacity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Review
Cell Biology
Divya Saro Varghese, Bassam R. Ali
Summary: oxLDL is a biomarker and pathological factor in CVD, T2DM, obesity and other diseases, with a link to ER stress. The cellular response to ER stress involves a defensive mechanism known as UPR, which can switch to apoptosis under excessive stress to eliminate defective cells. ER stress is a major hallmark in metabolic syndromes and other diseases, with potential therapeutic interventions being explored.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Laszlo Madar, Lilla Juhasz, Zsuzsanna Szucs, Lorant Kerkovits, Mariann Harangi, Istvan Balogh
Summary: This study presents the clinical and molecular data of 44 unrelated individuals with suspected familial hypercholesterolemia (FH) in Hungary. Variants in LDLR and APOB genes were found to be the most common, with the c.10580G>A p.(Arg3527Gln) alteration in APOB gene being the most frequent. Several missense variants in the LDLR gene were detected in multiple index patients. The LDLR variants in the Hungarian population largely overlap with those detected in neighboring countries.
Article
Biochemistry & Molecular Biology
Imre Juhasz, Szilvia Ujfalusi, Ildiko Seres, Hajnalka Lorincz, Viktoria Evelin Varga, Gyoergy Paragh, Sandor Somodi, Mariann Harangi, Gyoergy Paragh
Summary: This study found that in non-diabetic, obese patients, Afamin levels were significantly higher and correlated with markers of metabolic syndrome. After multiple regression analysis, HbA1c levels and small HDL subfractions were identified as independent predictors of Afamin.
Review
Medicine, General & Internal
Beata Kovacs, Orsolya Cseprekal, Agnes Dioszegi, Szabolcs Lengyel, Laszlo Maroda, Gyorgy Paragh, Mariann Harangi, Denes Pall
Summary: Cardiovascular diseases, mainly caused by atherosclerosis, are the leading cause of mortality worldwide. Patients with familial hypercholesterolemia are at a high cardiovascular risk, and non-invasive measurement of arterial stiffness can be used to screen for vascular dysfunction in this genetic disorder. Statin treatment has a beneficial effect on arterial stiffness in these patients. If conventional drug therapy fails, PCSK9 inhibitor therapy or selective LDL apheresis can be considered.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Emergency Medicine
Imre Juhasz, Janka Juhasz, Hajnalka Loerincz, Ildiko Seres, Lilla Vegh, Szilvia Ujfalusi, Mariann Harangi, Zoltan Szabo, Gyoergy Paragh
Summary: This study aimed to evaluate the possible effects of diabetes mellitus and poor glycemic control on the diagnosis of sepsis. The results showed a significant positive correlation between glucose and HbA1c in diabetic patients, as well as significant negative correlations between white blood cell count (WBC) and glucose, WBC and HbA1c levels in certain subgroups. Furthermore, length of hospital stay was significantly correlated with HbA1c in a specific subgroup.
EMERGENCY MEDICINE INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Biborka Nadro, Hajnalka Lorincz, Lilla Juhasz, Anita Szentpeteri, Ferenc Sztanek, Eva Varga, Denes Pall, Gyorgy Paragh, Mariann Harangi
Summary: This study found significant correlations between PGRN concentrations and triglyceride, inflammatory markers, sVCAM-1, and HDL subfractions in patients with FH. Furthermore, PGRN may exert its anti-atherogenic effect by altering HDL composition and improving inflammation.
Review
Genetics & Heredity
Eszter Berta, Noemi Zsiros, Miklos Bodor, Istvan Balogh, Hajnalka Lorincz, Gyorgy Paragh, Mariann Harangi
Summary: Familial hypercholesterolemia (FH) is a common monogenic metabolic disorder with wide phenotypic heterogeneity, posing challenges in cardiovascular risk prediction and therapeutic strategy determination. Beyond lifetime low-density lipoprotein cholesterol (LDL-C) accumulation, other genetic and non-genetic risk factors may exacerbate the development of the disease. This review summarizes the most important genetic and non-genetic factors that might affect the risk prediction and therapeutic strategy in FH, emphasizing the need for an interdisciplinary approach in finding the best treatment methods.
Article
Medicine, General & Internal
Akos Nemeth, Mariann Harangi, Balint Daroczy, Lilla Juhasz, Gyorgy Paragh, Peter Fulop
Summary: This study aimed to assess the prevalence of familial chylomicronemia syndrome (FCS) in Central Europe and evaluate the diagnostic applicability of the FCS score. Through the analysis of medical records and machine learning models, it was found that FCS has a higher prevalence in the region, and additional features can improve the accuracy of the FCS score calculation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Reka Szentimrei, Hajnalka Lorincz, Anita Szentpeteri, Viktoria E. Varga, Mariann Harangi, Ildiko Seres, Reka P. Szabo, Balazs Nemes, Gyorgy Paragh
Summary: The study found that renal transplant patients had significantly higher PEDF levels before transplantation, which decreased to the level of healthy controls after 1 month post-transplant and remained low during the 6-month follow-up period. Additionally, there were significant correlations between PEDF and lipid parameters, indicating that PEDF may play an important role in oxidative stress and atherogenesis in renal transplant patients.
Article
Biochemistry & Molecular Biology
Hajnalka Lorincz, Balazs Ratku, Sara Csiha, Ildiko Seres, Zoltan Szabo, Gyorgy Paragh, Mariann Harangi, Sandor Somodi
Summary: Altered organokine expression contributes to increased cardiometabolic risk in obesity. This study aimed to evaluate the associations of serum afamin with glucose homeostasis, atherogenic dyslipidemia, and other adipokines in severe obesity to clarify the early metabolic alterations. The results showed that afamin and PAI-1 were significantly higher in obese subjects compared to controls, while RBP4 was unexpectedly lower. Afamin was negatively correlated with mean LDL size and RBP4, but positively correlated with anthropometric, glucose/lipid parameters, and PAI-1. BMI, glucose, intermediate HDL, and small HDL were predictors of afamin. This suggests that afamin may serve as a biomarker for the severity of cardiometabolic disturbances in obesity and draws attention to the diverse spectrum of obesity-related comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lilla Juhasz, Hajnalka Lorincz, Anita Szentpeteri, Nora Toth, Eva Varga, Gyorgy Paragh, Mariann Harangi
Summary: This study found that serum SDF-1 levels were significantly lower in HeFH patients compared to healthy controls, and showed correlations with lipid fractions and subfractions, highlighting potential common pathways of SDF-1 and lipoprotein metabolism and supporting its role in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Beata Kovacs, Akos Nemeth, Balint Daroczy, Zsolt Karanyi, Laszlo Maroda, Agnes Dioszegi, Mariann Harangi, Denes Pall
Summary: Cardiovascular diseases are a leading cause of death worldwide, and hypertension is a preventable risk factor for major cardiovascular events. A comprehensive study was conducted to investigate the complex metabolic status of hypertensive patients in Central and Eastern Europe. The study found a prevalence of hypertension of 32.2%, similar to international findings, and highlighted the extensive association of metabolic abnormalities. Early recognition and immediate treatment of cardiometabolic abnormalities are crucial for improving the quality of life and life expectancy of hypertensive patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Hajnalka Lorincz, Sara Csiha, Balazs Ratku, Sandor Somodi, Ferenc Sztanek, Ildiko Seres, Gyorgy Paragh, Mariann Harangi
Summary: This study investigates the association between betatrophin and lipoprotein subfractions. The results show that betatrophin concentrations are significantly higher in obese patients with type 2 diabetes (T2D) and nondiabetic obese (NDO) subjects compared to healthy controls, particularly in females. The findings highlight the importance of measuring serum betatrophin for cardiovascular risk assessment in obese patients, with consideration of gender differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
