Article
Endocrinology & Metabolism
Federico Oldoni, Kevin Bass, Julia Kozlitina, Hannah Hudson, Lisa M. Shihanian, Viktoria Gusarova, Jonathan C. Cohen, Helen H. Hobbs
Summary: Plasma A8 levels vary significantly across different racial/ethnic groups and are associated with BMI, fasting glucose, insulin, and TG levels. However, genetic variants in the A8 locus do not appear to have a causal relationship with the metabolic phenotypes associated with A8 levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and storage, facilitated by lipoprotein lipase (LPL) which acts as a gatekeeper for fatty acid uptake. LPL activity is regulated by extracellular proteins including members of the angiopoietin-like family of proteins. This review delves into how ANGPTL3, ANGPTL4, and ANGPTL8 regulate LPL activity and coordinate triglyceride metabolism and fat partitioning.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Anna Stefanska, Katarzyna Bergmann, Magdalena Krintus, Magdalena Kuligowska-Prusinska, Karolina Murawska, Grazyna Sypniewska
Summary: This study found that ANGPTL8 predicts early triglyceride elevation better than ANGPTL3, especially in postmenopausal women. The association of ANGPTL3 with triglyceride levels is weaker than ANGPTL8 and depends on menopausal status. Therefore, the choice of treatment for dyslipidemia with inhibitors of angiopoietin-like proteins may depend on menopausal status.
Article
Biochemistry & Molecular Biology
Hana Th. Almajed, Mohamed Abu-Farha, Eman Alshawaf, Sriraman Devarajan, Zahra Alsairafi, Ashraf Elhelaly, Preethi Cherian, Irina Al-Khairi, Hamad Ali, Rose Mol Jose, Thangavel Alphonse Thanaraj, Ebaa Al-Ozairi, Fahd Al-Mulla, Abdulnabi Al Attar, Jehad Abubaker
Summary: This study found a significant increase in circulating ANGPTL8 levels in patients with diabetic nephropathy (DN), and the levels of ANGPTL8 were positively correlated with IGFBP-4 levels. This suggests a potential role of both ANGPTL8 and IGFBP-4 in the pathophysiology of DN. These findings highlight the significance of these biomarkers and suggest them as promising diagnostic molecules for the detection of DN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Amra Jujic, Joao P. P. Vieira, Hana Matuskova, Peter M. Nilsson, Ulf Lindblad, Michael H. Olsen, Joao M. N. Duarte, Anja Meissner, Martin Magnusson
Summary: Epidemiological studies have found associations between plasma galectin-4 (Gal-4) levels and diabetes as well as coronary artery disease. However, there is a lack of data on the association between plasma Gal-4 and stroke. This study investigated the association between plasma Gal-4 and prevalent stroke in a population-based cohort, as well as the response of plasma Gal-4 to ischemic stroke in mice fed a high-fat diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fredrik Landfors, Elin Chorell, Sander Kersten
Summary: Angiopoietin-like proteins (ANGPTL3, ANGPTL4, and ANGPTL8) play a role in regulating plasma lipids. This study analyzed genetic variants in several genes related to lipid metabolism and found that ANGPTL4 primarily affects plasma metabolic parameters through LPL. On the other hand, ANGPTL3 affects these parameters by targeting both LPL and EL. The impact of the ANGPTL3-ANGPTL8 complex was found to be stronger on EL inhibition than on LPL inhibition. Overall, this analysis provides strong genetic evidence for the involvement of the ANGPTL3-ANGPTL8 complex in regulating plasma metabolic parameters.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Chatchon Kaewkrasaesin, Waralee Chatchomchuan, Suwanna Muanpetch, Weerapan Khovidhunkit
Summary: The study found that plasma levels of ANGPTL3 and ANGPTL8 varied in patients with hyperalphalipoproteinemia and severe hypertriglyceridemia, suggesting that they may play different roles in lipid regulation in these two extreme conditions of dyslipidemia.
JOURNAL OF CLINICAL LIPIDOLOGY
(2021)
Article
Oncology
Fangfang Xu, Dandan Tian, Xiaoyang Shi, Kai Sun, Yuqing Chen
Summary: The study analyzed the expression of ANGPTL8/betatrophin in various cancer types using multiple databases and found that its expression levels were significantly altered in certain cancers, affecting the prognosis of patients.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hajnalka Lorincz, Sara Csiha, Balazs Ratku, Sandor Somodi, Ferenc Sztanek, Ildiko Seres, Gyorgy Paragh, Mariann Harangi
Summary: This study investigates the association between betatrophin and lipoprotein subfractions. The results show that betatrophin concentrations are significantly higher in obese patients with type 2 diabetes (T2D) and nondiabetic obese (NDO) subjects compared to healthy controls, particularly in females. The findings highlight the importance of measuring serum betatrophin for cardiovascular risk assessment in obese patients, with consideration of gender differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Vehbi Pehlivan, Mehmet Ferit Gursu, Onur Citak, Erhan Onalan, Burkay Yakar, Emir Donder
Summary: The objective of this study was to determine the levels of serum betatrophin and cartonectin and their relationship with biochemical parameters in diabetic and non-diabetic retinopathy. By evaluating patients with diabetic retinopathy, non-diabetic retinopathy, type 2 diabetes mellitus without retinopathy, and healthy controls, it was found that serum betatrophin levels were higher in the diabetic retinopathy group, while cartonectin levels were lower in both the diabetic retinopathy and non-diabetic retinopathy groups. Therefore, estimation of serum betatrophin and cartonectin may be helpful in the early diagnosis and differential diagnosis of diabetic and non-diabetic retinopathy cases.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2023)
Article
Endocrinology & Metabolism
Fangfang Xu, Lijun Shen, Yongguang Yang, Limin Kong, Wufan Zu, Dandan Tian, Xuanchao Cao, Gairong Huang
Summary: This study investigated the expression of ANGPTL3, 4, and 8 in hypertensive patients and their association with overweight/obesity, T2D, and hyperlipidemia. The results showed that ANGPTL3 was associated with T2D and hyperlipidemia status, while ANGPTL8 was independently associated with T2D status. These findings suggest that targeting ANGPTL3 and ANGPTL8 levels may be beneficial for the comorbidities of hypertension in patients with overweight/obesity or hyperlipidemia.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Biology
Hendra Susanto, Sugiharto, Ahmad Taufiq, Adi Pranoto, Jerry Dwi Trijoyo Purnomo
Summary: Obesity is a metabolic disease caused by a lack of physical activity and lipid disturbances. This study found that moderate-intensity exercise can decrease the plasma level of full-length betatrophin, which is correlated with BMI, fasting blood glucose, and VO2max.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Genetics & Heredity
Anna Lessmark, Gad Hatem, Gyoergyi Kovacs, Marta Vitai, Emma Ahlqvist, Tiinamaija Tuomi, Laszlo Koranyi, Leif Groop, Rashmi B. Prasad
Summary: This study explores whether genetic variants previously associated with lipid traits have parent-of-origin effects (POE) on blood lipid levels and obesity, as well as sex-specific parental effects. The results show that certain genetic variants exhibit POE and sex-specific effects on lipid traits and obesity, highlighting the importance of including POE analysis in genetic studies of complex traits.
Article
Urology & Nephrology
Yue Li, Qingju Liu, Chengdong Kang, Weijing Cui, Zichuan Xu, Fu Zhong, Xia Gao
Summary: This study demonstrated a correlation between serum and urine ANGPTL8 levels in primary nephrotic syndrome patients with blood lipid levels and proteinuria, suggesting a potential role of ANGPTL8 in the development of hyperlipidemia and proteinuria in primary nephrotic syndrome.
Article
Biochemistry & Molecular Biology
Sajid Iqbal, Farida Begum, Dorothy Wavinya Nyamai, Nasir Jalal, Peter Shaw
Summary: The study identifies high-risk nsSNPs in ANGPTL3 and ANGPTL8 genes that may contribute to cancer development. Protein-protein interaction analysis reveals a strong association of ANGPTL proteins with tumor-suppressor proteins. Gene-expression profiling analysis demonstrates downregulation of ANGPTL3 in sarcoma, cholangio carcinoma, kidney chromophobe carcinoma, kidney renal clear cell carcinoma, and kidney renal papillary cell carcinoma, and downregulation of ANGPTL8 in cholangio carcinoma, glioblastoma, and breast invasive carcinoma. Survival rate analysis indicates that both upregulation and downregulation of ANGPTL3 and ANGPTL8 are associated with low survival rates in various types of cancer.
Article
Environmental Sciences
Jagan Kumar Baskaradoss, Mary Tavares, Fahd Al-Mulla, Ebaa Al-Ozairi, Mohamed Abu-Farha, Saadoun Bin-Hasan, Aishah Alsumait, Sriraman Devarajan, Hend Alqaderi
Summary: This study reveals a relationship between the frequency of toothbrushing and the development of metabolic syndrome components. Healthy adolescents have a higher frequency of toothbrushing compared to those with MetS components. Furthermore, adolescents who transition from a healthy state to MetS have a higher frequency of dining-out. Healthy adolescents also exhibit lower levels of certain biomarkers compared to those with MetS components.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Ghadeer Alhamar, Ernesto Maddaloni, Abdullah Al Shukry, Salman Al-Sabah, Mohannad Al-Haddad, Sarah Al-Youha, Mohammed Jamal, Sulaiman Almazeedi, Abdullah A. Al-Shammari, Mohamed Abu-Farha, Jehad Abubaker, Abdulnabi T. Alattar, Ebaa AlOzairi, Francesco Alessandri, Luca D'Onofrio, Gaetano Leto, Carlo Maria Mastroianni, Carmen Mignogna, Giuseppe Pascarella, Francesco Pugliese, Hamad Ali, Fahd Al Mulla, Raffaella Buzzetti, Paolo Pozzilli
Summary: The study developed a clinical risk score to aid risk stratification among hospitalised COVID-19 patients. The score was built using data of 417 consecutive COVID-19 patients from Kuwait and validated internally and externally.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Nutrition & Dietetics
Victor M. Oguoma, Mohamed Abu-Farha, Neil T. Coffee, Saad Alsharrah, Faisal H. Al-Refaei, Jehad Abubaker, Mark Daniel, Fahd Al-Mulla
Summary: Obesity is a major public health crisis in Kuwait. This study examines the prevalence of metabolically healthy obese (MHO) phenotype and its relationship with inflammation markers, liver function, and insulin resistance in Arab and South Asian ethnic groups. The results show a high prevalence of MHO in Kuwait.
Article
Clinical Neurology
M. Leentjens, P. F. N. Bosschieter, Abdulmohsen Al-Terki, C. A. L. de Raaff, C. E. E. de Vries, Maha Hammad, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Mohamed Abu-Farha, N. de Vries, Jehad Abubaker
Summary: The study aims to evaluate the level of ANGPTL5 in patients with OSA of different severity levels before and after bariatric surgery. The results showed that ANGPTL5 levels were higher in the moderate-to-severe OSA group and decreased significantly after surgery in both groups.
SLEEP AND BREATHING
(2023)
Article
Endocrinology & Metabolism
Mohamed Abu-Farha, Mariam Alatrach, Jehad Abubaker, Irina Al-Khairi, Preethi Cherian, Krisitn Agyin, Siham Abdelgani, Luke Norton, John Adams, Dalal Al-Saeed, Ebaa Al-Ozairi, Ralph A. DeFronzo, Fahd Al-Mulla, Muhammad Abdul-Ghani
Summary: It was found that the increase in plasma levels of ANGPTL8 is due to the increase in plasma insulin concentration following food ingestion, not the rise in plasma glucose.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Abdulmohsen Alterki, Mohamed Abu-Farha, Eman Al Shawaf, Fahd Al-Mulla, Jehad Abubaker
Summary: Obstructive sleep apnoea (OSA) is a prevalent but underdiagnosed disorder that disrupts the circadian rhythm and is characterized by frequent interruptions in breathing during sleep, leading to systemic consequences. OSA is a well-recognized risk factor for cardiovascular and cerebrovascular diseases, and it is also linked to obesity. The pathogenesis of both OSA and obesity involve oxidative stress, inflammation, and metabolic dysregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Anwar Mohammad, Eman Alshawaf, Hossein Arefanian, Sulaiman K. Marafie, Abbas Khan, Dong-Qing Wei, Fahd Al-Mulla, Jehad Abubaker
Summary: In this study, natural medicinal compounds were investigated as potential inhibitors of SARS-CoV-2-NSP3 macrodomain-I. Computational modeling and simulation tools were used to explore the structural dynamics and binding affinity of the compounds. Two significant hits were identified, with strong binding affinity and inhibitory potential. The findings provide a basis for novel drug development against SARS-CoV-2 and its variants.
Article
Nutrition & Dietetics
Rashed Alhammad, Mohamed Abu-Farha, Abdur Rahman, Thangavel Alphonse Thanaraj, Lemia Shaban, Reem Alsabah, Samar Hamad, Maha M. Hammad, Arshad Channanath, Fahd Al-Mulla, Jehad Abubaker
Summary: This study investigated the association between LRG1 and iron deficiency anemia markers in school-aged children. High LRG1 levels were observed in anemic children compared to non-anemic children. Significant correlations were found between LRG1 and various markers including Hb, albumin, iron, and RDW. This research provides valuable insights into the relationship between LRG1 and iron deficiency anemia in children.
Article
Cell Biology
Mohamed Abu-Farha, Dhanya Madhu, Prashantha Hebbar, Anwar Mohammad, Arshad Channanath, Sina Kavalakatt, Nada Alam-Eldin, Fatima Alterki, Ibrahim Taher, Osama Alsmadi, Mohammad Shehab, Hossein Arefanian, Rasheed Ahmad, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Jehad Abubaker
Summary: The ANGPTL8 R59W variant is associated with increased levels of TNF alpha, IL7, and NF-kappa B p65 activity. The weak transient binding of the ANGPTL8 R59W variant explains its regulatory role on the NF-kappa B pathway and inflammation.
Article
Biochemistry & Molecular Biology
Mohamed Abu-Farha, Shibu Joseph, Anwar Mohammad, Arshad Channanath, Ibrahim Taher, Fahd Al-Mulla, Muhammad Mujammami, Thangavel Alphonse Thanaraj, Jehad Abubaker, Anas M. Abdel Rahman
Summary: This study used metabolomics to investigate the impact of the ANGPTL8 R59W variant on metabolites in Arab individuals. The results showed significant associations between the variant and concentrations of lipid- and inflammation-related metabolites, highlighting the importance of this gene in lipid metabolism.
Article
Biochemistry & Molecular Biology
Hana Th. Almajed, Mohamed Abu-Farha, Eman Alshawaf, Sriraman Devarajan, Zahra Alsairafi, Ashraf Elhelaly, Preethi Cherian, Irina Al-Khairi, Hamad Ali, Rose Mol Jose, Thangavel Alphonse Thanaraj, Ebaa Al-Ozairi, Fahd Al-Mulla, Abdulnabi Al Attar, Jehad Abubaker
Summary: This study found a significant increase in circulating ANGPTL8 levels in patients with diabetic nephropathy (DN), and the levels of ANGPTL8 were positively correlated with IGFBP-4 levels. This suggests a potential role of both ANGPTL8 and IGFBP-4 in the pathophysiology of DN. These findings highlight the significance of these biomarkers and suggest them as promising diagnostic molecules for the detection of DN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)