Article
Urology & Nephrology
Joshua D. Bundy, Mahboob Rahman, Kunihiro Matsushita, Byron C. Jaeger, Jordana B. Cohen, Jing Chen, Rajat Deo, Mirela A. Dobre, Harold I. Feldman, John Flack, Radhakrishna R. Kallem, James P. Lash, Stephen Seliger, Tariq Shafi, Shoshana J. Weiner, Myles Wolf, Wei Yang, Norrina B. Allen, Nisha Bansal, Jiang He, CRIC Study Investigators
Summary: This study developed 10-year ASCVD risk prediction models in patients with CKD, including novel biomarkers, which performed better than models using only traditional risk factors developed for the general population.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Hematology
Anne Cornelissen, Daniela T. Fuller, Raquel Fernandez, Xiaoqing Zhao, Robert Kutys, Elizabeth Binns-Roemer, Marco Delsante, Atsushi Sakamoto, Ka Hyun Paek, Yu Sato, Rika Kawakami, Masayuki Mori, Kenji Kawai, Teruhiko Yoshida, Khun Zaw Latt, Clint L. Miller, Paul S. de Vries, Frank D. Kolodgie, Renu Virmani, Myung Kyun Shin, Maarten Hoek, Jurgen Heymann, Jeffrey B. Kopp, Avi Z. Rosenberg, Harry R. Davis, Liang Guo, Aloke V. Finn
Summary: The study found that APOL1 risk alleles are associated with coronary artery disease, with carriers being more prone to thrombotic events. Individuals with 2 APOL1 risk alleles have larger necrotic cores in plaques, suggesting a role of APOL1 in determining plaque stability.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Health Care Sciences & Services
Hendri Susilo, Mochammad Thaha, Budi Susetyo Pikir, Mochamad Yusuf Alsagaff, Satriyo Dwi Suryantoro, Citrawati Dyah Kencono Wungu, Nando Reza Pratama, Cennikon Pakpahan, Delvac Oceandy
Summary: Plasma IL-6 levels play an important role in ASCVD risk and cardiovascular mortality risk in Javanese patients with CKD.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Transplantation
Sarah J. Schrauben, Hima Sapa, Dawei Xie, Xiaoming Zhang, Amanda Hyre Anderson, Michael G. Shlipak, Chi-yuan Hsu, Tariq Shafi, Rupal Mehta, Zeenat Bhat, Julie Brown, Jeanne Charleston, Jing Chen, Jiang He, Joachim H. Ix, Pandurango Rao, Ray Townsend, Paul L. Kimmel, Ramachandran S. Vasan, Harold Feldman, Jesse C. Seegmiller, Henri Brunengraber, Thomas H. Hostetter, Jeffrey R. Schelling
Summary: This study found that chronic kidney disease is associated with atherosclerotic cardiovascular disease risk, especially among individuals with diabetes. Decreased kidney excretion of asymmetric dimethylarginine (ADMA) leads to increased plasma concentrations and increased risk of atherosclerotic cardiovascular disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Li-Chin Sung, Chuen-Chau Chang, Chao-Shun Lin, Chun-Chieh Yeh, Yih-Giun Cherng, Ta-Liang Chen, Chien-Chang Liao
Summary: The study found that patients with acute and chronic pancreatitis are at an increased risk of acute ASCVD, especially when also suffering from alcohol-related illness, liver cirrhosis, or diabetes. The use of metformin was associated with a reduced risk of acute ASCVD in the acute pancreatitis cohort.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Constance C. F. M. J. Baaten, Sonja Vondenhoff, Heidi Noels
Summary: The endothelium plays a crucial role in maintaining and regulating vascular integrity. In patients with chronic kidney disease, endothelial cell dysfunction contributes to increased cardiovascular complications due to the proinflammatory, prothrombotic, and uremic environment caused by declining kidney function. This review discusses the functioning of endothelial cells in healthy conditions, the phenotypic changes in chronic kidney disease patients, and the relationship between endothelial cell dysfunction and cardiovascular risk in chronic kidney disease. Additionally, it considers potential pharmacological interventions to improve endothelial health.
CIRCULATION RESEARCH
(2023)
Article
Medicine, General & Internal
Thomas Ebert, Linnea Widman, Peter Stenvinkel, Hannes Hagstrom
Summary: Nonalcoholic fatty liver disease (NAFLD) is bidirectionally linked to other cardiometabolic disorders but its long-term risk for microvascular outcomes is unclear. This study used nationwide Swedish patient data to identify individuals with NAFLD and matched them with reference individuals. The study found that NAFLD is independently and positively associated with the development of microvascular diseases. Rating: 8/10.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Setor K. Kunutsor, Sae Young Jae, Jussi Kauhanen, Jari A. Laukkanen
Summary: In a cohort of Caucasian men, socioeconomic status (SES) and cardiorespiratory fitness (CRF) were found to be independently associated with the risk of chronic kidney disease. High CRF levels appeared to offset the increased risk of kidney disease associated with low SES.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Natalia Chebotareva, Anatoliy Vinogradov, Valerie McDonnell, Natalia V. Zakharova, Maria I. Indeykina, Sergey Moiseev, Evgeny N. Nikolaev, Alexey S. Kononikhin
Summary: CKD is a non-specific kidney disease that causes gradual decline in kidney function, posing significant risks for death and other complications. Protein/peptide biomarkers can be used for early non-invasive diagnosis and may provide new approaches for targeted therapy. Mass spectrometry approaches offer valuable insights into understanding CKD progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Zhenxing Li, Qiao Wang, Jiahui Ma, Zhi Li, Dong Huang, Yuzhao Huang, Haocheng Zhou
Summary: The study found that CKD patients undergoing dialysis and immunosuppressant therapy are at greater risk of developing herpes zoster. It is recommended to consider zoster vaccination for these patients.
Article
Biochemistry & Molecular Biology
Ahmed Chaudhry, Nur Karyatee Kassim, Siti Lailatul Akmar Zainuddin, Haslina Taib, Hanim Afzan Ibrahim, Basaruddin Ahmad, Muhammad Hafiz Hanafi, Azreen Syazril Adnan
Summary: This study found that inflammatory biomarkers levels were higher in patients with chronic kidney disease (CKD) and chronic periodontitis (CP). After non-surgical periodontal therapy (NSPT), the levels of inflammatory biomarkers in CKD patients significantly reduced, and they showed a good response to the treatment. Therefore, it is important to screen and monitor the periodontal health of CKD patients.
Article
Medicine, Research & Experimental
Ting-Fang Chiu, Tung-Min Yu, Chih-Wei Chiu, Brian K. Lee, Tsuo-Hung Lan, Chi-Yuan Li, Mei-Chen Lin, Chia-Hung Kao
Summary: This study found that PKD is associated with a significantly increased risk of TB infection, particularly in patients with extrapulmonary TB. The risk of TB infection is also high in PKD patients without any comorbidities.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Urology & Nephrology
Johannes Ruhe, Jennifer Nadal, Barbara Barthlein, Heike Meiselbach, Ulla T. Schultheiss, Fruzsina Kotsis, Helena Stockmann, Vera Krane, Claudia Sommerer, Ivonne Loeffler, Turgay Saritas, Jan T. Kielstein, Thomas Sitter, Markus P. Schneider, Matthias Schmid, Christoph Wanner, Kai-Uwe Eckardt, Gunter Wolf, Martin Busch
Summary: Diabetes mellitus (DM) and chronic kidney disease (CKD) are known risk factors for cardiovascular disease and mortality. This study found that DM significantly increased the risk of cardiovascular and non-cardiovascular death, major adverse cardiovascular events, and hospitalization for heart failure in patients with moderate to severe CKD. The increased risk was similar in patients with CKD caused by cardiovascular/metabolic diseases and those with genuine CKD. Patients with DM and CKD caused by cardiovascular/metabolic diseases were particularly susceptible to heart failure.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Wei-Ting Liao, Wei-Ling Chen, You-Lin Tain, Chien-Ning Hsu
Summary: Cardiovascular disease is the leading cause of death among patients with chronic kidney disease, including both adults and children. Hypertension is one of the risk factors for cardiovascular disease. Monitoring blood pressure, cardiac sonography, and assessing arterial stiffness can help detect subclinical cardiovascular disease in pediatric chronic kidney disease patients. Congenital anomalies of the kidney and urinary tract are the main causes of pediatric chronic kidney disease. Complement factor H and related proteins are associated with cardiovascular disease risk in children with chronic kidney disease.
Article
Medicine, General & Internal
Yuri Battaglia, Fulvio Fiorini, Pietro Gisonni, Massimo Imbriaco, Paolo Lentini, Matthias Zeiler, Luigi Russo, Michele Prencipe, Domenico Russo
Summary: Although atherosclerotic renal artery stenosis (ARAS) is associated with high cardiovascular risk and mortality, it is often masked by co-morbidities in elderly patients. Duplex ultrasound can be used to detect ARAS, with atherosclerosis of the abdominal aorta and/or peripheral arteries being the best predictor.
Editorial Material
Cardiac & Cardiovascular Systems
Maciej Banach, Christopher P. Cannon, Francesco Paneni, Peter E. Penson
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Adrian V. Hernandez, Vinay Pasupuleti, Nancy Scarpelli, Jack Malespini, Maciej Banach, Agata M. Bielecka-Dabrowa
Summary: This study assessed the benefits and harms of Sacubitril/valsartan (S/V) compared to ACEI or ARB in heart failure patients. The results showed that S/V reduced HF hospitalizations by 20%, CV mortality by 14%, and all-cause mortality by 11% compared to ACEI or ARB. However, S/V had negative effects on renal function and increased hypotension events.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Amir Vahedian-Azimi, Farshad Heidari Beni, Zlatko Fras, Maciej Banach, Seyede Momeneh Mohammadi, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: AKI is a common and severe complication in critically ill patients, with high mortality rates. Statin therapy may have beneficial effects on the disease by reducing mortality rates and overall hospital length of stay. However, the impact of statin treatment on the development of AKI and ICU stay is inconclusive.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Kamila Ryczkowska, Weronika Adach, Kamil Janikowski, Maciej Banach, Agata Bielecka-Dabrowa
Summary: Cardiovascular diseases are common for both men and women, but there are differences in terms of symptoms, pathophysiology, and treatment response. Women often have a lower perception of the risk, leading to delayed diagnosis and recognition of symptoms. The risk of cardiovascular diseases and the importance of monitoring women's health increase after menopause due to the loss of estrogen's protective effect.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Letter
Medicine, General & Internal
Shabnam Radbakhsh, Moein Mobini, Eric Gumpricht, Maciej Banach, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: In this study, a female child with multiple sulfatase deficiency (MSD) received trehalose treatment for 3 months. The efficacy of trehalose was evaluated through various measurements, and it was found that trehalose improved the quality of life assessment and led to a slight decrease in spleen dimensions. Further research with a larger MSD population and longer-term follow-up is needed to confirm these findings.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
George Howard, Maciej Banach, Brett Kissela, Mary Cushman, Paul Muntner, Suzanne E. Judd, Virginia J. Howard
Summary: This study assessed the association between stroke risk factors and incident stroke, and evaluated whether the magnitude of this association is uniform across different age groups. The results showed that the associations of hypertension and diabetes with stroke significantly decreased in older age groups, while the associations of smoking, atrial fibrillation, and left ventricular hypertrophy with stroke did not vary with age.
Article
Pharmacology & Pharmacy
Stanislaw Surma, Amirhossein Sahebkar, Maciej Banach
Summary: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of premature death worldwide. Inflammation, along with other risk factors such as hypertension, lipid disorders, and diabetes, may contribute to the residual risk of cardiovascular disease (CVD). While modern lipid-lowering treatments are not fully effective in reducing inflammation, selected nutraceuticals with anti-inflammatory properties, including tea and coffee, may have a significant impact on reducing cardiovascular risk and mortality. However, the clinical significance of the anti-inflammatory effects of tea and coffee remains uncertain due to inconsistent results from studies and confounding factors.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Medicine, General & Internal
Bozena Sosnowska, Weronika Adach, Stanislaw Surma, Robert S. Rosenson, Maciej Banach
Summary: Familial hypercholesterolemia (FH) is an inherited disorder characterized by high levels of LDL-C. Inhibiting ANGPTL3 has shown promise as a therapeutic approach for reducing LDL-C and TG levels in FH patients. Evinacumab, a monoclonal antibody that inhibits ANGPTL3, has been found to be effective and safe in patients with both homozygous and heterozygous FH, as well as resistant hypercholesterolemia and hypertriglyceridemia. This paper provides a summary of the role of ANGPTL3, 4, and 8 in lipoprotein metabolism, clinical trial findings with evinacumab, and its potential as a new agent in lipid-lowering therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Arrigo F. G. Cicero, Federica Fogacci, Giuliano Tocci, Sergio D'Addato, Elisa Grandi, Maciej Banach, Claudio Borghi
Summary: This study aimed to compare the effect of different lipid-lowering nutraceuticals. The results showed that dietary supplementation with red yeast rice and berberine or artichoke extract significantly reduced cholesterol and improved cardiovascular risk factors. The placebo group had weaker effects in comparison.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Green & Sustainable Science & Technology
Julia Nowak, Roman Jaskulski, Wojciech Kubissa, Bartlomiej Matusiak, Maciej Banach
Summary: This study investigated the strength and thermal properties of concrete with crumb rubber from used tyres replacing part of the aggregate. The results showed a decrease in compressive strength and improved insulation properties with an increase in rubber content. A thermomechanical index was introduced to evaluate the functionality of the concrete, and only three out of twelve series failed to meet the performance requirements.
Review
Cardiac & Cardiovascular Systems
Katarzyna Gryglewska-Wawrzak, Krzysztof Cienkowski, Alicja Cienkowska, Maciej Banach, Agata Bielecka-Dabrowa
Summary: COVID-19 is a severe respiratory syndrome caused by SARS-CoV-2. Heart failure is associated with poor prognosis in COVID-19 patients and can also result from myocardial damage. Understanding the interactions between the disease and viruses is crucial for optimal treatment. Currently, the validity of screening for cardiovascular complications after COVID-19 is uncertain, and individualized diagnosis procedures based on clinical symptoms are recommended. We present a structured approach to COVID-19 patients with heart involvement.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Letter
Medicine, General & Internal
Kamal Awad, Maged Mohammed, Seth S. Martin, Maciej Banach
Summary: This study found that electronic nicotine delivery systems (ENDS) use was significantly associated with an increased risk of stroke compared to non-users, while there was no association between former ENDS use and the risk of stroke.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Peripheral Vascular Disease
Maciej Banach, Giuseppe Danilo Norata
Summary: Elevated levels of LDL-C increase the risk of atherosclerotic cardiovascular disease (ASCVD), and reducing LDL-C levels can lower the risk of cardiovascular adverse events. Red yeast rice (RYR) has cholesterol-lowering effects due to its bioactive components (monacolins) that inhibit the activity of HMG-CoA reductase. However, the use of RYR as a food supplement at a dose of 10 mg/day raises significant safety concerns, and serious adverse effects have been reported at even lower doses.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Review
Immunology
Alexandr Ceasovschih, Victorita Sorodoc, Annabelle Shor, Raluca Ecaterina Haliga, Lynn Roth, Catalina Lionte, Viviana Onofrei Aursulesei, Oana Sirbu, Nicolae Culis, Albina Shapieva, Mohammed A. R. Tahir Khokhar, Cristian Statescu, Radu A. Sascau, Adorata Elena Coman, Alexandra Stoica, Elena-Daniela Grigorescu, Maciej Banach, Costas Thomopoulos, Laurentiu Sorodoc
Summary: The COVID-19 pandemic, which started in Wuhan, China, in early 2020, has caused a global health crisis. The disease mainly affects the respiratory system but can also have an impact on other systems, including the cardiovascular system. The relationship between atherosclerosis and COVID-19 is bidirectional, with both conditions exacerbating each other. The pandemic has also led to reduced access to healthcare amenities, an increase in sedentary lifestyles and unhealthy eating habits, resulting in a high prevalence of overweight and obese individuals. The long-term healthcare challenges posed by COVID-19 can be mitigated by the lessons learned and the advancements made in patient care during this crisis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Correction
Cardiac & Cardiovascular Systems
Maciej Banach
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)