期刊
ANTIOXIDANTS
卷 12, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/antiox12030757
关键词
cerium oxide nanoparticles; SOD and catalase mimetic; keratinocytes; UV exposure; DNA damage; mutagenesis; UV protection
Cerium oxide nanoparticles (nanoceria) are biocompatible and multifunctional nanozymes that mimic the activities of superoxide-dismutase and catalase. They can shield from UV exposure, protect tissues from oxidative damage, and accelerate the recovery of skin cells. Nanoceria can also neutralize the side effects of titanium dioxide nanoparticles, a common ingredient in UV-shielding lotions. These properties make nanoceria a promising solution for preventing UV-induced skin damage and carcinogenesis.
Cerium oxide nanoparticles (nanoceria), biocompatible multifunctional nanozymes exerting unique biomimetic activities, mimic superoxide-dismutase and catalase through a self-regenerating, energy-free redox cycle driven by Ce3+/4+ valence switch. Additional redox-independent UV-filter properties render nanoceria ideal multitask solar screens, shielding from UV exposure, simultaneously protecting tissues from UV-oxidative damage. Here, we report that nanoceria favour basal proliferation of primary normal keratinocytes, and protects them from UVB-induced DNA damage, mutagenesis, and apoptosis, minimizing cell loss and accelerating recovery with flawless cells. Similar cell-protective effects were found on irradiated noncancerous, but immortalized, p53-null HaCaT keratinocytes, with the notable exception that here, nanoceria do not accelerate basal HaCaT proliferation. Notably, nanoceria protect HaCaT from oxidative stress induced by irradiated titanium dioxide nanoparticles, a major active principle of commercial UV-shielding lotions, thus neutralizing their most critical side effects. The intriguing combination of nanoceria multiple beneficial properties opens the way for smart and safer containment measures of UV-induced skin damage and carcinogenesis.
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