Article
Immunology
Masaki Machida, Itaru Nakamura, Takako Kojima, Reiko Saito, Tomoki Nakaya, Tomoya Hanibuchi, Tomoko Takamiya, Yuko Odagiri, Noritoshi Fukushima, Hiroyuki Kikuchi, Shiho Amagasa, Hidehiro Watanabe, Shigeru Inoue
Summary: This study investigated the acceptance and hesitancy towards the COVID-19 vaccine in Japan, finding that 62.1% of participants were willing to get vaccinated. The research also revealed that vaccine acceptance was lower among women, adults aged 20-49 years, and those with a low-income level. Psychological factors, such as the perceived effectiveness of the vaccine and willingness to protect others, were identified as important factors associated with vaccine acceptance.
Review
Immunology
Fathema Ghare, Rehab Meckawy, Michael Moore, Marta Lomazzi
Summary: This review analyzes the sentiments and determinants of healthcare workers' and public health professionals' acceptance of COVID-19 vaccination across different countries. The study finds variations in vaccine acceptance rates, with the highest being in Italy (98.9%) and the lowest in Cyprus (30%). Factors associated with vaccine acceptance include age, gender, profession, education level, comorbidities, and previous influenza vaccination. Factors for low acceptance include perceived side effects, lack of effectiveness, and lack of information. The study also highlights the need for research on public health professionals' sentiments towards vaccination. Interventions, including vaccination campaigns, are necessary to improve COVID-19 vaccine acceptance.
Review
Immunology
Christopher J. Peterson, Benjamin Lee, Kenneth Nugent
Summary: The COVID-19 pandemic and its associated vaccine have brought attention to vaccine hesitancy among healthcare workers. Reasons for hesitancy include concerns about safety and efficacy, mistrust of government and institutions, waiting for more data, and feeling that personal rights are being infringed upon. Being a physician, having more advanced education, and previous vaccination habits are frequently associated with vaccine acceptance.
Article
Public, Environmental & Occupational Health
Maria Falcon, Carmen Rodriguez-Blazquez, Maria Romay-Barja, Alba Ayala, Alfredo Burgos, Maria Jose De Tena-Davila, Maria Joao Forjaz
Summary: The present study investigates the reasons for vaccine hesitancy among those who have not been vaccinated in the later stage of the vaccine rollout in Spain. Cluster and logistic regression analyses were conducted using two samples of unvaccinated individuals, revealing that the main reasons for not being vaccinated were concerns about the speed of vaccine development, experimental nature, and safety. The analysis further identified two clusters, with individuals in Cluster 2 showing lower trust in health professionals' information, lower willingness to get vaccinated in the future, and fewer avoidances of social/family events compared to Cluster 1. Promoting reliable information and addressing misinformation and myths through information campaigns is crucial. These findings can guide strategies to increase vaccination uptake among those who are hesitant about the COVID-19 vaccine.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Serena Barello, Lorenzo Palamenghi, Guendalina Graffigna
Summary: In March 2021, the possible link between the Oxford-AstraZeneca vaccine and blood clots led to the suspension of the vaccine in several countries. This had an impact on people's trust in health authorities and their willingness to get vaccinated against COVID-19.
Article
Immunology
Sallee Brandt, Ryan T. Demmer, Sara Walsh, John F. Mulcahy, Evelyn Zepeda, Stephanie Yendell, Craig Hedberg, Angela K. Ulrich, Timothy Beebe
Summary: This cross-sectional study aimed to describe the demographics and behaviors of Minnesota adults who have not received the primary series of the COVID-19 vaccine or the booster shot. The study used data from the Minnesota COVID-19 Antibody Study (MCAS) collected through a web-based survey sent to individuals who responded to a similar survey in 2020 and their adult household members. The study found that a significant proportion of the US population remains unvaccinated, with safety concerns being the most frequently reported reason.
Letter
Public, Environmental & Occupational Health
Raymond John D. Vergara, Philip Joseph D. Sarmiento, James Darwin N. Lagman
Summary: The rollout of COVID-19 vaccines has led to both optimistic and negative attitudes among people, with a significant rate of distrust against the vaccines. Research suggests that vaccine hesitancy is present even among medical students, highlighting the importance of localized public education and role-modeling from public officials and health authorities in building public trust. This study aims to contribute to the development of public health mechanisms in the distribution of COVID-19 vaccines.
JOURNAL OF PUBLIC HEALTH
(2021)
Article
Immunology
Heloise Lucaccioni, Giorgi Chakhunashvili, Carl Jason McKnight, Tamila Zardiashvili, Pernille Jorgensen, Richard Pebody, Esther Kissling, Mark A. Katz, Lia Sanodze
Summary: A study conducted in six large hospitals in Georgia found that factors associated with COVID-19 vaccination among healthcare workers (HWs) included age, perception of vaccine effectiveness, previous seasonal influenza vaccination, and previous SARS-CoV-2 infection. Nurses, administrative staff, and ancillary staff were less likely to have received the vaccine compared to physicians. Tailoring the vaccine communication campaign to younger and non-physician HWs and emphasizing the benefits of the vaccine could help increase vaccine coverage among HWs in Georgia.
Article
Immunology
Megumi Hara, Motoki Ishibashi, Atsushi Nakane, Takashi Nakano, Yoshio Hirota
Summary: A survey in Japan revealed that healthcare workers, especially nurses, had lower acceptance rates of the COVID-19 vaccine compared to the general population. Women and young adults were more likely to be hesitant about vaccination, while smokers were more likely to accept it. Nurses showed a higher hesitancy rate compared to the general population.
Article
Immunology
Isabel King, Petra Heidler, Roy Rillera Marzo
Summary: The survey on vaccine acceptance showed that most respondents believe that the COVID-19 vaccine is an effective way to prevent and control the virus, but there is still some hesitancy. Doctor's recommendation greatly influences the decision-making process, and tailored vaccine information can support a higher vaccine coverage.
Article
Immunology
Ana Aleksandric, Henry Isaac Anderson, Sarah Melcher, Shirin Nilizadeh, Gabriela Mustata Wilson
Summary: This study reveals a negative correlation between vaccination rates among the Hispanic population and negative sentiment and fear found in social media posts. The findings suggest that monitoring social media can be a valuable tool for measuring attitudes towards public health interventions.
Article
Immunology
Taoran Liu, Zonglin He, Jian Huang, Ni Yan, Qian Chen, Fengqiu Huang, Yuejia Zhang, Omolola M. Akinwunmi, Babatunde O. Akinwunmi, Casper J. P. Zhang, Yibo Wu, Wai-Kit Ming
Summary: High acceptance rates of COVID-19 vaccination were observed in both China and the United States, but differences exist between the two countries. Chinese respondents are more concerned about adverse effects of vaccines, while respondents from the U.S. prioritize vaccine efficacy and cost.
Article
Medicine, General & Internal
Ju Hwan Kim, Dongwon Yoon, Yunha Noh, Jaehun Jung, Young June Choe, Ju-Young Shin
Summary: This cross-sectional study explored factors associated with hesitancy towards COVID-19 vaccination for children. The findings showed a high prevalence of parental hesitancy, particularly among mothers, those residing outside metropolitan areas, and those with a history of COVID-19 or with a child who recently had COVID-19. On the other hand, parents with three or more children or with a child with underlying medical conditions were less likely to be hesitant. The study calls for targeted outreach efforts to promote vaccine uptake in this pediatric population.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Vivian Hsing-Chun Wang, Diana Silver, Jose A. Pagan
Summary: Despite evidence of the effectiveness of COVID-19 vaccines, there are differences in vaccine beliefs across generations. The study suggests that generational imprinting and different experiences may contribute to these differences. Additional policy strategies may be needed to overcome this public health barrier.
PREVENTIVE MEDICINE
(2022)
Article
Immunology
Sabina Kleitman, Dayna J. Fullerton, Marvin K. H. Law, Matthew D. Blanchard, Rachel Campbell, Margaret-Ann Tait, Jennifer Schulz, Jihyun Lee, Lazar Stankov, Madeleine T. King
Summary: This study identifies three distinct profiles of attitudes towards COVID-19 vaccination, including the willingness to get a booster dose. The hesitant and resistant groups showed lower concern about COVID-19, used fewer official information sources, and were more conservative and prone to persecutory thinking. This research provides insights for tailored approaches to increasing booster uptake and optimizing public health messaging.
Article
Pharmacology & Pharmacy
Soumya Narayana, Arfa Nasrine, Mohammed Gulzar Ahmed, Rokeya Sultana, B. H. Jaswanth Gowda, Suprith Surya, Mansour Almuqbil, Syed Mohammed Basheeruddin Asdaq, Sultan Alshehri, Syed Arif Hussain
Summary: This study evaluated the potential of chitosan hydrogel (CHI-HYD) and chitosan silk fibroin hydrogel (CHI-SF-HYD) in blood clotting and wound healing. The results showed that CHI-SF-HYD could accelerate the regeneration of the damaged area, improve blood coagulation and re-epithelialization, indicating its potential for developing novel wound healing devices.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Kuntal Das, A. Muthukumar, Mansour Almuqbil, Mohd. Imran, Ali A. Rabaan, Muhammad A. Halwani, Mohammed Garout, Abdulmonem A. Alsaleh, Mohammed Alissa, Ameen S. S. Alwashmi, Ahmad A. Alshehri, Ahmed Alsayyah, Keserla Bhavani, Swati Mittal, R. Gayathri, Nasser Fawzan Alomar, Syed Imam Rabbani, Syed Mohammed Basheeruddin Asdaq
Summary: This study aimed to investigate the nephroprotective effect of ethanolic root extract of Polyalthia Longifolia (PL) on vancomycin-induced nephrotoxicity using curative and protective models. The results showed that PL provided only modest protection to nephrons, requiring selenium support to prevent vancomycin-induced kidney damage.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Thekra Ali Alhandod, Syed Imam Rabbani, Mansour Almuqbil, Sultan Alshehri, Syed Arif Hussain, Nasser Fawzan Alomar, Manzoor Ahmad Mir, Syed Mohammed Basheeruddin Asdaq
Summary: Comprehensive safety and efficacy studies of COVID-19 vaccines can alleviate concerns about adverse reactions and duration of protection. A systemic review was conducted on four COVID-19 vaccines approved in Saudi Arabia (AstraZeneca, Pfizer, Moderna, and Janssen) using published articles from electronic databases. The review analyzed eighteen articles and found the vaccines to be safe and effective, with common local and systemic reactions reported. Efficacy was above the WHO threshold, but precautions are necessary for special populations and further studies are needed on rare adverse events.
Article
Public, Environmental & Occupational Health
Nasser Ali Aljarallah, Mansour Almuqbil, Sultan Alshehri, Amro Mohammed Sawadi Khormi, Reshaidan Mohammed AlReshaidan, Fayez Hadi Alomran, Nasser Fawzan Alomar, Fayez Faleh Alshahrani, Majed Sadun Alshammari, Walaa F. F. Alsanie, Majid Alhomrani, Abdulhakeem S. S. Alamri, Syed Mohammed Basheeruddin Asdaq
Summary: This study aimed to assess patient satisfaction with medical care and services in tertiary care facilities in Riyadh, Saudi Arabia. The overall satisfaction rate was 73.77%, with the financial aspect receiving the highest rating and the time spent with the doctor receiving the lowest rating. Regression analysis showed a positive correlation between employment, university education, and marital status with satisfaction. These findings could serve as a benchmark for healthcare services in Saudi Arabia and guide quality assurance procedures.
FRONTIERS IN PUBLIC HEALTH
(2023)
Correction
Multidisciplinary Sciences
Ahmed S. Alanazi, Sameh Awwad, Tahir M. Khan, Syed Mohammed Basheeruddin Asdaq, Yahya Mohzari, Foz Alanazi, Ahmed Alrashed, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Mohammed AlMotairi
Article
Multidisciplinary Sciences
Kuntal Das, Paramita Das, Mansour Almuqbil, Syed Mohammed Basheeruddin Asdaq, K. Nikhil, K. Preethi, A. Angelinkiruba, Nasser Fawzan Alomar, Rawabi M. Al Harbi, Walaa A. Al Abdullah, Sami M. Alshehri, Yahya A. Laghabi, Ahmed R. Alsaegh, Yahya Mohzari, Sultan Alshehri, Basheerahmed Abdulaziz Mannasaheb, Syed Imam Rabbani
Summary: This study evaluated the efficacy of phytochemicals obtained from AYUSH-listed medicinal plants against SARS-CoV-2 proteins using computational techniques. The results showed that these plants have therapeutic efficacy and low toxicity. Further research is suggested to validate the computational findings.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Health Care Sciences & Services
Mansour Almuqbil, Sarah Alshaikh, Nura Alrumayh, Fay Alnahdi, Eiman Fallatah, Shahad Almutairi, Mohd Imran, Mehnaz Kamal, Mazen Almehmadi, Ahad Amer Alsaiari, Wafa Ali Abdulrhman Alqarni, Ali Mohammed Alasmari, Sara Alwarthan, Ali A. Rabaan, Moneer E. Almadani, Syed Mohammed Basheeruddin Asdaq
Summary: A study conducted in Saudi Arabia between February and April 2022 investigated the use of natural products (NPs) for COVID-19 prevention and treatment. Out of 677 participants, 65% reported using NPs, with honey and ginger being the most commonly used. The study also found that close friends and family members were the main sources of information about NPs. This study suggests that the use of NPs for treating COVID-19 is widespread in Saudi Arabia.
Article
Chemistry, Analytical
Nazrul Haq, Faiyaz Shakeel, Mohammed M. Ghoneim, Syed Mohammed Basheeruddin Asdaq, Prawez Alam, Fahad Obaid Aloatibi, Sultan Alshehri
Summary: A rapid and sensitive HPLC method was used to quantify pterostilbene (PTT) in commercial capsule dosage form, solubility, and stability samples. The HPLC method utilized an RP C-18 column and a mobile phase of acetonitrile and water. PTT was detected at a wavelength of 254 nm. The HPLC method was found to be linear, accurate, precise, and sensitive, with a high determination coefficient. The method was successfully applied to determine PTT in commercial products, solubility, and stability samples.
Article
Pharmacology & Pharmacy
Bansilal R. Tiwari, Mohammed Naseeruddin Inamdar, Mansour Almuqbil, Moneer E. Almadani, Mohammad Al Zahrani, Ebtesam Abdul Rahman Jibreel, Syed Arif Hussain, Syed Imam Rabbani, Syed Mohammed Basheeruddin Asdaq
Summary: This study investigated the spasmolytic activity of commonly used herbal extracts using isolated rat fundus and rabbit jejunum preparations. The results showed that all five herbal extracts, including Zingiber officinale, Piper longum, Piper nigrum, Terminalia bellerica, and Terminalia chebula, suppressed 5-HT-induced responses in a concentration-dependent manner. Terminalia chebula extract exhibited the strongest effect. These herbal extracts have the potential to affect the functioning of gastrointestinal smooth muscles.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Kuntal Das, Keerthana Ramesh Iyer, Raha Orfali, Syed Mohammed Basheeruddin Asdaq, Norah S. Alotaibi, Faisal S. Alotaibi, Sultan Alshehri, Mohammed Sharique Ahmed Quadri, Ahamd Almarek, Nada Bin Makhashin, Ahmed A. Alrashed, Yahya A. Mohzari, Mohammed Ghoneim
Summary: In this study, the ethanol seed extract of Coscinium fenestratum (CF) was found to have potential antidiabetic activity through in silico molecular docking study and in vitro experiments. Berberine was identified as a key compound responsible for the antidiabetic activity.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Health Care Sciences & Services
Mansour Almuqbil, Moneer E. Almadani, Salem Ahmad Albraiki, Ali Musharraf Alamri, Ahmed Alshehri, Adel Alghamdi, Sultan Alshehri, Syed Mohammed Basheeruddin Asdaq
Summary: University students are susceptible to psychological burdens, and vitamin D deficiency is widely recognized worldwide. This study aimed to investigate the relationship between vitamin D deficiency and psychological burden among university students in Riyadh, Saudi Arabia.
Article
Health Care Sciences & Services
Mansour Almuqbil, Ali Ibrahim Almoteer, Alwaleed Mohammed Suwayyid, Abdulaziz Hussain Bakarman, Raed Fawaz Alrashed, Majed Alrobish, Fahad Alasalb, Abdulaziz Abdulrahman Alhusaynan, Mohammed Hadi Alnefaie, Abdullah Saud Altayar, Saad Ebrahim Alobid, Moneer E. Almadani, Ahmed Alshehri, Adel Alghamdi, Syed Mohammed Basheeruddin Asdaq
Summary: This study aimed to analyze the characteristics of COVID-19 patients in the ICU of a multispecialty hospital in Saudi Arabia. The findings showed that male patients and those with diabetes and hypertension had a higher risk of severe illness and death. Despite a significant number of intubated patients, the study center's ICU had a lower fatality rate due to excellent healthcare management.
Article
Pharmacology & Pharmacy
Shailaja P. Desai, S. K. Mohite, Saad Alobid, M. G. Saralaya, Ashwini S. Patil, Kuntal Das, Moneer E. Almadani, Syed Arif Hussain, Bader Hussain Alamer, Ebtesam Abdulrahman Jibreel, Ali Ibrahim Almoteer, Syed Mohammed Basheeruddin Asdaq
Summary: Utilizing the k-Nearest Neighbor-Molecular Field Analysis (kNN-MFA) method, a 3D QSAR evaluation was conducted on substituted 1, 2, and 4-triazole derivatives for their anti-cancer potential. The study revealed a strong correlation between biological activity and descriptors, demonstrating the significant pharmacological role of these derivatives in potentially identifying chemical compounds with optimal anticancer activity and minimal side effects.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Ibrahim Ahmed Shaikh, Mater H. Mahnashi, H. Joy Hoskeri, Arun K. Shettar, Basheerahmed Abdulaziz Mannasaheb, Mohammed M. Ghoneim, Syed Mohammed Basheeruddin Asdaq, Aejaz Abdullatif Khan
Summary: Tissue regeneration is a process where damaged tissue is repaired, and new cells are produced to replace lost cells. The use of scaffolds is crucial in tissue regeneration, providing a supportive substance that aids in new tissue formation. Both natural and synthetic polymers can be used as scaffolds, with desirable qualities such as biodegradability, biocompatibility, and enhanced porosity.
LATIN AMERICAN JOURNAL OF PHARMACY
(2023)