The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9

Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs

(2016) Roman Galeev et al.   Cell Reports

Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse

(2015) M. Garg et al.   BLOOD

Leukemogenic Activity of Cohesin Rings True

(2015) Mark S. Williams et al.   Cell Stem Cell

Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation

(2015) Claire Mazumdar et al.   Cell Stem Cell

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis

(2015) Aaron D. Viny et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

(2015) Jasper Mullenders et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells

(2015) D H Spencer et al.   LEUKEMIA

The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79

(2015) Shoudeng Chen et al.   MOLECULAR CELL

Clustering of mammalianHoxgenes with other H3K27me3 targets within an active nuclear domain

(2015) Maxence Vieux-Rochas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic alterations of the cohesin complex genes in myeloid malignancies

(2014) S. Thota et al.   BLOOD

CTCF Controls HOXA Cluster Silencing and Mediates PRC2-Repressive Higher-Order Chromatin Structure in NT2/D1 Cells

(2014) M. Xu et al.   MOLECULAR AND CELLULAR BIOLOGY

CTCF: an architectural protein bridging genome topology and function

(2014) Chin-Tong Ong et al.   NATURE REVIEWS GENETICS

CTCF and cohesin cooperate to organize the 3D structure of the mammalian genome

(2014) L. Baranello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

(2014) Daan Noordermeer et al.   eLife

Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications

(2013) F. Thol et al.   BLOOD

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

(2013) Jacqueline K. White et al.   CELL

CTCF and Cohesin: Linking Gene Regulatory Elements with Their Targets

(2013) Matthias Merkenschlager et al.   CELL

Cohesin: Functions beyond sister chromatid cohesion

(2013) Gunjan D. Mehta et al.   FEBS LETTERS

Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments

(2013) V. C. Seitan et al.   GENOME RESEARCH

Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put

(2013) Jeffrey A. Simon et al.   MOLECULAR CELL

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

(2013) Ayana Kon et al.   NATURE GENETICS

The landscape of somatic mutations in Down syndrome–related myeloid disorders

(2013) Kenichi Yoshida et al.   NATURE GENETICS

Transcriptional regulation by Polycomb group proteins

(2013) Luciano Di Croce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Clustering of Tissue-Specific Sub-TADs Accompanies the Regulation of HoxA Genes in Developing Limbs

(2013) Soizik Berlivet et al.   PLoS Genetics

PBX3 is an important cofactor of HOXA9 in leukemogenesis

(2012) Z. Li et al.   BLOOD

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

A unique role of cohesin-SA1 in gene regulation and development

(2012) Silvia Remeseiro et al.   EMBO JOURNAL

The long-range interaction landscape of gene promoters

(2012) Amartya Sanyal et al.   NATURE

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

(2011) Kathrin M. Bernt et al.   CANCER CELL

Therapeutic Advances in Acute Myeloid Leukemia

(2011) Alan Burnett et al.   JOURNAL OF CLINICAL ONCOLOGY

A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation

(2011) Vlad C. Seitan et al.   NATURE

The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis

(2010) Andrew G. Muntean et al.   CANCER CELL

Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines

(2010) Stefan Nagel et al.   Molecular Cancer

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

Rad21-Cohesin Haploinsufficiency Impedes DNA Repair and Enhances Gastrointestinal Radiosensitivity in Mice

(2010) Huiling Xu et al.   PLoS One

CTCF: Master Weaver of the Genome

(2009) Jennifer E. Phillips et al.   CELL

Premature chromatid separation is not a useful diagnostic marker for Cornelia de Lange syndrome

(2009) Paola Castronovo et al.   CHROMOSOME RESEARCH

Cornelia de Lange syndrome, cohesin, and beyond

(2009) J Liu et al.   CLINICAL GENETICS

Multiple Organ System Defects and Transcriptional Dysregulation in the Nipbl+/− Mouse, a Model of Cornelia de Lange Syndrome

(2009) Shimako Kawauchi et al.   PLoS Genetics

HOXA9 is required for survival in human MLL-rearranged acute leukemias

(2008) J. Faber et al.   BLOOD

CTCF Regulates Allelic Expression of Igf2 by Orchestrating a Promoter-Polycomb Repressive Complex 2 Intrachromosomal Loop

(2008) T. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Cohesin mediates transcriptional insulation by CCCTC-binding factor

(2008) Kerstin S. Wendt et al.   NATURE