Article
Cardiac & Cardiovascular Systems
Zhaoqing Sun, Yongchen Hao, Jun Liu, Na Yang, Yue Qi, Danqing Hu, Yiqian Yang, Haimei Wang, Dong Zhao, Caihua Sang, Jing Liu, CCC-AF Investigators
Summary: The prevalence of hypertension is high in Chinese patients hospitalized with atrial fibrillation (AF), but the treatment and control rates are low. Factors associated with uncontrolled hypertension include being young, having rural insurance, alcohol drinking, history of heart failure, valvular AF, first diagnosed AF, and permanent AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Maria Dorobantu, Oana-Florentina Gheorghe-Fronea, Alexandru Scafa-Udriste, Sebastian Onciul, Calin Pop, Lucian Dorobantu, Roxana Darabont
Summary: Gender differences play a significant role in hypertension epidemiology, with clear disparities in prevalence, awareness, treatment, and control between different age groups of men and women, mainly influenced by hormonal status. In high cardiovascular risk European countries like Romania, gender gaps in hypertension prevalence may decrease over time, with females expected to maintain higher awareness and treatment rates than males, while an upward trend in blood pressure control is predicted only for women.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Peripheral Vascular Disease
Eva L. van der Linden, Brandon N. Couwenhoven, Erik J. A. J. Beune, Joost G. Daams, Bert-Jan H. van den Born, Charles Agyemang
Summary: The study found differences in hypertension awareness, treatment, and control levels between ethnic minority populations (EMPs) and European host populations (EHPs). African origin populations were more likely to be aware and treated for hypertension, but less likely to have their blood pressure controlled. South Asian populations were more likely to be aware of hypertension, but had similar treatment and control rates compared to EHPs.
JOURNAL OF HYPERTENSION
(2021)
Article
Public, Environmental & Occupational Health
Junxiang Wei, Yang Mi, Yan Li, Bo Xin, Youfa Wang
Summary: The study found that over a quarter of Chinese adults have hypertension, but only about one-fifth have their blood pressure under control, indicating low levels of hypertension awareness, treatment, and control in China. Factors associated with higher hypertension treatment include older age, urban residency, living in the Eastern region, and being overweight/obese, while hypertension awareness is also linked to being female. Poor hypertension control, on the other hand, is associated with being overweight/obese and belonging to a minority ethnicity.
Article
Public, Environmental & Occupational Health
Mahin Amini, Mahdi Moradinazar, Fatemeh Rajati, Moslem Soofi, Sadaf G. Sepanlou, Hossein Poustchi, Sareh Eghtesad, Mahmood Moosazadeh, Javad Harooni, Javad Aghazadeh-Attari, Majid Fallahi, Mohammad Reza Fattahi, Alireza Ansari-Moghaddam, Farhad Moradpour, Azim Nejatizadeh, Mehdi Shahmoradi, Fariborz Mansour-Ghanaei, Alireza Ostadrahimi, Ali Ahmadi, Arsalan Khaledifar, Mohammad Hossien Saghi, Nader Saki, Iraj Mohebbi, Reza Homayounfar, Mojtaba Farjam, Ali Esmaeili Nadimi, Mahmood Kahnooji, Farhad Pourfarzi, Bijan Zamani, Abbas Rezaianzadeh, Masoumeh Ghoddusi Johari, Masoud Mirzaei, Ali Dehghani, Seyed Fazel Zinat Motlagh, Zahra Rahimi, Reza Malekzadeh, Farid Najafi
Summary: This study examined the socioeconomic inequality in prevalence, awareness, treatment, and control of hypertension in Iran. It found that individuals with low socioeconomic status had higher prevalence of hypertension, but treatment and control were more concentrated among those with higher socioeconomic status.
Article
Peripheral Vascular Disease
Brent M. Egan, Jiexiang Li, Susan E. Sutherland, Michael K. Rakotz, Gregory D. Wozniak
Summary: The study found that hypertension control in the United States plateaued from 2009 to 2010, then declined from 2015 to 2018. Despite unchanged access to healthcare, awareness, treatment, and treatment effectiveness for hypertension all decreased. Hypertension control fell across different age and race-ethnicity groups.
Article
Cardiac & Cardiovascular Systems
Lu-Ming Fan, Fang Wang, Min Zhao, Wen-Long Cui, Le Cai
Summary: From 2009 to 2016, the prevalence of hypertension substantially increased in rural southwestern China, with awareness and control rates also rising. Individuals with higher education levels had higher awareness and control rates, but there were no significant differences in improvement among different education levels. Both awareness and control rates increased in individuals with high income, while only awareness rate increased in individuals with low income. Additionally, the prevalence and treatment of hypertension were higher in the Han people compared to ethnic minorities.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
J. S. Thakur, Ria Nangia
Summary: Hypertension and diabetes are major public health problems in certain states of India, particularly in Punjab and Haryana, with low rates of awareness, treatment, and control. The study found that family history is associated with the awareness, treatment, and control of blood glucose and blood pressure levels.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Hua Peng, Mei Sun, Xin Hu, Huiwu Han, Jing Su, Emin Peng, James Wiley, Lisa Lommel, Jyu-Lin Chen
Summary: This study found a high prevalence of high blood pressure among young Chinese female migrant workers, with a majority being unaware of their condition. Factors associated with high blood pressure included having rural medical insurance, awareness of having HBP, physical inactivity, and being overweight/obese.
Article
Peripheral Vascular Disease
Shujing Ma, Liu Yang, Min Zhao, Costan G. Magnussen, Bo Xi
Summary: This study analyzed the trends in the prevalence, awareness, treatment, and control of hypertension among Chinese adults from 1991 to 2015 based on the 2018 Chinese Guideline. The results showed a significant increase in hypertension prevalence over the two decades, with slight to moderate improvements in awareness, treatment, and control rates which remained very low. These findings highlight the importance of effective measures to prevent and control hypertension among Chinese adults.
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, General & Internal
Rahul Aggarwal, Robert W. W. Yeh, Karen E. Joynt E. Maddox, Rishi K. K. Wadhera
Summary: In the US, there has been an increase in diabetes and obesity among young adults aged 20 to 44 years since 2009, while hypertension remained unchanged and hyperlipidemia declined. There were variations in these trends among different races and ethnicities.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Tingxin Li, Ping Shuai, Jinghong Wang, Lin Wang
Summary: The prevalence of hypertension among Ngawa Tibetans in China was 24.6%, with awareness rate at 32.3%, treatment rate at 21.7%, and control rate at 6.2%. While awareness and treatment have improved in recent years, the control rate remains low. The government needs to strengthen basic medical care and health education for this population.
Article
Medicine, General & Internal
Xuexue Zhang, Xujie Wang, Miaoran Wang, Hua Qu, Biaoyan Hu, Qiuyan Li
Summary: This study aimed to describe the trend in the prevalence, awareness, and treatment of isolated diastolic hypertension (IDH) in the United States from 2001 to 2018. The results showed that the prevalence of IDH decreased from 2001-2002 to 2017-2018, and although there were increases in awareness and treatment, they remained below 50%.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Hui Liu, Weiquan Lin, Kexin Tu, Qin Zhou, Chang Wang, Minying Sun, Yaohui Li, Xiangyi Liu, Guozhen Lin, Sidong Li, Wei Bao
Summary: This study evaluated the prevalence, awareness, treatment, and risk factor control among individuals with high 10-year atherosclerotic cardiovascular disease (ASCVD) risk in Guangzhou, China. The findings showed low awareness rates, inadequate treatment, and suboptimal risk factor control, especially for lipid management, indicating the need for substantial improvement in ASCVD prevention in this population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Md Nuruzzaman Khan, John C. Oldroyd, Enayet K. Chowdhury, Mohammad Bellal Hossain, Juwel Rana, Stefano Renzetti, Rakibul M. Islam
Summary: The study aimed to estimate the prevalence, awareness, treatment, and control of hypertension in Bangladeshi adults, finding that hypertension is highly prevalent with low awareness, treatment, and control levels. Risk factors for hypertension included increasing age, higher BMI, female gender, diabetes, and specific administrative divisions of residence.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Hematology
Ziqian Zeng, Mahussi Fagnon, Tanmaye Nallan Chakravarthula, Nathan J. Alves
THROMBOSIS RESEARCH
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Tanmaye Chakravarthula, Ziqian Zeng, Nathan Alves
Article
Multidisciplinary Sciences
Ziqian Zeng, Tanmaye Nallan Chakravarthula, Nathan J. Alves
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Engineering, Biomedical
Ziqian Zeng, Phuong T. Lam, Michael L. Robinson, Katia Del Rio-Tsonis, Justin M. Saul
Summary: Researchers have designed a scaffold system mimicking the choroid and Bruch's membrane for the treatment of AMD, with elastic moduli similar to the native tissues. Cells attached to the polycaprolactone fibers, remained viable for one week, and proliferated to form a monolayer, making these constructs suitable for testing cell and/or drug treatment strategies for AMD.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Hematology
Alexei Christodoulides, Ziqian Zeng, Nathan J. Alves
Summary: Conducting in-vitro thrombosis research presents challenges due to limited functional shelf-lives of blood products. Fractionating and recombining whole blood can prolong clotting functionality and improve accessibility in thrombosis research. Storage of fractionated whole blood components allows for prolonged usability and formation of clots resembling freshly drawn whole blood.
BLOOD COAGULATION & FIBRINOLYSIS
(2021)
Article
Endocrinology & Metabolism
Justin J. Crowder, Ziqian Zeng, Alissa N. Novak, Nathan J. Alves, Amelia K. Linnemann
Summary: Metabolic dysfunction of beta-cells contributes to diabetes pathogenesis. This study introduces a novel 3D-printed islet stabilization device to improve conventional Oxygraph respirometry of pancreatic islets by preserving natural islet structure and function.
Article
Chemistry, Medicinal
Tanmaye Nallan Chakravarthula, Ziqian Zeng, Nathan J. Alves
Summary: This study explores the effect of multivalent benzamidine inhibitors with varying valency and linker length on plasmin inhibition. The findings suggest that increasing valency and decreasing linker length can enhance the inhibition of plasmin, providing guidance for designing multivalent inhibitors.
Article
Biotechnology & Applied Microbiology
Ziqian Zeng, Alexei Christodoulides, Nathan J. Alves
Summary: There is a need for a more representative in-vitro model to screen thrombolytic therapies. In this study, a flowing clot lysis platform with real-time fibrinolysis monitoring was designed and validated. The platform showed tPA-dependent thrombolysis and can be adapted to produce pulsatile flows, mimicking hemodynamics of human main pulmonary artery. These findings suggest that the platform offers a versatile testing platform for thrombolytic drug screening.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Meeting Abstract
Hematology
Ziqian Zeng, Alexei Christodoulides, Nathan J. Alves
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Meeting Abstract
Hematology
Tanmaye Nallan Chakravarthula, Liliana Patino, Ziqian Zeng, Nathan J. Alves
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Meeting Abstract
Hematology
Alexei Christodoulides, Ziqian Zeng, Nathan J. Alves
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Materials Science, Biomaterials
Ziqian Zeng, Tanmaye Nallan Chakravarthula, Charanya Muralidharan, Abigail Hall, Amelia K. Linnemann, Nathan J. Alves
Summary: The fluorescently labeled fibrin clot lysis assay introduced in this study uses a unique annular clot geometry and a microplate reader for detection. The optimized physiologically relevant clot substrate showed nearly physiological clot properties, making it suitable for evaluating patient fibrinolytic potential and screening thrombolytic drug activities in personalized medical applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Tanmaye Nallan Chakravarthula, Ziqian Zeng, Nathan Alves
Letter
Biochemistry & Molecular Biology
Tanmaye Nallan Chakravarthula, John Zagorski, Ziqian Zeng, Jeffrey A. Kline, Nathan J. Alves
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
