Article
Endocrinology & Metabolism
Takuto Inoue, Koya Shimoyama, Momoko Saito, Marty Kwok-Shing Wong, Kiriko Ikeba, Ryo Nozu, Rui Matsumoto, Kiyomi Murakumo, Keiichi Sato, Kotaro Tokunaga, Kazuya Kofuji, Wataru Takagi, Susumu Hyodo
Summary: This study successfully monitored the egg-laying cycle of the cloudy catshark for the first time using portable ultrasound devices, and revealed cycling patterns of estradiol-17 beta, testosterone and progesterone through measurement of plasma sex steroids. The findings suggest that progesterone may be associated with ovulation and/or egg-case formation in the catshark.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hannah Collden, Maria E. Nilsson, Anna-Karin Norlen, Andreas Landin, Sara H. Windahl, Jianyao Wu, Karin L. Gustafsson, Matti Poutanen, Henrik Ryberg, Liesbeth Vandenput, Claes Ohlsson
Summary: This study established a comprehensive atlas of sex hormone concentrations in tissues and serum of male mice, revealing the distribution characteristics of sex hormones. Brain sex hormone levels are well correlated with serum levels, and white adipose tissue serves as a major reservoir of sex hormones in mice. Progesterone is the most abundant sex hormone in castrated mice.
Review
Medicine, General & Internal
Le-Tian Huang, Jia-He Wang
Summary: Sarcopenia is characterized by excessive loss of skeletal muscle mass, strength, and function, associated with overall poor muscle performance status in the elderly and chronic disease patients. Its causes are multifactorial, involving molecular mechanisms such as mitochondrial function, inflammatory pathways, and circulating hormones. Age-related changes in sex steroid hormone concentrations play a significant role in the pathogenesis of sarcopenia, suggesting therapeutic interventions targeting these hormones may be beneficial in combination with specific exercise and nutrition regimens.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Victoria-Luise Batury, Friederike I. Tam, Inger Hellerhoff, Marie-Louis Wronski, Katrin Borucki, Kerstin Weidner, Veit Roessner, Wei Gao, Stefan Ehrlich
Summary: Anorexia nervosa (AN) is a complex psychiatric disorder that affects endocrine system. Previous short-term measurement methods have shown altered levels of sex steroid hormones in AN patients. This study aimed to use hair-based assessments to investigate sex steroid hormone levels in underweight AN patients compared to healthy controls, as well as the changes in hormone levels during inpatient treatment. The results indicate that hair hormone levels of DHEA were similar between the groups, but progesterone was suppressed in underweight AN patients. There was no significant change in hair hormone levels during weight restoration. Hair analysis can be used to detect suppressed progesterone levels in severe AN patients.
Review
Endocrinology & Metabolism
Lovlesh Thakur, Sunil Thakur
Summary: This review summarizes the role of miRNAs in endometrial cancer regulated by sex steroid hormone pathways. Dysregulation of miRNAs has been linked to abnormal sex steroid hormone signaling and the development of endometrial cancer. Various miRNAs have been identified as modulators of estrogen and progesterone receptor expression, and the miRNA expression profile has been shown to be a predictor of response to hormone therapy. Future studies should focus on elucidating the functional roles of specific miRNAs in sex steroid hormone signaling and identifying novel miRNA targets for hormone therapy in endometrial cancer management.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Pavel Deryabin, Alisa Domnina, Inga Gorelova, Maxim Rulev, Mariya Petrosyan, Nikolay Nikolsky, Aleksandra Borodkina
Summary: This study focuses on developing a genetic tool for patient-specific optimization of hormonal supplementation during the luteal phase to maintain endometrial receptivity. Utilizing a cell differentiation model and RNA sequencing, the research identified a core decidual regulatory network that reflects the sensitivity of the endometrium to steroid hormones.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pattarasiri Rangsrikitphoti, Diana C. Marquez-Garban, Richard J. Pietras, Eileen McGowan, Viroj Boonyaratanakornkit
Summary: Sex steroid hormones (SSHs) play a crucial role in modulating the sensitivity of cancer cytotoxic treatment. The dysregulation of these hormones can lead to abnormal DNA repair, promoting cancer progression and resistance to cancer treatment. Different SSHs interact with DNA repair components and impact DNA repair regulation and response to genotoxic therapies.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Biology
Amani A. Mahbub
Summary: Several epidemiological studies have suggested that the use of female sex steroid hormones can reduce the risk of colon cancer. This review summarizes the available data on the effects of estradiol and progesterone treatments in male and female in vitro and in vivo models of colon cancer, along with their potential molecular mechanisms. The studies showed that estradiol treatment and activation of its beta receptor inhibited cell proliferation, induced cell cycle arrest, and promoted apoptosis through molecular pathway modulation. Similarly, the inhibition of the alpha receptor also had antitumorigenic effects. Limited studies on progesterone revealed promising tumoricidal actions. Furthermore, the combination of estradiol and progesterone showed enhanced anticancer activities compared to monotherapy. Overall, these studies suggest that female sex steroid hormones could be a novel and effective therapeutic strategy against colon cancer.
Review
Endocrinology & Metabolism
Claudia Bello-Alvarez, Ignacio Camacho-Arroyo
Summary: Glioblastoma, the most common malignant primary brain tumor, shows a higher prevalence in men than in women, suggesting that male gonadal steroid hormones, such as testosterone, may promote its growth. On the other hand, the protective role of female gonadal steroid hormones (estradiol and progesterone) against glioblastomas has been questioned.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Microbiology
Clariano Pires de Oliveira Neto, Beatriz Medeiros-Fonseca, Diogo Estevao, Veronica F. Mestre, Natalia R. Costa, Fabio Evangelista de Andrade, Paula A. Oliveira, Margarida M. S. M. Bastos, Rui Medeiros, Diogo Assis, Ana Felix, Fernanda Ferreira Lopes, Rui M. Gil da Costa, Haissa O. Brito, Luciane M. O. Brito
Summary: This study found that HPV+OPSCC is more common in men than in women, and female mice with HPV16-transgenic mutations exhibited a higher incidence of cancer with marked expression of estrogen receptors and collagen remodeling. These results suggest a potential role of female sex hormones in the sexual predisposition for HPV+OPSCC.
Article
Fisheries
Ariffin Hidir, Mohd Amran Aaqillah-Amr, Muda Mohd-Sabri, Ibrahim Mohd-Zaidi, Md Sheriff Shahreza, Muyassar H. Abualreesh, Teoh Hong Peng, Hongyu Ma, Khor Waiho, Hanafiah Fazhan, Akhmad Taufiq Mukti, Mhd Ikhwanuddin
Summary: The temperature has a significant influence on the sex determination of mud crab, with different mechanisms being activated at different temperatures. The steroidal pathway also shows variations at different temperatures.
AQUACULTURE RESEARCH
(2022)
Article
Cell Biology
Takuya Omotehara, Rex A. Hess, Hiroki Nakata, Lynn A. Birch, Gail S. Prins, Masahiro Itoh
Summary: Through three-dimensional reconstruction analysis of the murine mesonephric tubules (MTs) and Wolffian duct (WD), it was found that androgens act first through the androgen receptor (AR) in the MTs, while estrogens influence the development of both the MTs and WD through the estrogen receptor (ESR1), and the role of progesterone via the progesterone receptor (PGR) is weak and delayed. This suggests a sequential androgen-estrogen-progesterone pathway in the development of male reproductive tracts.
CELL AND TISSUE RESEARCH
(2023)
Article
Chemistry, Analytical
Xi-yang Tang, Zi-qin Dai, Dan-feng Shi, Jia-xing Zeng, Xin-luan Wang, Ling Li, Xin-sheng Yao, Yi Dai
Summary: A reliable method for simultaneous quantitative analysis of ten sex steroid hormones in rat and mouse serum was developed, which was then successfully applied to study osteoporosis and drug intervention effects.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Agriculture, Dairy & Animal Science
K. Hazano, S. Haneda, M. Kayano, M. Matsui
Summary: This study characterized the local endocrine environment of the oviduct by examining the concentrations of E2 and P4 and their receptors' mRNA expression. The results showed that the oviductal endocrine milieu varies according to the estrous cycle phase and the oviductal region and side.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2021)
Article
Developmental Biology
Patrycja Kurowska, Monika Sroka, Monika Dawid, Ewa Mlyczynska, Natalia Respekta, Malgorzata Jurek, Dominika Klimczyk, Malgorzata Grzesiak, Joelle Dupont, Agnieszka Rak
Summary: The study found that resistin and its receptors exhibit different expression levels in the porcine corpus luteum during different luteal phases, and they can be regulated by hormones. Additionally, resistin can regulate progesterone and estradiol secretion by influencing steroidogenic enzyme expression and kinase phosphorylation.
Article
Biology
Yuki Honda, Wataru Takagi, Marty K. S. Wong, Nobuhiro Ogawa, Kotaro Tokunaga, Kazuya Kofuji, Susumu Hyodo
JOURNAL OF EXPERIMENTAL BIOLOGY
(2020)
Article
Zoology
Naotaka Aburatani, Wataru Takagi, Marty Kwok-Sing Wong, Mitsutaka Kadota, Shigehiro Kuraku, Kotaro Tokunaga, Kazuya Kofuji, Kazuhiro Saito, Waichiro Godo, Tatsuya Sakamoto, Susumu Hyodo
ZOOLOGICAL SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Yoshinao Katsu, Islam M. D. Shariful, Xiaozhi Lin, Wataru Takagi, Hiroshi Urushitani, Satomi Kohno, Susumu Hyodo, Michael E. Baker
Summary: Orthologs of human glucocorticoid receptor (GR) and human mineralocorticoid receptor (MR) first appear in cartilaginous fishes. Subsequently, the MR and GR diverged to respond to different steroids. The study revealed partial functional divergence of elephant shark GR from the MR, with N-terminal domain (NTD) playing a crucial role in the response to corticosteroids. Swapping of NTDs between elephant shark GR and MR generated a chimeric receptor with altered activation properties. This suggests that NTD activation of human GR may have evolved early in the divergence from the MR.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biology
Wataru Takagi, Fumiaki Sugahara, Shinnosuke Higuchi, Rie Kusakabe, Juan Pascual-Anaya, Iori Sato, Yasuhiro Oisi, Nobuhiro Ogawa, Hiroshi Miyanishi, Noritaka Adachi, Susumu Hyodo, Shigeru Kuratani
Summary: The thyroid gland in hagfish develops directly from the ventrorostral pharyngeal endoderm, contradicting previous findings of an endostyle-like primordium. The developmental pattern and gene expression profiles of hagfish thyroid closely resemble those found in modern jawed vertebrates. Unlike jawed vertebrates, but similar to non-vertebrate chordates, lamprey and hagfish share a broad expression domain of a key regulatory gene in the pharyngeal epithelium during early development.
Article
Multidisciplinary Sciences
Yuki Honda, Nobuhiro Ogawa, Marty Kwok-Shing Wong, Kotaro Tokunaga, Shigehiro Kuraku, Susumu Hyodo, Wataru Takagi
Summary: Forms of embryonic nutrition in cartilaginous fishes are diverse, and the roles of the embryonic intestine and yolk sac membrane (YSM) were compared in this study. The study found enhanced nutrient digestion and absorption in both the intestine and YSM after a developmental event called "pre-hatching" in catshark embryos, supporting rapid growth at late developmental stages.
Article
Physiology
Naotaka Aburatani, Wataru Takagi, Marty Kwok-Shing Wong, Shigehiro Kuraku, Chiharu Tanegashima, Mitsutaka Kadota, Kazuhiro Saito, Waichiro Godo, Tatsuya Sakamoto, Susumu Hyodo
Summary: This study investigated the molecular mechanisms of dilute urine production in the kidney of Japanese red stingray when transferred from seawater to low-salinity environments. The results showed that the stingray maintained high levels of plasma NaCl and urea by reabsorbing more osmolytes in the kidney when acclimating to low salinity. Gene analyses revealed the upregulation of genes involved in osmolyte reabsorption, supporting enhanced urea reabsorption and dilute urine production in freshwater-acclimated individuals.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Takuto Inoue, Koya Shimoyama, Momoko Saito, Marty Kwok-Shing Wong, Kiriko Ikeba, Ryo Nozu, Rui Matsumoto, Kiyomi Murakumo, Keiichi Sato, Kotaro Tokunaga, Kazuya Kofuji, Wataru Takagi, Susumu Hyodo
Summary: This study successfully monitored the egg-laying cycle of the cloudy catshark for the first time using portable ultrasound devices, and revealed cycling patterns of estradiol-17 beta, testosterone and progesterone through measurement of plasma sex steroids. The findings suggest that progesterone may be associated with ovulation and/or egg-case formation in the catshark.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2022)
Article
Zoology
Takashi Horie, Wataru Takagi, Naotaka Aburatani, Manabu Yamazaki, Mayu Inokuchi, Masaya Tachizawa, Kataaki Okubo, Ritsuko Ohtani-Kaneko, Kotaro Tokunaga, Marty Kwok-Sing Wong, Susumu Hyodo
Summary: To adapt to a high salinity marine environment, cartilaginous fishes have evolved a ureosmotic strategy which involves a complex four-loop nephron in the kidney. However, the function and regulation of the four-loop nephron are still largely unknown. In this study, the researchers optimized fixation methods for laser microdissection and RNA-seq analysis, and found specific membrane transporter genes that characterize each segment of the nephron.
ZOOLOGICAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Yoko Yamaguchi, Wataru Takagi, Hiroyuki Kaiya, Norifumi Konno, Masa-aki Yoshida, Shigehiro Kuraku, Susumu Hyodo
Summary: Vertebrate neurohypophysial hormones exert versatile physiological actions through different G protein-coupled receptors. The neurohypophysial hormone receptor family is diversified through multiple gene duplication events at different scales. This study focuses on the inshore hagfish and Arctic lamprey and identifies new neurohypophysial hormone receptor homologs and expression patterns, providing new insights into the molecular and functional evolution of the neurohypophysial hormone system in vertebrates.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2023)
Article
Evolutionary Biology
Yuta Ohishi, Shogo Arimura, Koya Shimoyama, Kazuyuki Yamada, Shinya Yamauchi, Taku Horie, Susumu Hyodo, Shigehiro Kuraku
Summary: The reproductive modes of vertebrates can be categorized into lecithotrophy and matrotrophy. In this study, the researchers focused on chondrichthyans, a group of cartilaginous fishes that have undergone multiple shifts from lecithotrophy to matrotrophy. Through transcriptome sequencing and molecular phylogenetic analysis, they identified several vitellogenin (VTG) and very low-density lipoprotein receptor (VLDLR) genes in chondrichthyans, including viviparous species. They also found that the expression patterns of VTG genes varied depending on the reproductive mode, suggesting that VTGs in chondrichthyans serve as both yolk nutrients and matrotrophic factors.
GENOME BIOLOGY AND EVOLUTION
(2023)
Article
Chemistry, Medicinal
Xiaozhi Lin, Wataru Takagi, Susumu Hyodo, Shigeho Ijiri, Yoshinao Katsu, Michael E. Baker
Summary: In this study, we investigated the activation of the elephant shark PR by progestin and corticosteroids, and compared it with the human PR to understand the evolution of steroid activation of the human PR. We found that the elephant shark PR was activated by multiple steroids, while the human PR showed increased specificity. We also discovered the importance of a key residue, Cys-528, in the elephant shark PR for RU486 inhibition of progesterone activation.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2022)
Meeting Abstract
Anatomy & Morphology
S. Higuchi, F. Sugahara, J. Pascual-Anaya, W. Takagi, Y. Oisi, S. Kuratani
JOURNAL OF MORPHOLOGY
(2019)