Article
Nanoscience & Nanotechnology
Xuanwen Xu, Yi Zhou, Kai Zheng, Xinyu Li, Lu Li, Yan Xu
Summary: Periodontitis is a chronic inflammatory disease that affects people worldwide and has an uncertain prognosis with surgical treatment. In this study, a three-dimensional scaffold made of electrospun polycaprolactone/gelatin fibrous membranes was developed to overcome the challenges of periodontal treatment. The scaffold showed good properties and promoted adhesion and proliferation of human periodontal ligament stem cells. In vivo experiments confirmed that the scaffold could guide cellular orientation and potentially facilitate periodontal regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Mahnaz Sadat Mirbagheri, Sahar Akhavan-Mahdavi, Anwarul Hasan, Mohammad Saeed Kharazmi, Seid Mahdi Jafari
Summary: Propolis-loaded electrospun nanofibers (PENs) with optimum levels of propolis and two polymer types (PCL and PVA) were developed using response surface methodology (RSM). The scaffold characteristics such as porosity, average diameter, wettability, release, and tensile strength were investigated. The overall optimum region was found to be at PCL/6% PRP and PVA/5% PRP. The cytotoxicity assay showed no toxicity for the optimal concentrations of PRP. Fourier transform infrared (FTIR) spectra revealed that no new chemical functional groups were introduced in the PENs. Uniform fibers were found in the optimum samples without the appearance of a bead-like structure in the fibers. In conclusion, nanofibers containing the optimal concentration of PRP with suitable properties can be used in biomedical and tissue engineering.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Aline O. Pereira, Isabella M. I. Lopes, Thiago R. Silva, Thaila Q. Correa, Rafaella T. Paschoalin, Natalia M. Inada, Ievgeniia Iermak, Francisco van Riel Neto, Juliana C. Araujo-Chaves, Alexandre Marletta, Jose R. Tozoni, Luiz Henrique C. Mattoso, Vanderlei S. Bagnato, Iseli L. Nantes-Cardoso, Osvaldo N. Oliveira Jr, Patricia T. Campana
Summary: This research demonstrates that nanofibers can be utilized as an alternative method for bacterial inactivation, instead of UV and blue irradiation. The use of PLGA nanofiber scaffolds can effectively kill Staphylococcus aureus and Escherichia coli bacteria at lower light intensities. The enhanced effect of PLGA scaffolds is attributed to their nanofiber structures, which could pave the way for a more cost-effective and environmentally friendly surface sterilization method.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Kongzhao Jiang, Guomin Liu, Zhiqiang Cheng, Maolei Sun, Yun Liu, Kun Jiao, Wenyuan Jia, Shaoru Wang, Zhihui Dai, Yuheng Yang, Liping Liu, Tao Yang, Xuanzuo Jiang, Yungang Luo, Zhihui Liu
Summary: A new method for preparing absorbable guided bone regeneration (GBR) membrane was proposed in this study by simply blending polycaprolactone and polyvinyl alcohol in different proportions (0%/100%, 25%/75%, 50%/50%, 75%/25%, and 100%/0%) in formic acid and obtaining nanofiber membrane by uniaxial electrospinning. The nano-structure was confirmed by scanning electron microscope, and the change of chemical functional groups was confirmed by Fourier transform infrared spectroscopy. The proper polymer proportion (75%/25%) was selected through some tests. The nanofiber membrane showed suitable wettability, sufficient Young's modulus, the lowest swelling rate and shrinkage rate, and no cytotoxicity, indicating its potential application in GBR.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Infectious Diseases
Sampada Bangar, Pratiksha Sonar, Arati Mane, Suvarna Sane, Abhijit Kadam, Tuman Lal Katendra, Girish Rahane, Anju Sinha, Seema Sahay
Summary: The effectiveness of lactobacilli-containing vaginal tablets in preventing bacterial vaginosis recurrence among women infected with HIV treated with standard oral metronidazole in Pune, India was studied. The study found that lactobacilli-containing vaginal tablets did not provide any additional benefit in preventing bacterial vaginosis recurrence in women infected with HIV.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Polymer Science
Zahra Shahravi, Mehdi Mehdikhani, Mohammad Amir Amirkhani, Mahsa Mollapour Sisakht, Shadi Farsaei
Summary: A novel drug-loaded nanofibrous membrane composed of PVA/GG and PCL was fabricated for wound healing. The scaffold showed suitable morphology, mechanical properties, and drug delivery capabilities.
Article
Engineering, Biomedical
Elahe Gholipour Choubar, Mohammad Hossein Nasirtabrizi, Farshid Salimi, Ali Sadeghianmaryan
Summary: Electrospun PCL/COL: PVP scaffolds loaded with Cephalexin and coated with hydroxyapatite were fabricated for bone regeneration. The scaffolds showed antibacterial properties, uniform nano-micro fibrous structure, good wettability, swelling, and biodegradation characteristics, as well as supporting cell adhesion and high alkaline phosphatase activity.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Polymer Science
Diana Querido, Tania Vieira, Jose Luis Ferreira, Celia Henriques, Joao Paulo Borges, Jorge Carvalho Silva
Summary: Hybrid scaffolds obtained by combining two or more biopolymers are studied in the context of tissue regeneration. This study produced a new type of hybrid polycaprolactone (PCL)/chitosan (CS) electrospun mat by controlling the deposition of CS flakes between PCL fibers. The morphology of the resulting fibers confirmed the presence of CS flakes. In vitro cell culture results showed that the addition of CS reduced cell adhesion and proliferation.
Article
Polymer Science
Elif Saatcioglu, Songul Ulag, Ali Sahin, Betul Karademir Yilmaz, Nazmi Ekren, Ahmet Talat Inan, Yuksel Palaci, Cem Bulent Ustundag, Oguzhan Gunduz
Summary: In this study, electrospinning was used to fabricate PCL scaffolds with different percentages of Chitosan, with 10wt.%PCL/3wt.%CS showing the highest tensile strength value and good viability for mesenchymal stem cells. The scaffolds exhibited a suitable geometry for ligament-like tissue and allowed for the attachment of MSCs in a network-like structure.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Iman Shirzaei Sani, Mostafa Rezaei, Ali Baradar Khoshfetrat, Donya Razzaghi
Summary: Chitosan and poly (epsilon-caprolactone) were combined to fabricate bone tissue engineering scaffolds with enhanced bioactivity and mechanical properties. The incorporation of chitosan-g-poly (epsilon-caprolactone) significantly decreased fiber diameter and hydroxyapatite nanoparticles enhanced mineralization and degradation of the scaffold. In vitro cytocompatibility assays showed high cell viability and proliferation, indicating the potential use of the microfabricated nanocomposite scaffolds in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Yashi Agarwal, P. S. Rajinikanth, Shivendu Ranjan, Upama Tiwari, J. Balasubramnaiam, Prashant Pandey, Dilip Kumar Arya, Sneha Anand, Payal Deepak
Summary: Electrospinning is a versatile technique for nanofibers fabrication, which is crucial for rapid healing of diabetic wounds. The combination of silk fibroin-curcumin based nanofibers with PCL and PVA strengthens the wound healing properties. The loaded nanofibers demonstrate sustained release of curcumin and show great potential for diabetic wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Maria I. Echeverria I. Molina, Chi-An Chen, Jeniree Martinez, Perry Tran, Kyriakos Komvopoulos
Summary: Fully functional skin regeneration is still difficult after decades of research. Scaffold engineering, a leading field in skin substitutes, can optimize the biomolecular exchange to promote the formation of high-quality tissue. This study designed and evaluated a new class of three-dimensional fibrous scaffolds that induce keratinocyte differentiation through calcium leaching, demonstrating their potential for tissue engineering.
Article
Engineering, Biomedical
Hugues Mondesert, Frederic Bossard, Denis Favier
Summary: This study investigates anisotropic fibrous scaffolds fabricated by template-assisted electrospinning, showing significant differences in mechanical properties along two orthogonal directions with an anisotropic ratio of 4.2. Through tensile test experiments and stress relaxation test, the study reveals the low contribution of viscosity in the mechanical response of the scaffold. An orthotropic linear elastic model is proposed to characterize the anisotropic behavior of the patterned membranes, offering potential benefits for soft regenerative medicine applications and custom-made scaffolds.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Polymer Science
L. A. Can-Herrera, A. I. Oliva, M. A. A. Dzul-Cervantes, O. F. Pacheco-Salazar, J. M. Cervantes-Uc
Summary: The study investigates the effect of applied voltage on electrospun PCL scaffolds, finding that increasing voltage significantly affects the morphology and mechanical properties of the fibers. This has important implications for tissue engineering applications.
Review
Obstetrics & Gynecology
Jacques Ravel, Inmaculada Moreno, Carlos Simon
Summary: Bacterial vaginosis, pelvic inflammatory disease, and endometritis can lead to infertility due to factors such as inflammation, immune response, bacterial toxins, and increased risk of sexually transmitted infections. Diagnosing and treating these conditions before attempting conception may improve outcomes of natural and assisted reproduction for symptomatic women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Dermatology
Olusola Ayanlowo, Olufolakemi Cole - Adeife, Margaret Ilomuanya, Cynthia Ebie, Abigail Adegbulu, Obumneke Ezeanyache, Oghogho Odiase, Viola Ikebudu, Basirat Akanbi
Summary: This study assessed the chemical properties, usage, benefits, and potential adverse effects of seven plant oils and animal fat commonly used in Nigeria for skin care. It highlighted the benefits of these oils in promoting healthy skin, wound healing, and anti-inflammatory and antimicrobial effects, while also emphasizing the need for further research on their potential in skincare products and dermatological therapies.
DERMATOLOGIC THERAPY
(2022)
Article
Engineering, Chemical
Andrew Nosakhare Amenaghawon, Priscilla Odika, Success Eghosa Aiwekhoe
Summary: This study investigated the impact of microbial stimulants on lipase production from waste cooking oil, finding that intermediate concentrations of olive oil, MgSO4, and KH2PO4 were optimal for maximizing lipase activity. The use of artificial neural networks was found to be superior in predicting lipase production compared to response surface methodology, indicating that biological stimulants can facilitate the fermentation process for optimal lipase production from WCO.
CHEMICAL ENGINEERING COMMUNICATIONS
(2022)
Article
Surgery
Lakmini Liyanage, Liam Musto, Charley Budgeon, Guy Rutty, Mike Biggs, Athanasios Saratzis, David A. Vorp, Vasileios Vavourakis, Matthew Bown, Alkiviadis Tsamis
Summary: The study assessed the proportion of collagen and elastin in the arterial wall and evaluated the collagen microstructure. The results showed that the aorta and iliac arteries are structurally non-uniform, with variations in the percentages of collagen and elastin and differences in collagen fiber diameter in different regions.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Energy & Fuels
Mike Uche Ajieh, Nosakhare Andrew Amenaghawon, Kesiena Owebor, Oghenero Henry Orugba, Esua Bassey Bassey
Summary: Water-soluble polymers are used to improve drilling operations, but excessive utilization of these additives may have negative implications on drilling outcomes, increasing the equivalent circulating density may lead to formation damage.
PETROLEUM SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Maurice Ekpenyong, Atim Asitok, Ubong Ben, Andrew Amenaghawon, Heri Kusuma, Anthony Akpan, Sylvester Antai
Summary: Peptidases, which are widely used in industries such as detergent, food, and pharmaceuticals, can be produced on a large scale using low-cost agro-industrial waste. A Bacillus cereus strain produced acidic peptidase from yam peels and fish processing waste, achieving high catalytic activity at pH 4.5. Bioprocess conditions were optimized using a response surface methodology and a Manta-ray foraging optimization-linked feed-forward artificial neural network. The optimized conditions resulted in a 5-fold increase in peptidase activity and stability for 240 minutes at pH 2.5-3.5. The bioprocess shows promise for sustainable enzyme-driven applications.
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2023)
Review
Environmental Sciences
Jude A. Okolie, Toheeb Jimoh, Olugbenga Akande, Patrick U. Okoye, Chukwuma C. Ogbaga, Adekunle A. Adeleke, Peter P. Ikubanni, Fatih Gulec, Andrew Nosakhare Amenaghawon
Summary: Human and animal waste pose a threat to the environment and human health when improperly disposed. This study explores different methods for converting waste into valuable resources and discusses the properties of waste and strategies for nutrient recovery. The research also highlights the leading countries and institutions in this field and suggests future directions for research, including on-site resource recovery technologies and safe waste processing methods.
Article
Materials Science, Multidisciplinary
Margaret O. Ilomuanya, Peace Ofonabasi Bassey, Ibilola M. Cardoso-Daodu, Yanhao Hou, Bright U. Nmesirionye, Andrew N. Amenaghawon, Olusola Ojo, Samson A. Adeosun, Weiguang Wang
Summary: Electrospinning is a major technology for fabricating tissue engineering membranes, which can mimic native tissue characteristics and control drug release. This research compares different electrospun polyvinyl alcohol/hyaluronic acid composite nanofiber membranes to identify the optimal material-fabrication combination for wound dressing and skin tissue engineering applications.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Green & Sustainable Science & Technology
Andrew Nosakhare Amenaghawon, Kessington Obahiagbon, Victor Isesele, Fauzan Usman
Summary: This study assessed the potential of a composite bio-based heterogeneous catalyst for the transesterification of waste cooking oil. The catalyst exhibited a high biodiesel yield and stability, with properties comparable to standards. The synthesized catalyst has advantages over conventional catalysts due to its reusability, ease of synthesis, stability, high surface area, and availability of precursor materials.
CLEANER ENGINEERING AND TECHNOLOGY
(2022)
Article
Polymer Science
Sabdat Ozichu Ekama, Margaret O. Ilomuanya, Chukwuemeka Paul Azubuike, James Babatunde Ayorinde, Oliver Chukwujekwu Ezechi, Cecilia Ihuoma Igwilo, Babatunde Lawal Salako
Summary: This study formulated and evaluated bigel and thermosensitive gel as alternative options to conventional microbicide gels. The results demonstrated that these gels have the potential for triggered release by the acid phosphatase enzyme, and exhibit a progressive decline in HIV infectivity.
Article
Engineering, Biomedical
Ibilola M. Cardoso-Daodu, Margaret O. Ilomuanya, Andrew N. Amenaghawon, Chukwuemeka P. Azubuike
Summary: Curcumin-loaded liposome formulation plays an important role in skin regeneration and wound healing. Optimization of the formulation using artificial neural network can improve encapsulation efficiency and flux.
PROGRESS IN BIOMATERIALS
(2022)
