Localized microglia dysregulation impairs central nervous system myelination in development

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

(2022) Sarah A. Neely et al.   NATURE NEUROSCIENCE

Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease

(2022) Jessica S. Sadick et al.   NEURON

CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging

(2022) Tuğberk Kaya et al.   NATURE NEUROSCIENCE

Microglia regulate central nervous system myelin growth and integrity

(2022) Niamh B. McNamara et al.   NATURE

Microglial inflammasome activation drives developmental white matter injury

(2021) Rebecca K. Holloway et al.   GLIA

Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke

(2021) Ligen Shi et al.   IMMUNITY

The spatial landscape of lung pathology during COVID-19 progression

(2021) André F. Rendeiro et al.   NATURE

Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation

(2021) Jianqin Niu et al.   NEURON

Motor learning promotes remyelination via new and surviving oligodendrocytes

(2020) Clara M. Bacmeister et al.   NATURE NEUROSCIENCE

Predicting motor outcome in preterm infants from very early brain diffusion MRI using a deep learning convolutional neural network (CNN) model

(2020) Susmita Saha et al.   NEUROIMAGE

Human fetal microglia acquire homeostatic immune-sensing properties early in development

(2020) L. Kracht et al.   SCIENCE

Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

(2020) Daan R.M.G. Ophelders et al.   Cells

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Altered human oligodendrocyte heterogeneity in multiple sclerosis

(2019) Sarah Jäkel et al.   NATURE

Central nervous system regeneration is driven by microglia necroptosis and repopulation

(2019) Amy F. Lloyd et al.   NATURE NEUROSCIENCE

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

(2019) Juliette Van Steenwinckel et al.   BRAIN

A novel role for osteopontin in macrophage-mediated amyloid-β clearance in Alzheimer’s models

(2018) Altan Rentsendorj et al.   BRAIN BEHAVIOR AND IMMUNITY

The Cerebrospinal Fluid Inflammatory Response to Preterm Birth

(2018) James P. Boardman et al.   Frontiers in Physiology

Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants

(2017) Michelle L. Krishnan et al.   Nature Communications

Impaired oligodendrocyte maturation in preterm infants: Potential therapeutic targets

(2016) Erik van Tilborg et al.   PROGRESS IN NEUROBIOLOGY

Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders

(2015) Katie Silva et al.   JOURNAL OF NEUROVIROLOGY

Association of brain injury and neonatal cytokine response during therapeutic hypothermia in newborns with hypoxic-ischemic encephalopathy

(2015) Janet E. Orrock et al.   PEDIATRIC RESEARCH

The effect of osteopontin and osteopontin-derived peptides on preterm brain injury

(2014) Anna-Maj Albertsson et al.   Journal of Neuroinflammation

Evaluating biomarkers of neuronal degeneration and neuroinflammation in CSF of patients with multiple sclerosis–osteopontin as a potential marker of clinical severity

(2013) Levente Szalardy et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

STAT3-Mediated astrogliosis protects myelin development in neonatal brain injury

(2012) Hiroko Nobuta et al.   ANNALS OF NEUROLOGY

Microglial Reaction in Axonal Crossroads Is a Hallmark of Noncystic Periventricular White Matter Injury in Very Preterm Infants

(2012) Catherine Verney et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Selective enrichment of newly synthesized proteins for quantitative secretome analysis

(2012) Katrin Eichelbaum et al.   NATURE BIOTECHNOLOGY

Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants

(2011) Joshua R. Buser et al.   ANNALS OF NEUROLOGY

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

(2011) Stephen P J Fancy et al.   NATURE NEUROSCIENCE

Osteopontin Enhances Endogenous Repair After Neonatal Hypoxic–Ischemic Brain Injury

(2011) Cindy T.J. van Velthoven et al.   STROKE

Towards improved animal models of neonatal white matter injury associated with cerebral palsy

(2010) J. C. Silbereis et al.   Disease Models & Mechanisms

Galectin-3 contributes to neonatal hypoxic–ischemic brain injury

(2010) Christina Doverhag et al.   NEUROBIOLOGY OF DISEASE

Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia

(2009) Robin L. Haynes et al.   ACTA NEUROPATHOLOGICA

Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances

(2008) Joseph J Volpe   LANCET NEUROLOGY