Brexanolone therapeutics in post-partum depression involves inhibition of systemic inflammatory pathways

Inhibition of human macrophage activation via pregnane neurosteroid interactions with toll-like receptors: Sex differences and structural requirements

(2022) Irina Balan et al.   Frontiers in Immunology

(3α,5α)3-hydroxypregnan-20-one (3α,5α-THP) regulation of hypothalamic and extrahypothalamic corticotropin releasing factor (CRF): Sexual dimorphism and brain region specificity in Sprague Dawley rats

(2021) Giorgia Boero et al.   NEUROPHARMACOLOGY

Neurosteroid allopregnanolone (3α,5α-THP) inhibits inflammatory signals induced by activated MyD88-dependent toll-like receptors

(2021) Irina Balan et al.   Translational Psychiatry

Allopregnanolone Mediates Affective Switching Through Modulation of Oscillatory States in the Basolateral Amygdala

(2021) Pantelis Antonoudiou et al.   BIOLOGICAL PSYCHIATRY

Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies

(2021) Philipp Frank et al.   AMERICAN JOURNAL OF PSYCHIATRY

Mechanisms Underlying Recovery From Postpartum Depression Following Brexanolone Therapy

(2021) A. Leslie Morrow et al.   BIOLOGICAL PSYCHIATRY

Allopregnanolone (1938-2019): A trajectory of 80 years of outstanding scientific achievments

(2020) Graziano Pinna   Neurobiology of Stress

Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Pro-inflammatory Signaling in Macrophages and Brain

(2019) Irina Balan et al.   Scientific Reports

Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression

(2019) Eric Achtyes et al.   BRAIN BEHAVIOR AND IMMUNITY

Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease

(2019) Giorgia Boero et al.   Neurobiology of Stress

Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials

(2018) Samantha Meltzer-Brody et al.   LANCET

Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial

(2017) Stephen Kanes et al.   LANCET

Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study

(2017) Lauren M. Osborne et al.   PSYCHONEUROENDOCRINOLOGY

Abnormal gene expression of proinflammatory cytokines and their membrane-bound receptors in the lymphocytes of depressed patients

(2016) Hooriyah S. Rizavi et al.   PSYCHIATRY RESEARCH

Role of neuro-immunological factors in the pathophysiology of mood disorders

(2016) Anindya Bhattacharya et al.   PSYCHOPHARMACOLOGY

Biological and Psychosocial Predictors of Postpartum Depression: Systematic Review and Call for Integration

(2015) Ilona S. Yim et al.   Annual Review of Clinical Psychology

Toll-like receptors in the depressed and suicide brain

(2014) Ghanshyam N. Pandey et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Quantification of ten neuroactive steroids in plasma in Withdrawal Seizure-Prone and -Resistant mice during chronic ethanol withdrawal

(2014) Christopher Snelling et al.   PSYCHOPHARMACOLOGY

Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats

(2014) C. A. Frye et al.   PSYCHOPHARMACOLOGY

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Simultaneous quantification of GABAergic 3α,5α/3α,5β neuroactive steroids in human and rat serum

(2009) Patrizia Porcu et al.   STEROIDS

Symptoms of Postpartum Depression Associated With Elevated Levels of Interleukin-1 Beta During the First Month Postpartum

(2008) E. J. Corwin et al.   Biological Research for Nursing

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE