Article
Chemistry, Analytical
Fang Wang, Hailin Cong, Jie Xing, Song Wang, Youqing Shen, Bing Yu
Summary: This study focused on a tri-block copolymer with double effects, which enhanced the anti-protein adsorption properties and elastic self-cleaning function of materials, contributing to the extension of material lifespan while maintaining excellent anti-fouling performance.
Article
Chemistry, Applied
Inae Han, Su Youn Kim, Seok-Pyo Hong, Insung S. Choi, Woo Kyung Cho
Summary: In this paper, a novel carboxybetaine L-3,4-dihydroxyphenylalanine derivative (CBDOPA) with excellent antifouling properties against bacterial adhesion was synthesized and studied. The coating efficiency was optimized by controlling oxidation-induced polymerization, and the coating was characterized using various methods. Among the conditions examined, the sodium periodate-mediated oxidation achieved the highest coating efficiency. The optimized coating showed high resistance to bacterial adhesion on various substrates.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Chemistry, Applied
Bin Peng, Xiaoling Xu, Yan Wang, Jingyu Zhang, Jing Chen, Qiang Zhang
Summary: A branched polymer coating was successfully synthesized via copper-based reversible deactivation radical polymerization and applied to membrane surfaces, resulting in improved fouling resistance and stability.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Engineering, Chemical
Parisa Salimi, Abdolreza Aroujalian, Davood Iranshahi
Summary: By grafting SBMA zwitterionic monomers onto PES membranes using corona-induced graft co-polymerization, the water-oil flux was significantly enhanced (over 1100%) without affecting oil rejection. The stability of the modified membranes over a long period was confirmed through a 10% reduction in flux after immersing in deionized water for 30 days. This study demonstrates the potential for practical applications in industrial settings.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Chuanxi Li, Yinqiang Xia, Chunjiang Liu, Renliang Huang, Wei Qi, Zhimin He, Rongxin Su
Summary: Zwitterionic peptides with loop-like structures exhibit better antifouling properties by resisting protein and bacteria adsorption, being more rigid compared to linear-like peptides, reducing interaction with foulants, improving hydrophilicity, and avoiding chain aggregation. This study provides a comprehensive understanding of the conformation effect of zwitterionic peptides, which may contribute to the design of novel antifouling materials in various biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Biwen Wang, Peng Wang, Baoluo He, Shuanhong Ma, Shujuan Liu, Qian Ye, Feng Zhou
Summary: A double-network hydrogel was prepared by embedding an initiator (HHy-Br) and reinforcing with Fe3+, followed by grafting the antifouling polymer (PSBVI) onto the HHy-Br substrate via subsurface-initiated atom transfer radical polymerization (sSIATRP) to obtain HHy-PSBVI. Fe3+ increased the crosslinking density of HHy-Br, resulting in improved tensile strength and anti-swelling properties of the hydrogel. The presence of Fe3+ also promoted the sSIATRP process. HHy-PSBVI exhibited decreased friction coefficient and excellent antibacterial and antifouling properties due to the hydration of the zwitterionic polymer and the bactericidal effect of the cationic imidazole group.
PROGRESS IN ORGANIC COATINGS
(2023)
Review
Chemistry, Multidisciplinary
Ruoyu Li, Weina Kong, Zesheng An
Summary: This Minireview discusses the key roles enzymes play in reversible deactivation radical polymerization (Enz-RDRP) and highlights their applications in surface brush fabrication, sensing, polymerization-induced self-assembly, and high-throughput synthesis. The authors also reflect on the challenges and future directions of this emerging area.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Esther Roeven, Luc Scheres, Maarten M. J. Smulders, Han Zuilhof
Summary: This study demonstrates two different routes to synthesize polymer-dendrimer hybrids with advantageous self-assembly properties onto silicon oxide surfaces. The first route yields network-like structures with crosslinked PLL and ZIDs, while a more defined linear PLL-ZID macromolecule is formed through a controlled CuAAC click reaction. The potential use of these hybrids as antifouling coatings and for selective detection of target analytes is confirmed through various testing methods.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Materials Science, Paper & Wood
Izabela Zaborniak, Pawel Chmielarz
Summary: This paper reviews the synthetic routes for functionalization of cellulose membranes by polymer chains with controlled structures. It evaluates prior research on ATRP techniques and compares low ppm ATRP methods with conventional approaches. The paper also highlights the advantages and prospects of using cellulose as a membrane-built substrate.
Article
Engineering, Chemical
Dao Thi Thanh Huyen, Saikat Sinha Ray, Young -Nam Kwon
Summary: This study focuses on the modification of a commercially available polyamide thin-film composite membrane with a zwitterionic material to enhance its fouling resistance. The modified membrane shows improved salt rejection and reduced permeability compared to the pristine membrane. Fouling tests demonstrate that the modified membrane has a lower fouling ratio and higher recovery ratio. The enhanced antifouling characteristics are attributed to the improved hydrophilicity resulting from the zwitterionic brushes and the salting-in effect.
Article
Polymer Science
Shuo Zeng, Jinwei Shi, Anchao Feng, Zhao Wang
Summary: This study successfully grafted poly (DMAEMA) chains/brushes onto electrospun regenerated cellulose nanofiber membrane via ATRP, and investigated the effects of different ATRP conditions on enzyme immobilization. The optimal initiation and monomer grafting times were found to be 1 and 2 hours, leading to a significant increase in the immobilization amount.
Review
Chemistry, Organic
Zhenlei Zou, Weigang Zhang, Yi Wang, Yi Pan
Summary: This review focuses on electron-induced radical fluorinations in the past decade, such as fluorination, difluoromethylation, trifluoromethylation, and perfluoroalkylation, providing researchers with representative mechanisms to understand the basic principles behind this technology.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Applied
Yixin Zeng, Peng Wang, Baoluo He, Shujuan Liu, Qian Ye, Feng Zhou
Summary: Marine biological pollution is a global challenge in marine engineering. MXene nanosheets and zwitterionic polymers have been investigated as effective materials for marine anti-biofouling. In this study, MXene-PDA was prepared by self-assembling polydopamine layer on the MXene nanosheets, followed by introducing the zwitterionic polymer PEIS through a Michael addition reaction to obtain MXene-PEIS. The resulting MXene-PEIS exhibited excellent antifouling performance through the cooperative antifouling effect of MXene nanosheets and PEIS (88% improved antibacterial rate and 98% decrease in microalgae adhesion density). Furthermore, the nanocomposite antifouling coatings (MXene-PEIS/SP) showed good antifouling performance due to the synergy among MXene, PEIS, and self-polishing coatings.
PROGRESS IN ORGANIC COATINGS
(2023)
Review
Materials Science, Multidisciplinary
Siew Kei Lau, Wai Fen Yong
Summary: This review discusses the application of various polymers and nanomaterials in the surface modification of membranes, with a focus on the unique properties of zwitterionic polymers. These modified membranes resist foulants through mechanisms such as hydration layer formation and steric repulsion effect.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Physical
Jian Ding, Xiangmin Ding, Jing Sun
Summary: A new type of zwitterionic polypeptoid was synthesized and used to prepare antifouling hydrogel and nanoparticles that resist protein adsorption and bacterial adhesion. These materials have promising potential for biomedical and industrial applications.
Article
Biophysics
Tianyu Li, Bo Liang, Zhichao Ye, Lei Zhang, Shiyi Xu, Tingting Tu, Yiming Zhang, Yu Cai, Bin Zhang, Lu Fang, Xiyu Mao, Shanshan Zhang, Guan Wu, Qifu Yang, Congcong Zhou, Xiujun Cai, Xuesong Ye
Summary: This study introduces a multifunctional and flexible hydrogel-paper patch that can simultaneously monitor glucose content in sweat and electrocardiogram signals during exercise, integrated with a flexible printed circuit board for real-time monitoring of electrophysiological and biochemical signals.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biotechnology & Applied Microbiology
Yuyang Yuan, Tianyu Li, Zhichao Ye, Yuyao Feng, Zhe Chen, Yusen Wang, Yiqiao Sun, Haoyu Wu, Zhaodong Yang, Yifan Wang, Yiran Zhang, Liquan Huang, Bo Liang
Summary: In this study, we developed an innovative electrochemical sensor for selective and simple detection of valproate. The sensor exhibited satisfying specificity and uniformity, making it a potential tool for rapid testing of valproate in clinical practice.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Lu Fang, Hangxu Ren, Xiyu Mao, Shanshan Zhang, Yu Cai, Shiyi Xu, Yi Zhang, Lihua Li, Xuesong Ye, Bo Liang
Summary: L-Dopa is an effective therapy for Parkinson's disease, but its short half-life and narrow therapeutic window may lead to side effects. Monitoring the concentration of L-Dopa using wearable biosensors is significant to reduce complications. However, the high concentration of interferents in the body poses challenges. A minimal-invasive L-Dopa biosensor based on a flexible differential microneedle array (FDMA) is proposed to address this. The sensor exhibits excellent anti-interference performance and accuracy.
Article
Nanoscience & Nanotechnology
Shanshan Zhang, Tingting Tu, Tianyu Li, Yu Cai, Zhaoyang Wang, Yue Zhou, Dong Wang, Lu Fang, Xuesong Ye, Bo Liang
Summary: MXene-based composite conductive aerogels have been extensively studied for wearable pressure sensors. In this work, a 3D porous Ti3C2Tx MXene/PEDOT:PSS composite aerogel was fabricated using the Cu-assisted electrogelation method. The fabricated pressure sensor demonstrated high sensitivity, fast response ability, and excellent stability. Additionally, a high-resolution pressure sensor microarray was successfully prepared, which can be attached to a robotic fingertip for tactile sensing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Yitao Liang, Bin Zhang, Zexin Xue, Xuesong Ye, Bo Liang
Summary: This study proposed a method for detecting global DNA methylation, using modified magnetic beads for immunorecognition and affinity enrichment, and electrochemical detection of DNA methylation level. This detection technique has low DNA input requirements and can detect methylation levels within a short time, offering a promising option for both academic and clinical applications.
Article
Polymer Science
Jie Zhang, Jing Wang, Guixiu Fan, Bingjie Zhang, Guanglong Ma, Haiyan Xiao, Longgang Wang
Summary: In this study, daptomycin-biomineralized silver nanoparticles (Dap-AgNPs) with good stability and high photothermal conversion efficiency were successfully prepared. Furthermore, they exhibited good biocompatibility and significant anti-tumor ability under irradiation.
Article
Chemistry, Analytical
Yu Cai, Tingting Tu, Tianyu Li, Shanshan Zhang, Bin Zhang, Lu Fang, Xuesong Ye, Bo Liang
Summary: The study on the application of nanomaterials in glucose biosensors demonstrates excellent electrochemical performance, taking a step towards the development of the third-generation glucose biosensor.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Ruyu Li, Liyuan Fan, Shengfu Chen, Longgang Wang, Yanshuai Cui, Guanglong Ma, Xiaoyu Zhang, Zhiwei Liu
Summary: In this study, the surface of platinum nanoparticles was modified using zwitterionic molecules, leading to enhanced catalytic activity and antitumor ability. Furthermore, a colorimetric method for dopamine detection based on the peroxidase activity of the modified nanoparticles was developed, with a wide detection range and high specificity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Lu Zhang, Quanling Guo, Ruixue Zheng, Qingyu Yu, Ying Liang, Guanglong Ma, Qiurong Li, Xiaoyu Zhang, Haiyan Xiao, Longgang Wang
Summary: Chemotherapy is the main method of treating malignant tumors, but commonly used drugs have high toxicity, poor solubility, low targeting ability, and high side effects. In this study, zwitterionic micelles assembled by modified amphiphilic dendrimers showed great stability and controlled drug release. Moreover, these micelles had higher cellular uptake rates and cytotoxicity, resulting in better tumor inhibition compared to free drugs. Therefore, the prepared targeting nanodrug has great potential for antitumor therapy.
Article
Chemistry, Analytical
Dong Wang, Xiyu Mao, Yitao Liang, Yu Cai, Tingting Tu, Shanshan Zhang, Tianyu Li, Lu Fang, Yue Zhou, Zhaoyang Wang, Yu Jiang, Xuesong Ye, Bo Liang
Summary: Urine analysis is widely used in clinical practice to indicate human health status and diagnose chronic kidney disease (CKD). This study developed NH4+, urea, and creatinine selective electrodes for urine analysis, achieving good selectivity, consistency, and stability. Integration into a paper-based device allowed for point-of-care testing using real human urine samples. This multi-parameter urine testing device has the potential to efficiently manage CKD.
Article
Chemistry, Multidisciplinary
Weili Xue, Xiaowei Lin, Liangbo Xu, Ashish Trital, Yi He, Guping Tang, Hongzhen Bai, Shengfu Chen
Summary: The quick diffusion and precise active targeting are two major challenges in nanomedicine. This study developed a camouflaged nanomedicine to demonstrate the mechanism of zwitterionic shell in barrier-penetration and active targeting. The nanomedicine showed a faster diffusion rate and more precise tumor targeting than similar-sized nanomedicines.
ADVANCED MATERIALS
(2023)
Article
Polymer Science
Shoubei Gao, Kai Liu, Xianbing Ji, Yanshuai Cui, Ruyu Li, Guanglong Ma, Yongqiang Zhang, Longgang Wang
Summary: This paper presents a novel colorimetric method for the detection of hydroquinone based on a peroxidase-like Pd nanozyme. The vancomycin-stabilized palladium nanoparticles (Van-Pd-n NPs) were prepared using vancomycin as a biological template. Van-Pd-2 NPs showed excellent biocompatibility and peroxidase-like activity, making them a promising candidate for the colorimetric detection of hydroquinone.
Article
Chemistry, Multidisciplinary
Xiaolei Guo, Yuzhen Xue, Ruixue Zheng, Shengfu Chen, Weili Xue, Xifa Lan, Longgang Wang, Haiyan Xiao
Summary: The synthesis of biocompatible and efficient polymeric micelles for drug delivery has attracted much attention. In this study, amphiphilic molecules (PMPC) were synthesized using zwitterionic linear polyethyleneimine (PEI) as the hydrophilic segment and mercapto-paclitaxel as the hydrophobic segment. Chemotherapeutic doxorubicin (DOX) was encapsulated in the PMPC micelles to prepare DOX-loaded micelles (PMPC-DOX micelles) through self-assembly. The results showed that the PMPC-DOX micelles exhibited good stability in protein solution and released DOX at a rate of 48.12% within 36 h at pH 5.5. Furthermore, the PMPC-DOX micelles demonstrated superior tumor targeting ability and antitumor effect compared to free DOX, with a tumor inhibition rate of 89.7% after 14 days of treatment. The PEI-based drug-loaded micelles provide a new approach for nanodrug delivery system design.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemical Research Methods
Di Huang, Yekai Zhao, Mengjun Fang, Peijie Shen, Hu Xu, Yichen He, Shengfu Chen, Zhenjun Si, Zhinan Xu
Summary: In this study, an integrated nucleic acid detection platform called "up and down chip" was developed for HIV-1 detection. It achieved highly sensitive and specific detection of the virus, without the need for professional instruments. The platform shows promising potential for clinical application.
Article
Biochemical Research Methods
Di Huang, Yekai Zhao, Mengjun Fang, Peijie Shen, Hu Xu, Yichen He, Shengfu Chen, Zhenjun Si, Zhinan Xu
Summary: In this study, an integrated nucleic acid detection platform named up and down chip was developed. It simplified the experimental procedures and detection processes, and reduced aerosol pollution risks. The platform combined RT-RAA technology for nucleic acid amplification, DNase-dead Cas12a-modified magnetic beads for specific recognition, and HRP-TMB chromogenic reaction for signal output. It achieved highly sensitive detection of the HIV-1 genome.
