Integrating single-cell analysis and machine learning to create glycosylation-based gene signature for prognostic prediction of uveal melanoma

By integrating single-cell RNA-seq and bulk RNA-seq in sphingolipid metabolism, CACYBP was identified as a potential therapeutic target in lung adenocarcinoma

(2023) Pengpeng Zhang et al.   Frontiers in Immunology

Dissecting the role of cancer‐associated fibroblast‐derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single‐cell transcriptomic study

(2023) Shaoquan Zheng et al.   Clinical and Translational Medicine

Future perspectives of uveal melanoma blood based biomarkers

(2022) Aaron B. Beasley et al.   BRITISH JOURNAL OF CANCER

AUP1 regulates lipid metabolism and induces lipid accumulation to accelerate the progression of renal clear cell carcinoma

(2022) Chen Chen et al.   CANCER SCIENCE

Dynamic observation: Immune-privileged microenvironment limited the effectiveness of immunotherapy in an intraocular metastasis mouse model

(2022) Tianchang Tao et al.   OPHTHALMIC RESEARCH

Glycosylation-Related Genes Predict the Prognosis and Immune Fraction of Ovarian Cancer Patients Based on Weighted Gene Coexpression Network Analysis (WGCNA) and Machine Learning

(2022) Chen Zhao et al.   Oxidative Medicine and Cellular Longevity

Recent Advances and Challenges in Uveal Melanoma Immunotherapy

(2022) Yihang Fu et al.   Cancers

Neoadjuvant relatlimab and nivolumab in resectable melanoma

(2022) Rodabe N. Amaria et al.   NATURE

Natural killer cell-related prognosis signature characterizes immune landscape and predicts prognosis of HNSCC

(2022) Hao Chi et al.   Frontiers in Immunology

Intermittent MEK inhibition for the treatment of metastatic uveal melanoma

(2022) Shaheer Khan et al.   Frontiers in Oncology

The Single‐Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer

(2022) Yutian Zou et al.   Advanced Science

Nomogram for predicting prognosis of patients with metastatic melanoma after immunotherapy: A Chinese population–based analysis

(2022) Jingjing Zhao et al.   Frontiers in Immunology

Myeloid Cell–associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing

(2021) Li Wang et al.   CLINICAL CANCER RESEARCH

The Next Decade of Immune Checkpoint Therapy

(2021) Padmanee Sharma et al.   Cancer Discovery

LAG3 and Its Ligands Show Increased Expression in High-Risk Uveal Melanoma

(2021) Zahra Souri et al.   Cancers

The importance of immune checkpoints in immune monitoring: A future paradigm shift in the treatment of cancer

(2021) Hajar Alemohammad et al.   BIOMEDICINE & PHARMACOTHERAPY

A review of cancer immunotherapy toxicity

(2020) Lucy Boyce Kennedy et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Single-cell analysis reveals new evolutionary complexity in uveal melanoma

(2020) Michael A. Durante et al.   Nature Communications

Uveal melanoma pathobiology: metastasis to the liver

(2020) Prisca Bustamante et al.   SEMINARS IN CANCER BIOLOGY

Ubiquitin–proteasome system-targeted therapy for uveal melanoma: what is the evidence?

(2020) Chen-xi Zhao et al.   ACTA PHARMACOLOGICA SINICA

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

(2020) Yuanyuan Zhang et al.   Cellular & Molecular Immunology

Targeting Epigenetic Modifications in Uveal Melanoma

(2020) Pooneh Chokhachi Baradaran et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Update on uveal melanoma: Translational research from biology to clinical practice (Review)

(2020) Miguel Ortega et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy

(2020) Yuka Igarashi et al.   Journal of Immunology Research

Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?

(2019) Stefan Mereiter et al.   CANCER CELL

Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives

(2019) Croce et al.   Cancers

Single-cell RNA sequencing: Technical advancements and biological applications

(2018) Eva Hedlund et al.   MOLECULAR ASPECTS OF MEDICINE

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Immune Privilege and Eye-Derived T-Regulatory Cells

(2018) Hiroshi Keino et al.   Journal of Immunology Research

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Role of protein glycosylation in cancer metastasis

(2017) Leticia Oliveira-Ferrer et al.   SEMINARS IN CANCER BIOLOGY

Uveal melanoma: From diagnosis to treatment and the science in between

(2016) Chandrani Chattopadhyay et al.   CANCER

Uveal melanoma: relatively rare but deadly cancer

(2016) S Kaliki et al.   EYE

Protein Glycosylation in Cancer

(2015) Sean R. Stowell et al.   Annual Review of Pathology-Mechanisms of Disease

Molecular profiling of primary uveal melanomas with tumor-infiltrating lymphocytes

(2014) Pierre L Triozzi et al.   OncoImmunology

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes

(2012) Youngah Jo et al.   MOLECULAR BIOLOGY OF THE CELL

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Uveal Melanoma: Trends in Incidence, Treatment, and Survival

(2011) Arun D. Singh et al.   OPHTHALMOLOGY

Immune escape mechanisms of intraocular tumors

(2009) Jerry Y. Niederkorn   PROGRESS IN RETINAL AND EYE RESEARCH

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS