Article
Cell Biology
Neda Feizi, Chiara Focaccetti, Ilenia Pacella, Gloria Tucci, Alessandra Rossi, Massimo Costanza, Rosetta Pedotti, John Sidney, Alessandro Sette, Claudia La Rocca, Claudio Procaccini, Giuseppe Matarese, Vincenzo Barnaba, Silvia Piconese
Summary: The study demonstrates that immune responses to cryptic apoptosis-associated epitopes (AEs) may contribute to immunopathology in neuroinflammation, as shown in a mouse model of MS (EAE). The presence of AE-specific CD8(+) T cells, their physiological control, and their exacerbation of disease severity when immunized with AEs during EAE induction were observed, supporting the role of AE-specific autoimmunity in neuroinflammation.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Artem Pilunov, Dmitrii S. Romaniuk, Anton Shmelev, Savely Sheetikov, Anna N. Gabashvili, Alexandra Khmelevskaya, Dmitry Dianov, Ksenia Zornikova, Naina T. Shakirova, Murad Vagida, Apollinariya Bogolyubova, Grigory A. Efimov
Summary: A relapse of malignant disease often occurs after allogeneic hematopoietic stem cell transplantation. Gene-edited MiHA-specific T cells can precisely eliminate malignant cells while sparing donor and non-hematopoietic patient cells. This therapeutic approach could be used to prevent and treat leukemia relapse.
Article
Oncology
Sabaria Shah, Katherine W. Cook, Peter Symonds, Juliane Weisser, Anne Skinner, Abdullah Al Omari, Samantha J. Paston, Ian Pike, Lindy G. Durrant, Victoria A. Brentville
Summary: This study discovers that homocitrullinated peptides can be processed and presented via MHC-I for tumor therapy. The modified peptides show enhanced binding to HLA-A2 and induce high avidity homocitrulline-specific CD8 T-cell responses, which can kill target cells expressing the peptide.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Multidisciplinary Sciences
Sidar Aydin, Javier Pareja, Vivianne M. Schallenberg, Armelle Klopstein, Thomas Gruber, Nicolas Page, Elisa Bouillet, Nicolas Blanchard, Roland Liblau, Jakob Koerbelin, Markus Schwaninger, Aaron J. Johnson, Mirjam Schenk, Urban Deutsch, Doron Merkler, Britta Engelhardt
Summary: Blood-brain barrier breakdown and immune cell infiltration are early markers of multiple sclerosis. Researchers have found that brain endothelial cells cross-present antigen to CD8(+) T cells, preventing their migration and initiating blood-brain barrier breakdown.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Emily S. Ford, Koshlan Mayer-Blackwell, Lichen Jing, Kerry J. Laing, Anton M. Sholukh, Russell St. Germain, Emily L. Bossard, Hong Xie, Thomas H. Pulliam, Saumya Jani, Stacy Selke, Carlissa J. Burrow, Christopher L. McClurkan, Anna Wald, Alexander L. Greninger, Michael R. Holbrook, Brett Eaton, Elizabeth Eudy, Michael Murphy, Elena Postnikova, Harlan S. Robins, Rebecca Elyanow, Rachel M. Gittelman, Matyas Ecsedi, Elise Wilcox, Aude G. Chapuis, Andrew Fiore-Gartland, David M. Koelle
Summary: Hybrid immunity, resulting from a combination of vaccination and previous infection, offers greater protection against SARS-CoV-2 than either vaccination or prior infection alone. This study investigated the dynamics of spike-reactive T cells in individuals with hybrid immunity, following either SARS-CoV-2 infection or mRNA vaccination. The findings show that vaccination leads to expansions of memory T cell clones, while also generating diverse new T cell clones. The study provides insights into T cell responses to vaccines and emerging pathogens.
Article
Multidisciplinary Sciences
Jae-Seung Moon, Shady Younis, Nitya S. Ramadoss, Radhika Iyer, Khushboo Sheth, Orr Sharpe, Navin L. L. Rao, Stephane Becart, Julie A. Carman, Eddie A. James, Jane H. Buckner, Kevin D. Deane, V. Michael Holers, Susan M. Goodman, Laura T. Donlin, Mark M. Davis, William H. Robinson
Summary: This study reveals that cytotoxic CD8(+) T cells targeting ACPA are involved in synovitis and joint tissue destruction in rheumatoid arthritis (RA), contributing to the understanding of the immune mechanisms underlying RA pathogenesis.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Eishiro Mizukoshi, Hidetoshi Nakagawa, Toshikatsu Tamai, Masaaki Kitahara, Kazumi Fushimi, Kouki Nio, Takeshi Terashima, Noriho Iida, Kuniaki Arai, Tatsuya Yamashita, Taro Yamashita, Yoshio Sakai, Masao Honda, Shuichi Kaneko
Summary: This study found that peptide-specific T cell responses can persist for more than 10 years following vaccination in hepatocellular carcinoma patients. Tumor-specific memory CD8 T cells are able to persist and possibly even proliferate in the peripheral blood of long-surviving patients.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Charlotte A. James, Yuexin Xu, Melissa S. Aguilar, Lichen Jing, Erik D. Layton, Martine Gilleron, Adriaan J. Minnaard, Thomas J. Scriba, Cheryl L. Day, Edus H. Warren, David M. Koelle, Chetan Seshadri
Summary: This study reveals the importance of CD4 and CD8 co-receptors in recognizing mycobacterial glycolipid antigens. The expression of either CD4 or CD8 increases the avidity of T cell receptors for mycolipids, leading to a higher intensity of fluorescence and decreased secretion threshold for interferon-gamma. Furthermore, CD8+ T cells show greater cytotoxicity compared to CD4+ T cells in individuals with active tuberculosis.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Marie Eliane Azoury, Fatoumata Samassa, Mijke Buitinga, Laura Nigi, Noemi Brusco, Aisha Callebaut, Matthieu Giraud, Magali Irla, Ana Ines Lalanne, Alexia Carre, Georgia Afonso, Zhicheng Zhou, Barbara Brandao, Maikel L. Colli, Guido Sebastiani, Francesco Dotta, Maki Nakayama, Decio L. Eizirik, Sylvaine You, Sheena Pinto, Mark J. Mamula, Yann Verdier, Joelle Vinh, Soren Buus, Chantal Mathieu, Lut Overbergh, Roberto Mallone
Summary: The destruction of autoimmune beta-cells in type 1 diabetes may be influenced by neoantigens with posttranslational modifications such as citrullination. CD8(+) T cells showed preference for native or citrullinated versions of GRP78 peptides and recognition patterns were shaped by cross-reactivity with bacterial mimotopes. Thymic citrullination may play a role in immune tolerance by driving deletion of citrulline-reactive T cells.
Article
Immunology
Roshni Roy Chowdhury, John R. Valainis, Megha Dubey, Lotta von Boehmer, Elsa Sola, Julie Wilhelmy, Jing Guo, Oliver Kask, Mane Ohanyan, Meng Sun, Huang Huang, Xianxi Huang, Patricia K. Nguyen, Thomas J. Scriba, Mark M. Davis, Sean C. Bendall, Yueh-hsiu Chien
Summary: Examined the response of gamma delta T cells in acute versus chronic phases of tuberculosis infection and found an expansion of CD8+ gamma delta T cells with memory inflation features in chronic infection. These cells are hyporesponsive to T cell receptor signaling but can mount cytotoxic responses mediated by CD16. Furthermore, CD8+ gamma delta T cells also expand in other chronic inflammatory conditions, suggesting similar effector programs and differentiation fates driven by persistent antigen exposure.
SCIENCE IMMUNOLOGY
(2023)
Article
Oncology
Tsung-Yi Lin, Jeong A. Park, Alan Long, Hong-Fen Guo, Nai-Kong Cheung
Summary: The study developed a T cell-engaging bispecific antibody named BC261, which demonstrated potent cytotoxicity against EFT, prostate cancer, and canine osteosarcoma cell lines and showed superior antitumor effects in vivo. BC261 not only promoted T cell infiltration into tumors but also exhibited significant antitumor efficacy against various cancer types.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Weiwei Wang, Jing Zhao, Changlong Hao, Shudong Hu, Chen Chen, Yi Cao, Zhengyu Xu, Jun Guo, Liguang Xu, Maozhong Sun, Chuanlai Xu, Hua Kuang
Summary: This study discovers the potential of chiral nanomaterials as immunoadjuvants for the prevention and treatment of cancer. Chiral nanoparticles enhance immune response and inhibit tumor growth through the stimulation of specific cell types, showing better therapeutic effects compared to achiral nanoparticles.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Valeria Ukrainskaya, Yuri Rubtsov, Dmitry Pershin, Nadezhda Podoplelova, Stanislav Terekhov, Igor Yaroshevich, Anstasiia Sokolova, Dmitry Bagrov, Elena Kulakovskaya, Victoria Shipunova, Sergey Deyev, Rustam Ziganshin, Aleksandr Chernov, Georgii Telegin, Eugene Maksimov, Oleg Markov, Anastasiya Oshchepkova, Marina Zenkova, Jia Xie, Hongkai Zhang, Alexander Gabibov, Michael Maschan, Alexey Stepanov, Richard Lerner
Summary: The development of CAR-T therapy has achieved success in the treatment of B cell leukemia, but the expansion of CAR-T cells remains challenging with current protocols. A novel approach using cell-derived membrane vesicles has been proposed, showing greater potential in stimulating, proliferating, and enhancing the functional activity of CAR-T cells.
Article
Immunology
Brendan W. MacNabb, Sravya Tumuluru, Xiufen Chen, James Godfrey, Darshan N. Kasal, Jovian Yu, Marlieke L. M. Jongsma, Robbert M. Spaapen, Douglas E. Kline, Justin Kline
Summary: This study demonstrates the importance of MHC-I cross-dressing in regulating anti-tumor immunity. In addition to quantitatively enhancing tumor antigen presentation, it also enables dendritic cells to more accurately mirror the cancer cell peptidome.
Article
Immunology
Gaelle Tilly, Marion Cadoux, Alexandra Garcia, Jeremy Morille, Sandrine Wiertlewski, Claire Pecqueur, Sophie Brouard, David Laplaud, Nicolas Degauque
Summary: The study found that 12 months of treatment with teriflunomide in patients with RRMS did not affect B cell or CD4 T cell compartments, but had a specific impact on CD8 T cells, including decreased proliferation and reduced production of inflammatory factors. DHODH inhibition also affected the migratory velocity of memory CD8 T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Johanna E. Huber, Yinshui Chang, Ingrid Meinl, Tania Kuempfel, Edgar Meinl, Dirk Baumjohann
JOURNAL OF IMMUNOLOGY
(2020)
Review
Oncology
Sarah Teuber-Hanselmann, Edgar Meinl, Andreas Junker
JOURNAL OF PATHOLOGY
(2020)
Article
Clinical Neurology
Jia Liu, Masahiro Mori, Hanna Zimmermann, Alexander Brandt, Joachim Havla, Satoru Tanaka, Kazuo Sugimoto, Satoru Oji, Akiyuki Uzawa, Susanna Asseyer, Graham Cooper, Sven Jarius, Judith Bellmann-Strobl, Klemens Ruprecht, Nadja Siebert, Hiroki Masuda, Tomohiko Uchida, Ryohei Ohtani, Kyoichi Nomura, Edgar Meinl, Tania Kuempfel, Friedemann Paul, Satoshi Kuwabara
Summary: This study revealed regional and ethnic differences in MOG-IgG-associated disorders between Japanese and German patients. Japanese patients tended to have a milder monophasic disease, while German patients had a more relapsing course and were more likely to experience myelitis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Caterina Macrini, Ramona Gerhards, Stephan Winklmeier, Lena Bergmann, Simone Mader, Melania Spadaro, Atay Vural, Michaela Smolle, Reinhard Hohlfeld, Tania Kuempfel, Stefan F. Lichtenthaler, Henri G. Franquelim, Dieter Jenne, Edgar Meinl
Summary: The study aimed to understand the essential structural features of MOG for recognition by autoantibodies in patients. The results showed that patients with MOG antibodies recognize full-length MOG better than its N-terminal part and require bivalent binding. This suggests that the pathogenicity of MOG antibodies may be mediated by mechanisms other than complement activation.
Review
Immunology
Edgar Meinl, Markus Krumbholz
Summary: BAFF and APRIL regulate B cell homeostasis by binding to their receptors, and shedding of BCMA and TACI receptors reduce signaling. Soluble forms of sBCMA and sTACI serve as biomarkers in diseases, while BCMA is a therapeutic target in multiple myeloma with potential implications for therapy using CAR T cells.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Immunology
Yossi Nishri, Nina Fainstein, Smadar Goldfarb, David Hampton, Caterina Macrini, Edgar Meinl, Siddharthan Chandran, Tamir Ben-Hur
Summary: The study found that chronic EAE in Biozzi mice exhibits similar clinical features to progressive MS, including relapsing and progressing disease, partial closure of the blood-brain barrier, reduced tissue inflammatory activity, and the development of meningeal ectopic lymphoid tissue. Late chronic Biozzi EAE also transitions from a T cell predominant disease to a B cell predominant disease, with high serum anti-MOG reactivity, making it suitable for developing disease modifying and regenerative therapies.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Clinical Neurology
Romain Marignier, Yael Hacohen, Alvaro Cobo-Calvo, Anne-Katrin Probstel, Orhan Aktas, Harry Alexopoulos, Maria-Pia Amato, Nasrin Asgari, Brenda Banwell, Jeffrey Bennett, Fabienne Brilot, Marco Capobianco, Tanuja Chitnis, Olga Ciccarelli, Kumaran Deiva, Jerome De Seze, Kazuo Fujihara, Anu Jacob, Ho Jin Kim, Ingo Kleiter, Hans Lassmann, Maria-Isabel Leite, Christopher Linington, Edgar Meinl, Jacqueline Palace, Friedemann Paul, Axel Petzold, Sean Pittock, Markus Reindl, Douglas Kazutoshi Sato, Krzysztof Selmaj, Aksel Siva, Bruno Stankoff, Mar Tintore, Anthony Traboulsee, Patrick Waters, Emmanuelle Waubant, Brian Weinshenker, Tobias Derfuss, Sandra Vukusic, Bernhard Hemmer
Summary: MOGAD is a recently identified autoimmune disorder characterized by CNS demyelination, distinct from multiple sclerosis and NMOSD. Diagnosis involves testing for anti-MOG antibodies and treatment is based on standard protocols for related conditions, with further evidence needed for optimal management strategies.
Article
Clinical Neurology
Miriam Schlueter, Eva Oswald, Stephan Winklmeier, Ingrid Meinl, Joachim Havla, Peter Eichhorn, Edgar Meinl, Tania Kuempfel
Summary: Natalizumab (NTZ) treatment in MS patients reduces intrathecally produced IgG and IgA levels, with minimal effect on IgM indices. Reductions in IgG index, serum IgM, and IgA are correlated with NTZ treatment duration. MRZ reaction remains unchanged and OCB persists.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Editorial Material
Clinical Neurology
Edgar Meinl, Reinhard Hohlfeld
ANNALS OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Stephan Winklmeier, Katharina Eisenhut, Damla Taskin, Heike Rubsamen, Ramona Gerhards, Celine Schneider, Paul R. Wratil, Marcel Stern, Peter Eichhorn, Oliver T. Keppler, Matthias Klein, Simone Mader, Tania Kumpfel, Edgar Meinl
Summary: A study found that SARS-CoV-2-specific B cells can persist in some COVID-19 patients even after 6 months, even when specific serum IgG levels have declined. These B cells have neutralizing activity and can recognize viral variants, although the response to certain variants is weaker. Therefore, detecting memory B cells may be more accurate in determining previous infections than measuring serum antibodies.
Article
Cell Biology
Stefan Preisendoerfer, Yoshihiro Ishikawa, Elisabeth Hennen, Stephan Winklmeier, Jonas C. Schupp, Larissa Knueppel, Isis E. Fernandez, Leonhard Binzenhofer, Andrew Flatley, Brenda M. Juan-Guardela, Clemens Ruppert, Andreas Guenther, Marion Frankenberger, Rudolf A. Hatz, Nikolaus Kneidinger, Jurgen Behr, Regina Feederle, Aloys Schepers, Anne Hilgendorff, Naftali Kaminski, Edgar Meinl, Hans Peter Baechinger, Oliver Eickelberg, Claudia A. Staab-Weijnitz
Summary: The study reveals that FKBP11 plays an important role in plasma cells, is regulated by XBP1, and sheds light on the important mechanisms involved in antibody production and folding.
Letter
Clinical Neurology
Daniel Engels, Simone Mader, Stefanie Foerderreuther, Markus Reindl, Joachim Havla, Edgar Meinl, Tania Kuempfel, Lisa Ann Gerdes
ANNALS OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Franziska S. Thaler, Edgar Meinl
Letter
Clinical Neurology
Vinicius Oliveira Boldrini, Simone Mader, Tania Kuempfel, Edgar Meinl
Summary: Ublituximab is a newly FDA-approved treatment for relapsing forms of Multiple Sclerosis (MS). It works by depleting B cells while sparing long-lived plasma cells. Different anti-CD20 monoclonal antibodies with varying dose regimens, routes of application, glycoengineering and mechanisms of action may lead to different clinical outcomes.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Eduardo Beltran, Manuela Paunovic, David Gebert, Emine Cesur, Markus Jeitler, Romana Hoeftberger, Joachim Malotka, Simone Mader, Naoto Kawakami, Edgar Meinl, Monika Bradl, Klaus Dornmair, Hans Lassmann
Summary: The study aimed to identify the target auto-antigen in the central nervous system recognized by the immune system of a unique patient, potentially induced by immunization with calf brain tissue, leading to a disease with characteristics between MS and MOG antibody-associated inflammatory demyelinating diseases.
ACTA NEUROPATHOLOGICA
(2021)