Review
Medicine, General & Internal
Jan Claassen, Soojin Park
Summary: Subarachnoid hemorrhage (SAH) is the third most common subtype of stroke. The incidence has decreased over the years, possibly due to lifestyle changes. A quarter of SAH patients die before hospital admission, and those admitted to the hospital have improved outcomes but may experience long-term neuropsychiatric complications. Severe sudden headache is the most common symptom, and diagnosis is typically made through CT scan and angiography. Treatment focuses on reducing the risk of rebleeding and early aneurysm treatment.
Article
Clinical Neurology
Chih-Hao Chen, Yung-Tsai Chu, Ya-Fang Chen, Tzu-Yu Ko, Yu-Wen Cheng, Ming-Jen Lee, Pei-Lung Chen, Sung-Chun Tang, Jiann-Shing Jeng
Summary: This study investigated the clinical/imaging features for identifying NOTCH3-mutation-related intracerebral haemorrhage (ICH) in a cohort of 749 cerebral small vessel disease (CSVD) patients. The study found that patients with NOTCH3 mutation were more likely to have thalamic haemorrhage, a family history of stroke and more severe CSVD neuroimaging markers. A NOTCH3-ICH score was developed to assist in identifying genetic causes of ICH.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Anesthesiology
Samuli Jokinen, Anne Kuitunen, Jukka Uotila, Arvi Yli-Hankala
Summary: This study compared the effectiveness of ROTEM-guided and conventional treatment for postpartum hemorrhage through a randomized controlled trial. The results showed that ROTEM-guided treatment can help reduce the need for blood transfusions, but may only have a slight effect on the total blood loss.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Cardiac & Cardiovascular Systems
Junchao Xu, Na Yan, Chunling Wang, Chao Gao, Xuexiang Han, Chengzhi Yang, Jiaqi Xu, Kun Wang, Michael J. J. Mitchell, Yinlong Zhang, Guangjun Nie
Summary: A study found that platelet-mimicking nanosponges can efficiently reverse the antiplatelet effect of drugs, reducing the risk of bleeding during surgery without causing thrombosis. This research provides a promising strategy for managing bleeding complications caused by antiplatelet therapy.
CIRCULATION RESEARCH
(2023)
Article
Neurosciences
Meng Wang, Yuyuan Yang, Yajuan Wang, Moxin Luan, Lulu Xu, Meixiang Zhong, Xueping Zheng
Summary: This study examined the influence of short-term single and dual antiplatelet therapy on the prognosis of patients with acute ischaemic stroke with and without cerebral microbleeds. The findings suggest that dual antiplatelet therapy may reduce the risk of recurrent ischaemic stroke caused by cerebral microbleeds, but increase the risk of intracerebral haemorrhage.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Obstetrics & Gynecology
A. S. Ducloy-Bouthors, F. J. Mercier, J. M. Grouin, F. Bayoumeu, J. Corouge, A. Le Gouez, T. Rackelboom, F. Broisin, F. Vial, A. Luzi, O. Capronnier, C. Huissoud, A. Mignon
Summary: This study aimed to assess the benefits and safety of early human fibrinogen concentrate in postpartum haemorrhage management, with results showing that 3 g fibrinogen concentrate did not significantly reduce blood loss or transfusion needs in PPH management, but did prevent plasma fibrinogen decrease and was considered safe.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Surgery
Adil M. Lokhandwala, Samer Asmar, Muhammad Khurrum, Mohamad Chehab, Letitia Bible, Lourdes Castanon, Michael Ditillo, Bellal Joseph
Summary: This study evaluated the role of platelet transfusion on outcomes after traumatic intracranial bleeding in patients on preinjury antiplatelet agents with traumatic brain injury. Results showed that receiving two units of pooled platelets was associated with a lower risk of IB progression, neurosurgical intervention, and mortality compared to not receiving platelet transfusion.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Clinical Neurology
Xiaodong Ye, Guo Li, Xiaoyan Liu, Guini Song, Yuchao Jia, Chunmei Wu, Xiong Wang, Shanshan Huang, Suiqiang Zhu
Summary: The study identified APOE epsilon 2 allele as a predictor of subarachnoid extension in spontaneous supratentorial ICH, especially in lobar ICH. The association between APOE epsilon 2 and SAHE suggests genetically driven vessel pathology.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Bon-Kwon Koo, Jeehoon Kang, Kyung Woo Park, Tae-Min Rhee, Han-Mo Yang, Ki-Bum Won, Seung-Woon Rha, Jang-Whan Bae, Nam Ho Lee, Seung-Ho Hur, Junghan Yoon, Tae-Ho Park, Bum Soo Kim, Sang Wook Lim, Yoon Haeng Cho, Dong Woon Jeon, Sang-Hyun Kim, Jung-Kyu Han, Eun-Seok Shin, Hyo-Soo Kim
Summary: This study compared the efficacy and safety of clopidogrel and aspirin monotherapy in patients undergoing coronary stenting during the chronic maintenance period. The findings showed that clopidogrel monotherapy was superior to aspirin in preventing adverse clinical events.
Article
Anesthesiology
L. Green, J. Daru, F. J. Gonzalez Carreras, D. Lanz, M. C. Pardo, T. Perez, S. Philip, T. Tanqueray, K. S. Khan
Summary: The study aimed to evaluate the feasibility of early cryoprecipitate transfusion in severe postpartum hemorrhage, and found that while the intervention group had lower treatment adherence, cryoprecipitate administration was associated with decreased red blood cell transfusion and overall surgical procedures risk.
Article
Medicine, Research & Experimental
Xiaodong Li, Ruili Jia, Yancong Guo
Summary: The study presents a case of an elderly male patient with uraemia who experienced sudden numbness and weakness in the right limbs during sleep at night, along with blurred and double vision, during haemodialysis induction. Imaging showed signs of brainstem haemorrhage. The patient's condition improved and the sensation and movement in the limbs returned to normal after conservative treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Surgery
Darla K. Eastman, Sarah K. Spilman, Kelly Tang, Richard A. Sidwell, Carlos A. Pelaez
Summary: The study investigated the use of platelet reactivity testing (PRT) to guide platelet transfusion for traumatic intracranial hemorrhage (tICH) patients suspected of taking aspirin. Results showed that some patients with suspected aspirin use did not require platelet transfusion based on PRT, suggesting that PRT can detect platelet inhibition related to aspirin and should guide transfusion decisions for head injured patients in the initial hours after trauma.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Respiratory System
Ramon Luengo-Fernandez, Filipa Landeiro, Rob Hallifax, Najib M. Rahman
Summary: This study conducted an economic evaluation and found that outpatient ambulatory management is a cost-effective option for the management of primary pneumothorax.
Article
Pharmacology & Pharmacy
Qiu-Ping Shi, Xing-Yu Luo, Bin Zhang, Xin-Gang Wang, Jing Zhao, Qiu-Fen Xie, Jia-Hui Liu, Yao-Kun Liu, Jie Jiang, Bo Zheng
Summary: This study compared the effect of indobufen and aspirin on platelet function in patients with stable coronary heart disease after percutaneous coronary intervention (PCI). The findings suggest that indobufen has similar antiplatelet effects to aspirin and may be an alternative for patients with aspirin intolerance after coronary stenting.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Riccardo Milani, Lucio Aniello Mazzeo, Daniela Vismara, Ilaria Salemi, Emanuele Dainese, Emanuela Maderna, Elisa Pellencin, Marcella Catania, Nicole Campanella, Giuseppe Di Fede, Giorgio Giaccone, Andrea Salmaggi
Summary: Cerebral amyloid angiopathy (CAA) is a small vessel disease that leads to spontaneous intracerebral hemorrhage (ICH) in the elderly and is strongly associated with Alzheimer's disease (AD). Recently, iatrogenic early-onset CAA has been identified in patients who had a history of traumatic brain injury or other cerebral and extra-cerebral lesions that required neurosurgery or other medical procedures. The transmission of A beta seeds from neurosurgical instruments or exposure to cadaveric dura mater is suspected to be involved.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Clinical Neurology
Quentin Thomas, Sophie Nambot, Yannick Bejot, Christophe Philippe, Laurence Faivre, Yannis Duffourd, Christel Thauvin-Robinet, Gwendoline Dupont
Summary: Early-onset Alzheimer's disease is linked to genetic variants in APP, PSEN1, and PSEN2 genes. PSEN1 mutations are responsible for the majority of cases of autosomal dominant AD. PSEN1-pathogenic variants can result in various phenotypes, such as cerebellar ataxia and spastic paraplegia.
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
(2023)
Article
Clinical Neurology
Valentin Pinguet, Gauthier Duloquin, Thomas Thibault, Herve Devilliers, Pierre-Olivier Comby, Valentin Crespy, Frederic Ricolfi, Catherine Vergely, Maurice Girouda, Yannick Bejota
Summary: This study examined whether pre-existing brain damage could explain the greater severity in cognitively impaired patients with ischemic stroke. The results showed that patients with mild cognitive impairment or dementia had higher severity at the onset of stroke, but the relationship between cognitive impairment and severity was not mediated by pre-existing visible brain damages. The conclusion is that impaired brain ischemic tolerance in patients with prior cognitive impairment may involve other mechanisms.
JOURNAL OF NEURORADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xavier Humbert, Idlir Licaj, Sophie Fedrizzi, Joachim Alexandre, Alessandro Menotti, Alain Manrique, Stephane Allouche, Emmanuel Touze, Oscar Terradura-Vagnarelli, Paolo E. Puddu
Summary: This study investigated the associations between lifestyle, anthropometric and biological measurements and blood pressure in a population residing in Gubbio. The results showed that in addition to age, BMI was positively associated with blood pressure in both sexes, while the associations between serum uric acid, fasting blood glucose and hypertension varied by sex.
Article
Public, Environmental & Occupational Health
Romain Schneckenburger, Marion Boulanger, Marguerite Watrin, Gwendoline Le Du, Remy Morello, Emmanuel Touze
Summary: The Normandy Stroke Study (NSS) is a prospective population-based study in France that aims to investigate the incidence and long-term prognosis of strokes. It uses multiple overlapping sources for case identification and follows patients for up to 3 years after the event to assess functional and cognitive prognosis as well as quality of life. The study will provide important data on stroke epidemiology and consequences at the population level, informing resource allocation decisions for care providers.
Article
Rheumatology
Thomas Thibault, Bastien Durand-Bailloud, Agnes Soudry-Faure, Helene Greigert, Clement Drouet, Herve Devilliers, Andre Ramon, Yannick Bejot, Laurent Martin, Catherine Creuzot-Garcher, Nicolas Falvo, Sylvain Audia, Alexandre Cochet, Bernard Bonnotte, Jean-Louis Alberini, Maxime Samson
Summary: This study investigates the performance of cranial PET/CT for the diagnosis of GCA and evaluates the combination of cranial and extracranial PET/CT. The results show that cranial PET/CT has good sensitivity and specificity in diagnosing GCA, and the combination of cranial and extracranial PET/CT improves diagnostic accuracy.
Article
Clinical Neurology
Wenjin Yang, Jazba Soomro, Ivo G. H. Jansen, Aashish Venkatesh, Albert J. Yoo, Demetrius Lopes, Ludo F. M. Beenen, Bart J. Emmerl, Charles B. L. M. Majoie, Henk A. Marquering
Summary: In order to address the coarseness and low interobserver agreement of the conventional Tan collateral score, we have introduced and evaluated an extended Tan score in this study. The results show that the extended score has good interobserver agreement and is consistent with quantitative assessment, indicating its potential to improve the prognostic value of collateral assessment in clinical practice.
CLINICAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Leon A. Rinkel, Chiel F. P. Beemsterboer, Nina-Suzanne Groeneveld, Nick H. J. Lobe, S. Matthijs Boekholdt, Berto J. Bouma, Fenna F. Muller, Ludo F. M. Beenen, Henk A. Marquering, Charles B. L. M. Majoie, Yvo B. W. E. M. Roos, Adrienne van Randen, R. Nils Planken, Jonathan M. Coutinho
Summary: Cardiac CT can detect cardiac thrombi in patients with acute ischemic stroke, and these patients have more severe symptoms and the thrombi are usually located in the left atrial appendage, which significantly affects the functional outcome.
EUROPEAN STROKE JOURNAL
(2023)
Article
Clinical Neurology
Alin Borha, Florent Lebrun, Emmanuel Touze, Evelyne Emery, Denis Vivien, Thomas Gaberel
Summary: Endovascular thrombectomy has changed the management of ischemic stroke. Decompressive craniectomy for ischemic stroke after thrombectomy could lead to a higher risk of hemorrhagic transformation, as shown in a mouse model of stroke induced by occlusion of the middle cerebral artery.
Article
Clinical Neurology
L. A. Rinkel, B. J. Bouma, S. M. Boekholdt, C. F. P. Beemsterboer, N. H. J. Lobe, L. F. M. Beenen, H. A. Marquering, C. B. L. M. Majoie, Y. B. W. E. M. Roos, A. van Randen, R. N. Planken, J. M. Coutinho
Summary: This study found that cardiac CT has low sensitivity in screening for PFO (patent foramen ovale) in patients with acute stroke, therefore it is not a suitable method for detecting PFO. For young patients with cryptogenic stroke, additional echocardiography is still needed after cardiac CT as a first-line screening method.
JOURNAL OF NEUROLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Valeria Vespasiano, Cornelis Klop, Catharina S. Mulder, Jan H. Koolstra, Nicolaas H. J. Lobe, Ludo. F. M. Beenen, Jitske W. Nolte, Alfred G. Becking
Summary: This study explores the normal variation of asymmetry in mandibles of children aged 1 to 12 years. 3D models of the mandibles were obtained from CT scans and different parameters of asymmetry were measured using a novel landmark-based method. The results showed that mandibular asymmetries in children occur and are unrelated to age, with different segments of the mandible compensating for each other to maintain functional equilibrium.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2023)
Article
Medicine, General & Internal
L. Robin Goossen, Marielle Verboom, Marielle Blacha, Illaa Smesseim, Ludo F. M. Beenen, David M. P. van Meenen, Frederique Paulus, J. Marcus Schultz
Summary: In this single-center cohort study in the Netherlands, the incidence of air leaks, including subcutaneous emphysema, pneumothorax, and pneumomediastinum, was found to be 8.4% in patients with COVID-19, which was comparable to previous reports in patients with acute hypoxemic respiratory failure.
Article
Cardiac & Cardiovascular Systems
Miou S. S. Koopman, Jan W. W. Hoving, Manon L. L. Tolhuisen, Peng Jin, Frank O. O. Thiele, Linda Bremer van der Heiden, Henk van Voorst, Olvert A. A. Berkhemer, Jonathan M. M. Coutinho, Ludo F. M. Beenen, Henk A. A. Marquering, Bart J. J. Emmer, Charles B. L. M. Majoie
Summary: This study aimed to analyze the volumetric and spatial agreement of the computed tomography perfusion (CTP) ischemic core estimated with different thresholds and compare it with the follow-up MRI infarct volume on diffusion-weighted imaging (DWI). The results showed moderate-good volumetric agreement between CTP ischemic core estimates and DWI infarct volume in patients with complete reperfusion, but poor agreement in patients with successful reperfusion. The spatial agreement was low for all four methods.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Multidisciplinary Sciences
C. F. P. Beemsterboer, L. A. Rinkel, V. Guglielmi, N. -S. Groeneveld, N. H. J. Lobe, S. M. Boekholdt, B. J. Bouma, F. F. Muller, L. F. M. Beenen, H. A. Marquering, C. B. L. M. Majoie, Y. B. W. E. M. Roos, A. van Randen, R. N. Planken, J. M. Coutinho
Summary: This observational pilot study found that cardiac thrombi can dissolve within days of ischemic stroke occurrence, with or without thrombolysis treatment.
Review
Public, Environmental & Occupational Health
Yannick Bejot
Summary: This review compared stroke patients from population-based studies to those included in RCTs in terms of age and found a gap in the inclusion of elderly patients in clinical trials. With the aging population, it is necessary to include older patients in future trials to reflect the true population of stroke patients and guide clinical decision-making.
Article
Computer Science, Artificial Intelligence
Lucas de Vries, Rudolf L. M. van Herten, Jan W. Hoving, Ivana Isgum, Bart J. Emmer, Charles B. L. M. Majoie, Henk A. Marquering, Efstratios Gavves
Summary: This paper proposes a novel approach for CT perfusion analysis using physics-informed learning, which accurately estimates perfusion parameters of affected cerebral tissue. The method is validated on simulated and real patient data, showing its effectiveness and reliability.
MEDICAL IMAGE ANALYSIS
(2023)