Article
Immunology
Cheng Zhang, Wangjian Zhang, Yongjie Shui, Ping Li, Zhifeng Tian, Shiwei Duan, Qichun Wei
Summary: This study suggests that m6A-associated snRNAs may serve as useful biomarkers for prognostic evaluation and immunotherapy response in HCC. By analyzing data from the TCGA database, we developed a risk model that can predict the prognosis and immunotherapy response in HCC patients based on snRNA expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaodi Guo, Jiamin Chen, Aizhong Fang, Qiang Ji, Feng Chen, Xingang Zhou, Xinyi Li, Wenbin Li
Summary: TAF12 has been found to be an oncogene in choroid plexus carcinoma, and this study investigated its role in glioma. The study found that high TAF12 expression was associated with reduced survival time and poor clinical indexes in glioma cases. Functional enrichment analysis revealed involvement of TAF12 in immune and inflammatory responses in glioma. These findings suggest that TAF12 may be a potential independent prognostic factor for glioma and could be targeted in immunotherapy.
Article
Oncology
Chen Xue, Xinyu Gu, Yalei Zhao, Junjun Jia, Qiuxian Zheng, Yuanshuai Su, Zhengyi Bao, Juan Lu, Lanjuan Li
Summary: Based on the analysis of genes related to tryptophan metabolism, we identified two metabolic phenotypes and established a risk model that can be used to predict the prognosis and guide immunotherapy in patients with hepatocellular carcinoma.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Bao-Ye Sun, Zhang-Fu Yang, Zhu-Tao Wang, Gao Liu, Cheng Zhou, Jian Zhou, Jia Fan, Wei Gan, Yong Yi, Shuang-Jian Qiu
Summary: This study investigates the role of CD73 in intrahepatic cholangiocarcinoma (ICC). The results show that high expression of CD73 is associated with poor prognosis and a suppressive tumor immune microenvironment in ICC, suggesting CD73 as a potential novel biomarker for prognosis and immunotherapy in ICC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Cell Biology
Tao Wang, Yi Yang, Ting Sun, Haizhou Qiu, Jian Wang, Cheng Ding, Ren Lan, Qiang He, Wentao Wang
Summary: This study reveals that the risk score of pyroptosis-related lncRNA is significantly associated with the overall survival and tumor characteristics of hepatocellular carcinoma patients, as well as the infiltration of tumor microenvironment cells. The risk score can serve as a potential prognostic biomarker and provide guidance for precision drug treatment and immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Guo Long, Dong Wang, Jianing Tang, Weifeng Tang
Summary: Tryptophan metabolism is closely linked to tumorigenesis and tumor immune response in various cancers, but its role in hepatocellular carcinoma (HCC) is not well understood. This study investigated the mutations of 42 tryptophan metabolism-related genes (TRPGs) in HCC cohorts and identified two distinct subtypes based on the expression profiles of these TRPGs. The TRPG signature was found to be an independent prognostic indicator for HCC patients and showed excellent predictive accuracy in survival analysis.
Article
Cell Biology
Rongfeng Shi, Hui Zhao, Suming Zhao, Hongxin Yuan
Summary: This study comprehensively integrated the transcriptome profiling of DNA methylation regulators in hepatocellular carcinoma, identifying three distinct DNA methylation regulator-related molecular subtypes and constructing a prognostic and immunotherapeutic relevant gene signature. These findings contribute to the advancement of individualized immunotherapy for hepatocellular carcinoma.
Article
Medicine, General & Internal
Xu Huang, Xu Wang, Ge Huang, Ruotao Li, Xingkai Liu, Lidong Cao, Junfeng Ye, Ping Zhang
Summary: This study bioinformatically identified differentially expressed genes (DEGs) associated with the prognosis of hepatocellular carcinoma (HCC). The GO and KEGG analyses revealed the involvement of these DEGs in HCC-related biological processes, molecular functions, and cell components. Additionally, the PPI network analysis identified core genes associated with the HCC prognosis. These DEGs have the potential to serve as prognostic biomarkers and therapeutic targets for HCC.
Article
Immunology
Wenli Li, Jun Liu
Summary: AHSA1 expression was up-regulated in tumor tissues, and its over-expression in LIHC, LUAD, and ESCA could affect the overall survival and disease-specific survival of patients. AHSA1 expression was greatly correlated with immune cell infiltrates, immune checkpoint inhibitors, tumor mutation load, and microsatellite instability. AHSA1 was identified as an independent prognostic factor of HCC and its knockdown decreased the proliferation, migration, and invasion ability of HCC cells. Therefore, AHSA1 may serve as a potential prognostic biomarker of tumors and play a significant role in the proliferation and migration of HCC cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaoyu Kong, Yuanpeng Xiong, Mei Xue, Jie He, Qinsheng Lu, Miaojuan Chen, Liping Li
Summary: In this study, a risk signature containing 8 cuproptosis-related lncRNAs was developed to predict the survival outcome of CC patients, and the reliability of the risk signature was appraised. Cox regression analyses indicated that the comprehensive risk score is an independent prognostic factor. Significant differences were found in various clinical parameters between risk subgroups, suggesting the potential clinical utility of the risk signature in assessing the efficacy of immunotherapy and chemotherapy for CC patients.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Yannan Bai, Yuane Lian, Xiaoping Chen, Jiayi Wu, Jianlin Lai, Funan Qiu, Songqiang Zhou, Zijing Zhu, Yifeng Tian, Yaodong Wang, Yinghong Yang, Maolin Yan
Summary: A newly developed 3-IHC-based classifier has been shown to accurately predict recurrence and survival outcomes in patients with early- and intermediate-stage HCC after curative liver resection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Tianyu Ren, Xiaofei Xue, Xiaogang Wang, Xingtong Zhou, Shengchun Dang
Summary: This study aimed to identify key genes in pancreatic cancer by analyzing gene expression profiling data. Through enrichment analysis, it was found that these genes were involved in important biological processes such as endodermal cell differentiation, cell adhesion, extracellular matrix-receptor interaction, and the PI3K-Akt signaling pathway. ITGA2 and ITGB6 were identified as key genes impacting the prognosis of pancreatic cancer, with experimental results showing that silencing ITGB6 can inhibit pancreatic cancer cell proliferation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Multidisciplinary Sciences
Svetlana Fedorova, Natalya V. Dorogova, Dmitriy A. Karagodin, Dmitry Yu Oshchepkov, Ilya I. Brusentsov, Natalya V. Klimova, Elina M. Baricheva
Summary: The GAGA protein is involved in transcription regulation in flies, and its deficiency can lead to cell death and metabolic imbalance. This study is important for understanding the role of GAGA in controlling cell death and regulating metabolic processes.
Article
Oncology
Yuanshuai Su, Chen Xue, Xinyu Gu, Wankun Wang, Yu Sun, Renfang Zhang, Lanjuan Li
Summary: This study constructed a TAM-related gene model that is associated with the prognosis and immunotherapeutic response of hepatocellular carcinoma (HCC) patients by analyzing single-cell transcriptomic data. The model can predict patient survival and response to immunotherapy, and characterize the immune landscape and tumor immune escape status.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ryo Morisue, Motohiro Kojima, Toshihiro Suzuki, Tetsuya Nakatsura, Hidenori Ojima, Reiko Watanabe, Motokazu Sugimoto, Shin Kobayashi, Shinichiro Takahashi, Masaru Konishi, Genichiro Ishii, Naoto Gotohda, Toshiyoshi Fujiwara, Atsushi Ochiai
Summary: Sarcomatoid hepatocellular carcinoma (SHCC), a rare histological subtype of hepatocellular carcinoma (HCC), exhibits distinct clinicopathologic, transcriptomic, and immunologic characteristics compared to ordinary HCC (OHCC). Comprehensive analyses support the classification of SHCC as a histological subtype of HCC.
INTERNATIONAL JOURNAL OF CANCER
(2021)
