Article
Neurosciences
Jie Cui, Ghania Ait-Ghezala, Kumar Sambamurti, Feng Gao, Yong Shen, Rena Li
Summary: This study identified an estrogen-specific BACE1 transcriptional regulation pathway, providing new clues for the study of sex differences and AD pathology, from cell and animal models to AD patients.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Cell Biology
Aarti Mishra, Yiwei Wang, Fei Yin, Francesca Vitali, Kathleen E. Rodgers, Maira Soto, Lisa Mosconi, Tian Wang, Roberta D. Brinton
Summary: Neurological aging is a dynamic nonlinear process, characterized by three phases in midlife in the female brain. Metabolic and immune systems are tightly integrated through a network of signaling cascades, shifting the brain's fuel reliance and leading to the emergence of a dynamic neuroimmune phenotype. Endocrinological aging is a critical period tipping point in midlife.
AGEING RESEARCH REVIEWS
(2022)
Article
Medicine, General & Internal
Pooja Girish Mhatre, Joseph H. Lee, Deborah Pang, Warren B. Zigman, Benjamin Tycko, Sharon J. Krinsky-McHale, Yuchen Yang, Wayne Silverman, Nicole Schupf
Summary: This study found that among adults with Down Syndrome, only males over 60 years old were significantly more likely to develop Alzheimer's Disease compared to age-matched females.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Harpreet Kaur, Drew Seeger, Svetlana Golovko, Mikhail Golovko, Colin Kelly Combs
Summary: Alzheimer's disease is a neurodegenerative disease characterized by progressive cognitive impairment, with studies suggesting the involvement of liver cholesterol and bile acid metabolism in its pathophysiology. Experimental results from two different AD mouse lines indicate fundamental deficiencies in liver cholesterol metabolism and bile acid synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Yuan Hou, Jessica Z. K. Caldwell, Justin D. Lathia, James B. Leverenz, Andrew A. Pieper, Jeffrey Cummings, Feixiong Cheng
Summary: This study investigated the cellular metabolism and immune responses in Alzheimer's disease (AD) patients, particularly focusing on sex differences. The results revealed sex-specific metabolites, genes, and pathways associated with AD diagnosis and progression. Female AD patients showed distinct immune metabolite profiles and decreased communication between excitatory neurons and microglia, providing new insights into the molecular basis of female predominance in AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Mariko Sawa, Cassia Overk, Ann Becker, Dominique Derse, Ricardo Albay, Kim Weldy, Ahmad Salehi, Thomas G. Beach, Eric Doran, Elizabeth Head, Y. Eugene Yu, William C. Mobley
Summary: DS and AD-DS show differences in all APP products compared to ND and AD. In AD-DS, levels of A beta 42 and A beta 40 exceed those in AD. Increased APP products in the Dp16 model are linked to loss of vulnerable neurons, tau pathology, and activation of astrocytes and microglia, highlighting the importance of APP gene dose in Alzheimer's disease associated with Down syndrome.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biochemistry & Molecular Biology
Pablo Bascunana, Mirjam Brackhan, Luisa Moehle, Jingyun Wu, Thomas Bruening, Ivan Eiriz, Baiba Jansone, Jens Pahnke
Summary: Alzheimer's disease is the most common cause of dementia, and the use of fingolimod as a treatment for Alzheimer's disease is controversial. The effectiveness of fingolimod treatment depends on the stage at which it is administered. In this study, treatment with fingolimod only reduced A beta load in male animals in the late treatment group, while no other treatment groups showed any differences compared to the control group.
Article
Neurosciences
Jessica L. Dennison, Claude-Henry Volmar, Danbing Ke, James Wang, Emilie Gravel, Sabrina Hammond-Vignini, Zuomei Li, James A. Timmons, Ines Lohse, Marshall A. Hayward, Shaun P. Brothers, Claes Wahlestedt
Summary: JOTROL, a novel oral formulation of resveratrol, has higher bioavailability compared to non-formulated resveratrol. It has been found to be effective in the prevention and treatment of AD by regulating AD-related gene expression, inhibiting inflammatory genes, and regulating cytokine levels.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Immunology
Sarah R. Ocanas, Kevin D. Pham, Jillian E. J. Cox, Alex W. Keck, Sunghwan Ko, Felix A. Ampadu, Hunter L. Porter, Victor A. Ansere, Adam Kulpa, Collyn M. Kellogg, Adeline H. Machalinski, Manu A. Thomas, Zsabre Wright, Ana J. Chucair-Elliott, Willard M. Freeman
Summary: This study compared the transcriptome and translatome of hippocampal microglia between young and old mice and found sex differences in microglial gene expression. In old age, these differences were primarily female-biased and enriched in markers of senescence and disease. These findings may explain the differences in susceptibility and disease progression in Alzheimer's disease between males and females. Further studies are needed to explore the role of sex differences in microglial heterogeneity and the involvement of sex-specific regulators in response to Alzheimer's pathology.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Federico Ravanelli, Laura Musazzi, Silvia Stella Barbieri, Gianenrico Rovati, Maurizio Popoli, Alessandro Barbon, Alessandro Ieraci
Summary: Alzheimer's disease is a neurodegenerative disease that causes memory loss and cognitive impairment in elderly people. The causes of this disease are not well understood and involve genetic, environmental, and epigenetic factors. In the study, SAMP8 mice were used as a model to investigate epigenetic changes in the dorsal hippocampus. The results showed differential regulation of epigenetic markers between male and female SAMP8 mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Jordan Williamson, Andriy Yabluchanskiy, Peter Mukli, Dee H. Wu, William Sonntag, Carrie Ciro, Yuan Yang
Summary: Research shows that females are more impacted by mild cognitive impairment (MCI) and experience greater cognitive deterioration than males in the same disease stage. These sex differences are linked to neuroimaging markers of brain pathology, such as hippocampal volumes. This study found that males have stronger connectivity between the hippocampus and the precuneus cortex and brain stem compared to females.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Tamar Smit, Natasja A. C. Deshayes, David R. Borchelt, Willem Kamphuis, Jinte Middeldorp, Elly M. Hol
Summary: This review focuses on the impact of reactive astrocytes on cognitive function in Alzheimer's disease, using a mouse model to study the potential effects of targeting reactive astrocytes as a treatment for AD. Studies suggest that interventions targeting astrocytes can benefit cognition in AD.
Article
Neurosciences
Camila Gherardelli, Pedro Cisternas, Roberto F. Vera-Salazar, Carolina Mendez-Orellana, Nibaldo C. Inestrosa
Summary: Alzheimer's disease is characterized by high etiological and clinical heterogeneity, with sex differences influencing glucose metabolism and age-dependent decline in metabolic responses, cognitive functions, and brain energy homeostasis observed. Andrographolide shows promise as a potential drug for personalized medicine in AD treatment.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
William K. Gottschalk, Scott Mahon, Dellila Hodgson, Julio Barrera, Delaney Hill, Angela Wei, Manish Kumar, Kathy Dai, Lauren Anderson, Mirta Mihovilovic, Michael W. Lutz, Ornit Chiba-Falek
Summary: We developed a humanized mouse model with the entire TOMM40 and APOE genes and their intact regulatory sequences. Our study revealed tissue specific and shared effects of the '523' polyT genotype, sex, and age on the regulation of the human TOMM40 and APOE genes.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Jordan Williamson, Shirley A. James, Peter Mukli, Andriy Yabluchanskiy, Dee H. Wu, William Sonntag, Yuan Yang
Summary: Alzheimer's disease is the fifth leading cause of death in older adults in the USA and has a disproportionate impact on females. Research has found that females with Alzheimer's disease have higher incidence rates, worse performance on neuropsychological tasks, and greater brain atrophy. Recent studies have linked these sex differences to neuroimaging markers, such as hippocampal volumes. A study from our lab discovered stronger functional connectivity from the hippocampus to the precuneus cortex and brain stem in males with mild cognitive impairment compared to females. This study aimed to investigate if these sex-specific functional connectivity biomarkers extend to individuals with Alzheimer's disease and different disease stages. The results showed that males had significantly stronger interhemispheric functional connectivity between the left and right hippocampus compared to females. These findings enhance our understanding of the role of the hippocampus in sex differences in Alzheimer's disease and may contribute to the development of sex-specific precision medicine for improved treatment.
Review
Biochemistry & Molecular Biology
Ying Feng, Xue Ma, Liwen Deng, Bin Yao, Ying Xiong, Yilun Wu, Lin Wang, Qianhong Ma, Fang Ma
Article
Agriculture, Dairy & Animal Science
Dong-Mei Su, Ying Feng, Lin Wang, Yi-Lun Wu, Ren-Shan Ge, Xue Ma
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2018)
Article
Medicine, Research & Experimental
Lin Yu, Yayun Zheng, Ying Feng, Fang Ma
MEDICAL HYPOTHESES
(2018)
Review
Immunology
Yayun Zheng, Xue Ma, Dongmei Su, Yue Zhang, Lin Yu, Fangfei Jiang, Xue Zhou, Ying Feng, Fang Ma
JOURNAL OF IMMUNOLOGY RESEARCH
(2020)
Review
Medicine, Research & Experimental
Yue Zhang, Ruohan Wang, Ying Feng, Fang Ma
Article
Endocrinology & Metabolism
Yan-Ju Gong, Ying Feng, Yuan-Yuan Cao, Jia Zhao, Wei Wu, Ya-Yun Zheng, Jia-Rui Wu, Xin Li, Gui-Zhi Yang, Xue Zhou
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Andrology
Ying Feng, Ruohan Wang, Dongmei Su, Yujia Zhai, Lin Wang, Lin Yu, Yan Zhang, Xue Ma, Fang Ma
Summary: The measurement of protein expression level is crucial in biological and medical studies. Choosing internal control proteins with stable expression is essential for data standardization in sperm research.
Article
Nutrition & Dietetics
Nuozhou Liu, Fang Ma, Ying Feng, Xue Ma
Summary: The study found a positive association between dietary inflammatory potential (DII) and total T4 levels, especially in the iodine-deficient and obese groups. However, these hormone variations were still within the normal clinical range, and more well-designed studies are needed to validate the causal relationship between DII and thyroid function.
Article
Public, Environmental & Occupational Health
Nuozhou Liu, Ying Feng, Xinyao Luo, Xue Ma, Fang Ma
Summary: This study reveals an association between a proinflammatory diet and decreased levels of SHBG in women, particularly in premenopausal women.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Nuozhou Liu, Ying Feng, Yuejuan Zhan, Fang Ma
Summary: This study aimed to evaluate the relationship between blood cadmium levels and abdominal aortic calcification (AAC). The results showed that there might be positive associations between blood cadmium levels and AAC scores and the risk of severe AAC. However, these associations were partially explained by smoking exposure. It is important to note that factors such as gender, smoking, and BMI may influence this relationship.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ruohan Wang, Ying Feng, Jiahe Chen, Yingjiao Chen, Fang Ma
Summary: The intake of polyunsaturated fatty acids (PUFAs) is only slightly associated with infertility risk. Higher docosahexaenoic acid (DHA) intake is associated with a lower risk of infertility, while higher intake of alpha-linolenic acid (ALA) and linoleic acid (LA) is associated with a higher risk of primary infertility.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Obstetrics & Gynecology
Yu-Jia Zhai, Ying Feng, Xue Ma, Fang Ma
Summary: This review summarizes the expression, distribution, and regulation of defensins in the reproductive tracts to reveal the updated research on the dual role of defensins in host defense and the protection of fertility.
HUMAN REPRODUCTION UPDATE
(2023)
Letter
Endocrinology & Metabolism
Nuozhou Liu, Ying Feng, Xue Ma, Fang Ma
Review
Reproductive Biology
Shiqi Yi, Ying Feng, Yan Wang, Fang Ma
Summary: Sperm development and fertilization rely on protein translation and post-translational modifications, including sialylation. Damage to sperm sialylation can cause male infertility, emphasizing the importance of understanding this process. Investigating the characteristics of sperm sialylation can lead to better infertility detection and treatment methods.
BIOLOGY OF REPRODUCTION
(2023)
Article
Urology & Nephrology
Nuozhou Liu, Ying Feng, Jili Li, Xue Ma, Fang Ma
Summary: This study aimed to investigate the association between the dietary inflammatory index and lifetime kidney stone prevalence. The results showed that participants with higher dietary inflammatory index had a higher odds of kidney stone prevalence. Subgroup analysis indicated that this association was significant in younger age, female, Mexican American groups, married individuals or those without diabetes, hypertension, low eGFR, and albuminuria.
WORLD JOURNAL OF UROLOGY
(2022)