Avoiding misleading estimates using mtDNA heteroplasmy statistics to study bottleneck size and selection

Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions

(2023) Robert C. Glastad et al.   PLoS Computational Biology

Sorting of mitochondrial and plastid heteroplasmy in Arabidopsis is extremely rapid and depends on MSH1 activity

(2022) Amanda K. Broz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stochastic survival of the densest and mitochondrial DNA clonal expansion in aging

(2022) Ferdinando Insalata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck

(2021) David M. Edwards et al.   PLOS BIOLOGY

Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission

(2021) Haixin Zhang et al.   Science Advances

Germline selection shapes human mitochondrial DNA diversity

(2019) Wei Wei et al.   SCIENCE

Mitochondrial Network State Scales mtDNA Genetic Dynamics

(2019) Juvid Aryaman et al.   GENETICS

Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations

(2019) Hanne Hoitzing et al.   PLoS Computational Biology

Varied Mechanisms and Models for the Varying Mitochondrial Bottleneck

(2019) Iain G. Johnston   Frontiers in Cell and Developmental Biology

Mutation-specific effects in germline transmission of pathogenic mtDNA variants

(2018) Auke B C Otten et al.   HUMAN REPRODUCTION

Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations

(2018) Joerg P. Burgstaller et al.   Nature Communications

Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division

(2015) Riikka Jokinen et al.   HUMAN MOLECULAR GENETICS

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

(2015) Iain G Johnston et al.   eLife

mtDNA Segregation in Heteroplasmic Tissues Is Common In Vivo and Modulated by Haplotype Differences and Developmental Stage

(2014) Joerg Patrick Burgstaller et al.   Cell Reports

Preventing the transmission of pathogenic mitochondrial DNA mutations: can we achieve long-term benefits from germ-line gene transfer?

(2013) D. C. Samuels et al.   HUMAN REPRODUCTION

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

(2012) Christoph Freyer et al.   NATURE GENETICS

Previous Estimates of Mitochondrial DNA Mutation Level Variance Did Not Account for Sampling Error: Comparing the mtDNA Genetic Bottleneck in Mice and Humans

(2010) Passorn Wonnapinij et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model system

(2010) Sophie Monnot et al.   HUMAN MUTATION

The Distribution of Mitochondrial DNA Heteroplasmy Due to Random Genetic Drift

(2008) Passorn Wonnapinij et al.   AMERICAN JOURNAL OF HUMAN GENETICS