Review
Endocrinology & Metabolism
Yanping Wang, Weihong Du, Yanyun Sun, Junfang Zhang, Chaolin Ma, Xinchun Jin
Summary: Aging can lead to organ dysfunction and blood-brain barrier (BBB) breakdown, which contributes to central nervous system disorders. Inflammation plays a crucial role in BBB injury during aging, specifically through vascular endothelial cell senescence. This review discusses the relationship between disruption of BBB integrity and cognitive deficits, as well as the involvement of inflammation, endothelial cell senescence, and BBB injury. Furthermore, the review highlights the potential role of CREB-regulated transcription co-activator 1 (CRTC1) in cognition, aging-induced CRTC1 changes, and the critical functions of CRTC1/cyclooxygenase-2 (COX-2) in regulating inflammation, endothelial cell senescence, and BBB injury. The review concludes by suggesting CRTC1 as a promising target for delaying aging-induced cognitive deficits by protecting BBB integrity through inhibiting inflammation-mediated endothelial cell senescence.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Haidy Abbas, Heba A. Gad, Mohamed A. Khattab, Mai Mansour
Summary: This study developed resveratrol-loaded bilosomes as a promising drug delivery system for Alzheimer's disease, showing superiority over traditional drug suspensions in enhancing therapeutic effects in an AD animal model.
Review
Biochemistry & Molecular Biology
Marina S. Hernandes, Qian Xu, Kathy K. Griendling
Summary: In this review, recent findings on the role of NADPH oxidases in BBB disruption induced by ischemic stroke were highlighted, emphasizing the impact of ROS on the function of the blood-brain barrier in neurological disorders.
Article
Chemistry, Analytical
Yi Xu, Shuainan Li, Chenguang Wang, Xiaoming Xie, Xianqiang Mi
Summary: The blood-brain barrier (BBB) is crucial for maintaining CNS stability, and neuroinflammation can disrupt its function. MiR-146a is closely associated with neuroinflammation and its expression is significantly upregulated after LPS induction. Studying miR-146a expression in the BBB can provide insights into the mechanisms of neurological diseases.
ANALYTICAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Dehua Kong, Wenyu Hong, Miao Yu, Yanxia Li, YaXin Zheng, Xue Ying
Summary: A novel multifunctional targeting carrier was developed to enhance drug delivery across the blood-brain barrier and target brain tumor tissues. The study demonstrated that the multifunctional liposomes exhibited significant inhibitory effects on brain tumor cells and improved drug uptake and apoptosis. In vivo experiments showed that the liposomes prolonged the median survival time of tumor-bearing rats.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Xiangliang Zeng, Guohua He, Xirong Yang, Guoyao Xu, Yidan Tang, Hanwen Li, Bing Yu, Zhen Wang, Wei Xu, Kangping Song
Summary: Zebularine preserves BBB integrity, reduces inflammation, and improves neurological deficits in ischemic stroke. It mitigates endothelial hyper-permeability by activating the AMPK alpha pathway.
Article
Biotechnology & Applied Microbiology
Lina You, Haidong Jiang
Summary: Cabergoline shows promising anti-inflammatory properties in the treatment of sepsis by repairing the disrupted blood-brain barrier integrity and reversing neurological deficits and inflammatory responses.
Article
Biotechnology & Applied Microbiology
Yuehong Pu, Lei Zhao, Yao Xi, Yichun Xia, Yiming Qian
Summary: The study evaluated the therapeutic effects of Mirtazapine, a central presynaptic alpha 2 receptor antagonist, on LPS-induced blood-brain barrier disruption. The results showed that Mirtazapine could protect the blood-brain barrier from LPS-induced damage and reverse the inflammatory response.
Article
Biochemistry & Molecular Biology
Anna D. Grabowska, Mateusz Watroba, Joanna Witkowska, Agnieszka Mikulska, Nuno Sepulveda, Dariusz Szukiewicz
Summary: The blood-brain barrier (BBB) plays a crucial role in regulating the flow of substances between the blood and the central nervous system. Disruption of the BBB due to imbalanced blood glucose levels can lead to neuroinflammation and increase the risk of neurodegenerative diseases. Resveratrol (RSV), a natural compound with anti-diabetic, anti-inflammatory, and neuroprotective properties, activates SIRT1, a key regulator of metabolism. This study aimed to assess the response of astrocyte SIRT1 to neuroinflammation and RSV treatment in different glycemic backgrounds. The results showed that abnormal glycemic states had a worse prognosis for RSV therapy effectiveness compared to normoglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Jyothi Dhuguru, Ryan W. W. Dellinger, Marie E. E. Migaud
Summary: Dietary vitamin B3 components have been found to increase NAD(+) levels, which decline with age and disease. Supplementation with NAD(+) biosynthetic intermediates, such as NR and NMN, can effectively raise NAD(+) levels. In addition, inhibiting NAD(+)-consuming enzymes or activating biosynthetic pathways is also a viable approach to increase NAD(+) and NADH. However, the pharmacological significance of NAD(H) catabolites is often overlooked, despite some of these metabolites serving as biomarkers in physiological disorders.
Article
Immunology
Xin Wang, Jia-ying Yu, Yan Sun, Heng Wang, Hu Shan, Shubai Wang
Summary: Baicalin, a bioactive extract from Scutellaria Baicalensis Georgi, has anti-inflammatory and anti-oxidative functions, and its preventive protection can improve cell apoptosis and Fluorescein sodium infiltration in the brain tissue. Baicalin can also inhibit pro-inflammatory cytokines production, up-regulate Claudin-5 and ZO-1 protein expression, reduce ROS and MDA production, promote SOD production, and activate Nrf2-mediated antioxidant stress pathway to protect blood-brain barrier damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Applied
Jingyu Wang, Elif Erdem, John M. Woodley
Summary: Biocatalytic oxidation holds promise for the selective synthesis of active pharmaceutical intermediates. Bubbling air or oxygen is an effective method to enhance oxygen transfer, but it leads to enzyme deactivation. This study investigates the stability of NAD-(P)H oxidase (NOX) at different gas-liquid interfaces and provides insights for improving biocatalyst performance.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Immunology
Qixia Yang, Juanjuan Yu, Hao Qin, Long Liu, Chao Di, Qiang Zhuang, Hang Yin
Summary: Irbesartan has a protective effect on the BBB by reducing permeability and restoring Occludin expression. It can also suppress the expression of inflammatory mediators and improve LPS-induced depressive-like behavior. These protective effects are mediated through the NF-kappa B/MLC/MLCK signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Nazneen Pathan, Pravin Shende
Summary: P-Glycoprotein plays a vital role in the blood-brain barrier, protecting the central nervous system from infections and external toxic molecules. It is essential in various brain-related conditions but also poses a significant challenge in drug delivery across the blood-brain barrier.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemistry & Molecular Biology
Chenmala Karthika, Agnieszka Najda, Joanna Klepacka, Mehrukh Zehravi, Rokeya Akter, Muhammad Furqan Akhtar, Ammara Saleem, Majed Al-Shaeri, Banani Mondal, Ghulam Md Ashraf, Priti Tagde, Sarker Ramproshad, Zubair Ahmad, Farhat S. Khan, Md Habibur Rahman
Summary: This article focuses on the concept, barriers, and possible treatments for brain tumors, as well as the relationship between brain diseases and the blood-brain barrier, multi-drug resistance, and the use of nanomedicine. The advantages of resveratrol as an antioxidant in treating brain diseases are also explored.
