Article
Environmental Sciences
Wei Zhao, Ye Yuan, Burong Feng, Yue Sun, Huiwei Jiang, Wei Zhao, Yuyang Zheng, Lihui Zhao, Tingting Chen, Yan Bai, Pengzhou Hang, Yingfu Chen, Zhimin Du
Summary: In conclusion, Aloe-emodin (AE) was found to protect against AZT-induced cardiomyocyte toxicity by activating the p90rsk/p-bad/bcl-2 signaling pathway, thereby inhibiting cardiomyocyte apoptosis.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Oncology
Zahra Hosseini-khah, Mohammad Reza Babaei, Mohsen Tehrani, Magali Cucchiarini, Henning Madry, Abolghasem Ajami, Nasser Rakhshani, Alireza Rafiei, Behrooz Nikbin
Summary: SOX2 and Bcl-2 are significantly overexpressed in HCC patients, correlating with TNM staging and tumor grading. Patients with SOX2 overexpression have a lower 5-year overall survival rate. There is no significant association between Bcl-2 expression and survival rate.
Article
Oncology
Baoyong Zhou, Changhong Yang, Xiong Yan, Zhengrong Shi, Heng Xiao, Xufu Wei, Ning Jiang, Zhongjun Wu
Summary: LETM1 is highly expressed in hepatocellular carcinoma (HCC), and its inhibition can suppress proliferation and promote apoptosis and autophagy in liver cancer cell lines. Knockdown of LETM1 dissociates the Beclin-1/Bcl-2 complex through AMPK and Bcl-2 phosphorylation, suggesting LETM1 as a potential therapeutic target in HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rui-li Sun, Huan-huan Wang, Zi-chen Gui, Lai-biao Shuang-guo, Lai-biao Lin, Jia-xin Fan, Geng Xue-Zhang, Bin-yan Mao, Geng Liu, Wei-Zhen Liu, Rui-Zhu Yue, Ya-ling Yin, Qian-qian Wang, Peng Li
Summary: Vitamin B6 (VitB(6)) supplement can alleviate DOX-induced cardiotoxicity and improve cardiac function by reducing NHE1 expression, exerting antioxidative and antiapoptosis effects.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Oncology
Shuangfen Tao, Jianchun Gu, Qing Wang, Leizhen Zheng
Summary: miR-383 reduces the survival of Fluorouracil-treated gastric cancer cells by downregulating Bcl-2, which is associated with high malignancy and metastasis in gastric carcinoma specimens.
Article
Oncology
Kuan-Lin Kuo, Wei-Chou Lin, Shing-Hwa Liu, Fu-Shun Hsu, Yu Kuo, Shih-Ming Liao, Shao-Ping Yang, Zuo-He Wang, Chen-Hsun Hsu, Kuo-How Huang
Summary: The study showed that CDK7 expression was higher in UC tumors and that the CDK7 inhibitor THZ1 in combination with gemcitabine exhibited significant cytotoxicity and apoptosis in UC cells. Co-treatment with THZ1 potentiated gemcitabine-induced cytotoxicity and suppressed Bcl-2 expression, providing important data for targeting CDK7 or Bcl-2 in UC treatment and overcoming chemoresistance.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Chemistry, Medicinal
Tao Liang, Jia Li, Yi Zhou, Xuben Hou, Xinying Yang, Hao Fang
Summary: BPFP1 is a new tool for Bcl-2 protein quantification, carcinoma cell visualization, and cell sorting. It can fluorescently label carcinoma cells by binding to overexpressed Bcl-2 protein and distinguish carcinoma cells from normal tissue cells based on the different Bcl-2 protein expression levels.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Shuai Zhao, Yichi Zhang, Xiuqin Lu, Han Ding, Bing Han, Xiaoling Song, Huijie Miao, Xuya Cui, Shiyin Wei, Wangrui Liu, Shuxian Chen, Jian Wang
Summary: This study found that CDC20 is highly expressed in HCC and is involved in radio resistance of HCC cells by affecting P53 mutation Bcl-2/Bax signaling pathway, enhancing the sensitivity of HCC to radiation therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Su-Jung Choi, Chi-Hyun Ahn, Kyoung-Ok Hong, Ji-Hoon Kim, Seong-Doo Hong, Ji-Ae Shin, Sung-Dae Cho
Summary: The study demonstrated that the ethanol extract of Pseudolarix kaempferi could inhibit the growth of mucoepidermoid carcinoma (MEC) cells through induction of caspase-mediated apoptosis accompanied by mitochondrial membrane depolarization. The altered Mcl-1 expression and JNK/Bcl-2 phosphorylation induced by EEPK were shown to play a crucial role in promoting apoptosis in MEC cells, providing potential targets for future clinical trials in the therapy of MEC patients.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Anna Santarsiero, Ilaria Pappalardo, Gabriella Margherita Rosa, Isabella Pisano, Stefano Superchi, Paolo Convertini, Simona Todisco, Patrizia Scafato, Vittoria Infantino
Summary: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and a significant cause of cancer-related deaths. In this study, a newly synthesized chalcone ETTC showed cytotoxic activity and induced apoptosis in HCC cells through the activation of the intrinsic pathway of apoptosis and mitochondrial targeting. These findings suggest the potential antitumor effect of ETTC in HCC.
Review
Gastroenterology & Hepatology
Katherine A. McGlynn, Jessica L. Petrick, Hashem B. El-Serag
Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), is a major global health concern. While HBV and HCV remain important risk factors for HCC, efforts in vaccination and treatment are showing promise. However, the increasing prevalence of metabolic risk factors like obesity and diabetes, as well as other factors like excessive alcohol consumption, present ongoing challenges in the prevention of liver cancer.
Article
Pharmacology & Pharmacy
Hua Wu, Yuyuan Chen, Bin Li, Chun Li, Jun Guo, Jia You, Xian Hu, Dong Kuang, Shibo Qi, Pin Liu, Lei Li, Chuanrui Xu
Summary: This study found that both ROCK1 and ROCK2 are over-expressed in human HCC tissues and cell lines, and their knockdown inhibited HCC cell growth. Pharmacological inactivation of ROCK1/2 with Fasudil blocked the growth and survival of HCC cells by inducing mitotic catastrophe instead of apoptosis. Targeting ROCK1 or ROCK2 may serve as a potential approach for HCC treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Xueyan Hu, Xiaodong Hu, Qinghui Wang
Summary: Propofol promotes apoptosis in HepG2 and Huh-7 cells, with miR-134 expression level being related to propofol concentration. MiR-134 reduces luciferase activity of BCL-2-wt, but not BCL2-mut.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Maria Reig, Giuseppe Cabibbo
Summary: The potential impact of DAAs in BCLC-B/C stage patients with HCC is understudied, as HCC patients have been excluded from DAA trials. The decision on using DAAs should be made based on individual patient profiles.
JOURNAL OF HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Aurelie Beaufrere, Julien Calderaro, Valerie Paradis
Summary: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a tumor with both hepatocytic and biliary differentiation, whose diagnosis is primarily based on morphology and immunostaining, with a prognosis worse than hepatocellular carcinoma and treatment limited to surgery.
JOURNAL OF HEPATOLOGY
(2021)