Review
Chemistry, Multidisciplinary
Jing Liang, Xiaohui Qiao, Luping Qiu, Huning Xu, Huijing Xiang, Hong Ding, Yu Chen
Summary: This comprehensive review summarizes the immunological effects induced by different therapeutic ultrasound technologies, including ultrasound-mediated microbubble destruction (UTMD), sonodynamic therapy (SDT), and focused ultrasound (FUS), as well as the main underlying mechanisms involved. It also discusses the recent research progress of engineering intelligent nanoplatform for improving the antitumor efficiency of therapeutic ultrasound technologies, and presents the key issues and challenges currently faced in clinical translation as well as the prospects for future clinical translation of these emerging nanomaterials and ultrasonic immunotherapy.
Review
Materials Science, Multidisciplinary
Li-Han Liu, Xian-Zheng Zhang
Summary: The past decade has seen significant advances in the development of carrier-free nanomedicines, which are attractive due to their high biosafety, drug loading capacities, simple compositions, and simplified synthesis procedures. Extensive efforts have been made to expand the scope of carrier-free nanomedicines and improve their therapeutic performance through the exploration of new excipients, therapeutic agents, self-assembly methods, and mechanisms. This review summarizes the research progress and practical applications of carrier-free nanomedicines in cancer therapy.
PROGRESS IN MATERIALS SCIENCE
(2022)
Review
Engineering, Biomedical
Hui Huang, Zeyu Wang, Liang Chen, Hong Yu, Yu Chen
Summary: Catalytic therapy has shown promise in enhancing therapeutic efficacy and reducing side effects by converting less toxic or nontoxic endogenous substances into highly toxic reactive species to induce cell death. This review summarizes the recent advances in the development and use of catalytic biomaterials and nanomedicines in various biomedical applications. The study focuses on the use of endogenous activators and exogenous stimuli to improve treatment efficacy, and discusses the biosafety and biocompatibility of these materials. The challenges and future opportunities for catalytic biomaterials and nanomedicines are also highlighted.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Medicine, Research & Experimental
Qinghu Zeng, Xiangyi Ma, Yangmeihui Song, Qiqing Chen, Qiuling Jiao, Liqiang Zhou
Summary: Nanomedicines have great potential in anticancer therapy, but they are limited by self-protection mechanisms and treatment resistance of cancer cells. Recent studies have shown that regulating cell death can enhance the therapeutic efficiency of tumors. This article introduces various strategies of regulated cell death-mediated synergistic tumor nanotherapeutics and discusses the coordination mechanisms.
Review
Engineering, Environmental
Xinxin Sun, Xiaohong Yang, Yao Chen, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: Nanomedicines are reliable for cancer theranostics, but limited tumor penetration is a challenge for accurate diagnosis and treatment. In situ self-assembly relies on exogenous molecules to induce spontaneous self-assembly of drug molecules into nanostructures, facilitating effective enrichment of nanodrugs into deep tumors for precise imaging and therapy. This review highlights recent breakthroughs in in situ self-assembly and its applications in cancer treatment and biomedical nanotechnology, including in situ self-assembled nanosystems for precise tumor imaging and high-efficiency therapy, as well as in situ nanoassembly-based multimodal therapy. It also discusses the potential and obstacles of in situ self-assembled nanomedicines for anticancer theranostics.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Inorganic & Nuclear
Shuai Zhang, Shuo Zhang, Siyuan Luo, Daocheng Wu
Summary: ICP nanomedicines have advantages of high therapeutic agent loading content, flexible adjustment, perfect therapeutic effect, minimal side effects, easy synergy, and functional expansion. However, there is relatively little research on the theoretical and biological mechanisms, as well as synergistic tumor therapy, due to the involvement of multiple disciplines.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Engineering, Biomedical
Xuan Meng, Lin Wang, Ning Zhao, Delong Zhao, Yongli Shen, Yuan Yao, Wenjie Jing, Shuli Man, Yujie Dai, Yanjun Zhao
Summary: This study reports a hybrid nanocarrier that targets glycolysis and redox balance simultaneously for cancer therapy. The nanocarrier, composed of pH-and ATP-responsive ZIF-8 core and poloxamer 407 coating, delivers glucose oxidase and 3-bromopyruvate to liver hepatocellular carcinoma cells, effectively inhibiting cellular energy metabolism and reducing cell viability. This approach enriches the available strategies for anti-tumor treatment.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Meng Li, Yijing Zhang, Qin Zhang, Jingchao Li
Summary: Nanomedicines have shown promise in cancer therapy due to their increased safety and efficiency compared to small-molecule drugs. However, the dense extracellular matrix (ECM) in tumors often hinders the accumulation and diffusion of nanoparticles, reducing their anticancer efficacy. To overcome this, strategies such as degrading ECM components and inhibiting ECM formation have been employed to enhance the therapeutic effects of nanomedicines. By degrading ECM components or inhibiting ECM formation, the accumulation and diffusion of nanoparticles in tumors can be improved, leading to enhanced chemotherapy and phototherapy. Additionally, ECM degradation can enhance the infiltration of immune cells into tumor tissues, resulting in a stronger immune response against tumors.
MATERIALS TODAY BIO
(2022)
Review
Pharmacology & Pharmacy
Yanyan Xu, Jingyuan Xiong, Xiyang Sun, Huile Gao
Summary: Cancer immunotherapy has flourished and revolutionized tumor therapies, but challenges such as low patient response rates and immune-related side effects remain. The immunosuppressive tumor microenvironment (TME) plays a pivotal role in tumor progression and metastasis, but also provides targets for remodeling the TME. Remodeling the TME and strengthening patients' immune systems can improve the effectiveness of immunotherapy.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Engineering, Biomedical
Yijing Zhang, Jingchao Li, Kanyi Pu
Summary: Nanomedicines with stimuli-responsive capabilities have shown potential in cancer treatment. However, traditional nanomedicines often cause severe side effects due to unintended drug retention in non-diseased tissues. Dual-and multi-responsive nanomedicines, which integrate different responsive components, provide a safer and more effective drug release mechanism, leading to improved therapeutic efficacy and reduced toxicity. This article summarizes recent advances in precision cancer therapy using dual-and multi-responsive nanomedicines and discusses their design strategies, working mechanisms, and applications in chemotherapy, phototherapy, and immunotherapy.
Review
Chemistry, Multidisciplinary
Xiaotong Cheng, Hai-Dong Xu, Huan-Huan Ran, Gaolin Liang, Fu-Gen Wu
Summary: Overexpression of glutathione in cancer cells leads to resistance to anticancer therapies, making GSH depletion a potential target for cancer treatments. By combining with mainstream cancer therapies, GSH-depleting agents can enhance cancer cells responses to cell death stimuli.
Review
Nanoscience & Nanotechnology
Mengbin Ding, Yijing Zhang, Jingchao Li, Kanyi Pu
Summary: Bioenzyme-based nanomedicines have shown great potential in improving the efficacy of cancer therapies by modulating the tumor microenvironment and increasing the penetration and retention of nanoparticles in deep tumors. These nanomedicines can enhance chemotherapy, phototherapy, and immunotherapy for cancer treatment.
Article
Chemistry, Multidisciplinary
Tasneem A. Nasser, Rawan Adel, Abdelrahman Badr, Mohamed Teleb, Adnan A. Bekhit, Kadria A. Elkhodairy, Ahmed S. Abdelhamid, Ahmed O. Elzoghby
Summary: Cancer is a major cause of death worldwide, and delayed diagnosis leads to decreased survival rates. Immunotherapy has revolutionized the treatment of various cancers, but many patients do not respond and experience severe immune-related side effects. Recent advances in nanomedicine and imaging have provided new approaches to improving the safety and efficacy of immunotherapy. The field of theranostics, which integrates diagnosis and therapy, shows promising results in animal studies by using nanoparticles. This article discusses the latest developments in nanotheranostics for tumor imaging and cancer immunotherapy.
Review
Chemistry, Multidisciplinary
Shaopeng Zhang, Hao Zhang, Peizhe Song, Daguang Wang, Yinghui Wang
Summary: Colorectal cancer is a highly malignant gastrointestinal tumor, and traditional chemotherapy and radiotherapy have limited efficacy. Nanomedicine-based therapeutic strategies have shown promise in recent years. This review focuses on the latest advances in nanomedicines for colorectal cancer treatment, including stimuli-responsive drug delivery systems and emerging therapies such as photothermal therapy, magnetothermal therapy, photodynamic therapy, sonodynamic therapy, and chemodynamic therapy. The challenges and future directions for the development of nanomedicines for clinical colorectal cancer treatment are also discussed.
CHEMICAL COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Zhi-Shan Liu, Jing Wen, Chu-Yu Huang, Pei-Wen Zhang, Ying-Ling Miao, Hong Cheng, Shi-Ying Li
Summary: Nanotechnology has great potential in tumor therapy, but traditional nanomedicines are limited. This review focuses on the application of stimuli-responsive nanocarriers in improving drug delivery efficiency, reducing side effects, and enhancing targeting. Responsive nanocarriers can release and activate drugs at specific sites under different stimuli, and the review discusses various pathways and design strategies for responsive nanocarriers.
ADVANCED THERAPEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Xinyi Lv, Leichen Wang, Anqing Mei, Yan Xu, Xiaohong Ruan, Wenjun Wang, Jinjun Shao, Dongliang Yang, Xiaochen Dong
Summary: Bacterial biofilm-related infectious diseases have a severe impact on human health. The low permeability and enrichment of therapeutic agents within the biofilm pose a challenge for treatment. This article summarizes the current progress in nanotechnology methods to improve the penetrability of therapeutic agents and discusses the challenges and future implementations of engineered delivery systems to manage biofilm infections.
Article
Materials Science, Biomaterials
Lihui Yuwen, Huayu Xiao, Pei Lu, Xiaolong Chen, Jianguang Li, Weijun Xiu, Siyu Gan, Dongliang Yang, Lianhui Wang
Summary: This study developed a nanoagent with biofilm degradation capability for efficient treatment of bacterial biofilm infections. The nanoagent showed the ability to accumulate in infected tissues, degrade the biofilm, and efficiently eliminate the infection through photothermal therapy.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Yu Zhang, Qiang Li, Meng Ding, Weijun Xiu, Jingyang Shan, Lihui Yuwen, Dongliang Yang, Xuejiao Song, Guangwen Yang, Xiaodan Su, Yongbin Mou, Zhaogang Teng, Heng Dong
Summary: Ti3C2 MXene-based nanoplatforms (MXP) with high-efficiency near-infrared photothermal conversion and immunocompetent loading capacity are prepared to form endogenous/exogenous nanovaccines. This study provides a two-pronged strategy for improving immunogenicity and killing tumor cells to achieve a favorable outcome in tumor patients.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Engineering, Biomedical
Yanling Hu, Shengke Li, Heng Dong, Lixing Weng, Lihui Yuwen, Yannan Xie, Jun Yang, Jinjun Shao, Xuejiao Song, Dongliang Yang, Lianhui Wang
Summary: The application of medical implants has greatly improved patients' survival rate and life quality. However, there is an increasing number of cases of implant dysfunction or failure due to bacterial infections in recent years. Conventional antibiotics have low efficacy in treating implant-related infections, thus innovative treatment strategies are urgently needed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Junjie Zhang, Kaiyuan Tang, Runqi Fang, Jiaming Liu, Ming Liu, Jiayi Ma, Hui Wang, Meng Ding, Xiaoxiao Wang, Yanni Song, Dongliang Yang
Summary: Hypoxia is a negative prognostic indicator of solid tumors, affecting their survival, invasiveness, and response to treatments. In this review, recent nanotechnological strategies to alleviate tumor hypoxia are summarized, including improving the tumor microenvironment, delivering oxygen to hypoxic tumors, and generating oxygen within hypoxic tumors. The challenges and prospects of these strategies are discussed.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Qinglin Xu, Weijun Xiu, Qiang Li, Yu Zhang, Xiaoye Li, Meng Ding, Dongliang Yang, Yongbin Mou, Heng Dong
Summary: With the widespread prevalence of drug-resistant pathogens, traditional antibiotics have limited effectiveness and do not yield the desired outcomes. Recently, alternative antibacterial therapies based on ultrasound (US) have been explored to overcome the crisis of bacterial pathogens. Antimicrobial sonodynamic therapy (aSDT) offers an excellent solution that relies on US irradiation to produce reactive oxygen species (ROS) and achieve antibiotic -free mediated antimicrobial effects.
MATERIALS TODAY BIO
(2023)
Review
Chemistry, Multidisciplinary
Siyuan Yang, Yingnan Song, Heng Dong, Yanling Hu, Jingai Jiang, Siyuan Chang, Jinjun Shao, Dongliang Yang
Summary: Antibacterial theranostic nanoplatforms with diagnostic and therapeutic properties have promising applications in precision medicine. However, traditional platforms suffer from poor specificity or selectivity. To overcome this challenge, stimuli-actuated turn-on nanoplatforms have been developed for simultaneous activation of diagnostic signals and antibacterial treatment, achieving accurate diagnosis rates and effective treatment effects. This review introduces commonly used imaging and treatment strategies, summarizes recent progress in stimuli-actuated turn-on theranostic nanoplatforms for bacterial infectious diseases, and outlines current bottlenecks and future opportunities.
Article
Engineering, Biomedical
Xinyi Lv, Jingai Jiang, Jie Ren, Hui Li, Dongliang Yang, Xuejiao Song, Yanling Hu, Wenjun Wang, Xiaochen Dong
Summary: A phototherapeutic nanoagent that releases nitric oxide (NO) has been developed to overcome biofilm-associated infections. Under laser irradiation, the nanoagent releases NO, enhances biofilm permeability, and generates reactive oxygen species (ROS) to effectively eliminate biofilm infections. It also stimulates collagen deposition and promotes angiogenesis in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Materials Science, Biomaterials
Jingai Jiang, Xiao Li, Hui Li, Xinyi Lv, Yan Xu, Yanling Hu, Yanni Song, Jinjun Shao, Shengke Li, Dongliang Yang
Summary: The slow healing of diabetic wounds has negatively impacted human health, and open wounds are prone to bacterial infection. Clinical methods such as antibiotic therapy, insulin treatment, and surgical debridement have been successful in treating diabetic wounds, but long-term antibiotic use leads to drug-resistant bacteria and decreased efficacy. Developing novel therapeutic strategies is crucial in effectively promoting diabetic wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Shufan Duan, Yanling Hu, Ying Zhao, Kaiyuan Tang, Zhijing Zhang, Zilu Liu, Ying Wang, Haiyang Guo, Yuchen Miao, Hengda Du, Dongliang Yang, Shengke Li, Junjie Zhang
Summary: Cancer is a significant global public health issue, and finding more effective methods of treatment is a major challenge in modern medicine. Photothermal therapy, using materials that convert light into heat to eliminate tumors, has gained attention as a precise and low-toxicity alternative treatment. This review summarizes the applications of organic (cyanine-based, porphyrin-based, polymer-based) and inorganic (noble metal-based, carbon-based) photothermal conversion materials in tumor treatment, and discusses the challenges of using these materials for antitumor therapy. Nanomaterial-based photothermal therapy shows promising prospects for future tumor treatment.
Review
Materials Science, Biomaterials
Kaiyuan Tang, Xiao Li, Yanling Hu, Xiaonan Zhang, Nan Lu, Qiang Fang, Jinjun Shao, Shengke Li, Weijun Xiu, Yanni Song, Dongliang Yang, Junjie Zhang
Summary: Malignant tumors pose a serious threat to human health. Traditional chemotherapy has achieved breakthrough improvements, but it also has significant side effects such as drug resistance, immunosuppression, and systemic toxicity. Photothermal therapy (PTT), an emerging cancer therapy, uses light irradiation to convert optical energy into thermal energy and induce hyperthermic death of target cells. Prussian blue (PB) nanoparticles are among the most promising photothermal agents due to their excellent physicochemical properties. By constructing PB-based nanotherapeutics, enhanced photothermal performance, targeting ability, multimodal therapy, and imaging-guided cancer therapy can be effectively achieved. This review comprehensively summarizes the recent advances in PB-based photothermal combinatorial therapy and imaging-guided cancer therapy, and discusses potential obstacles for future research and clinical translation.
BIOMATERIALS SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Yanling Hu, Hui Li, Xinyi Lv, Yan Xu, Yannan Xie, Lihui Yuwen, Yingnan Song, Shengke Li, Jinjun Shao, Dongliang Yang
Summary: Diabetic wound infection is a common disease that poses challenges due to the diabetic wound environment and bacterial resistance. Nanobiomaterial-based therapeutic systems with stimuli-responsive performance can address these challenges by delivering therapeutic agents on demand.
Review
Chemistry, Multidisciplinary
Yanqing Su, Meng Ding, Heng Dong, Yanling Hu, Dongliang Yang, Jinjun Shao, Bin Huang
Summary: Bacterial infection poses a significant threat to global public health. The overuse and misuse of antibiotics have led to the emergence of antibiotic-resistant strains, exacerbated by the COVID-19 pandemic. Thus, there is an urgent need for alternative antibacterial treatments. Nanozymes, with their broad-spectrum antibacterial activity, low drug resistance, and high stability, have emerged as promising new antibacterial agents.
MATERIALS CHEMISTRY FRONTIERS
(2022)
