Review
Cell Biology
Sheng Gao, Yun Zhang, Meixia Zhang
Summary: This article summarizes the mechanisms of three types of regulated cell death (RCD) in diabetic retinopathy (DR) and analyzes the recent advances in the association between novel RCD forms and DR. These findings provide new insights into the underlying pathogenic mechanisms of DR and propose potential therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Jian Yang, Shasha Hu, Yangyang Bian, Jiangling Yao, Dong Wang, Xiaoqian Liu, Zhengdong Guo, Siyuan Zhang, Lei Peng
Summary: New research has shown that the development of osteoarthritis is influenced by different mechanisms of cell death and types of cytokines. Understanding the interaction between cytokines, cell death processes, and osteoarthritis is crucial for better understanding the pathogenesis and progression of the disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Qi Zhang, Xin-xing Wan, Xi-min Hu, Wen-juan Zhao, Xiao-xia Ban, Yan-xia Huang, Wei-tao Yan, Kun Xiong
Summary: Stem cell therapies show promising effects in restoring damaged tissue, but multiple types of programmed cell death post-transplantation can compromise their efficiency. Understanding and targeting cell death signaling pathways are crucial for successful stem cell therapies in treating diabetes and related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jinhao Chen, Mujie Ye, Jianan Bai, Chunhua Hu, Feiyu Lu, Danyang Gu, Ping Yu, Qiyun Tang
Summary: N6-methyladenosine (m6A) methylation is the most prevalent and abundant RNA modification in eukaryotes and has recently gained attention in research. Studies have shown that dysregulation of m6A modification is associated with the progression of various diseases, particularly cancer. Programmed cell death (PCD) is an active and orderly form of cell death, and there is growing evidence of the mutual regulation between m6A modification and PCD, which can affect cancer treatment sensitivity. This review summarizes recent advances in the interplay and potential mechanisms of m6A modification and PCD, as well as their relevance to cancer therapeutic resistance.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Immunology
Jianan Zhao, Kai Wei, Ping Jiang, Cen Chang, Lingxia Xu, Linshuai Xu, Yiming Shi, Shicheng Guo, Yu Xue, Dongyi He
Summary: Gout is a chronic inflammatory arthritis disease characterized by hyperuricemia and triggered by interactions among various factors. Recent studies have shown that multiple programmed cell death pathways are involved in the inflammatory response, contributing to the initiation of inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Youke Wang, Yali Wang, Jing Pan, Lu Gan, Jianxin Xue
Summary: This review summarizes the molecular mechanisms and recent research progress related to radiotherapy-induced ferroptosis, necroptosis, and pyroptosis in tumor cells, as well as discusses the role of tumor cells undergoing these types of cell death in immune activation after radiotherapy. It also highlights some unresolved questions on the association of radiotherapy with ferroptosis, necroptosis, and pyroptosis. This review can improve our current understanding of the relationship between radiotherapy and different cell death pathways and provide a theoretical framework to improve the therapeutic effect of tumor radiotherapy in the future.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Cell Biology
Chang Liu, Zecheng Jiang, Zhongjie Pan, Liang Yang
Summary: Atherosclerosis is a chronic inflammatory vascular disease, and macrophages play a significant role in its progression. Recent studies have highlighted the critical role of programmed cell death in macrophages in the development of vulnerable plaques in atherosclerosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Jianan Zhao, Ping Jiang, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis is a chronic inflammatory joint disease characterized by chronic synovial inflammation and degeneration of bones and joints. Despite the variety of treatment options available, some patients still have a poor prognosis due to the complex mechanism of the disease. Programmed cell death has been identified as one of the essential pathological mechanisms of RA, contributing to its development through dysregulation in various cell types.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Xuhui Tong, Rong Tang, Mingming Xiao, Jin Xu, Wei Wang, Bo Zhang, Jiang Liu, Xianjun Yu, Si Shi
Summary: This article discusses the molecular processes and effects of necroptosis, pyroptosis, ferroptosis, and cuproptosis on tumor cell proliferation and cancer metastasis, as well as the complex effects of these novel types of tumor cell death on the tumor microenvironment and regulated death of other cells in the microenvironment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Medicine, General & Internal
Linjing Gong, Dong Huang, Yujun Shi, Zong'an Liang, Hong Bu
Summary: Regulated cell death (RCD) pathways, including apoptosis, pyroptosis, necroptosis, and ferroptosis, are important for development and tissue homeostasis. Recent studies have identified crosstalk between these pathways, leading to the concept of PANoptosis. However, the roles of RCD pathways in cancer are still unclear and require further investigation.
CHINESE MEDICAL JOURNAL
(2023)
Review
Microbiology
Thomas J. Williams, Luis E. Gonzales-Huerta, Darius Armstrong-James
Summary: Fungal infections are a significant health concern with high mortality rates despite available antifungal treatments, prompting further research into fungal pathogenic mechanisms. Researchers discuss the induction of programmed cell death by microbes and how fungi manipulate these pathways.
Review
Immunology
Chunmei Zhang, Ning Liu
Summary: This review summarizes the recent advances in ferroptosis, necroptosis, and pyroptosis in the occurrence, development, and therapeutic potential of ovarian cancer (OC).
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Zhao Deng, Zhipeng Yang, Jian Peng
Summary: This review discusses the impact of bioactive peptides on inflammatory diseases and cancer through regulating programmed cell deaths, and explores their potential and pathways in treatment.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Multidisciplinary
Lu Wang, Yiqi Wu, Renqi Yao, Yun Li, Yurou Wei, Yuan Cao, Zicheng Zhang, Mengyao Wu, Hanyu Zhu, Yongming Yao, Hongjun Kang
Summary: Mesenchymal stem cells (MSCs) have been extensively studied for their immunomodulatory properties in inflammatory diseases. Recently, MSC-derived extracellular vesicles (MSC-EVs) have gained attention as a major pathway for intercellular communication. This review summarizes the potential influences of MSC-EVs on different types of programmed cell death and diseases, and discusses the therapeutic effects, current research progress, and challenges of clinical applications of MSC-EVs. Understanding the regulation of inflammation-associated programmed cell death by MSC-EVs is important for identifying molecular mechanisms and modulatory targets.
Review
Oncology
Manuel Scimeca, Valentina Rovella, Valeria Palumbo, Maria Paola Scioli, Rita Bonfiglio, Gerry Melino, Mauro Piacentini, Luigi Frati, Massimiliano Agostini, Eleonora Candi, Alessandro Mauriello
Summary: Cholangiocarcinoma is a highly aggressive cancer arising from the bile ducts. Recent studies have highlighted the importance of programmed cell death mechanisms in its development and progression. Targeting these cell death pathways may increase the susceptibility of cholangiocarcinoma cells to chemotherapy and immunotherapy. However, further research is necessary to fully understand the intricacies of programmed cell death in cholangiocarcinoma and potentially identify effective therapeutic strategies.