Aerosolized Pulmonary Delivery of mRNA Constructs Attenuates Severity of Escherichia coli Pneumonia in the Rat

Safe and effective aerosolization of in vitro transcribed mRNA to the respiratory tract epithelium of horses without a transfection agent

(2021) Rebecca M. Legere et al.   Scientific Reports

An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In Vivo

(2021) Md. Motiar Rahman et al.   Vaccines

The prognostic value of IL-8 for the death of severe or critical patients with COVID-19

(2021) Hui Li et al.   MEDICINE

The Limitless Future of RNA Therapeutics

(2021) Tulsi Ram Damase et al.   Frontiers in Bioengineering and Biotechnology

Non-Immunotherapy Application of LNP-mRNA: Maximizing Efficacy and Safety

(2021) Irena Vlatkovic   Biomedicines

An overview of rational design of mRNA-based therapeutics and vaccines

(2021) Kenneth K.W. To et al.   Expert Opinion on Drug Discovery

Calming the cytokine storm in COVID-19

(2021) Randy Q. Cron et al.   NATURE MEDICINE

Influence of IL-6 levels on patient survival in COVID-19

(2021) Nishkantha Arulkumaran et al.   JOURNAL OF CRITICAL CARE

Precise Targeting of miRNA Sites Restores CFTR Activity in CF Bronchial Epithelial Cells

(2020) Chiara De Santi et al.   MOLECULAR THERAPY

Aerosol Delivery of Synthetic mRNA to Vaginal Mucosa Leads to Durable Expression of Broadly Neutralizing Antibodies against HIV

(2020) Kevin E. Lindsay et al.   MOLECULAR THERAPY

RNA therapeutics on the rise

(2020) Feng Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Pathogenesis of COVID-19-induced ARDS: implications for an aging population

(2020) Manuel A. Torres Acosta et al.   EUROPEAN RESPIRATORY JOURNAL

Emerging pharmacological therapies for ARDS: COVID-19 and beyond

(2020) Shahd Horie et al.   INTENSIVE CARE MEDICINE

COVID ‐19 acute respiratory distress syndrome ( ARDS ): clinical features and differences from typical pre‐ COVID ‐19 ARDS

(2020) Peter G Gibson et al.   MEDICAL JOURNAL OF AUSTRALIA

Future Trends in Nebulized Therapies for Pulmonary Disease

(2020) Sean D. McCarthy et al.   Journal of Personalized Medicine

IL-6 and other biomarkers as predictors of severity in COVID-19

(2020) N Broman et al.   ANNALS OF MEDICINE

Aerosolized drug-loaded nanoparticles targeting migration inhibitory factors inhibit Pseudomonas aeruginosa-induced inflammation and biofilm formation

(2020) Mohammad Doroudian et al.   Nanomedicine

Is Viral Vector Gene Delivery More Effective Using Biomaterials?

(2020) Yi Wang et al.   Advanced Healthcare Materials

COVID-19-associated acute respiratory distress syndrome (CARDS): Current knowledge on pathophysiology and ICU treatment – A narrative review

(2020) Carmen A. Pfortmueller et al.   Best Practice & Research-Clinical Anaesthesiology

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

(2019) Asha Kumari Patel et al.   ADVANCED MATERIALS

Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases

(2019) Itishri Sahu et al.   MOLECULAR THERAPY

The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response

(2019) Lili Hu et al.   Redox Biology

Biopolymer-Based Nanoparticles for Cystic Fibrosis Lung Gene Therapy Studies

(2018) Elena Fernández Fernández et al.   Materials

Neutrophil-To-Lymphocyte Ratio: An Emerging Marker Predicting Prognosis in Elderly Adults with Community-Acquired Pneumonia

(2017) Emanuela Cataudella et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Safety Evaluation of Lipid Nanoparticle–Formulated Modified mRNA in the Sprague-Dawley Rat and Cynomolgus Monkey

(2017) Maja Sedic et al.   VETERINARY PATHOLOGY

Modified Vaccinia Virus Ankara Preferentially Targets Antigen Presenting Cells In Vitro, Ex Vivo and In Vivo

(2017) Arwen F. Altenburg et al.   Scientific Reports

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

(2016) Giacomo Bellani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aerosol-Mediated Delivery of AAV2/6-IκBα Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Rats

(2015) Ronan J. MacLoughlin et al.   HUMAN GENE THERAPY

Nebulisation of IVT mRNA Complexes for Intrapulmonary Administration

(2015) Sarah M. Johler et al.   PLoS One

Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat

(2015) J. Devaney et al.   THORAX

Pulmonary overexpression of inhibitor κBα decreases the severity of ventilator-induced lung injury in a rat model

(2014) M. Hayes et al.   BRITISH JOURNAL OF ANAESTHESIA

Early-Stage Development of Novel Cyclodextrin-siRNA Nanocomplexes Allows for Successful Postnebulization Transfection of Bronchial Epithelial Cells

(2014) A. Hibbitts et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Magnetic core-shell nanoparticles for drug delivery by nebulization

(2013) Navin Kumar Verma et al.   JOURNAL OF NANOBIOTECHNOLOGY

Extracellular Superoxide Dismutase in Macrophages Augments Bacterial Killing by Promoting Phagocytosis

(2011) Michelle L. Manni et al.   AMERICAN JOURNAL OF PATHOLOGY

Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury

(2011) Patrick Hassett et al.   INTENSIVE CARE MEDICINE

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Generation of liposome aerosols with the Aeroneb Pro and the AeroProbe nebulizers

(2010) Maria Manuela Gaspar et al.   JOURNAL OF LIPOSOME RESEARCH

Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM

(2010) H. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SOD3 Reduces Inflammatory Cell Migration by Regulating Adhesion Molecule and Cytokine Expression

(2009) Juha P. Laurila et al.   PLoS One