Endogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration
出版年份 2023 全文链接
标题
Endogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration
作者
关键词
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出版物
Nature Communications
Volume 14, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2023-02-21
DOI
10.1038/s41467-023-36649-z
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Antibody response to HML‐2 may be protective in Amyotrophic Lateral Sclerosis
- (2022) Marta Garcia‐Montojo et al. ANNALS OF NEUROLOGY
- Human Endogenous Retrovirus K Envelope in Spinal Fluid of Amyotrophic Lateral Sclerosis Is Toxic
- (2022) Joseph P. Steiner et al. ANNALS OF NEUROLOGY
- Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice
- (2021) Xuebing Ding et al. Acta Neuropathologica Communications
- Activation of endogenous retroviruses during brain development causes an inflammatory response
- (2021) Marie E Jönsson et al. EMBO JOURNAL
- Intercellular viral spread and intracellular transposition of Drosophila gypsy
- (2021) Richard M. Keegan et al. PLoS Genetics
- The role of retrotransposable elements in ageing and age-associated diseases
- (2021) Vera Gorbunova et al. NATURE
- TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity
- (2020) Giulia Romano et al. BMC BIOLOGY
- Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders
- (2020) Marie E. Jönsson et al. TRENDS IN GENETICS
- TAR DNA-Binding Protein 43 is Cleaved by the Protease 3C of Enterovirus A71
- (2020) Xiaoman Wo et al. VIROLOGICA SINICA
- The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
- (2020) Myungjin Jo et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations
- (2020) Anna Konopka et al. Molecular Neurodegeneration
- A connectome and analysis of the adult Drosophila central brain
- (2020) Louis K Scheffer et al. eLife
- TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage
- (2020) Marta Giannini et al. PLoS Genetics
- ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
- (2019) Joseph R. Klim et al. NATURE NEUROSCIENCE
- Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
- (2019) Joy Mitra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The proteostasis network and its decline in ageing
- (2019) Mark S. Hipp et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- L1 drives IFN in senescent cells and promotes age-associated inflammation
- (2019) Marco De Cecco et al. NATURE
- Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD
- (2019) Rodrigo Lopez-Gonzalez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons
- (2019) Elaine Y. Liu et al. Cell Reports
- Cellular labeling of endogenous retrovirus replication (CLEVR) reveals de novo insertions of the gypsy retrotransposable element in cell culture and in both neurons and glial cells of aging fruit flies
- (2019) Yung-Heng Chang et al. PLOS BIOLOGY
- The Gypsy Endogenous Retrovirus Drives Non-Cell-Autonomous Propagation in a Drosophila TDP-43 Model of Neurodegeneration
- (2019) Yung-Heng Chang et al. CURRENT BIOLOGY
- Proteostasis collapse is a driver of cell aging and death
- (2019) Mantu Santra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia
- (2019) Oliver H. Tam et al. Cell Reports
- The Retrotransposon storm and the dangers of a Collyer's genome
- (2018) Josh Dubnau CURRENT OPINION IN GENETICS & DEVELOPMENT
- RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition
- (2018) Maria Benitez‐Guijarro et al. EMBO JOURNAL
- Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies
- (2018) Wenyan Sun et al. NATURE NEUROSCIENCE
- Tau Activates Transposable Elements in Alzheimer’s Disease
- (2018) Caiwei Guo et al. Cell Reports
- Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
- (2018) Mathias Jucker et al. NATURE NEUROSCIENCE
- Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
- (2018) Sílvia Porta et al. Nature Communications
- The glia of the adult Drosophila nervous system
- (2017) Malte C. Kremer et al. GLIA
- Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients
- (2017) Mercedes Prudencio et al. HUMAN MOLECULAR GENETICS
- Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
- (2017) Lisa Krug et al. PLoS Genetics
- Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects
- (2017) Jer-Cherng Chang et al. PLoS One
- TDP-43 regulates endogenous retrovirus-K viral protein accumulation
- (2016) Mamneet Manghera et al. NEUROBIOLOGY OF DISEASE
- In vitro prion-like behaviour of TDP-43 in ALS
- (2016) Phillip Smethurst et al. NEUROBIOLOGY OF DISEASE
- PNAS Plus Significance Statements
- (2016) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span inDrosophila
- (2016) Jason G. Wood et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues
- (2016) Marco De Cecco et al. Aging-US
- Cytoplasmic translocation, aggregation and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis
- (2015) G Fung et al. CELL DEATH AND DIFFERENTIATION
- Spreading of pathology in neurodegenerative diseases: a focus on human studies
- (2015) Johannes Brettschneider et al. NATURE REVIEWS NEUROSCIENCE
- Biology and Genetics of Prions Causing Neurodegeneration
- (2013) Stanley B. Prusiner Annual Review of Genetics
- Activation of transposable elements during aging and neuronal decline in Drosophila
- (2013) Wanhe Li et al. NATURE NEUROSCIENCE
- Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
- (2013) Shuo-Chien Ling et al. NEURON
- RNA editing regulates transposon-mediated heterochromatic gene silencing
- (2013) Yiannis A. Savva et al. Nature Communications
- Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains
- (2013) Takashi Nonaka et al. Cell Reports
- Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1
- (2013) Ke Zhao et al. Cell Reports
- Transposable Elements in TDP-43-Mediated Neurodegenerative Disorders
- (2012) Wanhe Li et al. PLoS One
- The Seeds of Neurodegeneration: Prion-like Spreading in ALS
- (2011) Magdalini Polymenidou et al. CELL
- Retrotransposon activation contributes to fragile X premutation rCGG-mediated neurodegeneration
- (2011) H. Tan et al. HUMAN MOLECULAR GENETICS
- TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR
- (2011) Fabienne C. Fiesel et al. NUCLEIC ACIDS RESEARCH
- Retrotransposition is associated with genome instability during chronological aging
- (2011) P. H. Maxwell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis
- (2010) Renée Douville et al. ANNALS OF NEUROLOGY
- Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1
- (2010) Owen A. Brady et al. JOURNAL OF NEUROCHEMISTRY
- A Drosophila model for TDP-43 proteinopathy
- (2010) Y. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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