DRAVP: A Comprehensive Database of Antiviral Peptides and Proteins

Viruses with rapid replication and easy mutation can become resistant to antiviral drug treatment. With novel viral infections emerging, such as the recent COVID-19 pandemic, novel antiviral therapies are urgently needed. Antiviral proteins, such as interferon, have been used for treating chronic hepatitis C infections for decades. Natural-origin antimicrobial peptides, such as defensins, have also been identified as possessing antiviral activities, including direct antiviral effects and the ability to induce indirect immune responses to viruses. To promote the development of antiviral drugs, we constructed a data repository of antiviral peptides and proteins (DRAVP). The database provides general information, antiviral activity, structure information, physicochemical information, and literature information for peptides and proteins. Because most of the proteins and peptides lack experimentally determined structures, AlphaFold was used to predict each antiviral peptide's structure. A free website for users (http://dravp.cpu-bioinfor.org/, accessed on 30 August 2022) was constructed to facilitate data retrieval and sequence analysis. Additionally, all the data can be accessed from the web interface. The DRAVP database aims to be a useful resource for developing antiviral drugs.

Automated summary

Viruses can develop resistance to antiviral drug treatment due to their rapid replication and easy mutation. The emergence of novel viral infections, like COVID-19, highlights the urgent need for new antiviral therapies. This study focuses on antiviral proteins and peptides, such as interferon and defensins, and constructs a comprehensive database (DRAVP) to provide information on their structures, activities, and literature references. With a user-friendly website, researchers can easily access and analyze the data to support the development of antiviral drugs.