Review
Clinical Neurology
Richard Milne, Daniele Altomare, Federica Ribaldi, Jose Luis Molinuevo, Giovanni B. Frisoni, Carol Brayne
Summary: This paper explores how Brain Health Services can best adapt to the social, cultural, and economic context to provide fair and equitable access to risk reduction for dementia prevention. The challenges associated with engaging at-risk individuals and ensuring equitable access are discussed, along with proposals for meeting these challenges. Addressing these challenges will allow Brain Health Services to balance individualized high-risk and population-focused approaches for public health prevention, while also meeting ethical standards of justice and health equity.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Review
Clinical Neurology
Janice M. Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J. Mummery, Blossom C. M. Stephan, Daniele Altomare, Giovanni B. Frisoni, Federica Ribaldi, Jose Luis Molinuevo, Philip Scheltens, David J. Llewellyn
Summary: The article discusses the development of new Brain Health Services for dementia prevention, emphasizing risk analysis and personalized risk reduction interventions. It suggests selecting appropriate risk assessment tools based on age and risk level, while considering modifiable risk factors.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Joseph E. Gaugler, Soo Borson, Fayron Epps, Regina A. Shih, Lauren J. Parker, Lisa C. Mcguire
Summary: This Perspective article highlights the intersection between social determinants of health and Alzheimer's disease and related dementia caregiving. It discusses how public health can support ADRD family caregivers through various actions to enhance their health and well-being.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Coles M. Hoffmann, Roch A. Nianogo, Kristine Yaffe, Amy Rosenwohl-Mack, Anna Carrasco, Deborah E. Barnes
Summary: This study compared the modifiable risk factors of Alzheimer's disease and related dementias (ADRD) between the U.S. and California, and found variations in risk factors among different regions and population groups. The findings emphasize the importance of tailoring dementia risk reduction strategies based on regional, sex, and race/ethnicity factors.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Clinical Neurology
Alina Solomon, Ruth Stephen, Daniele Altomare, Emmanuel Carrera, Giovanni B. Frisoni, Jenni Kulmala, Jose Luis Molinuevo, Peter Nilsson, Tiia Ngandu, Federica Ribaldi, Bruno Vellas, Philip Scheltens, Miia Kivipelto
Summary: Despite the lack of established prevention strategies, there have been multidomain dementia prevention trials targeting various risk factors and disease mechanisms. This suggests the potential for precision risk reduction strategies through Brain Health Services, but more research is needed to determine the effectiveness and implementation of such interventions, especially in low- and middle-income countries.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Neurosciences
Jeroen Bruinsma, Irene Heger, Vasileios S. Loukas, Thomas Kassiotis, Georgia Karanasiou, Dimitrios I. Fotiadis, Sten Hanke, Rik Crutzen
Summary: This study explores the public's openness towards dementia risk reduction and willingness towards changing lifestyle behavior to reduce future dementia risk. The results indicate that many individuals have difficulty understanding the concept of dementia risk reduction and hold ambivalent attitudes towards behavior change. Support is needed for individuals who face barriers such as negative self-image, engaging in multiple unhealthy behaviors, and holding unrealistic perceptions about lifestyle change.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Medicine, General & Internal
Mathilde Barbier, Caroline Schulte, Anna Kornadt, Carine Federspiel, Jean-Paul Steinmetz, Claus Vogele
Summary: This scoping review aims to identify social marketing strategies used to promote health behavior and advance research in using these strategies to promote cognitive health. The study will use a five-stage methodological framework to analyze articles published in English since 2010, focusing on program design, implementation, outcomes, and evaluation related to health promotion and cognitive health. The results will be used to develop interventions and will be disseminated to key stakeholders in the field.
Review
Clinical Neurology
Leonie N. C. Visser, Carolina Minguillon, Gonzalo Sanchez-Benavides, Marc Abramowicz, Daniele Altomare, Karine Fauria, Giovanni B. Frisoni, Jean Georges, Federica Ribaldi, Philip Scheltens, Jetske van der Schaar, Marissa Zwan, Wiesje M. van der Flier, Jose Luis Molinuevo
Summary: As evidence suggests dementia incidence can be reduced through prevention programs targeting risk factors, a new generation of brain health services is envisioned to accelerate the implementation of such programs. Specifically, risk communication plays a crucial role in enabling individuals at risk to make informed decisions and take action to protect themselves. However, communication about dementia risk is complex and challenging, highlighting the need for further research to develop effective communication strategies.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Editorial Material
Neurosciences
Timothy Daly, Ignacio Mastroleo, Vincent Henry, Mathieu Bourdenx
Summary: Two potential approaches for modifying the progression of dementia are being tested: early targeting of AD neuropathology and multi-domain lifestyle interventions. The web of information model of clinical translation is applied to argue for simple treatment tests and separate building of treatments from public health policy.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Marco Canevelli, Alessandra Di Pucchio, Fabrizio Marzolini, Flavia Mayer, Marco Massari, Emanuela Salvi, Ilaria Palazzesi, Eleonora Lacorte, Ilaria Bacigalupo, Teresa Di Fiandra, Nicola Vanacore
Summary: This study provides insights into the administrative features, service quality, and inequalities in Centers for Cognitive Disorders and Dementias (CCDDs) in Italy. Results reveal that over half of the centers are open only once or twice weekly, with the majority of patients suffering from dementia or mild cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Minjee Kim, Mary J. Kwasny, Stacy C. Bailey, Julia Y. Benavente, Pauline Zheng, Morgan Bonham, Han Q. Luu, Patrick Cecil, Prophecy Agyare, Rachel O'Conor, Laura M. Curtis, Scott Hur, Fangyu Yeh, Rebecca M. Lovett, Andrea Russell, Yuan Luo, Phyllis C. Zee, Michael S. Wolf
Summary: The MidCog study aims to investigate midlife determinants of later life cognitive outcomes and will be linked to the existing LitCog study. The results will be disseminated through peer-reviewed journals and summaries provided to funders and patients.
Article
Geriatrics & Gerontology
Eddy Roccati, Jessica Marie Collins, Aidan David Bindoff, Jane Elizabeth Alty, Larissa Bartlett, Anna Elizabeth King, James Clement Vickers
Summary: This study examined the associations between modifiable dementia risk factors, cognition, and plasma phosphorylated p-tau 181. The results showed that lower education was associated with lower cognitive scores, but modifiable dementia risk factors were not associated with plasma p-tau 181. Nonmodifiable factors such as age, education, sex, and apolipoprotein E epsilon 4 displayed significant associations with cognition and plasma p-tau 181. This study contributes to the understanding of confounding factors in the interpretation of blood-based biomarkers for dementia.
NEUROBIOLOGY OF AGING
(2023)
Article
Health Care Sciences & Services
Jamie Bryant, Natasha Noble, Megan Freund, Jennifer Rumbel, Sandra Eades, Rob Sanson-Fisher, Michael Lowe, Justin Walsh, Leon Piterman, Susan Koch, Claudia Meyer, Elaine Todd
Summary: The study found that most participants perceived limited understanding of dementia in their communities. Key enablers to high quality dementia care included routine health assessments for diagnosis, community relationships for support, comprehensive care models, and tailored visual resources. Key barriers included denial and stigma, low priority perception of dementia, limited community awareness, lack of staff education, and gaps in service delivery.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Nursing
Angela Schnelli, Stefan Ott, Hanna Mayer, Adelheid Zeller
Summary: This study aimed to investigate the frequency of documented aggression towards health professionals in home care services by cognitively impaired individuals. Factors such as cognitive, communication, and mobility difficulties were found to be associated with aggressive incidents. Specific educational and training interventions for healthcare specialists assisting clients with cognitive impairments are indicated based on the study findings.
Article
Medicine, General & Internal
Kevin Lu, Xiaomo Xiong, Ashley Horras, Bin Jiang, Minghui Li
Summary: Financial barriers to healthcare have a negative impact on the health status, healthcare utilization, and costs among patients with cognitive impairment, resulting in worsened health, increased use of emergency department and hospital stays, and higher economic burden.
Article
Geriatrics & Gerontology
Robyn W. Birkeland, Hayley R. McCarron, Manka Nkimberg, Joseph E. Gaugler
Summary: The study found that memory clinics in Minnesota have differences in financial issues, staffing, and appointment logistics, but they all emphasize patient-centered care and align with national memory care recommendations. Common challenges such as maintaining financial stability and clinic efficiency have a significant impact on clinic functioning and survival.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Manka Nkimbeng, Nwakaego A. Nmezi, Zachary G. Baker, Janiece L. Taylor, Yvonne Commodore-Mensah, Tetyana P. Shippee, Sarah L. Szanton, Joseph E. Gaugler
Summary: This study conducted secondary data analyses of older African immigrants in the Baltimore-Washington area to describe and identify correlates of depressive symptoms. The findings revealed that a percentage of participants had depressive symptoms, with trouble falling asleep being the most prevalent symptom. Longitudinal designs may be necessary to further investigate depressive symptoms within this population.
CLINICAL GERONTOLOGIST
(2023)
Article
Gerontology
Eric Jutkowitz, Lauren L. Mitchell, Barbara H. Bardenheier, Joseph E. Gaugler
Summary: This study identified different subgroups of caregiving arrangements for people with dementia, including spouse-dominant care, children-dominant care, and shared care, with varying proportions of caregiving hours provided by spouses, children, other family/friends, and paid individuals.
JOURNAL OF AGING & SOCIAL POLICY
(2022)
Article
Geriatrics & Gerontology
Joseph E. Gaugler, Lauren L. Mitchell
Summary: This article examines the state of family involvement in residential long-term care (RLTC) and the impact of the COVID-19 pandemic on family involvement.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Editorial Material
Geriatrics & Gerontology
Sheryl Zimmerman, Matteo Cesari, Joseph E. Gaugler, Howard Gleckman, David C. Grabowski, Paul R. Katz, R. Tamara Konetzka, Katherine S. McGilton, Vincent Mor, Debra Saliba, Tetyana P. Shippee, Philip D. Sloane, Robyn Stone, Rachel M. Werner
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Editorial Material
Geriatrics & Gerontology
Sheryl Zimmerman, Barbara Resnick, Joseph Ouslander, Cari Levy, Joseph E. Gaugler, Philip D. Sloane, Vincent Mor
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Cari Levy, Sheryl Zimmerman, Vincent Mor, David Gifford, Sherry A. Greenberg, Juliet Holt Klinger, Cathy Lieblich, Sunny Linnebur, Angie McAllister, Arif Nazir, Douglas Pace, Robyn Stone, Barbara Resnick, Philip D. Sloane, Joseph Ouslander, Joseph E. Gaugler
Summary: Randomized controlled trials are considered rigorous research designs, but face challenges in real-world settings. Pragmatic trials are viewed as a design that overcomes these challenges. Long-term care researchers and providers need to consider stakeholder engagement, diversity and inclusion, organizational strain and readiness, and learning from adaptations in the implementation of pragmatic trial interventions.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Barbara Resnick, Sheryl Zimmerman, Joseph Gaugler, Joseph Ouslander, Kathleen Abrahamson, Nicole Brandt, Cathleen Colon-Emeric, Elizabeth Galik, Stefan Gravenstein, Lona Mody, Philip D. Sloane, Kathleen Unroe, Hilde Verbeek
Summary: This article introduces pragmatic trials as a research method to generate results applicable to real-world care. It discusses the challenges and solutions of conducting pragmatic trials in long-term care, focusing on three clinical areas and provides recommendations for future research in this field.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Gerontology
Zachary G. Baker, Manka Nkimbeng, Pearl Ed G. Cuevas, Ana R. Quinones, Harmeet Kaur Kang, Joseph E. Gaugler, Ladson Hinton, Laura N. Gitlin, Tetyana P. Shippee
Summary: Most research dollars for interventions targeting older adults are awarded to researchers in high-income countries, even though the majority of older adults reside in low- and middle-income countries. One approach to improve implementation of evidence-based innovations in these countries is to design interventions relevant to both high-income and LMICs. This study suggests that partnering with stakeholders in LMICs during the intervention design process can help facilitate implementation. Considerations and incentives for researchers, intervention designers, and funders are also discussed.
Article
Gerontology
Lauren J. Parker, Katherine A. Marx, Manka Nkimbeng, Elma Johnson, Sokha Koeuth, Joseph E. Gaugler, Laura N. Gitlin
Summary: This article discusses the cultural adaptation process of an Adult Day Service Plus intervention for Hispanic/Latino caregivers, highlighting the importance of understanding cultural nuances and care preferences in the development and implementation of evidence-based interventions.
Article
Geriatrics & Gerontology
Colleen M. Peterson, Robyn W. Birkeland, Katie W. Louwagie, Stephanie N. Ingvalson, Lauren L. Mitchell, Theresa L. Scott, Jacki Liddle, Nancy A. Pachana, Louise Gustafsson, Joseph E. Gaugler
Summary: The CarFreeMe(TM)-Dementia program was adapted for drivers in the United States, aiming to assist drivers living with dementia and their care partners in planning for or adjusting to driving retirement. The study found that the program was feasible, acceptable, and useful, providing education and support on driving retirement, lifestyle planning, stress management, and alternative transportation options. Further investigations of the program's efficacy in the United States and other cultural contexts are needed.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Gerontology
Eric Jutkowitz, Derek Lake, Peter Shewmaker, Joseph E. Gaugler
Summary: Increases in state minimum wage were not associated with changes in caregiving consumed by adults age 65+, regardless of whether they had dementia or were Medicaid beneficiaries.
JOURNAL OF APPLIED GERONTOLOGY
(2023)
Article
Health Care Sciences & Services
Noelle L. Fields, Ling Xu, Ishan C. Williams, Joseph E. Gaugler, Daisha J. Cipher, Jessica Cassidy, Gretchen Feinhals
Summary: Research shows that African American adults are disproportionately affected by Alzheimer's disease and related dementias (ADRD) and are underrepresented in research. To address the disparities in dementia care, a study evaluated the effectiveness of a culturally informed training program called Senior Companion Program/SCP Plus for African American ADRD family caregivers. The results demonstrated significant improvements in knowledge of ADRD, caregiving competence, and preparedness for caregiving. The SCP Plus training shows promise as a scalable and culturally relevant intervention for ADRD.
Editorial Material
Gerontology
Joseph E. Gaugler
Article
Health Care Sciences & Services
Hannah T. Neprash, John F. Mulcahy, Dori A. Cross, Joseph E. Gaugler, Ezra Golberstein, Ishani Ganguli
Summary: This study investigates variations in primary care visit length and the association between visit length and potentially inappropriate prescribing decisions. The findings suggest that shorter visit lengths are associated with a higher likelihood of inappropriate antibiotic prescribing and coprescribing of opioids and benzodiazepines. These results highlight the importance of improving visit scheduling and prescribing decisions in primary care.
