Article
Geriatrics & Gerontology
Yurun Cai, Suzanne G. Leveille, Ling Shi, Ping Chen, Tongjian You
Summary: The study found that chronic pain interference and pain distribution in older adults are associated with an increased risk of injurious falls, especially in women. Short-term moderate-to-severe pain also increases the risk of injurious falls in the subsequent month.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Yurun Cai, Suzanne G. Leveille, Jeffrey M. Hausdorff, Jonathan F. Bean, Brad Manor, Robert R. McLean, Tongjian You
Summary: This study found an association between chronic pain and slower foot reaction time in older adults, with pain severity and knee pain being linked to slower foot reaction time. Cognitive measures had little impact on this relationship, and it was only observed in participants with lower education levels. These findings suggest that chronic pain may increase fall risk in older adults by affecting foot reaction time.
Article
Geriatrics & Gerontology
Yurun Cai, Suzanne G. Leveille, Ling Shi, Ping Chen, Tongjian You
Summary: Chronic pain in older adults is associated with specific circumstances of falls, such as indoor falls in living or dining rooms, and falls due to health problems or feeling dizzy. However, fallers with moderate-to-severe pain are less likely to fall while going down stairs or due to a slip or trip.
Article
Geriatrics & Gerontology
Young-Sang Kim, Yao Yao, So-Won Lee, Nicola Veronese, Soo-Jin Ma, Yeon-Hee Park, Sang-Yhun Ju
Summary: This study analyzed panel data from Korean older adults and found that frailty was associated with a higher risk of falls. Social isolation and exhaustion were significantly associated with fall events, while weakness did not show a significant association. These findings suggest that interventions should focus on addressing social and psychological frailty in older adults.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Geriatrics & Gerontology
Andrea L. Rosso, Zachary A. Marcum, Xiaonan Zhu, Nicolaas Bohnen, Caterina Rosano
Summary: Anticholinergic medication use is associated with an increased risk of falls, while higher dopaminergic signaling may provide protection against this.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Orthopedics
Kazunari Ninomiya, Naonobu Takahira, Takashi Ikeda, Koji Suzuki, Ryoji Sato, Kazuo Hirakawa
Summary: This study evaluated the prevalence of locomotive syndrome (LS) in patients more than 10 years after total hip arthroplasty (THA) and found that LS is associated not only with motor diseases but also with cardiometabolic diseases.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Maxim Devine, Canchen Ma, Jing Tian, Benny Antony, Flavia Cicuttini, Graeme Jones, Feng Pan
Summary: The study found that Class 1 and/or Class 2 had a higher risk of incident fractures and falls risk score than Class 3, highlighting the need for targeted preventive strategies to reduce the risk of fractures and falls in pain population.
Article
Critical Care Medicine
Kevin Hamdard, Ian A. Harris, Pooria Sarrami, Chen-Chun Shu, Julie Brown, Hardeep Singh, Jean-Frederic Levesque, Michael Dinh
Summary: Fall from ladders is a significant cause of injury and mortality, and research into ladder fall outcomes and trends is limited. This study found that increasing age and fall height are associated with more severe injuries and higher mortality rates.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Geriatrics & Gerontology
Olivier Beauchet, Jacqueline Matskiv, Yves Rolland, Anne-Marie Schott, Gilles Allali
Summary: This study examines the association between ER2 risk levels and falls, their recurrence, and post-fall fractures in older community women. The results suggest that ER2 low and high risk levels are associated with incident fall outcomes.
Article
Endocrinology & Metabolism
Nicholas C. Harvey, Eric Orwoll, Timothy Kwok, Magnus K. Karlsson, Bjorn E. Rosengren, Eva Ribom, Jane A. Cauley, Peggy M. Cawthon, Kristine Ensrud, Enwu Liu, Alfonso J. Cruz-Jentoft, Roger A. Fielding, Cyrus Cooper, John A. Kanis, Mattias Lorentzon, Claes Ohlsson, Dan Mellstrom, Helena Johansson, Eugene McCloskey
Summary: Adjustment for femoral neck bone mineral density (fnBMD) reduces the predictive value for fracture of sarcopenia definitions based on appendicular lean mass (ALM), but inclusion of physical performance measures strengthens it. Severe sarcopenia definitions incorporating chair stand time, gait speed, and grip strength demonstrate the highest predictability for fracture, even at low prevalence levels.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Tobia V. Zanotto, Laura V. Rice, Jacob V. Sosnoff
Summary: This study investigated the prevalence of frailty in individuals with severe disability due to multiple sclerosis (MS) and found that frailty was present in this population. The frailty index was identified as a valuable tool in evaluating fall risk in wheelchair users with MS.
Article
Medicine, General & Internal
Takafumi Saito, Tao Chen, Harukaze Yatsugi, Tianshu Chu, Xin Liu, Hiro Kishimoto
Summary: The number of chronic pain sites is positively associated with the presence and severity of neuropathic-like symptoms in older Japanese adults with chronic pain.
Article
Geriatrics & Gerontology
Yurun Cai, Jeffrey M. Hausdorff, Jonathan F. Bean, Brad Manor, Tongjian You, Suzanne G. Leveille
Summary: Participation in cognitive activities is associated with better neuromotor performance and mobility in older adults, potentially reducing the risk of falls. Prospective and intervention studies are needed to further investigate the effects of cognitive activities on preventing mobility decline over time.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Matthew C. Lohman, Amanda J. Fairchild, Anwar T. Merchant
Summary: Antidepressant medication plays a significant mediating role in the association between depression and fall risk in older adults, explaining approximately 19% and 18% of the association with falls and fall injuries, respectively. The study found that individuals with major depressive disorder were more likely to experience a fall and a fall injury.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Rehabilitation
Giovana A. Aoyagi, Rafael Z. Pinto, Italo R. Lemes, Carlos M. Pastre, Bianca Y. Eto, Maira S. Faria, Priscila K. Morelhao, Marcia R. Franco
Summary: This study investigated the relationship between FOF and self-reported physical activity levels among older adults. The results showed that FOF did not predict self-reported physical activity levels in community-dwelling older adults. These findings question the role of FOF in influencing self-reported physical activity levels among older adults living in the community.
Article
Geriatrics & Gerontology
Mary E. Winger, Paolo Caserotti, Jane A. Cauley, Robert M. Boudreau, Sara R. Piva, Peggy M. Cawthon, Eric S. Orwoll, Kristine E. Ensrud, Deborah M. Kado, Elsa S. Strotmeyer
Summary: This study investigated the application of lower-extremity power and upper-extremity strength in fall injuries and found that lower leg power and grip strength predicted future fall injury risk in older men, independent of physical performance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Lisa Langsetmo, John T. Schousboe, Brent C. Taylor, Jane A. Cauley, Howard A. Fink, Peggy M. Cawthon, Marcia L. Stefanick, Deborah M. Kado, Allyson M. Kats, Kristine E. Ensrud
Summary: This study evaluated the risks of clinical fracture, hip fracture, and mortality prior to fracture among men aged at least 80 years. The results showed that fall history, hip bone mineral density, and recent fracture were strong predictors of clinical fracture and hip fracture. Age and multimorbidity were strong predictors of mortality before fracture. The study results have important implications for guiding osteoporosis drug treatment decisions.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Alexandra Cours, Mei-Hua Huang, Howard Fink, Kristine E. Ensrud, John T. Schousboe, Wendy Katzman, Diane Schneider, Nancy E. Lane, Peggy Cawthon, Deborah M. Kado
Summary: This study found that increasing blocks-measured kyphosis is associated with a higher risk of mortality in older men, indicating that hyperkyphosis should be considered as a clinically significant problem.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Terri L. Blackwell, Mariana G. Figueiro, Gregory J. Tranah, Jamie M. Zeitzer, Kristine Yaffe, Sonia Ancoli-Israel, Deborah M. Kado, Kristine E. Ensrud, Nancy E. Lane, Yue Leng, Katie L. Stone
Summary: This study found that older men with worse alignment of activity and light had lower levels of cognition and increased rates of cognitive decline. However, there was no association between phasor angle and cognition. Interventions that improve the alignment of light and activity may help slow cognitive decline in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Letter
Cardiac & Cardiovascular Systems
Charles Ginsberg, Andrew N. Hoofnagle, Ronit Katz, Jonathan H. Cheng, Simon Hsu, Matthew J. Budoff, Deborah M. Kado, Bryan Kestenbaum, David S. Siscovick, Erin D. Michos, Joachim H. Ix, Ian H. de Boer
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Margaret P. Seaton, Jeanne F. Nichols, Mitchell J. Rauh, Deborah M. Kado, Julie Loebach Wetherell, Eric J. Lenze, David Wing
Summary: This study examined the associations between total body and trunk lean mass, maximal muscular strength, gait speed, and trabecular bone score (TBS) in 141 older adults. The results showed that upper body strength significantly predicted TBS, while total body lean mass index showed a trend in the expected direction.
JOURNAL OF CLINICAL DENSITOMETRY
(2023)
Article
Endocrinology & Metabolism
Charles Ginsberg, Terri Blackwell, Jonathan H. Cheng, O. Alison Potok, Jane A. Cauley, Kristine E. Ensrud, Simon Hsu, Deborah M. Kado, Eric Orwoll, Peggy M. Cawthon, Joachim H. Ix
Summary: This study evaluated the impact of the ratio of 24,25-dihydroxyvitamin D3 to 25(OH)D3 (VMR) and 25(OH)D3 on vBMD and bone strength in the distal radius and tibia of older men. The results showed that higher VMR was associated with higher vBMD and bone strength, while 25(OH)D3 had no impact on these outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Lauren S. Roe, Stephanie Harrison, Peggy M. Cawthon, Kristine Ensrud, Kelley Pettee Gabriel, Deborah M. Kado, Jane A. Cauley
Summary: In addition to the volume of physical activity, frequent breaks from sedentary behavior and active bouts can reduce the risk of falls and fractures. A study found that there is a long-term relationship between the frequency of breaks from sedentary behavior and the occurrence of recurrent falls and fractures. The study also concluded that breaking up extended periods of sedentary time can reduce fall risk, regardless of the total sedentary time.
Article
Endocrinology & Metabolism
Lisa T. Langsetmo, John C. Schousboe, Brent A. Taylor, Jane A. Cauley, Howard M. Fink, Peggy M. Cawthon, Deborah E. Kado, Kristine Ensrud
Summary: Targeted fracture prevention strategies among late-life adults should consider both fracture risk and competing mortality risk. A machine learning method was used to evaluate risk factors and create models for hip fractures and competing mortality among adults aged 80 years and older. Random forest models were compared to Fine-Gray models with six variables. Top variables for predicting hip fractures were bone mineral density, while frailty was associated with competing mortality. Random forest models performed slightly better than Fine-Gray models for predicting mortality, but similarly for predicting hip fractures.
Meeting Abstract
Endocrinology & Metabolism
Kristine Ensrud, John Schousboe, Howard Fink, William Leslie, Brent Taylor, Peggy Cawthon, Deborah Kado, Nancy Lane, Carolyn Crandall, Jane Cauley, Lisa Langsetmo
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
Tiffany Kim, Trisha Hue, Susan Ewing, Xiaojuan Li, Sigurour Sigurosson, Vilmundur Guonason, Annegreet Velduis-Vlug, Deborah Kado, Eric Vittinghoff, Karin Wu, Eileen Koh, Clifford Rosen, Mone Zaidi, Ann Schwartz, Anne Schafer
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
Lisa Langsetmo, John T. Schousboe, Brent C. Taylor, Jane A. Cauley, Howard A. Fink, Peggy M. Cawthon, Marcia L. Stefanick, Deborah M. Kado, Kristine E. Ensrud
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
John Schousboe, Lisa Langsetmo, Howard Fink, Deborah Kado, Jane Cauley, Brent Taylor, Kristine Ensrud
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Meeting Abstract
Urology & Nephrology
Julia H. Yuan, Dena E. Rifkin, Charles Ginsberg, Peggy Cawthon, Deborah M. Kado, Scott R. Bauer, Kristine Ensrud, Andrew Hoffman, O. Alison Potok
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Rheumatology
Karen Y. Cheng, Elsa S. Strotmeyer, Deborah M. Kado, John T. Schousboe, Simon Schenk, Michael Nevitt, Nancy E. Lane, Jan M. Hughes-Austin
Summary: Metabolic syndrome (MetS) was associated with hip osteoarthritis (OA) in women, while obesity was associated with hip OA in men. These findings suggest different mechanisms of hip OA development in men and women.
ACR OPEN RHEUMATOLOGY
(2023)