Article
Public, Environmental & Occupational Health
Erik De Clercq, Yike Jiang, Guangdi Li
Summary: Therapeutic and vaccine development for human poxvirus infections have been neglected since the eradication of smallpox in 1980. However, a recent outbreak of monkeypox has highlighted the urgent need for effective antiviral agents and vaccines. This review discusses potential therapeutic options and strategies for managing human poxvirus infections worldwide, including tecovirimat, brincidofovir, cidofovir, vaccines, and intravenous vaccinia immune globulin.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Obstetrics & Gynecology
Mar Ramirez, Vanesa Delso, Maria J. Sanchez, Inigo Sagastagoitia, Sara Vargas, Alejandro Garcia, Pluvio J. Coronado
Summary: This article presents a case of monkeypox virus infection in a 28-year-old woman, where the only clinical manifestation was lesions in the cervix and vulva, which disappeared spontaneously after 2 weeks. Therefore, gynecologists should be aware that monkeypox virus infection can involve the cervix.
OBSTETRICS AND GYNECOLOGY
(2023)
Review
Immunology
Shiza Malik, Amna Ahmed, Omar Ahsan, Khalid Muhammad, Yasir Waheed
Summary: This review provides comprehensive insights into various aspects of monkeypox disease, including its nature, epidemiology, etiology, and biological characteristics. It also highlights host interaction, viral infectious cycle, immune responses, and clinical developments in therapeutics against monkeypox. This study will aid scientists in understanding the disease and help clinicians in diagnosis, treatment, and prevention.
Article
Multidisciplinary Sciences
Severino Jefferson Ribeiro da Silva, Alain Kohl, Lindomar Pena, Keith Pardee
Summary: The emergence and rapid spread of the monkeypox virus (MPXV) has brought global attention to this previously obscure pathogen.The challenges in diagnosing patients based on clinical signs and symptoms, due to the similarity of skin lesions and atypical manifestations, highlight the critical role of laboratory-based diagnosis. This review discusses the clinical features of mpox patients, available laboratory tests for diagnosis, and the potential of diagnostic platforms in guiding clinical response.
Review
Virology
Durre Aden, Sufian Zaheer, Rohit Kumar, Sunil Ranga
Summary: Monkeypox infection, caused by the Orthopoxvirus genus, is similar to smallpox. The recent outbreak in May 2022 led the World Health Organization (WHO) to declare it a public health emergency. Monkeypox has been reported primarily in central and west African countries, with cases outside Africa linked to international travel or imported animals. With declining smallpox vaccine-induced immunity, the global population is at risk. The current transmission is suspected to be primarily through sexual activity, affecting mainly gay or bisexual men, and there is a need to further study its epidemiology and potential behavior change to a sexually transmitted infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ao Shi, Joe El Haddad, Peng Cai, Shijie Song, Yuan Jia Wang, Qi Liu, Pengyang Li
Summary: This study analyzed the content, information quality, and audience engagement of mpox-related videos on TikTok. The findings revealed that many of these videos provide incomplete and inaccurate information, highlighting the potential risks of using TikTok as a source of health information.
Article
Sport Sciences
James M. Smoliga
Summary: Monkeypox virus infections in humans have been increasing since its discovery in 1970, with emphasis on sexual contact transmission and the role of the men who have sex with men community. However, the potential transmission through contact sports has been largely overlooked. This article aims to provide a brief review of infectious skin diseases in athletes, an overview of monkeypox, and recommendations to reduce its transmission in sports settings.
Review
Virology
Yuan Zong, Koju Kamoi, Jing Zhang, Mingming Yang, Kyoko Ohno-Matsui
Summary: Currently, the world is on the brink of an mpox outbreak, which has been declared a 'public health emergency of international concern' by the World Health Organization. Research has shown that mpox is associated with various ocular manifestations. Given the severity of the current mpox outbreak, it is crucial for healthcare providers, especially ophthalmologists, to be knowledgeable about these ocular symptoms and their management.
Review
Biology
Mitesh Patel, Mohd Adnan, Abdu Aldarhami, Abdulrahman S. Bazaid, Nizar H. Saeedi, Almohanad A. Alkayyal, Fayez M. Saleh, Ibrahim B. Awadh, Amir Saeed, Khalid Alshaghdali
Summary: Monkeypox (Mpox), a viral infection, has become a serious global health threat as it spreads beyond its endemic area in Africa to countries like UK, USA, and Australia. This review provides updated information on the epidemiology, clinical features, diagnosis, prevention, and treatment of Mpox, highlighting the challenges in diagnosis and the need for comprehensive measures to combat this emerging disease.
Article
Immunology
Yuanyi Chen, Yuwei Li, Leiwen Fu, Xinyi Zhou, Xinsheng Wu, Bingyi Wang, Xin Peng, Yinghui Sun, Qi Liu, Yi-Fan Lin, Yinguang Fan, Hongbo Jiang, Xiaojun Meng, Huachun Zou
Summary: This study aimed to assess mpox knowledge and attitude towards mpox vaccination among male sex workers (MSW) in China. Results showed that 49.4% of the MSWs had good knowledge of mpox and 63.0% were willing to be vaccinated against it. Factors associated with good knowledge included being single, being unemployed, and willingness to be vaccinated. Age, history of chronic diseases, and agreement with prioritizing high-risk groups for vaccination were related to willingness to get vaccinated.
Review
Virology
Nilanjan Ghosh, Leena Chacko, Jayalakshmi Vallamkondu, Tanmoy Banerjee, Chandrima Sarkar, Birbal Singh, Rajkumar Singh Kalra, Jasvinder Singh Bhatti, Ramesh Kandimalla, Saikat Dewanjee
Summary: An outbreak of monkeypox, caused by a double-stranded DNA virus, has become a global public health emergency. This report summarizes new knowledge on the epidemiology, pathology, and prevention strategies of monkeypox, including diagnosis, clinical management, vaccines, and antiviral drugs. The re-emergence of monkeypox highlights the need to reassess current clinical strategies and therapeutics.
Review
Immunology
Shiza Malik, Tahir Ahmad, Omar Ahsan, Khalid Muhammad, Yasir Waheed
Summary: This article aims to trace recent developments in the scientific field that have defined new preventive and treatment strategies against monkeypox. A methodological approach has been used to gather data from the latest literature to provide a comprehensive overview of emerging treatment options. The results section will cover details on the prevention of monkeypox and provide a brief description of contemporary vaccines and antiviral agents that have shown potential in treating the disease. These treatment options are crucial in controlling the widespread monkeypox infection and preventing it from becoming another pandemic in this decade.
Review
Immunology
Mohamed Lounis, Abanoub Riad
Summary: In May 2022, human monkeypox (MPOX), a new zoonotic viral disease, emerged in multiple non-endemic countries. This literature review examined studies on MPOX-related knowledge, awareness, and vaccination attitudes. The results indicated inadequate levels of knowledge and awareness among certain groups. Vaccine hesitancy was common among healthcare professionals, except for Chinese healthcare professionals, with a vaccine acceptance rate of 90.1%. This review provides insights into the initial months of MPOX emergence and the evolution of knowledge, awareness, and vaccine hesitancy.
Article
Virology
Margaret G. Mills, Kate B. Juergens, Jolene P. Gov, Carter J. McCormick, Reigran Sampoleo, Alisa Kachikis, John K. Amory, Ferric C. Fang, Ailyn C. Perez-Osorio, Nicole A. P. Lieberman, Alexander L. Greninger
Summary: This study validated three clinically proven qPCR assays that can reliably detect monkeypox virus without cross-reactivity with other viruses. These assays performed well in different types of specimens.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Review
Virology
Ola Khallafallah, Charles Grose
Summary: In West and Central Africa, monkeypox primarily affects older children, adolescents, and young adults. Coinfections of chickenpox and monkeypox have been observed, suggesting that chickenpox may be a risk factor for acquiring monkeypox. The hypothesis is that the skin lesions from chickenpox provide an entry site for the monkeypox virus, which is present in the patient's environment. Additionally, prior chickenpox infection moderates the severity of the secondary monkeypox infection.
