Article
Biochemistry & Molecular Biology
Zhuofan Li, Ki-Hye Kim, Noopur Bhatnagar, Bo Ryoung Park, Subbiah Jeeva, Yu-Jin Jung, Jannatul Raha, Sang-Moo Kang, Xinyuan Chen
Summary: This study presents a physical radiofrequency adjuvant (RFA) that can conveniently and effectively enhance the immunogenicity and efficacy of H5N1 vaccine. The RFA treatment on the skin induces thermal stress to enhance immune responses and does not cause significant adverse reactions. The RFA significantly increases antibody titers, reduces viral titers, body weight loss, and improves survival rates in murine models. It has no gender difference in its effects.
Article
Immunology
Lilin Lai, Nadine Rouphael, Yongxian Xu, Sarah Kabbani, Allison Beck, Amy Sherman, Evan J. Anderson, Abbie Bellamy, Julia Weiss, Kaitlyn Cross, Mark J. Mulligan
Summary: This study found that the use of MF59 adjuvant in A/H7N9 influenza vaccine enhances the immune response compared to the unadjuvanted vaccine. The activation of cTFH cells is associated with hemagglutination inhibition and neutralizing antibody responses, suggesting that cTFH can be used as an early biomarker for the serological response to vaccination.
Article
Virology
Thomas R. R. Henson, Katherine A. A. Richards, Siva K. K. Gandhapudi, Jerold G. G. Woodward, Andrea J. J. Sant
Summary: New approaches are needed to promote broadly protective immunity to viral pathogens that are prone to mutation and escape from antibody-mediated immunity. T cells, particularly CD8 T cells targeting highly conserved peptide epitopes, can contribute greatly to protective immunity but are often poorly recruited by current vaccine strategies. Research on a pure enantio-specific cationic lipid R-DOTAP has shown its potential as an immune stimulant for next-generation prophylactic recombinant protein-based vaccines.
Article
Immunology
Athena P. Y. Li, Carolyn A. Cohen, Nancy H. L. Leung, Vicky J. Fang, Shivaprakash Gangappa, Suryaprakash Sambhara, Min Z. Levine, A. Danielle Iuliano, Ranawaka A. P. M. Perera, Dennis K. M. Ip, J. S. Malik Peiris, Mark G. Thompson, Benjamin J. Cowling, Sophie A. Valkenburg
Summary: The study indicates that using vaccines with higher antigen content or adjuvants can enhance the efficacy of standard-dose seasonal influenza vaccines in older adults. Enhanced vaccines showed better induction of specific antibodies and cellular responses compared to standard-dose vaccines, especially in enhancing cellular cytotoxicity and T cell responses.
Article
Oncology
Minglu Xiao, Luoyingzi Xie, Guoshuai Cao, Shun Lei, Pengcheng Wang, Zhengping Wei, Yuan Luo, Jingyi Fang, Xingxing Yang, Qizhao Huang, Lifan Xu, Junyi Guo, Shuqiong Wen, Zhiming Wang, Qing Wu, Jianfang Tang, Lisha Wang, Xiangyu Chen, Cheng Chen, Yanyan Zhang, Wei Yao, Jianqiang Ye, Ran He, Jun Huang, Lilin Ye
Summary: The study demonstrates that heterologous prime-boost vaccination can effectively inhibit tumor growth and enhance the expansion, effector function, and clonal breadth of tumor-specific CD8(+) T cells. Additionally, this vaccination strategy also enhances the antitumor effects of PD-1/PD-L1 immunotherapy, while preventing the re-exhaustion of tumor-specific CD8(+) T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Priyadharshini Devarajan, Allen M. Vong, Catherine H. Castonguay, Olivia Kugler-Umana, Bianca L. Bautista, Michael C. Jones, Karen A. Kelly, Jingya Xia, Susan L. Swain
Summary: This study investigates the mechanisms that drive the T follicular helper cell (T-FH) response during influenza infection. The results suggest that infection and antigen presentation at the effector phase are essential for the differentiation of CD4 effectors into T-FH and GC-T-FH. Additionally, concurrent signals from infection are necessary for T-FH development. Providing these signals with a second dose of live attenuated influenza vaccine at the effector phase can drive T-FH development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Luis Romero-Martin, Ferran Tarres-Freixas, Nuria Pedreno-Lopez, Maria L. Rodriguez de la Concepcion, Francesc Cunyat, Dennis Hartigan-O'Connor, Jorge Carrillo, Beatriz Mothe, Julia Blanco, Marta Ruiz-Riol, Christian Brander, Alex Olvera
Summary: T cell responses, particularly CD8(+) T cell responses, play a critical role in controlling HIV infection. CD8(+) T cell responses are associated with antibody isotype class switching and antibody-dependent cell cytotoxicity, which contribute to effective virus control in HIV controllers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Mikel J. Ruterbusch, Brian D. Hondowicz, Kennidy K. Takehara, Kurt B. Pruner, Thomas S. Griffith, Marion Pepper
Summary: CD4(+) lung-resident memory T cells generated in response to influenza infection can be altered by subsequent exposure to allergens, leading to changes in their function and impact on disease outcomes upon reinfection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Microbiology
Helena Strand Clemmensen, Jean-Yves Dube, Fiona McIntosh, Ida Rosenkrands, Gregers Jungersen, Claus Aagaard, Peter Andersen, Marcel A. Behr, Rasmus Mortensen
Summary: The study indicates that constitutively expressed antigens drive highly differentiated CD4 T cells with diminished protective capacity. Immunization with such antigens can counteract this phenomenon by maintaining antigen-specific T cells in a state of low differentiation. Future vaccine strategies should explore combinations of multiple highly expressed antigens with the use of T cell differentiation as a measurable parameter in studies.
Article
Immunology
Di Long, Bingyi Yang, Ming Yang, Feng Xiong, Xuejing Zhu, Yixin Tan, Haijing Wu
Summary: Bach2 plays an important regulatory role in T and B cells, and it is also involved in the pathogenesis of systemic lupus erythematosus (SLE). The expression of Bach2 in helper T-cell subsets is elevated in SLE patients and negatively correlated with disease severity and autoantibody levels. Silencing Bach2 in CD4(+) T cells promotes the increase of CD19(+) B-cell count, plasmablasts, and secretion of IgG.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Ian Shannon, Chantelle L. White, Hongmei Yang, Jennifer L. Nayak
Summary: This study compared influenza-specific CD4 T-cell responses in children who were either acutely infected with influenza or vaccinated with IIV. The results showed that infection primed a stronger CD4 T-cell response specific for the infecting HA and NP proteins, with more robust NP-specific immunity persisting through year 2.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Tim K. Tsang, Kwok-Tai Lam, Yinping Liu, Vicky J. Fang, Xiaofeng Mu, Nancy H. L. Leung, J. S. Malik Peiris, Gabriel M. Leung, Benjamin J. Cowling, Wenwei Tu
Summary: The study found that T cell response, especially CD4 T cell response, is associated with homosubtypic and cross-strain protection against influenza infections. This protection is independent of the protection associated with HAI titer.
Article
Dermatology
Cheryl Yi-Pin Lee, Guillaume Carissimo, Teck-Hui Teo, Samuel Jia Ming Tong, Zi Wei Chang, Ravisankar Rajarethinam, Tze Kwang Chua, Zheyuan Chen, Rhonda Sin -Ling Chee, Alicia Tay, Shanshan Wu Howland, Kok Siong Ang, Jinmiao Chen, Laurent Renia, Lisa F. P. Ng
Summary: This study demonstrates that adoptive transfer of CD8+ T cells can significantly reduce viral load in a T-cell-deficient mouse model of Zika virus (ZIKV) infection. The study also shows that ZIKV infection can induce CD8+ T cell-mediated skin inflammation. These findings suggest a potential role for CD8+ T cell-associated pathologies in patients with CD4+ T cell immunodeficiency after ZIKV infection.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Obstetrics & Gynecology
Matthew J. Zuber, David M. Stamilio, Beth C. Holbrook, Beverly M. Snively, Elizabeth T. Jensen, Martha A. Alexander-Miller
Summary: The objective of this study was to evaluate the antibody response to the influenza vaccine during pregnancy and its transfer to the infant. The results showed that hemagglutinin stem-specific IgG was boosted more robustly than whole vaccine titers. Additionally, hemagglutinin stem-specific IgG was found to be concentrated in cord blood and dominated by IgG1 subclass.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Multidisciplinary Sciences
Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu
Summary: The study found that the SPY1 vaccine increased the expression of IL-27 and its specific receptor (WSX-1), promoting vaccine protection through activation of the STAT3 and NF-κB signaling pathways and production of memory CD4(+)T cells to enhance Th17 cell polarization. Additionally, the immune protection of the vaccine was independent of aerobic glycolysis.
Article
Immunology
K. L. Flannigan, V. L. Ngo, D. Geem, A. Harusato, S. A. Hirota, C. A. Parkos, N. W. Lukacs, A. Nusrat, V. Gaboriau-Routhiau, N. Cerf-Bensussan, A. T. Gewirtz, T. L. Denning
MUCOSAL IMMUNOLOGY
(2017)
Meeting Abstract
Gastroenterology & Hepatology
Lewins Walter, Adani Pujada, Hamed Laroui, Timothy L. Denning, Pallavi Garg
Article
Medicine, Research & Experimental
Miguel Quiros, Hikaru Nishio, Philipp A. Neumann, Dorothee Siuda, Jennifer C. Brazil, Veronica Azcutia, Roland Hilgarth, Monique N. O'Leary, Vicky Garcia-Hernandez, Giovanna Leoni, Mingli Feng, Gabriela Bernal, Holly Williams, Priya H. Dedhia, Christian Gerner-Smidt, Jason Spence, Charles A. Parkos, Timothy L. Denning, Asma Nusrat
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Immunology
A. Harusato, H. Abo, V. L. Ngo, S. W. Yi, K. Mitsutake, S. Osuka, J. E. Kohlmeier, J. D. Li, A. T. Gewirtz, A. Nusrat, T. L. Denning
MUCOSAL IMMUNOLOGY
(2017)
Review
Obstetrics & Gynecology
Timothy W. Denning, Amina M. Bhatia, Andrea F. Kane, Ravi M. Patel, Patricia W. Denning
SEMINARS IN PERINATOLOGY
(2017)
Article
Oncology
Adani Pujada, Lewins Walter, Aashka Patel, Tien Anh Bui, Zhan Zhang, Yuchen Zhang, Timothy Luke Denning, Pallavi Garg
Article
Oncology
Aliyah M. Weinstein, Lu Chen, Emily A. Brzana, Prashanti R. Patil, Jennifer L. Taylor, Kellsye L. Fabian, Callen T. Wallace, Sabrina D. Jones, Simon C. Watkins, Binfeng Lu, David F. Stroncek, Timothy L. Denning, Yang-Xin Fu, Peter A. Cohen, Walter J. Storkus
Meeting Abstract
Gastroenterology & Hepatology
Adani Pujada, Tien Anh Bui, Lewins Walter, Timothy L. Denning, Pallavi Garg
Review
Immunology
Kyle L. Flannigan, Timothy L. Denning
Meeting Abstract
Gastroenterology & Hepatology
Adani Pujada, Tien Anh Bui, Lewins Walter, Timothy L. Denning, Pallavi Garg
INFLAMMATORY BOWEL DISEASES
(2018)
Article
Immunology
Alexander N. Wein, Paul R. Dunbar, Sean R. McMaster, Zheng-Rong Tiger Li, Timothy L. Denning, Jacob E. Kohlmeier
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Sean R. McMaster, Alexander N. Wein, Paul R. Dunbar, Sarah L. Hayward, Emily K. Cartwright, Timothy L. Denning, Jacob E. Kohlmeier
MUCOSAL IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Vu L. Ngo, Hirohito Abo, Estera Maxim, Akihito Harusato, Duke Geem, Oscar Medina-Contreras, Didier Merlin, Andrew T. Gewirtz, Asma Nusrat, Timothy L. Denning
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Chemistry, Multidisciplinary
Bo Xiao, Qiubing Chen, Zhan Zhang, Lixin Wang, Yuejun Kang, Timothy Denning, Didier Merlin
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Gastroenterology & Hepatology
Brandon S. B. Canup, Heliang Song, Vu Le Ngo, Xiangxiao Meng, Timothy L. Denning, Pallavi Garg, Hamed Laroui
DIGESTIVE AND LIVER DISEASE
(2017)