Article
Immunology
Qiang Li, Xiaohui Li, Hongkun Quan, Yihui Wang, Guanggang Qu, Zhiqiang Shen, Cheng He
Summary: The study revealed that IL-10(-/-) mice and IL-10 inhibitor mice showed higher survival rates during C. psittaci infection, while mice with DC depletion had lower survival rates. IL-10(-/-) upregulated the function of deficient DCs by activating OX40-OX40L, T cells, and the NLPR3 inflammasome, and inhibiting IDO and regulatory T cells, leading to enhanced clearance of C. psittaci.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jingyu Xu, Zihao Zhou, Yidan Zheng, Sai Yang, Kun Huang, Huili Li
Summary: Viral myocarditis (VMC) is a life-threatening disease caused by viral infection-induced inflammation, which is associated with dilated cardiomyopathy or heart failure. Innate immunity plays a crucial role in the inflammation, with inflammasomes providing a platform for cytokine secretion and mediating pyroptosis. In this review, we summarized the pathways involving inflammasomes in VMC and discussed potential therapies targeting inflammasomes and related pathways.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Elisa Toppi, Laura Sireno, Micaela Lembo, Nerisa Banaj, Beatrice Messina, Sedigheh Golesorkhtafti, Gianfranco Spalletta, Paola Bossu
Summary: Homotaurine is a potential therapeutic compound for Alzheimer's disease (AD) and has anti-inflammatory properties. This study suggests that supplementation of homotaurine in patients with mild cognitive impairment (MCI) increases the levels of anti-inflammatory cytokines IL-10 and IL-33, while decreasing the levels of pro-inflammatory cytokine IL-18. The elevation of IL-10 and IL-33 is associated with improved episodic memory in treated patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hugo Barrague, Jessica Fontaine, Florence Abravanel, Emilie Maure, Jean-Marie Peron, Laurent Alric, Martine Dubois, Jacques Izopet, Eric Champagne
Summary: Alterations in the gamma delta T cell compartment have been reported in individuals infected with hepatitis E virus (HEV)-g3, with a specific increase in ND2 cells in HCMV-positive patients. HEV-specific responses were observed in gamma delta subsets of HCMV-positive individuals, suggesting an involvement of gamma delta cells in IL-10 production during acute phase infection.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Birte Weber, Ramona Sturm, Dirk Henrich, Ludmila Lupu, Katrin Rottluff, Ingo Marzi, Liudmila Leppik
Summary: Trauma is a major cause of death and disability, and accurate diagnosis is crucial for polytraumatized patients to prevent complications. This study suggests that cytokines in exosomes have a longer half-life and can be used as diagnostic and prognostic markers in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Matheus Braga, Fernanda Formaggi Lara-Armi, Janisleya Silva Ferreira Neves, Marco Antonio Rocha-Loures, Mariana de Souza Terron-Monich, Larissa Danielle Bahls-Pinto, Quirino Alves de Lima Neto, Joana Maira Valentini Zacarias, Ana Maria Sell, Jeane Eliete Laguila Visentainer
Summary: The IL10 -1082 A>G (rs1800896) genotype is associated with AS, with AS patients having higher levels of IL-10 in serum, and the IL17F rs763780 polymorphism can affect the levels of IL-17F in the serum.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Kun Chen, Xiangyu Li, Di Wang, Yanchun Ma, Bobin Chen, Qingping Wang, Jingjing Ma, Ming Guan
Summary: Aqueous humor can serve as a potential sample type for the diagnosis of intraocular lymphoma when detecting IL-6 and IL-10, showing higher diagnostic value and lower operating risk compared to vitreous specimens.
CLINICA CHIMICA ACTA
(2021)
Article
Microbiology
Xia Zhu, Yongtao Liu, Ning Xu, Xiaohui Ai, Yibin Yang
Summary: In this study, homologous compounds of IL-10 and IL-6 were identified in channel catfish, and their immune responses were analyzed. The expression of IL-10 and IL-6 genes was observed in multiple tissues, with IL-10 highly expressed in the liver and IL-6 highly expressed in the spleen, heart, and gonad. The results suggest that IL-10 and IL-6 are involved in the immune response against pathogens.
Article
Multidisciplinary Sciences
Akimichi Inaba, Zewen Kelvin Tuong, Tian X. X. Zhao, Andrew P. P. Stewart, Rebeccah Mathews, Lucy Truman, Rouchelle Sriranjan, Jane Kennet, Kourosh Saeb-Parsy, Linda Wicker, Frank Waldron-Lynch, Joseph Cheriyan, John A. A. Todd, Ziad Mallat, Menna R. R. Clatworthy
Summary: Activation of B cells expressing CD25 can be enhanced by low-dose recombinant IL-2, leading to increased secretion of IL-10. Administration of low dose IL-2 to patients results in an increase in IL-10-producing B cells. Single-cell RNA sequencing reveals enrichment of regulatory B cell gene signature in plasma cell populations from IL-2-treated patients, with significant down-regulation of the transcriptional repressor BACH2. BACH2 suppression leads to increased B cell IL-10, suggesting its role in promoting an immunoregulatory phenotype in B cells through IL-2 modulation.
NATURE COMMUNICATIONS
(2023)
Review
Clinical Neurology
Shaohui Zhang, Feng Chen, Feng Zhai, Shuli Liang
Summary: This review examines the association between epilepsy and neuroinflammatory responses, focusing on the roles of the HMGB1/TLR4 and IL-1β/IL-1R1 signaling pathways and their potential as biomarkers in the prediction, prognosis, and targeted therapy of epilepsy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Jiarui Mi, Zhengye Liu, Shengduo Pei, Xia Wu, Nan Zhao, Lingjuan Jiang, Zhenjie Zhang, Xiaoyin Bai
Summary: This study using Mendelian randomization found that IL-18 is causally associated with an increased risk of IBD, while IL-1Ra is inversely associated with the risk of IBD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Celina Dubin, Ester Del Duca, Emma Guttman-Yassky
Summary: Atopic dermatitis is a common inflammatory skin disease with a complex pathophysiology involving immune dysregulation and barrier defects. The IL-4, IL-13, and IL-31 pathways play key roles in the disease's pathogenesis, and novel therapeutics targeting these pathways are being developed for potential treatments.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Qifeng Liu, Yan Liu
Summary: This study found that IL-10 and IL-22 are significantly imbalanced in active ITP patients, and may predict the clinical course of the disease.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Immunology
Gunjan Kak, Zachary Van Roy, Cortney E. E. Heim, Rachel W. W. Fallet, Wen Shi, Axel Roers, Bin Duan, Tammy Kielian
Summary: The study found that IL-10 derived from granulocytes plays a role in suppressing the clearance of Staphylococcus aureus during craniotomy infection, possibly by inhibiting neutrophil bactericidal activity and TNF production.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Alberto Ponciano-Gomez, Martha Iris Valle-Solis, Myriam Campos-Aguilar, Rafael Jijon-Lorenzo, Elena De La C. Herrera-Cogco, Roberto Ramos-Alor, Cesar Isaac Bazan-Mendez, Gustavo Antonio Perez-Gil Cervantes, Ricardo Avila-Garcia, Abdiel Gonzalez Aguilar, Moises Geovani Salmeron Texale, Wilfrido David Tapia-Sanchez, Carlos Leonardo Duarte-Martinez, Sandra Olivas-Quintero, Santiago Cristobal Sigrist-Flores, Itzell Alejandrina Gallardo-Ortiz, Rafael Villalobos-Molina, Adolfo Rene Mendez-Cruz, Rafael Jimenez-Flores, Leopoldo Santos-Argumedo, Juan Pedro Luna-Arias, Hector Romero-Ramirez, Victor Hugo Rosales-Garcia, Bartolo Avendano-Borromeo
Summary: This study analyzed the immune response of individuals with previous SARS-CoV-2 infection after vaccination. The results showed that individuals with earlier infection had higher antibody concentrations, which could be attributed to increased production of plasma cells and reduced presence of memory B cells in the bloodstream. This could be related to the high baseline expression of cytokines (IL-6 and IL-10) before vaccination.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Tierra Smiley Evans, Peter A. Barry, Kirsten V. Gilardi, Tracey Goldstein, Jesse D. Deere, Joseph Fike, JoAnn Yee, Benard J. Ssebide, Dibesh Karmacharya, Michael R. Cranfield, David Wolking, Brett Smith, Jonna A. K. Mazet, Christine K. Johnson
PLOS NEGLECTED TROPICAL DISEASES
(2015)
Article
Multidisciplinary Sciences
Jesse D. Deere, W. L. William Chang, Andradi Villalobos, Kimberli A. Schmidt, Ashlesha Deshpande, Luis D. Castillo, Joseph Fike, Mark R. Walter, Peter A. Barry, Dennis J. Hartigan-O'Connor
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Health Care Sciences & Services
Edwin Lauritz Fundingsland, Joseph Fike, Joshua Calvano, Jeffrey Beach, Deborah Lai, Shuhan He
Summary: With the increasing importance of web communication, industries have utilized web analytics to improve their performance. However, the healthcare industry has been slower in adopting web analytics. This study provides methods for evaluating healthcare websites using web analytics and offers actionable recommendations for improvement. By analyzing engagement, users, acquisition, content, and platform, healthcare organizations can assess their websites and communicate better with the public.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Emergency Medicine
Edwin Fundingsland, Joseph Fike, Joshua Calvano, Ali Raja, Deborah Lai, Sara Silacci, Mary Haas, Teresa Chan, Shuhan He
Summary: Measuring usability can help EM residency programs identify ways to improve their Web presence. To effectively promote their programs, residencies need quality content that communicates their key features. Our recommendation is for all residency programs to periodically perform website audits and apply the usability measures outlined to improve their digital presence, especially during times when face-to-face interactions will be limited.
AEM EDUCATION AND TRAINING
(2021)