Direct conversion of a general antibody to its catalytic antibody and corresponding applications —Importance and role of Pro95 in CDR-3—

Experimental Autoimmune Encephalomyelitis of Mice: Enzymatic Cross Site-Specific Hydrolysis of H4 Histone by IgGs against Histones and Myelin Basic Protein

(2022) Andrey E. Urusov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Catalytic Antibodies: Design, Expression, and Their Applications in Medicine

(2022) Daqun Zhao et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

A new catalytic site functioning in antigen cleavage by H34 catalytic antibody light chain

(2022) Emi Hifumi et al.   Scientific Reports

Broad-Spectrum Antiviral Activity of 3D8, a Nucleic Acid-Hydrolyzing Single-Chain Variable Fragment (scFv), Targeting SARS-CoV-2 and Multiple Coronaviruses In Vitro

(2021) Gunsup Lee et al.   Viruses-Basel

Noncanonical Functions of Antibodies

(2020) Jordan D. Dimitrov et al.   TRENDS IN IMMUNOLOGY

A new algorithm to convert a normal antibody into the corresponding catalytic antibody

(2020) Emi Hifumi et al.   Science Advances

Emergence of antibodies endowed with proteolytic activity against High-mobility group box 1 protein (HMGB1) in patients surviving septic shock

(2019) Stéphanie Barnay-Verdier et al.   CELLULAR IMMUNOLOGY

Production of Abzymes in Th, CBA, and C57BL/6 Mice before and after MOG Treatment: Comparing Changes in Cell Differentiation and Proliferation

(2019) Kseniya S. Aulova et al.   Biomolecules

Role of the constant region domain in the structural diversity of human antibody light chains

(2017) Emi Hifumi et al.   FASEB JOURNAL

Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome

(2017) Harutsugu Tatebe et al.   Molecular Neurodegeneration

Tau passive immunization inhibits not only tau but also Aβ pathology

(2017) Chun-ling Dai et al.   Alzheimers Research & Therapy

A Monoclonal Antibody toCryptococcus neoformansGlucuronoxylomannan Manifests Hydrolytic Activity for Both Peptides and Polysaccharides

(2016) Anthony Bowen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical features and antiviral activity of a monomeric catalytic antibody light-chain 23D4 against influenza A virus

(2015) Emi Hifumi et al.   FASEB JOURNAL

Specific Amyloid β Clearance by a Catalytic Antibody Construct

(2015) Stephanie A. Planque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic Immunoglobulin Gene Delivery in a Mouse Model of Alzheimer’s Disease: Prophylactic and Therapeutic Applications

(2014) Jinghong Kou et al.   MOLECULAR NEUROBIOLOGY

Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody

(2014) Natalia Ponomarenko et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Biochemical Features of a Catalytic Antibody Light Chain, 22F6, Prepared from Human Lymphocytes

(2013) Emi Hifumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

(2013) Omid Hamid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Constitutive Production of Catalytic Antibodies to a Staphylococcus aureus Virulence Factor and Effect of Infection

(2012) Eric L. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel molecular analysis of genes encoding catalytic antibodies

(2012) Damien Le Minoux et al.   MOLECULAR IMMUNOLOGY

DNase, RNase, and phosphatase activities of antibodies formed upon immunization by DNA, DNase I, and DNase II

(2011) M. A. Krasnorutskii et al.   BIOCHEMISTRY-MOSCOW

Highly efficient method of preparing human catalytic antibody light chains and their biological characteristics

(2011) Emi Hifumi et al.   FASEB JOURNAL

Catalytic and Biochemical Features of a Monoclonal Antibody Heavy Chain, JN1-2, Raised against a Synthetic Peptide with a Hemagglutinin Molecule of Influenza Virus

(2011) Emi Hifumi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics

(2011) I. Smirnov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-hydrolyzing activity of IgG antibodies from the sera of patients with tick-borne encephalitis

(2010) Taisiya A. Parkhomenko et al.   BIOCHIMIE

Catalytic digestion of human tumor necrosis factor-α by antibody heavy chain

(2010) Emi Hifumi et al.   FEBS Journal

Molecular analysis of multicatalytic monoclonal antibodies

(2010) Haggag S. Zein et al.   MOLECULAR IMMUNOLOGY

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

(2009) L. Zhang et al.   BLOOD

A Human Germ Line Antibody Light Chain with Hydrolytic Properties Associated with Multimerization Status

(2009) Vikram Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strategies for induction of catalytic antibodies toward HIV-1 glycoprotein gp120 in autoimmune prone mice

(2009) Oxana M. Durova et al.   MOLECULAR IMMUNOLOGY

The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

(2008) D. Y.-w. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA