Here, a method for synthesizing carbohydrate-DNA conjugates by radical addition is reported. This method utilizes readily available, bench-stable, and unprotected glycosyl sulfinates as precursors to glycosyl radicals. The reaction, which is redox neutral, proceeds under mild and simple conditions and allows for a broad substrate scope. A small library of carbohydrate-DNA conjugates was successfully prepared.
Herein, we report a method that enables the synthesis of carbohydrate-DNA conjugates by radical addition. Key to the success is the use of readily available, bench-stable, and unprotected glycosyl sulfinates as precursors to glycosyl radicals. The redox neutral reaction proceeds under mild and simple conditions and tolerates a broad substrate scope. A small library of carbohydrate-DNA conjugates was prepared.
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