Article
Ophthalmology
Giampaolo Greco, Maxwell Pistilli, Penny A. Asbell, Maureen G. Maguire
Summary: The study found that the severity of dry eye disease (DED) symptoms is associated with decreased work productivity and activity impairment. Higher Ocular Surface Disease Index (OSDI) symptom scores were linked to increased absenteeism, presenteeism, and activity impairment. Corneal staining and TBUT were also associated with work productivity and activity level.
Article
Public, Environmental & Occupational Health
Ilaria Vetrani, Veruscka Leso, Luca Fontana, Claudia Vetrani, Emanuela Spadarella, Francesca Sessa, Tommaso Porcelli, Ivo Iavicoli
Summary: The study found that patients with thyroid diseases may have decreased work ability, especially those with Graves disease and follicular carcinoma. Thyroid diseases and job duration were associated with poorer work ability.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Review
Medicine, General & Internal
Tzu-Hao Wang, Yuan-Jen Tsai, Yuan-Hung Wang, Chien-Liang Wu, I-Chan Lin
Summary: This systematic review explores the relationship between dry eye disease (DED) and dyslipidemia using quantitative data. The findings suggest a significant association between dyslipidemia and DED. However, only total cholesterol and high-density lipoprotein cholesterol values showed statistically significant differences.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Maurizio Rolando, Stefano Barabino
Summary: Dry eye disease is a multifactorial condition that is caused by reduced tear secretion, increased tear water evaporation, or the production of poor-quality tears. Recent studies have found that vitamin D supplementation may be an effective alternative therapy for patients with DED who do not respond to conventional treatments, possibly due to its positive effect on modulating immune and inflammatory responses. This review focuses on the pathogenesis and treatment of DED, with a special emphasis on the potential role of systemic administration of vitamin D as a therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Julia Prinz, Nicola Maffulli, Matthias Fuest, Peter Walter, Frank Hildebrand, Filippo Migliorini
Summary: This systematic review investigated the effectiveness and feasibility of using acupuncture for dry eye disease (DED) and found that acupuncture significantly improved symptoms and signs of DED without severe adverse effects.
FRONTIERS OF MEDICINE
(2022)
Review
Medicine, General & Internal
Atena Tamimi, Farzad Sheikhzadeh, Sajjad Ghane Ezabadi, Muhammad Islampanah, Peyman Parhiz, Amirhossein Fathabadi, Mohadeseh Poudineh, Zahra Khanjani, Hossein Pourmontaseri, Shirin Orandi, Reyhaneh Mehrabani, Mohammad Rahmanian, Niloofar Deravi
Summary: LASIK is a corneal stromal laser ablation method that uses an excimer laser. Dry eye disease is a common complication after LASIK and can affect quality of life and visual perception. Early treatment is necessary to improve surgical outcomes and patient comfort.
FRONTIERS IN MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Liandi Huang, Huanhuan Gao, Zhigang Wang, Yixin Zhong, Lan Hao, Zhiyu Du
Summary: The study successfully synthesized PFOB@LIP-Tet, which effectively treats dry eye disease through anti-inflammation with minimal impact on intraocular pressure.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Medicine, Research & Experimental
Pinal Chaudhari, Sairaj Satarker, Rinu Thomas, Nagarajan Theruveethi, Vivek Ghate, Madhavan Nampoothiri, Shaila A. Lewis
Summary: Dry eye disease is a common ocular condition that greatly impacts life quality and presents challenges in ophthalmology. Animal models were used to compare and standardize two rodent models of dry eye disease, and explore their recovery aspects. The study found chronic inflammation in the cornea and lacrimal gland in benzalkonium-treated group, while the scopolamine-treated group showed chronic inflammation in the lacrimal gland initially and later in the cornea. The recovery study suggested the usefulness of the models in evaluating dry eye treatments.
Article
Biochemistry & Molecular Biology
Alice Rocha Teixeira Netto, Jose Hurst, Karl-Ulrich Bartz-Schmidt, Sven Schnichels
Summary: A porcine ex vivo dry eye model was established in this study by incubating porcine corneas in low humidity. The model exhibited increased expression of dry eye markers and higher cell death rate compared to the controls. Treatment with dexamethasone and hyaluronic acid was able to reverse some of these effects. The model provides a valuable tool for animal-free testing of novel dry eye treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Gaia Favero, Enrico Moretti, Kristina Krajcikova, Vladimira Tomeckova, Rita Rezzani
Summary: Dry eye disease is a multifactorial pathology that affects the quality of life of patients, with current therapeutic strategies being unable to fully address the underlying causes. Polyphenols show promise in counteracting the main pathologic mechanisms of dry eye disease, reducing inflammation, oxidative stress, and apoptosis, and modulating tear film to potentially develop new ophthalmic drugs for treating the condition effectively and safely.
Article
Biochemistry & Molecular Biology
Fredrik A. Fineide, Behzod Tashbayev, Katja B. P. Elgstoen, Elise M. Sandas, Helge Rootwelt, Havard Hynne, Xiangjun Chen, Sten Raeder, Jelle Vehof, Darlene Dartt, Janicke L. Jensen, Tor P. Utheim
Summary: Accurate diagnosis of dry eye disease (DED) is challenging, and there is no gold standard biomarker of DED. Global metabolomic studies of tears and saliva from DED patients have the potential to discover metabolites and pathways affected in the pathophysiology of DED, and to find possible biomarkers. This pilot study found different levels of several metabolites in patients with decreased tear film break-up time that may have associations with DED.
Article
Medicine, General & Internal
Azadeh Tavakoli, Maria Markoulli, Eric Papas, Judith Flanagan
Summary: This study found that oral probiotics and prebiotics can effectively manage dry eye disease through a double-masked, randomized controlled clinical trial, with the treatment group showing significantly better symptom scores compared to the control group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Lifei Yu, Chunjing Yu, He Dong, Yanan Mu, Rui Zhang, Qiaosi Zhang, Wei Liang, Wenjia Li, Xun Wang, Lijun Zhang
Summary: Dry eye disease is a common ophthalmology condition with increasing incidence, and immune inflammation is recognized as the core basis of the disease. This review systematically examines previous research on treating dry eye disease with immune inflammation, analyzing the latest viewpoints and research hotspots to provide references for prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Ophthalmology
Andrea M. Storas, Inga Strumke, Michael A. Riegler, Jakob Grauslund, Hugo L. Hammer, Anis Yazidi, Pal Halvorsen, Kjell G. Gundersen, Tor P. Utheim, Catherine J. Jackson
Summary: Dry eye disease (DED) has a high prevalence, but is often underdiagnosed and undertreated. Artificial intelligence (AI) can provide more objective diagnosis, with significant advancements in machine learning. AI has been extensively used in the research and clinical applications of DED, particularly in image interpretation, showing promising initial results.
Review
Pharmacology & Pharmacy
Noriaki Nagai, Hiroko Otake
Summary: This review presents research results on diagnostic methods for dry eye disease (DED), current treatment options, promising pharmaceuticals, and new ocular drug delivery systems. Nanotechnology has made remarkable progress in the design of ophthalmic formulations for the management of anterior eye diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Ophthalmology
Bjornar Kamoy, Morten Magno, Sara T. Noland, Morten C. Moe, Goran Petrovski, Jelle Vehof, Tor P. Utheim
Summary: This study assessed and evaluated methods for preventing VDT-associated dry eye disease (DED) and ocular discomfort. The results showed that preventive measures aimed at increasing blink rate, preventing tear film instability, and improving ergonomics had a positive effect on symptoms and signs of VDT-associated DED. Further research is needed to compare the efficacy of different interventions and gather more evidence on the effects of increased humidity, VDT filters, and ergonomic practices.
ACTA OPHTHALMOLOGICA
(2022)
Review
Ophthalmology
Haakon Fjaervoll, Ketil Fjaervoll, Morten Magno, Emily Moschowits, Jelle Vehof, Darlene A. Dartt, Tor P. Utheim
Summary: The majority of studies have shown an association between VDT use and DED or DED-related signs and symptoms. The prevalence of definite or probable DED in VDT and office workers ranged from 26% to 70%, with as few as 1-2 hours of VDT exposure per day being associated with DED. VDT use is strongly associated with DED, but further research is needed to determine the exact prevalence and establish a safe lower limit of daily VDT use. More studies are also required to understand the impact of digitalization and digital transformation, especially during the time of the COVID-19 pandemic.
ACTA OPHTHALMOLOGICA
(2022)
Review
Ophthalmology
Morten Schjerven Magno, Jonatan Olafsson, Marie Beining, Emily Moschowits, Neil Lagali, James S. Wolffsohn, Jennifer P. Craig, Darlene A. Dartt, Jelle Vehof, Tor P. Utheim
Summary: The literature review highlighted that chambered warm moist air eyelid warming devices are effective in raising eyelid temperature, improving dry eye symptoms, lipid layer thickness, and tear film breakup time. However, it remains unclear whether they provide greater benefits compared to other eyelid warming therapies. Further well-conducted research, especially comparing moist and dry heat devices in patients with different severities of dry eye disease, is necessary.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Morten Schjerven Magno, Tor P. Utheim, Mathias Kaurstad Morthen, Harold Snieder, Nomdo M. Jansonius, Christopher J. Hammond, Jelle Vehof
Summary: The purpose of this study was to investigate the association between caffeine intake and dry eye disease (DED) in a large population-based cohort in the Netherlands. The results showed that higher caffeine intake was associated with a decreased risk of DED, but this effect disappeared after adjusting for medical comorbidities. Therefore, dietary caffeine intake does not seem to be a risk factor for DED in the general population.
Article
Ophthalmology
Mathias Kaurstad Morthen, Morten Schjerven Magno, Tor Paaske Utheim, Harold Snieder, Nomdo Jansonius, Christopher J. Hammond, Jelle Vehof
Summary: This study investigated the relationship between dry eye disease (DED) and vision-related quality of life (VR-QoL). The results showed that DED was associated with reductions in all domains of VR-QoL, and the burden on VR-QoL caused by DED was higher than that of other common vision-affecting eye disorders.
Review
Ophthalmology
Marie Wangen Beining, Morten Schjerven Magno, Emily Moschowits, Jonatan Olafsson, Jelle Vehof, Darlene A. Dartt, Tor Paaske Utheim
Summary: Dry eye disease affects millions worldwide, with meibomian gland dysfunction being a major cause. Treatment involves heat and pressure applied to the glands, but in-office thermal systems like LipiFlow, iLux, and TearCare offer a second line of treatment for non-responders. Short-term studies show effectiveness, but long-term efficacy and cost comparisons with at-home treatments need further evaluation.
SURVEY OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Leif Hynnekleiv, Morten Magno, Ragnheidur R. Vernhardsdottir, Emily Moschowits, Kim Alexander Tonseth, Darlene A. Dartt, Jelle Vehof, Tor P. Utheim
Summary: This review evaluates the safety and efficacy of artificial tears containing hyaluronic acid (HA) in the treatment of dry eye disease (DED). The results show that artificial tears with 0.1% to 0.4% HA are effective in improving both signs and symptoms of DED, with no major complications or adverse events reported. However, two major gaps in the literature have been identified: the ideal drop frequency for HA-containing eyedrops has not been studied, and there is insufficient evidence to recommend any specific HA formulation over another. Future research should focus on exploring the optimal drop frequency for different concentrations and molecular weights of HA, as well as different drop formulations, taking into account DED severity and etiology.
ACTA OPHTHALMOLOGICA
(2022)
Review
Ophthalmology
Ketil Fjaervoll, Haakon Fjaervoll, Morten Magno, Sara Tellefsen Noland, Darlene A. Dartt, Jelle Vehof, Tor P. Utheim
Summary: This study conducted a review on pathophysiological mechanisms promoting VDT-associated DED. It found that VDT use causes dry eye mainly through impaired blinking patterns. Although there are additional hypotheses, they lack sufficient scientific support. The results suggest that VDT use may lead to reduced function of tear film, lacrimal gland, goblet cells, and meibomian glands, contributing to the development of dry eye disease.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Long Nguyen, Morten Schjerven Magno, Tor P. Utheim, Nomdo M. Jansonius, Christopher J. Hammond, Jelle Vehof
Summary: According to this large population-based study, greater water intake is associated with a modest increased risk of dry eye disease (DED), rather than a reduced risk.
ACTA OPHTHALMOLOGICA
(2023)
Review
Ophthalmology
Ragnheidur R. Vernhardsdottir, Morten S. Magno, Leif Hynnekleiv, Neil Lagali, Darlene A. Dartt, Jelle Vehof, Catherine J. Jackson, Tor P. Utheim
Summary: Oral and topical antibiotics have short-term positive effects on the signs and symptoms of blepharitis- or MGD-related DED, but these improvements often revert upon cessation of treatment. The need for repeated treatments and mild adverse events are common. The existing evidence is not sufficient to conclude that antibiotics are useful in long-term MGD management.
Review
Ophthalmology
Leif Hynnekleiv, Morten Magno, Emily Moschowits, Kim Alexander Tonseth, Jelle Vehof, Tor P. Utheim
Summary: Dry eye disease (DED) is a common and debilitating condition. Hyaluronic acid (HA) has been widely used as a safe and effective treatment for DED. This study aimed to summarize and critically evaluate the literature comparing HA with other active ingredients in the treatment of DED.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Long Nguyen, Morten Schjerven Magno, Tor P. Utheim, Christopher J. Hammond, Jelle Vehof
Summary: This study investigated the association between sedentary behavior and dry eye disease (DED). It found that increased sedentary time was linked to an increased risk of DED, especially in individuals with lower levels of physical activity than WHO recommendations. However, the association became non-significant when computer-related sitting time was excluded.
Editorial Material
Ophthalmology
M. S. Magno, J. Olafsson, M. Beining, E. Moschowits, N. Lagali, J. S. Wolffsohn, J. P. Craig, J. Vehof, D. A. Dartt, T. P. Utheim
CONTACT LENS & ANTERIOR EYE
(2023)
Review
Ophthalmology
Fredrik Fineide, Morten S. Magno, Ayyad Zartasht Khan, Xiangjun Chen, Jelle Vehof, Tor P. Utheim
Summary: Dry eye disease is a prevalent condition that significantly affects quality of life, work productivity, and vision. Intense pulsed light therapy has shown potential in treating meibomian gland dysfunction. However, more studies are needed to determine its efficacy, optimal treatment regimens, and underlying mechanisms of action.
ACTA OPHTHALMOLOGICA
(2023)