Review
Endocrinology & Metabolism
Rachel Agius, Nikolai P. Pace, Stephen Fava
Summary: Research has shown that normal body weight does not always indicate metabolic health, and lean individuals can have metabolic abnormalities typically associated with obesity. Conversely, excess adiposity does not always lead to an abnormal metabolic profile. Different fat depots and other factors, such as genetics and lifestyle, play important roles in determining an individual's metabolic profile and body composition phenotypes.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Wen-qiang Wang, Bin Wei, Yan-peng Song, Heng Guo, Xiang-hui Zhang, Xin-ping Wang, Yi-zhong Yan, Jiao-long Ma, Kui Wang, Mulatibieke Keerman, Jing-yu Zhang, Ru-lin Ma, Shu-xia Guo, Jia He
Summary: The prevalence of metabolically healthy obesity (MHO) among rural adults in Xinjiang is higher, while the prevalence of metabolically unhealthy normal weight (MUNW) is lower compared to Han adults. In both obese and normal weight participants, higher age, more red meat consumption, and larger waist circumference increase the risk of metabolic abnormality, while higher vegetable consumption reduces the risk of metabolic abnormality.
Article
Endocrinology & Metabolism
Shan Cai, Jiajia Dang, Panliang Zhong, Ning Ma, Yunfei Liu, Di Shi, Zhiyong Zou, Yanhui Dong, Jun Ma, Yi Song
Summary: This study analyzed the sex differences in the prevalence of obesity phenotypes and their risk factors among children and adolescents in China. The results showed higher prevalence of obesity phenotypes in boys and identified various risk factors such as parental smoking, birth weight, and lifestyle factors. The findings highlight the importance of considering sex differences in managing obesity phenotypes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Saioa Gomez-Zorita, Maite Queralt, Maria Angeles Vicente, Marcela Gonzalez, Maria P. Portillo
Summary: The relationship between obesity and metabolically healthy obese (MHO) as well as metabolically obese normal weight (MONW) individuals is complex and varied. Different classifications have been used in studies, making it difficult to define MHO and MONW. Main determinants of MHO include growth type, anatomical location, adipose tissue inflammation, while MONW is mainly influenced by genetic background and lifestyle factors.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Ozra Tabatabaei-Malazy, Sahar Saeedi Moghaddam, Masoud Masinaei, Nazila Rezaei, Sahar Mohammadi Fateh, Arezou Dilmaghani-Marand, Elham Abdolhamidi, Farideh Razi, Patricia Khashayar, Alireza Mahdavihezaveh, Siamak Mirab Samiee, Bagher Larijani, Farshad Farzadfar
Summary: The prevalence of metabolically healthy obesity (MHO) and metabolic unhealthiness in obese individuals was 7.5% and 18.3% respectively. Factors such as low physical activity, urban residence, and higher education were associated with metabolic unhealthiness. Dyslipidemia was the most common component of MetS among different weight categories.
Review
Food Science & Technology
Behnaz Abiri, Majid Valizadeh, Lara Nasreddine, Farhad Hosseinpanah
Summary: This systematic review investigated the relationship between nutritional and dietary factors and metabolic heterogeneity in individuals with obesity or normal weight. The findings suggest that adherence to healthy dietary patterns and specific foods/nutrients is associated with a higher likelihood of having a healthy metabolic phenotype, while adherence to unhealthy dietary patterns and specific foods/nutrients is associated with a lower likelihood of having a healthy metabolic phenotype.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Nutrition & Dietetics
Xiaonan Zheng, Ruilin Peng, Hang Xu, Tianhai Lin, Shi Qiu, Qiang Wei, Lu Yang, Jianzhong Ai
Summary: This study presents pooled data comparing cancer risk between patients with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO), and found a lower cancer incidence for MHO phenotype regardless of population heterogeneity or the definitions of obesity and metabolic status.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Ruziana Mona Wan Mohd Zin, Muhammad Yazid Jalaludin, Abqariyah Yahya, Ahmad Kamil Nur Zati Iwani, Fuziah Md Zain, Janet Yeow Hua Hong, Abdul Halim Mokhtar, Wan Nazaimoon Wan Mohamud
Summary: This study aimed to compare several parameters related to obesity between metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) children, and to examine the predictors associated with the MHO phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jianan Ye, Keyu Guo, Xia Li, Lin Yang, Zhiguang Zhou
Summary: This study conducted the first nationally representative study on the epidemiological data of metabolically unhealthy normal weight individuals in China and found that the risk of developing diabetes is higher in this group. This research is of great importance to the health of the Chinese population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Mitra Kazemi Jahromi, Amir Ebadinejad, Maryam Barzin, Maryam Mahdavi, Mahtab Niroomand, Davood Khalili, Majid Valizadeh, Fereidoun Azizi, Farhad Hosseinpanah
Summary: This study aimed to examine the association between obesity severity and duration and the transition from metabolically healthy obese/overweight (MHO) phenotype to metabolically unhealthy obese (MUO) phenotype. The study found that in women participants, the accumulation of body weight and waist circumference was significantly associated with the transition from MHO to MUO, while there was no significant association in men participants. More research is needed to confirm and explain these differences.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Endocrinology & Metabolism
Junaid Iqbal, Hui-Xuan Wu, Muhammad Asad Nawaz, Hong-Li Jiang, Shi-Na Xu, Bi-Ling Huang, Long Li, Jun-Min Cai, Hou-De Zhou
Summary: This study evaluated the risk of developing chronic kidney disease in individuals with metabolically healthy obesity and metabolically unhealthy normal weight. The results show that obesity, regardless of metabolic health, increases the risk of chronic kidney disease.
Article
Nutrition & Dietetics
Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Giulia de Alteriis, Annamaria Colao, Silvia Savastano
Summary: This study found that compared to PCOS MHO patients, PCOS MUO patients have more severe metabolic parameters and higher inflammation levels, as well as lower adherence to the Mediterranean diet. Additionally, MUO patients also exhibit more severe hyperandrogenism and cardio-metabolic indices.
Article
Nutrition & Dietetics
Matina Kouvari, Nathan M. D'Cunha, Thomas Tsiampalis, Manja Zec, Domenico Sergi, Nikolaj Travica, Wolfgang Marx, Andrew J. McKune, Demosthenes B. Panagiotakos, Nenad Naumovski
Summary: The aim of this study was to evaluate the association between metabolically healthy overweight/obesity (MHO) status and longitudinal cognitive function while considering the stability of the condition. The study found that maintaining a healthy metabolic status over time has a greater impact on cognitive function than body weight alone.
Article
Biochemistry & Molecular Biology
Carolina Gutierrez-Repiso, Teresa Maria Linares-Pineda, Andres Gonzalez-Jimenez, Francisca Aguilar-Lineros, Sergio Valdes, Federico Soriguer, Gemma Rojo-Martinez, Francisco J. Tinahones, Sonsoles Morcillo
Summary: This study found that DNA methylation status is associated with the stability/worsening of the MHO phenotype, identifying two potential biomarkers for transitioning to an unhealthy state and highlighting immune system-related pathways as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Shiori Kawai, Hajime Yamakage, Kazuhiko Kotani, Mitsuhiko Noda, Noriko Satoh-Asahara, Koshi Hashimoto
Summary: The study highlights the importance of adiponectin in maintaining metabolic homeostasis in individuals with metabolically healthy obesity (MHO). Both MHO and metabolically unhealthy obesity (MUO) groups exhibit chronic inflammation, and even individuals with MHO show anti-inflammatory responses during weight reduction therapy.
