Article
Biochemistry & Molecular Biology
Azat Gainutdinov, Dmitrii Shipkov, Mikhail Sintsov, Lorenzo Fabrizi, Azat Nasretdinov, Roustem Khazipov, Guzel Valeeva
Summary: In this study, scientists observed that somatosensory stimulation in newborn rats can evoke similar electrical activity as spontaneous early sharp waves (eSPWs), suggesting that sensory feedback from movements is involved in the association of eSPWs with myoclonic movements in neonatal rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Kara J. Blacker, Daniel G. McHail
Summary: Reduced levels of environmental oxygen can lead to hypoxic hypoxia, which poses a primary threat in tactical aviation. This study found that early sensory processing is not impaired during hypoxia, but the auditory system is affected at the level of attentional processing. The consistency of hypoxia symptoms reported by individuals exhibited high variability.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biophysics
Phenghai Li, Can Yin, Mingji Li, Hongji Li, Baohe Yang
Summary: A semi-flexible polydopamine (PDA)/Pt-TiO2 electrode was prepared for dry-contact acquisition of EEG signals, with low interface impedance with the scalp. In SSVEP-based BCI system, the dry electrode can collect high-quality EEG feedback signals and effectively control external devices.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Anesthesiology
Kunihiro Mitsuzawa, Takashi Ishida, Ryusuke Tanaka, Mariko Ito, Satoshi Tanaka, Mikito Kawamata
Summary: The study evaluated the effects of remifentanil, propofol, and sevoflurane on nociceptive evoked potentials (NEPs) generated by selective stimulation of nociceptive intraepidermal nerve fibers. The results showed that remifentanil significantly suppressed the amplitude of NEPs, while propofol and sevoflurane did not have a significant effect.
JOURNAL OF ANESTHESIA
(2023)
Article
Clinical Neurology
Sophie-Charlotte Fabig, Dilara Kersebaum, Josephine Lassen, Manon Sendel, Swantje Jendral, Alexandra Muntean, Ralf Baron, Philipp Huellemann
Summary: The study aimed to establish an objective neurophysiological test protocol to assess the somatosensory nervous system, finding functional loss in patients with polyneuropathy through the application of various stimuli. Despite technical challenges, preliminary patient data appear promising for potential future clinical applications.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Maria Pyasik, Irene Ronga, Dalila Burin, Adriana Salatino, Pietro Sarasso, Francesca Garbarini, Raffaella Ricci, Lorenzo Pia
Summary: Studies have shown that sensory attenuation triggered by the own hand and by the embodied fake hand have similar behavioral and neurophysiological signatures, indicating that body ownership plays a crucial role in distinguishing the source of perceived sensations.
Article
Engineering, Biomedical
Ali Asghar Zarei, Armita Faghani Jadidi, Eugen Romulus Lontis, Winnie Jensen
Summary: TENS has been reported to alleviate pain by cortical inhibition, and high-frequency TENS intervention significantly suppresses cortical activity and reduces the intensity and area size of perceived sensations.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Review
Critical Care Medicine
Sarah Benghanem, Estelle Pruvost-Robieux, Eleonore Bouchereau, Martine Gavaret, Alain Cariou
Summary: This study summarizes the application of electroencephalography (EEG) and evoked-potentials (EPs) in predicting neurological outcome of comatose patients. EEG records brain electrical fields while EPs represent the summated activities of large populations of neurons firing in synchrony. Different brain generators and prognostic values make EPs provide more detailed and specific information compared to EEG. Future research will focus on reducing prognostic uncertainty.
ANNALS OF INTENSIVE CARE
(2022)
Article
Biology
Julia G. Casorso, Allegra N. DePasquale, Suheidy Romero Morales, Saul Cheves Hernandez, Ronald Lopez Navarro, Kimberley J. Hockings, Matthew A. Carrigan, Amanda D. Melin
Summary: Studying fruit traits and their interactions with seed dispersers can help us understand biodiversity patterns, ecosystem function, and evolution. Fruit ethanol is common and variable, and may influence seed dispersers. In this study, we investigated fruit ethanol content in a Costa Rican tropical dry forest and found that phylogeny and seed dispersal syndrome explain variation in ethanol levels, with mammal-dispersed fruits having higher ethanol concentrations than bird-dispersed fruits. These findings contribute to our understanding of the role of fruit ethanol as a selective pressure on frugivore sensory systems and metabolism.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Lena Pokorny, Tomasz Antoni Jarczok, Stephan Bender
Summary: This study focused on the topography and lateralization of long-latency trigeminal somatosensory evoked potentials (SSEPs), comparing them with TMS-evoked potentials. The results showed a contralateral lateralization of the somatosensory N140 generated by trigeminal stimulation. Therefore, caution should be exercised when interpreting contralateral potentials after transcranial magnetic stimulation, as they may include somatosensory components.
CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Critical Care Medicine
Claudio Sandroni, Antonello Grippo, Erik Westhall
Summary: In comatose cardiac arrest survivors, the EEG is commonly used to assess the severity of brain injury and guide antiseizure treatment. However, there are various EEG patterns described in literature and the value of postarrest seizure treatment is uncertain. Recent findings suggest that certain EEG patterns can accurately predict irreversible brain injury, while continuous normal-voltage EEG indicates potential recovery. Additionally, a prognostic approach based on SSEP amplitude shows promise for outcome prediction.
CURRENT OPINION IN CRITICAL CARE
(2023)
Article
Cell Biology
Xiaoyi Lin, Daoming Zhu, Kaiyang Wang, Pengbo Luo, Gang Rui, Youshui Gao, Fuan Liu, Hongping Yu
Summary: Activated ALDH 2 has been demonstrated to have a protective role in ethanol-induced ONFH by promoting new bone formation, reducing adipogenesis, and stimulating vascularization.
CELL PROLIFERATION
(2022)
Article
Neurosciences
Yue Yuan, Zhouyan Feng, Gangsheng Yang, Xiangyu Ye, Zhaoxiang Wang
Summary: This study investigated the post-stimulation effects of high-frequency electrical pulse stimulation in the brain. The results showed that after the stimulation, there was a silent period followed by gradual recovery of neuronal firing. Additionally, the excitability of neurons decreased after the stimulation. These findings suggest the potential use of post-stimulation effects for designing intermittent stimulations.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Dandan Wang, Brian W. Howell, Eric C. Olson
Summary: The study found that alcohol exposure can induce tyrosine phosphorylation response in the fetal brain, affecting cortical development. This initial phosphorylation response activated by alcohol has the potential to disrupt multiple developmentally important signaling systems.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Gabriele Sebastianelli, Chiara Abagnale, Francesco Casillo, Ettore Cioffi, Vincenzo Parisi, Cherubino Di Lorenzo, Mariano Serrao, Camillo Porcaro, Jean Schoenen, Gianluca Coppola
Summary: This study compared the effects of visual stimulation on somatosensory processing in healthy volunteers and migraine patients. The results suggest a malfunctioning multisensory integration process in migraine patients, potentially caused by abnormal excitability of thalamo-cortical loops.
Review
Physiology
Rosa Cossart, Roustem Khazipov
Summary: This review focuses on the development and self-organized dynamics of hippocampal circuits, exploring their role in learning and memory. It is found that the development of hippocampal cells and circuits starts during embryonic neurogenesis, and later experiences are integrated onto this framework. The article reviews the development of hippocampal cells and circuits at anatomical and functional levels, and describes the emergence of network dynamics in the hippocampus. Finally, open questions are posed in the article.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Cindy Guerrero-Toro, Kseniia Koroleva, Elizaveta Ermakova, Oleg Gafurov, Polina Abushik, Pasi Tavi, Guzel Sitdikova, Rashid Giniatullin
Summary: This study investigated the role of glutamate in trigeminal nociception. The results showed that peripheral glutamate receptors have a pro-nociceptive effect in the trigeminovascular system, and this effect is enhanced by CGRP. NMDA also activated slowly desensitizing currents in some TG neurons. These findings suggest that using magnesium supplements may be effective in the treatment of migraine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elena Gerasimova, Olga Yakovleva, Daniel Enikeev, Ksenia Bogatova, Anton Hermann, Rashid Giniatullin, Guzel Sitdikova
Summary: This study found that prenatal hyperhomocysteinemia increased the development of migraine-related symptoms and enhanced sensitivity to the migraine trigger nitroglycerin, suggesting that high levels of homocysteine may be a risk factor for migraine development.
Article
Endocrinology & Metabolism
Daria Vinokurova, Andrey Zakharov, Kseniya Chernova, Gulshat Burkhanova-Zakirova, Viktor Horst, Coline L. Lemale, Jens P. Dreier, Roustem Khazipov
Summary: The study investigates the development of ischemic lesions in the cortical depths using direct current coupled recordings in the rat barrel cortex. The results show that the lesions progress from the surface to the cortical depth and early changes in electrical activity can predict the severity of damage.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Kseniia Koroleva, Svetlana Svitko, Anton Ananev, Anastasiia Buglinina, Ksenia Bogatova, Olga Yakovleva, Dinara Nurmieva, Ilnar Shaidullov, Guzel Sitdikova
Summary: This study investigated the interaction between nitric oxide (NO) and TRPV1 and P2X3 receptors in the nociceptive activity of the meningeal trigeminal afferents. The results showed that both exogenous and endogenous NO increased the activity of the trigeminal nerve independent of the inhibition of TRPV1 and P2X3 receptors. Chronic NO administration did not increase the number of degranulated mast cells in the rat meninges, but it positively modulated the activity of TRPV1 receptors by S-nitrosylation, which may contribute to the sensitization of meningeal afferents in chronic migraine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marat A. Mukhamedyarov, Aydar N. Khabibrakhmanov, Venera F. Khuzakhmetova, Arthur R. Giniatullin, Guzalia F. Zakirjanova, Nikita V. Zhilyakov, Kamilla A. Mukhutdinova, Dmitry V. Samigullin, Pavel N. Grigoryev, Andrey V. Zakharov, Andrey L. Zefirov, Alexey M. Petrov
Summary: Amyotrophic lateral sclerosis (ALS) is a disease characterized by skeletal muscle denervation, motor neuron loss, and respiratory failure. Mutations in the FUS gene are a common genetic cause of ALS, resulting in degeneration. In mutant FUS mice at the pre-onset stage, early structural and functional alterations in diaphragm neuromuscular junctions (NMJs) were observed. Lipid peroxidation and decreased lipid raft staining were found in the mutant mice. Despite preserved end-plate structure, increased levels of presynaptic proteins and impaired neurotransmitter release were observed in FUS mice. These findings suggest that alterations in membrane properties, synapsin 1 levels, and calcium kinetics could be early indicators of nascent NMJ pathology in ALS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Konstantin N. Zabegalov, Fabiano Costa, Yuliya A. Viktorova, Gleb O. Maslov, Tatiana O. Kolesnikova, Elena Gerasimova, Vladimir P. Grinevich, Evgeny A. Budygin, Allan Kalueff
Summary: This study investigated the behavioral effects of GBR 12909, a selective dopamine transporter (DAT) blocker, in zebrafish. The results showed that acute treatment with GBR 12909 resulted in hypolocomotion, anxiety-like state, and impaired spatial cognition in zebrafish. These behavioral effects are similar to those observed in DAT knockout rodents and zebrafish, as well as other DAT-inhibiting drugs of abuse such as cocaine and D-amphetamine.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Azat Gainutdinov, Dmitrii Shipkov, Mikhail Sintsov, Lorenzo Fabrizi, Azat Nasretdinov, Roustem Khazipov, Guzel Valeeva
Summary: In this study, scientists observed that somatosensory stimulation in newborn rats can evoke similar electrical activity as spontaneous early sharp waves (eSPWs), suggesting that sensory feedback from movements is involved in the association of eSPWs with myoclonic movements in neonatal rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bulat Mingazov, Daria Vinokurova, Andrei Zakharov, Roustem Khazipov
Summary: Brain ischemia leads to slow voltage shifts in the cerebral cortex, including spreading depolarization (SD) and negative ultraslow potentials (NUPs), which are markers of brain injury. Different electrode materials and locations result in varying SD and NUP features. This study compared terminal cortical events during isoflurane or sevoflurane euthanasia using iridium and Ag/AgCl-based electrodes in the rat somatosensory cortex. The findings suggest that Ag and Ir electrodes can reliably assess early manifestations of terminal brain injury, but the late phase of NUP, which is present only on Ir electrodes, may be related to a yet unidentified factor associated with brain death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Aleksey V. Zaitsev, Roustem Khazipov
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Maxim Sheroziya, Roustem Khazipov
Summary: During the critical period of postnatal development, the brain is highly sensitive to external stimuli. In newborn rodents, the interaction between strong excitatory and inhibitory synapses and weak intrinsic currents in the thalamocortical system contributes to sensory-evoked early gamma oscillations and spindle bursts.
Editorial Material
Biochemistry & Molecular Biology
Guzel Sitdikova, Anton Hermann
Meeting Abstract
Medicine, General & Internal
A. Detterer, K. Koroleva, E. Ermakova, S. Svitko, G. Sitdikova
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Medicine, General & Internal
A. Detterer, I. Shaidullov, D. Sorokina, F. Sitdikov, G. Sitdikova
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
