期刊
NEUROLOGIA I NEUROCHIRURGIA POLSKA
卷 57, 期 1, 页码 14-25出版社
VIA MEDICA
DOI: 10.5603/PJNNS.a2023.0014
关键词
SARS-CoV-2; spike protein; blood-brain barrier; encephalopathy; stroke; cytokine storm; neuroinflammation
The typical manifestation of COVID-19 is severe acute respiratory syndrome and pneumonia, but it can also affect the brain, causing chronic neurological symptoms known as long COVID-19. The virus can enter the brain through interactions with host molecules, leading to complications such as stroke or encephalopathy. The molecular mechanism of how the virus affects the brain still needs further research.
The typical manifestation of coronavirus 2 (CoV-2) infection is a severe acute respiratory syndrome (SARS) accompanied by pneumonia (COVID-19). However, SARS-CoV-2 can also affect the brain, causing chronic neurological symptoms, variously known as long, post, post-acute, or persistent COVID-19 condition, and affecting up to 40% of patients. The symptoms (fatigue, dizziness, headache, sleep disorders, malaise, disturbances of memory and mood) usually are mild and resolve spontaneously. However, some patients develop acute and fatal complications, including stroke or encep-halopathy. Damage to the brain vessels mediated by the coronavirus spike protein (S-protein) and overactive immune responses have been identified as leading causes of this condition. However, the molecular mechanism by which the virus affects the brain still needs to be fully delineated. In this review article, we focus on interactions between host molecules and S-protein as the mechanism allowing the transit of SARS-CoV-2 through the blood-brain barrier to reach the brain structures. In addition, we discuss the impact of S-protein mutations and the involvement of other cellular factors condi-tioning the pathophysiology of SARS-CoV-2 infection. Finally, we review current and future COVID-19 treatment options.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据